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Article ; Online: Radial artery pseudoaneurysm following pediatric arterial cannulation.

Munaf, Mamatha / Gadhinglajkar, Shrinivas / N Nayanar, V Krishna / Dash, Prasanta K / Puthuvasserry, Suneel / Sagar, Sunil

Annals of cardiac anaesthesia

2023 Volume 26, Issue 3, Page(s) 359–360

MeSH term(s)	Humans ; Child ; Radial Artery/diagnostic imaging ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Catheterization, Peripheral/adverse effects ; Ultrasonography, Interventional
Language	English
Publishing date	2023-07-19
Publishing country	India
Document type	Letter
ZDB-ID	2106866-5
ISSN	0974-5181 ; 0971-9784
ISSN (online)	0974-5181
ISSN	0971-9784
DOI	10.4103/aca.aca_171_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photosensitized reactive chlorine species-mediated therapeutic destruction of drug-resistant bacteria using plasmonic core-shell Ag@AgCl nanocubes as an external nanomedicine.

Thangudu, Suresh / Kulkarni, Sagar Sunil / Vankayala, Raviraj / Chiang, Chi-Shiun / Hwang, Kuo Chu

Nanoscale

2020 Volume 12, Issue 24, Page(s) 12970–12984

Abstract: Due to the rapid growth of drug-resistant bacterial infections, there is an urgent need to develop innovative antimicrobial strategies to conquer the bacterial antibiotic resistance problems. Although a few nanomaterial-based antimicrobial strategies ... ...

Abstract	Due to the rapid growth of drug-resistant bacterial infections, there is an urgent need to develop innovative antimicrobial strategies to conquer the bacterial antibiotic resistance problems. Although a few nanomaterial-based antimicrobial strategies have been developed, the sensitized formation of cytotoxic reactive chlorine species (RCS), including chlorine gas and chlorine free radicals, by photo-activatable plasmonic nanoparticles for evading drug-resistant bacterial infections has not yet been reported. To address this challenge, herein, we report the synthesis of an unprecedented plasmonic core-shell Ag@AgCl nanocrystal through an in situ oxidation route for the photo-induced generation of highly cytotoxic RCS. We present the detailed in vitro and in vivo investigations of visible light activated Ag@AgCl nanostructure-mediated evasion of drug-resistant bacteria. In particular, the in vivo results demonstrate the complete reepithelialization of the methicillin-resistant Staphylococcus aureus (MRSA) infected wounds on skin upon phototherapeutic treatment mediated Ag@AgCl NCs. To the best of our knowledge, this is the first unique example of using Ag@AgCl NCs as an external nanomedicine for photo-induced generation of RCS to mediate effective killing of both Gram-positive and Gram-negative drug resistance bacteria and healing of the subcutaneous abscesses in an in vivo mouse model.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Chlorine ; Methicillin-Resistant Staphylococcus aureus ; Mice ; Nanomedicine ; Pharmaceutical Preparations ; Silver
Chemical Substances	Anti-Bacterial Agents ; Pharmaceutical Preparations ; Silver (3M4G523W1G) ; Chlorine (4R7X1O2820)
Language	English
Publishing date	2020-06-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d0nr01300e
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Article ; Online: Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics

Esau, Luke / Zhang, Guishan / Sagar, Sunil / Stingl, Ulrich / Bajić, V. B. / Kaur, Mandeep

BMC Complement Altern Med. 2019 Dec., v. 19, no. 1 p.142-142

2019

Abstract: BACKGROUND: Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions ... ...

Abstract	BACKGROUND: Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions require a large suite of secondary metabolites, these microbes have a huge potential as a source of novel anticancer molecules. METHODS: A total of 60 ethyl-acetate extracts of newly isolated strains from extreme environments of the Red-Sea were isolated and tested against several human cancer cell lines for potential cytotoxic and apoptotic activities. RESULTS: Isolates from the Erba brine-pool accounted for 50% of active bacterial extracts capable of inducing 30% or greater inhibition of cell growth. Among the 60 extracts screened, seven showed selectivity towards triple negative BT20 cells compared to normal fibroblasts. CONCLUSION: In this study, we identified several extracts able to induce caspase-dependent apoptosis in various cancer cell lines. Further investigations and isolation of the active compounds of these Red Sea brine pool microbes may offer a chemotherapeutic potential for cancers with limited treatment options.
Keywords	apoptosis ; cancer therapy ; cell growth ; complement ; cytotoxicity ; drug therapy ; ethyl acetate ; fibroblasts ; humans ; microbial communities ; neoplasm cells ; oxygen ; salinity ; secondary metabolites ; temperature ; Red Sea
Language	English
Dates of publication	2019-12
Size	p. 142.
Publishing place	BioMed Central
Document type	Article ; Online
Note	Resource is Open Access
ZDB-ID	2050429-9
ISSN	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-019-2554-0
Database	NAL-Catalogue (AGRICOLA)

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Article: Identification of

Esau, Luke / Sagar, Sunil / Bangarusamy, Dhinoth / Kaur, Mandeep

Genes & cancer

2016 Volume 7, Issue 9-10, Page(s) 309–322

Abstract: Cholesterol and its metabolites act as steroid hormone precursors, which promote estrogen receptor positive (ER+) breast cancer (BC) progression. Development of cholesterol targeting anticancer drugs has been hindered due to the lack of knowledge of ... ...

