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Article ; Online: Past, Present and Future of Human Milk Research.

De Castro, Sarabeth V / Thakkar, Sagar K

Nestle Nutrition Institute workshop series

2023 Volume 97, Page(s) 20–29

Abstract: Human milk is the best source of infant nutrition and is recognized as a biological fluid vital for optimal growth and development. It has established short- and long-term benefits to infants and mothers. Sapiens' milk has coevolved with mammalian ... ...

Abstract	Human milk is the best source of infant nutrition and is recognized as a biological fluid vital for optimal growth and development. It has established short- and long-term benefits to infants and mothers. Sapiens' milk has coevolved with mammalian species for millennia which has resulted in this remarkable secretory product of nutrient-rich milk. The nutritional composition and nonnutritive bioactive factors in human milk are uniquely appropriate for the infant, which provides survival and healthy development. Research over the past 2-3 decades focused on increasing the understanding about the composition of human milk and different factors that influence the composition such as stage of lactation, impact of maternal diet, geographical location, gestational age at infant birth, and circadian rhythm. Presently, collaborative efforts are ongoing in communicating the clinical advantages of human milk composition in relation to public health. Different groups are also working on the establishment of reference in the form of databases using reference and growth standard methodology. Toward the future, with computational and modeling methods, the next stage is to understand human milk as a biological system. Cellular agriculture is also the next exciting field of human milk research.
MeSH term(s)	Female ; Humans ; Infant ; Breast Feeding ; Diet ; Infant Nutritional Physiological Phenomena ; Lactation ; Milk, Human
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1664-2155
ISSN (online)	1664-2155
DOI	10.1159/000529009
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Article ; Online: Everything That Wheezes Is Not Asthma: A Case Report.

Shah, Sagar K / Sabzghabaei, Natalie

Pediatric allergy, immunology, and pulmonology

2021 Volume 34, Issue 3, Page(s) 119–123

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Asthma/complications ; Asthma/diagnosis ; Asthma/drug therapy ; Bronchitis/diagnosis ; Bronchoscopy ; Child ; Heart Defects, Congenital ; Humans ; Male ; Univentricular Heart
Language	English
Publishing date	2021-06-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2566338-0
ISSN	2151-3228 ; 2151-321X
ISSN (online)	2151-3228
ISSN	2151-321X
DOI	10.1089/ped.2021.0006
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Article ; Online: Miniaturized double transit magnetic field measurement probe using the Faraday rotation principle.

Kanchi, Sunil / Shukla, Rohit / Dey, Premananda / Dubey, A K / Sagar, K / Sharma, Archana

Applied optics

2022 Volume 62, Issue 4, Page(s) 1123–1129

Abstract: This paper presents the design and experimental results of a double transit magnetic field measurement probe based on the Faraday rotation principle using terbium doped borosilicate glass as a sensor element. When the magnetic field is applied in the ... ...

Abstract	This paper presents the design and experimental results of a double transit magnetic field measurement probe based on the Faraday rotation principle using terbium doped borosilicate glass as a sensor element. When the magnetic field is applied in the direction of propagation of light through the glass, the Faraday effect produces non-reciprocal circular birefringence. This property of the Faraday effect adds rotations when the light beam is reflected using a mirror placed at the other end of the glass and passed through the glass, making double transit of light through the sensor element. Experiments were carried out to verify the characteristics of the designed probe by inserting it inside the solenoid load coil. The Verdet constant of the glass is determined using the slope of the linear least-squares fitted curve between the Faraday rotation angle and the applied magnetic field, obtained as 89.22
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.479671
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Article ; Online: Inflammation-induced sialin mediates nitrate efflux in dysfunctional endothelium affecting NO bioavailability.

