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Article ; Online: Corrigendum to ‘Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults

Pauline Versteegen / Marta Valente Pinto / Alex M. Barkoff / Pieter G.M. van Gageldonk / Jan van de Kassteele / Marlies A. van Houten / Elisabeth A.M. Sanders / Ronald de Groot / Dimitri A. Diavatopoulos / Sagida Bibi / Raakel Luoto / Qiushui He / Anne-Marie Buisman / Dominic F. Kelly / Jussi Mertsola / Guy A.M. Berbers

EBioMedicine, Vol 68, Iss , Pp 103420- (2021)

A collaborative study in Finland, the Netherlands, and the United Kingdom’

2021

Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rapid escape of new SARS-CoV-2 Omicron variants from BA.2-directed antibody responses

Aiste Dijokaite-Guraliuc / Raksha Das / Daming Zhou / Helen M. Ginn / Chang Liu / Helen M.E. Duyvesteyn / Jiandong Huo / Rungtiwa Nutalai / Piyada Supasa / Muneeswaran Selvaraj / Thushan I. de Silva / Megan Plowright / Thomas A.H. Newman / Hailey Hornsby / Alexander J. Mentzer / Donal Skelly / Thomas G. Ritter / Nigel Temperton / Paul Klenerman /

Eleanor Barnes / Susanna J. Dunachie / Cornelius Roemer / Thomas P. Peacock / Neil G. Paterson / Mark A. Williams / David R. Hall / Elizabeth E. Fry / Juthathip Mongkolsapaya / Jingshan Ren / David I. Stuart / Gavin R. Screaton / Christopher Conlon / Alexandra Deeks / John Frater / Siobhan Gardiner / Anni Jämsén / Katie Jeffery / Tom Malone / Eloise Phillips / Barbara Kronsteiner-Dobramysl / Priyanka Abraham / Sagida Bibi / Teresa Lambe / Stephanie Longet / Tom Tipton / Miles Carrol / Lizzie Stafford

Cell Reports, Vol 42, Iss 4, Pp 112271- (2023)

2023

Abstract: Summary: In November 2021, Omicron BA.1, containing a raft of new spike mutations, emerged and quickly spread globally. Intense selection pressure to escape the antibody response produced by vaccines or severe acute respiratory syndrome coronavirus 2 ( ... ...

Abstract	Summary: In November 2021, Omicron BA.1, containing a raft of new spike mutations, emerged and quickly spread globally. Intense selection pressure to escape the antibody response produced by vaccines or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection then led to a rapid succession of Omicron sub-lineages with waves of BA.2 and then BA.4/5 infection. Recently, many variants have emerged such as BQ.1 and XBB, which carry up to 8 additional receptor-binding domain (RBD) amino acid substitutions compared with BA.2. We describe a panel of 25 potent monoclonal antibodies (mAbs) generated from vaccinees suffering BA.2 breakthrough infections. Epitope mapping shows potent mAb binding shifting to 3 clusters, 2 corresponding to early-pandemic binding hotspots. The RBD mutations in recent variants map close to these binding sites and knock out or severely knock down neutralization activity of all but 1 potent mAb. This recent mAb escape corresponds with large falls in neutralization titer of vaccine or BA.1, BA.2, or BA.4/5 immune serum.
Keywords	CP: Immunology ; CP: Microbiology ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil

Sue Ann Costa Clemens / Pedro M. Folegatti / Katherine R. W. Emary / Lily Yin Weckx / Jeremy Ratcliff / Sagida Bibi / Ana Verena De Almeida Mendes / Eveline Pipolo Milan / Ana Pittella / Alexandre V. Schwarzbold / Eduardo Sprinz / Parvinder K. Aley / David Bonsall / Christophe Fraser / Michelle Fuskova / Sarah C. Gilbert / Daniel Jenkin / Sarah Kelly / Simon Kerridge /

Teresa Lambe / Natalie G. Marchevsky / Yama F. Mujadidi / Emma Plested / Maheshi N. Ramasamy / Peter Simmonds / Tanya Golubchik / Merryn Voysey / Andrew J. Pollard / the AMPHEUS Project / Oxford COVID Vaccine Trial Team

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 10

Abstract: Emerging variants of SARS-CoV-2 raise concerns about vaccine efficiency. Here, the authors present a post-hoc analysis for the ChAdOx1 nCoV-19 (AZD1222) vaccine trial in Brazil and provide efficacy against symptomatic COVID-19 caused by the Zeta (P.2) ... ...

