Article: New cut-off point for D-dimer in the diagnosis of pulmonary embolism during pregnancy.
2021 Volume 56, Issue 3, Page(s) 150–155
Abstract: Background: Considering that pulmonary embolism (PE) is one of the leading causes of mortality among pregnant women and that the D-dimer level in pregnancy can be highly fluctuating, a new and reliable D-dimer reference value is essential to identifying ...
| Abstract | Background: Considering that pulmonary embolism (PE) is one of the leading causes of mortality among pregnant women and that the D-dimer level in pregnancy can be highly fluctuating, a new and reliable D-dimer reference value is essential to identifying PE in this group of patients. Hence, the present study aimed to evaluate the diagnostic effect of D-dimer testing in pregnant women with suspected PE. Methods: This study recruited 100 women with confirmed pregnancy or six weeks after delivery or abortion with suspected PE symptoms. Wells criteria, D-dimer values, and pregnancy trimesters were recorded. Definitive PE results were obtained using multidetector computed tomography (MDCT) or pulmonary ventilation/perfusion scans. Results: D-dimer cut-off point in PE diagnosis was higher than 1,447 µg/L [sensitivity, 87.5%; specificity, 63.04%; area under the curve (AUC)=0.735; Conclusion: The new cut-off points of 1,447 and 1,962 µg/L were determined for D-dimer in pregnant women with likely and unlikely PE, respectively. Moreover, the new cut-off points in the first and second trimesters of pregnancy were 1,701 µg/L and 1,451 µg/L, respectively, which indicated no statistically acceptable diagnostic value. |
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| Language | English |
| Publishing date | 2021-08-16 |
| Publishing country | Korea (South) |
| Document type | Journal Article |
| ZDB-ID | 2711910-5 |
| ISSN | 2288-0011 ; 2287-979X |
| ISSN (online) | 2288-0011 |
| ISSN | 2287-979X |
| DOI | 10.5045/br.2021.2021069 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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