Akhtar, Shamima / Sagar, Komal / Singh, Aishwarya / Hote, Milind P / Roy, Ambuj / Sharma, Alpana

Nitric oxide : biology and chemistry

2024 Volume 146, Page(s) 37–47

Abstract: Aim: The mechanism of NO bioavailability in endothelial dysfunction, the trigger for atherogenesis is still unclear as exogenous nitrate therapy fails to alleviate endothelial dysfunction. Recently, sialin, a nitrate transporter, has been linked to ... ...

Abstract	Aim: The mechanism of NO bioavailability in endothelial dysfunction, the trigger for atherogenesis is still unclear as exogenous nitrate therapy fails to alleviate endothelial dysfunction. Recently, sialin, a nitrate transporter, has been linked to affect tissue nitrate/nitrite levels. Hence, we investigated the role of sialin in NO bioavailability in endothelial dysfunction. Methods: Serum-starved HUVECs were stimulated with either TNFα or AT-2 for 24 h either alone or in the presence of autophagy inducer or autophagy inhibitor alone. Nitric oxide, nitrite, and nitrate levels were measured in cell supernatant and cell lysate. Quantitative real-time PCR, Annexin V-PI, and monocyte adhesion assays were performed. Immunofluorescence staining for sialin, vWF, and LC3 was performed. STRING database was used to create protein interacting partners for sialin. Results: Sialin is strongly expressed in activated EC in vitro and atherosclerotic plaque as well as tumor neo-vessel ECs. Sialin mediates nitrate ion efflux and is negatively regulated by autophagy via mTOR pathway. Blocking sialin enhances NO bioavailability, autophagy, cell survival, and eNOS expression while decreasing monocyte adhesion. PPI shows LGALS8 to directly interact with sialin and regulate autophagy, cell-cell adhesion, and apoptosis. Conclusion: Sialin is a potential novel therapeutic target for treating endothelial dysfunction in atherosclerosis and cancer.
MeSH term(s)	Humans ; Nitric Oxide/metabolism ; Nitrates/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Autophagy ; Inflammation/metabolism ; Cell Adhesion ; Sialomucins/metabolism
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Nitrates ; Sialomucins
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1362794-6
ISSN	1089-8611 ; 1089-8603
ISSN (online)	1089-8611
ISSN	1089-8603
DOI	10.1016/j.niox.2024.04.002
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Article ; Online: Ensuring vaccine potency and availability: how evidence shaped Gavi's Immunization Supply Chain Strategy.

Prosser, Wendy / Sagar, Karan / Seidel, Michelle / Alva, Soumya

BMC health services research

2022 Volume 22, Issue 1, Page(s) 1237

Abstract: Background: In 2014, Gavi and partners developed a global Immunization Supply Chain (iSC) Strategy, 2015-2020, which prioritized functioning cold chain equipment (CCE) and additional storage capacity. In 2016, Gavi launched the Cold Chain Equipment ... ...

Abstract	Background: In 2014, Gavi and partners developed a global Immunization Supply Chain (iSC) Strategy, 2015-2020, which prioritized functioning cold chain equipment (CCE) and additional storage capacity. In 2016, Gavi launched the Cold Chain Equipment Optimization Platform (CCEOP) as a funding mechanism to improve CCE availability. In 2018, Gavi commissioned an evaluation of CCEOP in Guinea, Kenya and Pakistan. The global iSC Strategy has recently been revised, drawing on findings from effective vaccine management assessments and practical experiences. This case study presents the CCEOP evaluation and how its findings reinforced the revision of the iSC strategy. Methods: The CCEOP evaluation used a prospective mixed-methods research design in all three countries involving key informant interviews at multiple levels of the health system, document reviews, direct observation (as and when possible), and a health facility assessment. Results: Results show that CCEOP was effective at increasing the number of available and reliable CCE, and establishing improved management processes using the project management team (PMT) approach for country management systems and the service bundle provider approach for installation and maintenance. CCEOP also extended the iSC and immunization services in countries. The evaluation results also show gaps in the overall supply chain system, including CCE maintenance. Discussion: Gavi has recently revised its iSC strategy, which has addressed gaps identified through assessments and practical experiences from stakeholders. Results of the CCEOP evaluation reinforce many of these findings. The strategy now provides more emphasis on supporting the fundamental infrastructure and establishing strong processes for maintenance. It also emphasizes strategic planning and forward thinking for iSC decisions, building on the processes established for the PMT through CCEOP. The original iSC strategy was an impetus for the establishment of CCEOP. The new strategy reflects shifting trends and priorities to fill gaps identified through practical experience, advocated for by stakeholders and thought leaders engaged in the iSC, and validated by the evaluation. It demonstrates the importance of aligning stakeholders with clear objectives and a sound strategy.
MeSH term(s)	Humans ; Immunization ; Immunization Programs ; Prospective Studies ; Vaccine Potency ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2022-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-022-08616-9
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Article: Mathematical modelling and characterization of drying of pre-treated sweet corn (