Abstract	Emerging variants of SARS-CoV-2 raise concerns about vaccine efficiency. Here, the authors present a post-hoc analysis for the ChAdOx1 nCoV-19 (AZD1222) vaccine trial in Brazil and provide efficacy against symptomatic COVID-19 caused by the Zeta (P.2) and other variants.
Keywords	Science ; Q
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Responses to an acellular pertussis booster vaccination in children, adolescents, and young and older adults

Pauline Versteegen / Marta Valente Pinto / Alex M. Barkoff / Pieter G.M. van Gageldonk / dr. Jan van de Kassteele / dr. Marlies A. van Houten / prof. Elisabeth A.M. Sanders / prof. Ronald de Groot / dr. Dimitri A. Diavatopoulos / dr. Sagida Bibi / dr. Raakel Luoto / prof. Qiushui He / dr. Anne-Marie Buisman / dr. Dominic F. Kelly / prof. Jussi Mertsola / dr. Guy A.M. Berbers

EBioMedicine, Vol 65, Iss , Pp 103247- (2021)

A collaborative study in Finland, the Netherlands, and the United Kingdom

2021

Abstract: Background: Pertussis can lead to serious disease and even death in infants. Older adults are more vulnerable to complications as well. In high-income countries, acellular pertussis vaccines are used for priming vaccination. In the administration of ... ...

Abstract	Background: Pertussis can lead to serious disease and even death in infants. Older adults are more vulnerable to complications as well. In high-income countries, acellular pertussis vaccines are used for priming vaccination. In the administration of booster vaccinations to different age groups and target populations there is a substantial between-country variation. We investigated the effect of age on the response to acellular pertussis booster vaccination in three European countries. Methods: This phase IV longitudinal intervention study performed in Finland, the Netherlands and the United Kingdom between October 2017 and January 2019 compared the vaccine responses between healthy participants of four age groups: children (7–10y), adolescents (11–15y), young adults (20–34y), and older adults (60–70y). All participants received a three-component acellular pertussis vaccine. Serum IgG and IgA antibody concentrations to pertussis antigens at day 0, 28, and 1 year were measured with a multiplex immunoassay, using pertussis toxin concentrations at day 28 as primary outcome. This trial is registered with ClinicalTrialsRegister.eu (2016–003,678–42). Findings: Children (n = 109), adolescents (n = 121), young adults (n = 74), and older adults (n = 75) showed high IgG antibody concentrations to pertussis toxin at day 28 with GMCs of 147 (95% CI 120–181), 161 (95% CI 132–196), 103 (95% CI 80–133), and 121 IU/ml (95% CI 94–155), respectively. A significant increase in GMCs for vaccine antigens in all age groups by 28 days was found which had decreased by 1 year. Differences in patterns of IgG GMCs at 28 days and 1 year post-vaccination did not have a consistent relationship to age. In contrast, IgA antibodies for all antigens increased with age at all timepoints. Interpretation: Acellular pertussis booster vaccination induces significant serum IgG responses to pertussis antigens across the age range which are not uniformly less in older adults. Acellular boosters could be considered for older adults to reduce the health ...
Keywords	Vaccination ; Pertussis ; IGG ; IgA ; Children ; Adults ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intravenous immunoglobulin treatment in childhood encephalitis (IgNiTE)