Abstract	Cholesterol and its metabolites act as steroid hormone precursors, which promote estrogen receptor positive (ER+) breast cancer (BC) progression. Development of cholesterol targeting anticancer drugs has been hindered due to the lack of knowledge of viable molecular targets. Till now, Cholesteryl ester transfer protein (CETP) has been envisaged as a feasible molecular target in atherosclerosis, but for the first time, we show that
Language	English
Publishing date	2016-12-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2538519-7
ISSN	1947-6027 ; 1947-6019
ISSN (online)	1947-6027
ISSN	1947-6019
DOI	10.18632/genesandcancer.122
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Article ; Online: Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics.

Esau, Luke / Zhang, Guishan / Sagar, Sunil / Stingl, Ulrich / Bajic, Vladimir B / Kaur, Mandeep

BMC complementary and alternative medicine

2019 Volume 19, Issue 1, Page(s) 142

Abstract: Background: Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions ... ...

Abstract	Background: Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions require a large suite of secondary metabolites, these microbes have a huge potential as a source of novel anticancer molecules. Methods: A total of 60 ethyl-acetate extracts of newly isolated strains from extreme environments of the Red-Sea were isolated and tested against several human cancer cell lines for potential cytotoxic and apoptotic activities. Results: Isolates from the Erba brine-pool accounted for 50% of active bacterial extracts capable of inducing 30% or greater inhibition of cell growth. Among the 60 extracts screened, seven showed selectivity towards triple negative BT20 cells compared to normal fibroblasts. Conclusion: In this study, we identified several extracts able to induce caspase-dependent apoptosis in various cancer cell lines. Further investigations and isolation of the active compounds of these Red Sea brine pool microbes may offer a chemotherapeutic potential for cancers with limited treatment options.
MeSH term(s)	Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Bacteria/chemistry ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Cell Line, Tumor ; Humans ; Indian Ocean ; Microbiota ; Salts/chemistry ; Seawater/microbiology
Chemical Substances	Antineoplastic Agents ; Salts ; brine
Language	English
Publishing date	2019-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-019-2554-0
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Article ; Online: Gamma Ray Irradiation Enhances the Linkage of Cotton Fabrics Coated with ZnO Nanoparticles

Aswin kumar Anbalagan / Shivam Gupta / Ashish kumar / Shu-Chih Haw / Sagar Sunil Kulkarni / Nyan-Hwa Tai / Fan-Gang Tseng / Kuo Chu Hwang / Chih-Hao Lee

ACS Omega, Vol 5, Iss 25, Pp 15129-

2020 Volume 15135

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pro-apoptotic activities of novel synthetic quinones in human cancer cell lines.

Sagar, Sunil / Green, Ivan R

Cancer letters

2009 Volume 285, Issue 1, Page(s) 23–27

Abstract: Four novel quinonoid compounds are evaluated for their apoptotic potential against three cancer cell lines, i.e. MCF-7, HeLa and MG-63. APOPercentage assay was used for the screening of the compounds and it was established that the apoptotic potential of ...

Abstract	Four novel quinonoid compounds are evaluated for their apoptotic potential against three cancer cell lines, i.e. MCF-7, HeLa and MG-63. APOPercentage assay was used for the screening of the compounds and it was established that the apoptotic potential of these compounds is cell line specific. The compound 2-(1',4'-benzoquinon-2'-yl)-5-hydroxy-7-methyl-1,4-naphthoquinone (S4) was found to be most active, which has a potential to kill approximately 99% of HeLa cancer cells in vitro after 72h at a concentration of 10microM. The compound's ability to induce specific markers of apoptosis in HeLa cells is further confirmed by DNA fragmentation and cell cycle assays.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Camptothecin/pharmacology ; Cell Cycle/drug effects ; Cell Survival/drug effects ; DNA Fragmentation ; Dose-Response Relationship, Drug ; HeLa Cells ; Humans ; Neoplasms/pathology ; Quinones/chemical synthesis ; Quinones/pharmacology ; Time Factors
Chemical Substances	Antineoplastic Agents ; Antineoplastic Agents, Phytogenic ; Quinones ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2009-11-18
Publishing country	Ireland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2009.04.036
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Zs.A 1177: Show issues

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Article ; Online: Evaluating the cytotoxic effects of novel quinone compounds.

Saibu, Morounke / Sagar, Sunil / Green, Ivan / Ameer, Farouk / Meyer, Mervin

Anticancer research

2014 Volume 34, Issue 8, Page(s) 4077–4086

Abstract: Background/aim: Quinone-containing compounds can induce cell death in cancer cells and are, therefore, promising lead compounds for the development of novel anti-cancer drugs.: Materials and methods: In the present study, we evaluated the cytotoxic ... ...