Kumar, Navneet / Sagar, Kachhadiya / Seth, Neeraj

Journal of food science and technology

2022 Volume 59, Issue 10, Page(s) 3989–3996

Abstract: The pre-treated sweet corn samples were dried at temperatures of 55, 60, 65 and 70 °C and thin layer drying characteristics of sweet corn were assessed. Mathematical models were fitted and evaluated using ... ...

Abstract	The pre-treated sweet corn samples were dried at temperatures of 55, 60, 65 and 70 °C and thin layer drying characteristics of sweet corn were assessed. Mathematical models were fitted and evaluated using R
Language	English
Publishing date	2022-04-01
Publishing country	India
Document type	Journal Article
ZDB-ID	242498-8
ISSN	0975-8402 ; 0022-1155
ISSN (online)	0975-8402
ISSN	0022-1155
DOI	10.1007/s13197-022-05438-9
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Article: Quantitative estimation of total phenols in Calyptocarpus vialis-An emerging weed in Karnataka

Sagar, Kavitha

Indian journal of weed science. 2016, v. 48, no. 4

2016

Abstract: Calyptocarpus vialis Less. (Asteraceae) commonly known as straggler daisy, has already become aggressive invasive species in Karnataka (Rao and Sagar 2012) in Mysuru, Bengaluru, Ballari, Dharwad, Hubballi, Vijayapura, Kalaburagi (South India). It is now ... ...

Abstract	Calyptocarpus vialis Less. (Asteraceae) commonly known as straggler daisy, has already become aggressive invasive species in Karnataka (Rao and Sagar 2012) in Mysuru, Bengaluru, Ballari, Dharwad, Hubballi, Vijayapura, Kalaburagi (South India). It is now spreading rapidly in other places in Karnataka. Due to its monoculture thickets, associated floras have been suppressed. This directly points towards its allelochemical released into the environment. Present study was carried out in order to quantify the total phenols which are responsible for the invasive and aggressive nature of C. vialis.
Keywords	Asteraceae ; invasive species ; weeds ; India
Language	English
Dates of publication	2016-01
Size	p. 470-472.
Publishing place	Indian Society of Weed Science
Document type	Article
Note	NAL-AP-2-clean
ISSN	0974-8164
DOI	10.5958/0974-8164.2016.00122.2
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Incidence and patient characteristics of venous thromboembolism during neoadjuvant chemotherapy for ovarian cancer.

Chokshi, Sagar K / Gaughan, John P / Krill, Lauren

Journal of thrombosis and thrombolysis

2021 Volume 53, Issue 1, Page(s) 202–207

Abstract: There is paucity of data on venous thromboembolism (VTE) in patients receiving neoadjuvant chemotherapy (NACT) for advanced stage ovarian cancer. We explored the incidence and predictors of VTE in this patient population. We performed a retrospective ... ...