Simon Nadel / Claire Cameron / David Pace / Rachel Kneen / Matilda Hill / Federico Martinón-Torres / Tom Solomon / Mandy Wan / Angela Vincent / Michael Absoud / Patrick Waters / Manish Sadarangani / Xinxue Liu / Andrew J Pollard / Sanjay Bhate / Ly-Mee Yu / John Alexander / Sarosh Irani / David Kerr /

Andrew Collinson / Ava Easton / William Whitehouse / Ming Lim / Emma Plested / Paul Heath / Dominic Smith / Michael Pike / Adilia Warris / Anna Riddell / Paddy McMaster / Simon Kerridge / Louise Willis / Christopher Clark / Victoria Gray / Jay Shetty / John Livingston / Kling Chong / Vishal Mehta / Charles Warlow / Jo Haviland / Alice Jollands / Shakeel Herwitker / Daniel O’Connor / Yama Mujadidi / Lauren Burke / Mildred Iro / Sagida Bibi / Liberty Cantrell / Mike Pike / Chris A. Clark / Sophie Bradshaw / Svetlana Milca / Mike Bale / Sonia Bale / Alan Percival / Meryn Voysey / Amy Beveridge / Amber Thompson / Parvinder Alley / Archana Desurkar / Elma Stephen / Steve Welch / Kayal Vijayakumar / Leena Mewasingh / Christian de Goede

BMJ Open, Vol 13, Iss

a randomised controlled trial

2023 Volume 11

Abstract: Objective To investigate whether intravenous immunoglobulin (IVIG) improves neurological outcomes in children with encephalitis when administered early in the illness.Design Phase 3b multicentre, double-blind, randomised placebo-controlled trial.Setting ... ...

Abstract	Objective To investigate whether intravenous immunoglobulin (IVIG) improves neurological outcomes in children with encephalitis when administered early in the illness.Design Phase 3b multicentre, double-blind, randomised placebo-controlled trial.Setting Twenty-one hospitals in the UK.Participants Children aged 6 months to 16 years with a diagnosis of acute or subacute encephalitis, with a planned sample size of 308.Intervention Two doses (1 g/kg/dose) of either IVIG or matching placebo given 24–36 hours apart, in addition to standard treatment.Main outcome measure The primary outcome was a ‘good recovery’ at 12 months after randomisation, defined as a score of≤2 on the Paediatric Glasgow Outcome Score Extended.Secondary outcome measures The secondary outcomes were clinical, neurological, neuroimaging and neuropsychological results, identification of the proportion of children with immune-mediated encephalitis, and IVIG safety data.Results 18 participants were recruited from 12 hospitals and randomised to receive either IVIG (n=10) or placebo (n=8) between 23 December 2015 and 26 September 2017. The study was terminated early following withdrawal of funding due to slower than anticipated recruitment, and therefore did not reach the predetermined sample size required to achieve the primary study objective; thus, the results are descriptive. At 12 months after randomisation, 9 of the 18 participants (IVIG n=5/10 (50%), placebo n=4/8 (50%)) made a good recovery and 5 participants (IVIG n=3/10 (30%), placebo n=2/8 (25%)) made a poor recovery. Three participants (IVIG n=1/10 (10%), placebo n=2/8 (25%)) had a new diagnosis of epilepsy during the study period. Two participants were found to have specific autoantibodies associated with autoimmune encephalitis. No serious adverse events were reported in participants receiving IVIG.Conclusions The IgNiTE (ImmunoglobuliN in the Treatment of Encephalitis) study findings support existing evidence of poor neurological outcomes in children with encephalitis. However, the study ...
Keywords	Medicine ; R
Subject code	150
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A haemagglutination test for rapid detection of antibodies to SARS-CoV-2

Alain Townsend / Pramila Rijal / Julie Xiao / Tiong Kit Tan / Kuan-Ying A. Huang / Lisa Schimanski / Jiandong Huo / Nimesh Gupta / Rolle Rahikainen / Philippa C. Matthews / Derrick Crook / Sarah Hoosdally / Susanna Dunachie / Eleanor Barnes / Teresa Street / Christopher P. Conlon / John Frater / Carolina V. Arancibia-Cárcamo / Justine Rudkin /