Abstract	Background/aim: Quinone-containing compounds can induce cell death in cancer cells and are, therefore, promising lead compounds for the development of novel anti-cancer drugs. Materials and methods: In the present study, we evaluated the cytotoxic effects of fifteen novel synthetic quinone-containing compounds in cell cultures in an attempt to establish structure/activity relationships for these compounds. The compounds were clustered into four groups (1, 2, 3, 4) based on common structural features. In vitro cell cultures were treated for 24 h with the compounds, after which cell viability was assessed by flow cytometry. The APOPercentage™ assay, the Terminal deoxynucleotidyl transferase mediated dUTP Nick End Labeling (TUNEL) assay and the caspase-3 assay was used to investigate the activation of apoptosis in the cells. Results: Compounds from groups 2 and 4 were highly toxic to the cells. The compounds induced apoptosis in some human cancer cell cultures and exhibited low toxicity towards the non-cancerous cell line, KMST-6. The induction of apoptosis in CHO cells was associated with the activation of caspase-3 cleavage, DNA fragmentation and the reactive oxygen species (ROS) generation. Conclusion: The present study demonstrates that five of the quinone-containing compounds induced apoptosis in human cancer cells and are therefore promising lead compounds for the development of novel anticancer drugs.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; CHO Cells ; Caspase 3/metabolism ; Cell Line, Tumor ; Cricetulus ; DNA Fragmentation ; Humans ; Quinones/pharmacology ; Reactive Oxygen Species/metabolism
Chemical Substances	Antineoplastic Agents ; Quinones ; Reactive Oxygen Species ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2014-08
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Zs.A 1642: Show issues

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Article ; Online: Synthesis and anticancer evaluation of spermatinamine analogues.

Moosa, Basem A / Sagar, Sunil / Li, Song / Esau, Luke / Kaur, Mandeep / Khashab, Niveen M

Bioorganic & medicinal chemistry letters

2016 Volume 26, Issue 6, Page(s) 1629–1632

Abstract: Spermatinamine was isolated from an Australian marine sponge, Pseudoceratina sp. as an inhibitor of isoprenylcysteine carboxyl methyltransferase (Icmt), an attractive and novel anticancer target. Herein, we report the synthesis of spermatinamine ... ...

Abstract	Spermatinamine was isolated from an Australian marine sponge, Pseudoceratina sp. as an inhibitor of isoprenylcysteine carboxyl methyltransferase (Icmt), an attractive and novel anticancer target. Herein, we report the synthesis of spermatinamine analogues and their cytotoxic evaluation against three human cancer cell lines, that is, cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF-7), and prostate carcinoma (DU145). Analogues 12, 14 and 15 were found to be the most potent against one or more cell lines with the IC50 values in the range of 5-10 μM. The obtained results suggested that longer polyamine linker along with aromatic oxime substitution provided the most potent analogue compounds against cancer cell lines.
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Spermine/analogs & derivatives ; Spermine/chemical synthesis ; Spermine/chemistry ; Spermine/pharmacology ; Structure-Activity Relationship ; Tyrosine/analogs & derivatives ; Tyrosine/chemical synthesis ; Tyrosine/chemistry ; Tyrosine/pharmacology
Chemical Substances	Antineoplastic Agents ; spermatinamine ; Spermine (2FZ7Y3VOQX) ; Tyrosine (42HK56048U)
Language	English
Publishing date	2016-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2016.01.083
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Zs.A 3203: Show issues

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Article ; Online: Gamma Ray Irradiation Enhances the Linkage of Cotton Fabrics Coated with ZnO Nanoparticles.

Anbalagan, Aswin Kumar / Gupta, Shivam / Kumar, Ashish / Haw, Shu-Chih / Kulkarni, Sagar Sunil / Tai, Nyan-Hwa / Tseng, Fan-Gang / Hwang, Kuo Chu / Lee, Chih-Hao

ACS omega

2020 Volume 5, Issue 25, Page(s) 15129–15135

Abstract: In this work, we aim to study zinc oxide (ZnO)-based functional materials over cotton fabrics and their effects after gamma ray exposure of 9 kGy. We found that the binding of the nanoparticles with cotton fabrics can be enhanced after irradiation. This ... ...

Abstract	In this work, we aim to study zinc oxide (ZnO)-based functional materials over cotton fabrics and their effects after gamma ray exposure of 9 kGy. We found that the binding of the nanoparticles with cotton fabrics can be enhanced after irradiation. This could be due to the oxygen deficiency or defects created in the interface between ZnO and cotton fabrics after irradiation. Near-edge X-ray absorption fine structure and X-ray photoelectron spectroscopy (XPS) were used to detect the oxygen inadequacies generated in the interior and at the surface of the ZnO nanoparticles after gamma ray exposure. XPS results showed that the binding energy of Zn shifts by 2 eV at 1.5 kGy and by 4 eV at 9 kGy. This huge shift of about 4 eV is completely different from other works due to the reaction that takes place on the interface between ZnO nanostructures and cotton fabrics after gamma ray irradiation. Overall, this work suggests that after gamma ray irradiation, there is an enhanced level of binding between the coated functional nanoparticles and cotton fabrics, which can be advantageous for the textile industries.
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.0c01050
Database	MEDical Literature Analysis and Retrieval System OnLINE

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