Abstract	There is paucity of data on venous thromboembolism (VTE) in patients receiving neoadjuvant chemotherapy (NACT) for advanced stage ovarian cancer. We explored the incidence and predictors of VTE in this patient population. We performed a retrospective review of women with primary ovarian, fallopian tube or peritoneal cancer who received NACT between January 2012 and October 2018 at Cooper University Hospital. Patients with history of VTE, heparin therapy or direct oral anticoagulant use prior to cancer diagnosis were excluded. The primary outcome was incidence of deep vein thrombosis (DVT) or pulmonary embolism (PE) after cancer diagnosis. We explored demographic and clinical variables associated with VTE. Of 90 patients included, 25 (28%) were diagnosed with VTE and 16 (64%) had PE. Eight patients were diagnosed after cancer diagnosis prior to the start of chemotherapy and 17 patients during NACT. Most patients had stage III disease and serous adenocarcinoma. There was a trend towards increased risk of VTE for Black patients (OR 3.22; CI 0.997-10.42; P = 0.051). Significantly fewer patients with VTE had debulking surgery (60% vs. 88%, P = 0.005). The risk of DVT increased by 8.7% per year of age (OR 1.087; 95% CI 1.01-1.17). Obesity, smoking status, medical comorbidities, disease stage, histology, invasive diagnostic surgery, and length of NACT were not associated with VTE. The incidence of VTE during neoadjuvant chemotherapy is high. Older age and Black race may increase the risk of VTE, and this morbid complication may adversely impact cancer treatment.
MeSH term(s)	Female ; Humans ; Incidence ; Neoadjuvant Therapy/adverse effects ; Ovarian Neoplasms/complications ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery ; Pulmonary Embolism/etiology ; Retrospective Studies ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology
Language	English
Publishing date	2021-06-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-021-02511-6
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Article ; Online: Acetate Assistance in Regioselective Hydroamination of Allenamides: A Combined Experimental and Density Functional Theory Study.

Pradhan, Tapas R / Farah, Abdikani Omar / Sagar, Kadiyala / Wise, Henry R / Srimannarayana, Malempati / Cheong, Paul Ha-Yeon / Park, Jin Kyoon

The Journal of organic chemistry

2024 Volume 89, Issue 9, Page(s) 5927–5940

Abstract: A key factor in the development of selective nucleophilic addition to allenamides is controlling the reactivity of electrophilic intermediates, which is generally achieved using an electrophilic activator via conjugated iminium intermediates. In this ... ...

Abstract	A key factor in the development of selective nucleophilic addition to allenamides is controlling the reactivity of electrophilic intermediates, which is generally achieved using an electrophilic activator via conjugated iminium intermediates. In this combined experimental and computational study, we show that a general and highly chemoselective hydroamination of allenamides can be accomplished using a combination of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) and NaOAc. Experimental mechanistic studies revealed that HFIP mediates proton transfer to activate the allenamide, while the acetate additive significantly contributes to N-selective interception. This strategy enables a general hydroamination of allenamides without the use of metals. We demonstrated that various functionalized 1,3-diamines could be readily synthesized and diversified into value-added structural motifs. Detailed mechanistic investigations using the density functional theory revealed the role of NaOAc in the formation of reactive electrophilic intermediates, which ultimately governed the selective formation of 1,3-diamine products. Critically, calculations of the potential energy surface around the proton-transfer transition state revealed that two different reactive electrophilic intermediates were formed when NaOAc was added.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02509
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Article ; Online: A novel rhodamine-based optical probe for mercury(II) ion in aqueous medium: A nanomolar detection, wide pH range and real water sample application.

Patil, Sagar K / Das, Dipanwita

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2019 Volume 225, Page(s) 117504

Abstract: In present work, we designed and synthesized new chemosensor RPy, containing the rhodamine and 2,6-pyridinedicarboxaldehyde functionality, for the selective detection of mercury (II) ( ... ...

Abstract	In present work, we designed and synthesized new chemosensor RPy, containing the rhodamine and 2,6-pyridinedicarboxaldehyde functionality, for the selective detection of mercury (II) (Hg
Language	English
Publishing date	2019-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2019.117504
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