Nicole Stoesser / Fredrik Karpe / Matthew Neville / Rutger Ploeg / Marta Oliveira / David J. Roberts / Abigail A. Lamikanra / Hoi Pat Tsang / Abbie Bown / Richard Vipond / Alexander J. Mentzer / Julian C. Knight / Andrew J. Kwok / Gavin R. Screaton / Juthathip Mongkolsapaya / Wanwisa Dejnirattisai / Piyada Supasa / Paul Klenerman / Christina Dold / J. Kenneth Baillie / Shona C. Moore / Peter J. M. Openshaw / Malcolm G. Semple / Lance C. W. Turtle / Mark Ainsworth / Alice Allcock / Sally Beer / Sagida Bibi / Donal Skelly / Lizzy Stafford / Katie Jeffrey

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 12

Abstract: Serological detection of antibodies against SARS-CoV-2 can help establish rates of seroconversion. Here the authors develop a red cell agglutination test to detect antibodies against the receptor binding domain for distribution free of charge to ... ...

Abstract	Serological detection of antibodies against SARS-CoV-2 can help establish rates of seroconversion. Here the authors develop a red cell agglutination test to detect antibodies against the receptor binding domain for distribution free of charge to qualified research groups.
Keywords	Science ; Q
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus [version 2; peer review

Monique I. Andersson / Carolina V. Arancibia-Carcamo / Kathryn Auckland / J. Kenneth Baillie / Eleanor Barnes / Tom Beneke / Sagida Bibi / Tim Brooks / Miles Carroll / Derrick Crook / Kate Dingle / Christina Dold / Louise O. Downs / Laura Dunn / David W. Eyre / Javier Gilbert Jaramillo / Heli Harvala / Sarah Hoosdally / Samreen Ijaz /

Tim James / William James / Katie Jeffery / Anita Justice / Paul Klenerman / Julian C. Knight / Michael Knight / Xu Liu / Sheila F. Lumley / Philippa C. Matthews / Anna L. McNaughton / Alexander J. Mentzer / Juthathip Mongkolsapaya / Sarah Oakley / Marta S. Oliveira / Timothy Peto / Rutger J. Ploeg / Jeremy Ratcliff / Melanie J. Robbins / David J. Roberts / Justine Rudkin / Rebecca A. Russell / Gavin Screaton / Malcolm G. Semple / Donal Skelly / Peter Simmonds / Nicole Stoesser / Lance Turtle / Susan Wareing / Maria Zambon

Wellcome Open Research, Vol

2 approved]

2020 Volume 5

Abstract: Background: Laboratory diagnosis of SARS-CoV-2 infection (the cause of COVID-19) uses PCR to detect viral RNA (vRNA) in respiratory samples. SARS-CoV-2 RNA has also been detected in other sample types, but there is limited understanding of the clinical ... ...

Abstract	Background: Laboratory diagnosis of SARS-CoV-2 infection (the cause of COVID-19) uses PCR to detect viral RNA (vRNA) in respiratory samples. SARS-CoV-2 RNA has also been detected in other sample types, but there is limited understanding of the clinical or laboratory significance of its detection in blood. Methods: We undertook a systematic literature review to assimilate the evidence for the frequency of vRNA in blood, and to identify associated clinical characteristics. We performed RT-PCR in serum samples from a UK clinical cohort of acute and convalescent COVID-19 cases (n=212), together with convalescent plasma samples collected by NHS Blood and Transplant (NHSBT) (n=462 additional samples). To determine whether PCR-positive blood samples could pose an infection risk, we attempted virus isolation from a subset of RNA-positive samples. Results: We identified 28 relevant studies, reporting SARS-CoV-2 RNA in 0-76% of blood samples; pooled estimate 10% (95%CI 5-18%). Among serum samples from our clinical cohort, 27/212 (12.7%) had SARS-CoV-2 RNA detected by RT-PCR. RNA detection occurred in samples up to day 20 post symptom onset, and was associated with more severe disease (multivariable odds ratio 7.5). Across all samples collected ≥28 days post symptom onset, 0/494 (0%, 95%CI 0-0.7%) had vRNA detected. Among our PCR-positive samples, cycle threshold (ct) values were high (range 33.5-44.8), suggesting low vRNA copy numbers. PCR-positive sera inoculated into cell culture did not produce any cytopathic effect or yield an increase in detectable SARS-CoV-2 RNA. There was a relationship between RT-PCR negativity and the presence of total SARS-CoV-2 antibody (p=0.02). Conclusions: vRNA was detectable at low viral loads in a minority of serum samples collected in acute infection, but was not associated with infectious SARS-CoV-2 (within the limitations of the assays used). This work helps to inform biosafety precautions for handling blood products from patients with current or previous COVID-19.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Wellcome
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antibody testing for COVID-19

Emily R. Adams / Mark Ainsworth / Rekha Anand / Monique I. Andersson / Kathryn Auckland / J. Kenneth Baillie / Eleanor Barnes / Sally Beer / John I. Bell / Tamsin Berry / Sagida Bibi / Miles Carroll / Senthil K. Chinnakannan / Elizabeth Clutterbuck / Richard J. Cornall / Derrick W. Crook / Thushan de Silva / Wanwisa Dejnirattisai / Kate E. Dingle /

Christina Dold / Alexis Espinosa / David W. Eyre / Helen Farmer / Maria Fernandez Mendoza / Dominique Georgiou / Sarah J. Hoosdally / Alastair Hunter / Katie Jefferey / Dominic F. Kelly / Paul Klenerman / Julian Knight / Clarice Knowles / Andrew J. Kwok / Ullrich Leuschner / Robert Levin / Chang Liu / César López-Camacho / Jose Martinez / Philippa C. Matthews / Hannah McGivern / Alexander J. Mentzer / Jonathan Milton / Juthathip Mongkolsapaya / Shona C. Moore / Marta S. Oliveira / Fiona Pereira / Elena Perez / Timothy Peto / Rutger J. Ploeg / Andrew Pollard / Tessa Prince / David J. Roberts / Justine K. Rudkin / Veronica Sanchez / Gavin R. Screaton / Malcolm G. Semple / Jose Slon-Campos / Donal T. Skelly / Elliot Nathan Smith / Alberto Sobrinodiaz / Julie Staves / David I. Stuart / Piyada Supasa / Tomas Surik / Hannah Thraves / Pat Tsang / Lance Turtle / A. Sarah Walker / Beibei Wang / Charlotte Washington / Nicholas Watkins / James Whitehouse / National COVID Testing Scientific Advisory Panel

Wellcome Open Research, Vol

A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved]

2020 Volume 5

Abstract: Background: The COVID-19 pandemic caused >1 million infections during January-March 2020. There is an urgent need for reliable antibody detection approaches to support diagnosis, vaccine development, safe release of individuals from quarantine, and ... ...

Abstract	Background: The COVID-19 pandemic caused >1 million infections during January-March 2020. There is an urgent need for reliable antibody detection approaches to support diagnosis, vaccine development, safe release of individuals from quarantine, and population lock-down exit strategies. We set out to evaluate the performance of ELISA and lateral flow immunoassay (LFIA) devices. Methods: We tested plasma for COVID (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) IgM and IgG antibodies by ELISA and using nine different LFIA devices. We used a panel of plasma samples from individuals who have had confirmed COVID infection based on a PCR result (n=40), and pre-pandemic negative control samples banked in the UK prior to December-2019 (n=142). Results: ELISA detected IgM or IgG in 34/40 individuals with a confirmed history of COVID infection (sensitivity 85%, 95%CI 70-94%), vs. 0/50 pre-pandemic controls (specificity 100% [95%CI 93-100%]). IgG levels were detected in 31/31 COVID-positive individuals tested ≥10 days after symptom onset (sensitivity 100%, 95%CI 89-100%). IgG titres rose during the 3 weeks post symptom onset and began to fall by 8 weeks, but remained above the detection threshold. Point estimates for the sensitivity of LFIA devices ranged from 55-70% versus RT-PCR and 65-85% versus ELISA, with specificity 95-100% and 93-100% respectively. Within the limits of the study size, the performance of most LFIA devices was similar. Conclusions: Currently available commercial LFIA devices do not perform sufficiently well for individual patient applications. However, ELISA can be calibrated to be specific for detecting and quantifying SARS-CoV-2 IgM and IgG and is highly sensitive for IgG from 10 days following first symptoms.
Keywords	Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Wellcome
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens

Esther Willems / Jolein Gloerich / Anouk Suppers / Michiel van der Flier / Lambert P. van den Heuvel / Nicole van de Kar / Ria H.L.A. Philipsen / Maurice van Dael / Myrsini Kaforou / Victoria J. Wright / Jethro A. Herberg / Federico Martinon Torres / Michael Levin / Ronald de Groot / Alain J. van Gool / Dirk J. Lefeber / Hans J.C.T. Wessels / Marien I. de Jonge / Amina Abdulla /

Christoph Aebi / Koen van Aerde / Rachel Agbeko / Philipp Agyeman / Umberto D’alessandro / Ladan Ali / Wynand Alkema / Karen Allen / Fernando Álvez González / Suzanne Anderson / Imran Ansari / Tasnim Araf / Tanja Avramoska / Bryan Baas / Natalija Bahovec / Cristina Balo Farto / Anda Balode / A.M. Barendregt / Ruth Barral-Arca / María Barreiro Castro / Arta Bārzdiņa / David Bath / Sebastian Bauchinger / Lucas Baumard / Hinrich Baumgart / Frances Baxter / Ashley Bell / Kathryn Bell / Xabier Bello / Evangelos Bellos / Martin Benesch / Mirian Ben García / Joshua Bennet / Christoph Berger / J.M. van den Berg / Sara Bernhard-Stirnemann / Sagida Bibi / Christoph Bidlingmaier / Alexander Binder / Vera Binder / Kalifa Bojang / Dorine M. Borensztajn / Ulrich von Both / Karen Brengel-Pesce / Bryan van den Broek / Judith Buschbeck / Leo Calvo-Bado / Sandra Carnota / Enitan D. Carrol / Michael J. Carter / Miriam Cebey-López / Samba Ceesay / Astrid Ceolotto / Adora Chan / Elizabeth Cocklin / Kalvin Collings / Stephen Crulley / Aubrey Cunnington / María José Curras-Tuala / Katharina Danhauser / Saffiatou Darboe / Sarah Darnell / Tisham De / Dārta Deksne / Kirsty Devine / Juan Emmanuel Dewez / Julia Dudley / Carlos Durán Suárez / Ernst Eber / Irini Eleftheriou / Marieke Emonts / Daniel Fabian / Tobias Feuchtinger / Katy Fidler / Colin Fink / A.M. van Furth / Rachel Galassini / Siegfried Gallistl / Luisa García Vicente / Dace Gardovska / J. Geissler / G.P.J.M. Gerrits / Eric Giannoni / Ilona van der Giessen / Alberto Gómez-Carballa / Jose Gómez Rial / Gunther Gores / Dagne Grāvele / Matthias Griese / Ilze Grope / Meeru Gurung / L. de Haan / Nikolaus Haas / Dominic Habgood-Coote / Nienke N. Hagedoorn / Harald Haidl / Shea Hamilton / Almuthe Hauer / J. Heidema / Ulrich Heininger / Stefanie Henriet / Jethro Herberg / Clive Hoggart / Susanne Hösele / Sara Hourmat / Christa Hude / Martijn Huijnen / Heather Jackson / Rebecca Jennings / Joanne Johnston / Ilse Jongerius / Rikke Jorgensen / Christian Kahlert / Rama Kandasamy / Matthias Kappler / Julia Keil / Markus Keldorfer / Dominic F. Kell / Eunjung Kim / Sharon King / Lieke Kloosterhuis / Daniela S. Kohlfürst / Benno Kohlmaier / Laura Kolberg / Mojca Kolnik / Larissa Krenn / Taco Kuijpers / M. van der Kuip / Pilar Leboráns Iglesias / Simon Leigh / Manuel Leitner / M. van Leur / Emma Lim / Naomi Lin / Ching-Chuan Liu / Sabine Löffler / Eberhard Lurz / Ian Maconochie / Christine Mackerness / François Mallet / Federico Martinón-Torres / Antonis Marmarinos / Alex Martin / Mike Martin / José María Martinón Sánchez / Nazareth Martinón-Torres / Paul McAlinden / Anne McDonnell / Sam McDonald / C.J. Miedema / Anija Meiere / Stephanie Menikou / G. van Mierlo / Alec Miners / Ravi Mistry / Henriëtte A. Moll / Marine Mommert / Belén Mosquera Pérez / David R. Murdoch / Sobia Mustafa / Giancarlo Natalucci / C. Neeleman / Karen Newall / Samuel Nichols / Tobias Niedrist / Anita Niederer-Loher / Ruud Nijman / Ieva Nokalna / Urzula Nora Urbāne / Gudrun Nordberg / C.C. Obihara / Daniel O'Connor / Wilma Oosthoek / Veronika Osterman / Alexandre Pachot / D. Pajkrt / Jacobo Pardo-Seco / Stéphane Paulus / Jana Pavāre / Ivonne Pena Paz / Salina Persand / Andreas Pfleger / Klaus Pfurtscheller / Ria Philipsen / Ailsa Pickering / Benjamin Pierce / Heidemarie Pilch / Lidia Piñeiro Rodríguez / Sara Pischedda / Tina Plankar Srovin / Marko Pokorn / Andrew J. Pollard / Lena Pölz / Klara M. Posfay-Barbe / Petra Prunk / Zanda Pučuka / Glorija Rajic / Aqeela Rashid / Lorenzo Redondo-Collazo / Christa Relly / Irene Rivero Calle / Sara Rey Vázquez / Mathew Rhodes / Vivien Richmond / Thomas Riedel / Anna RocaIsatou Sarr / Siegfried Rödl / Carmen Rodríguez-Tenreiro / Sam Romaine / Emily Rowlands / Miguel Sadiki Ora / Manfred G. Sagmeister / Momodou Saidykhan / Antonio Salas / Luregn J. Schlapbach / D. Schonenberg / Fatou Secka / Katrīna Selecka / Sonia Serén Fernández / Cristina Serén Trasorras / Priyen Shah / Ching-Fen Shen / Shrijana Shrestha / Aleksandra Sidorova / Andrea Skrabl-Baumgartner / Giselle D’Souza / Matthias Sperl / Evelien Sprenkeler / Nina A. Schweintzger / Laura Stampfer / Molly Stevens / Martin Stocker / Volker Strenger / Dace Svile / Kelly Syggelou / Maria Tambouratzi / Chantal Tan / Emma Tavliavini / Evelyn Thomson / Stephen Thorson / Holger Till / G.A. Tramper-Stranders / Andreas Trobisch / Maria Tsolia / Effua Usuf / Lucille Valentine / Clementien L. Vermont / Marisol Vilas Iglesias / Katarina Vincek / Marie Voice / Gabriella de Vries / Diane Wallia / Shih-Min Wang / Clare Wilson / Amanda Wood / Phil Woodsford / Victoria Wright / Marietta Xagorari / Shunmay Yeung / Joany Zachariasse / Dace Zavadska / Syed M.A. Zaman / Judith Zandstra / Werner Zenz / Christoph Zurl / Manuela Zwerenz

iScience, Vol 26, Iss 8, Pp 107257- (2023)

2023

Abstract: Summary: Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an ... ...

Abstract	Summary: Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection.
Keywords	Health sciences ; Glycobiology ; Immunology ; Glycomics ; Science ; Q
Subject code	572
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED