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Article ; Online: Heparin-induced hyperkalemia, can LMWH cause hyperkalemia? A systematic review.

Amdetsion, Gedion Yilma / Gudeta, Aron / Lumley, Guy / Sagoo, Harkiran / Aliledhin, Ehab

EJHaem

2023 Volume 4, Issue 4, Page(s) 1110–1116

Abstract: Hyperkalemia, an elevated blood potassium concentration exceeding 5.0 mEq/L, is associated with adverse outcomes and is frequently observed in hospitalized patients. Drug-induced hyperkalemia accounts for a significant proportion of cases, with heparin, ... ...

Abstract	Hyperkalemia, an elevated blood potassium concentration exceeding 5.0 mEq/L, is associated with adverse outcomes and is frequently observed in hospitalized patients. Drug-induced hyperkalemia accounts for a significant proportion of cases, with heparin, commonly used for venous thrombosis prevention, suspected to contribute, though less recognized than other heparin-related side effects. Both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) have been implicated in inducing hyperkalemia, primarily through the suppression of aldosterone levels and modulation of angiotensin II receptors. This systematic review examines the relationship between heparin, particularly LMWH, and hyperkalemia. Thirteen studies involving 1407 patients were analyzed. Findings indicated a lack of highquality evidence, with no significant increase in potassium levels associated with LMWH use. LMWH did not exhibit a dose-response relationship with hyperkalemia incidence. Additionally, mechanisms underlying the hypothetical LMWHinduced hyperkalemia remained inconclusive. While this suggests that LMWH is unlikely to be a primary cause of hyperkalemia, caution is warranted, especially in patients with elevated baseline potassium levels.
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.801
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Compliance of systematic reviews in ophthalmology with the PRISMA statement.

Lee, Seon-Young / Sagoo, Harkiran / Farwana, Reem / Whitehurst, Katharine / Fowler, Alex / Agha, Riaz

BMC medical research methodology

2017 Volume 17, Issue 1, Page(s) 178

Abstract: Background: Systematic reviews and meta-analyses are becoming increasingly important methods to summarize published research. Studies of ophthalmology may present additional challenges because of their potentially complex study designs. The aim of this ... ...

Abstract	Background: Systematic reviews and meta-analyses are becoming increasingly important methods to summarize published research. Studies of ophthalmology may present additional challenges because of their potentially complex study designs. The aim of this study was to evaluate the reporting quality of systematic reviews and meta-analyses on topics in ophthalmology to determine compliance with the PRISMA guidelines. We assessed articles published between 2010 and 2015 in the five major relevant journals with the highest impact factors. Methods: The MEDLINE and EMBASE databases were searched to identify systematic reviews published between January 2010 and December 2015 in the following 5 major ophthalmology journals: Progress in Retinal and Eye Research, Ophthalmology, Archives of Ophthalmology, American Journal of Ophthalmology, and Survey of Ophthalmology. The screening, identification, and scoring of articles were independently performed by two teams, and the results were submitted to statistical analysis to determine medians, ranges, and 95% CIs. Results: A total of 115 articles were included. The median compliance was 15 out of 27 items (56%), the range was 5-26 (26-96%), and the inter-quartile range was 10 (37%). Compliance was highest in items related to the 'description of rationale' (item 3, 100%) and sequentially lower in 'the general interpretation of results' (item 26, 96%) and 'the inclusion of a structured summary in the abstract' (item 2, 90%). Compliance was poorest in the items 'indication of review protocol and registration' (item 5, 9%), 'specification of risk of biases that may affect the cumulative evidence' (item 15, 24%), and 'description of clear objectives in the introduction' (item 4, 26%). Conclusion: The reporting quality of systematic reviews and meta-analyses in ophthalmology should be significantly improved. While we recommend the use of the PRISMA criteria as a guideline before journal submission, additional research aimed at identifying potential barriers to compliance may be required to improve compliance with PRISMA guidelines.
MeSH term(s)	Bias ; Guideline Adherence/standards ; Guidelines as Topic/standards ; Humans ; Meta-Analysis as Topic ; Ophthalmology ; Periodicals as Topic/standards ; Publishing/standards ; Quality Control ; Review Literature as Topic
Language	English
Publishing date	2017--28
Publishing country	England
Document type	Journal Article
ISSN	1471-2288
ISSN (online)	1471-2288
DOI	10.1186/s12874-017-0450-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An assessment of the compliance of systematic review articles published in craniofacial surgery with the PRISMA statement guidelines: A systematic review.

Pidgeon, Thomas Edward / Wellstead, Georgina / Sagoo, Harkiran / Jafree, Daniyal J / Fowler, Alexander J / Agha, Riaz A

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2016 Volume 44, Issue 10, Page(s) 1522–1530

Abstract: Context: Systematic review evidence is increasing within craniofacial surgery. Compliance with recognised reporting guidelines for systematic review evidence has not been assessed.: Objective: To assess the compliance of systematic reviews published ... ...

Abstract	Context: Systematic review evidence is increasing within craniofacial surgery. Compliance with recognised reporting guidelines for systematic review evidence has not been assessed. Objective: To assess the compliance of systematic reviews published in craniofacial journals with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting criteria. Data sources, search terms and study selection: Thomson Reuters impact factor was used to identify three top craniofacial journals. A search for all systematic review articles published in these journals from 1st May 2010 to 30th April 2015 was conducted using MEDLINE PubMed. Data extraction: Two independent researchers assessed each study for inclusion and performed the data extraction. Data included the article reference information; the pathology and interventions examined and compliance of each review article with the PRISMA checklist. Data synthesis and results: 97 studies were returned by the search. 62 studies proceeded to data extraction. The mean percentage of applicable PRISMA items that were met across all studies was 72.5% (range 28.6-96.2%). The area of poorest compliance was with the declaration of a study protocol (19.4% of studies). Only 37.1% of studies declared their source of funding. Conclusions: Compliance of systematic review articles within craniofacial surgery with areas of the PRISMA checklist could be improved.
MeSH term(s)	Guideline Adherence/statistics & numerical data ; Humans ; Orthognathic Surgery/standards ; Orthognathic Surgery/statistics & numerical data ; Periodicals as Topic/standards ; Periodicals as Topic/statistics & numerical data ; Review Literature as Topic
Language	English
Publishing date	2016-08-03
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2016.07.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Compliance of Systematic Reviews in Plastic Surgery With the PRISMA Statement.

Lee, Seon-Young / Sagoo, Harkiran / Whitehurst, Katharine / Wellstead, Georgina / Fowler, Alexander J / Agha, Riaz A / Orgill, Dennis

JAMA facial plastic surgery

2016 Volume 18, Issue 2, Page(s) 101–105

Abstract: Importance: Systematic reviews attempt to answer research questions by synthesizing the data in primary articles. They are an increasingly important tool within evidence-based medicine, guiding clinical practice, future research, and health care policy.! ...

Abstract	Importance: Systematic reviews attempt to answer research questions by synthesizing the data in primary articles. They are an increasingly important tool within evidence-based medicine, guiding clinical practice, future research, and health care policy. Objective: To determine the reporting quality of recent systematic reviews and meta-analyses in plastic surgery with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Methods: MEDLINE and EMBASE were searched for systematic reviews published between January 1, 2013, and December 31, 2014, in 5 major plastic surgery journals. Screening, identification, and data extraction were performed independently by 2 teams. Articles were reviewed for compliance with reporting of 27 items in the PRISMA checklist. Data analysis was conducted from January 1 to July 30, 2015. Main outcomes and measures: The sum of PRISMA checklist items (1-27) per systematic review. Results: From an initial set of 163 articles, 79 met the inclusion criteria. The median PRISMA score was 16 of 27 items (59%) (range, 6%-26%; 95% CI, 14%-17%). Compliance varied between individual PRISMA items. It was poorest for items related to the use of review protocol (item 5; 4 articles [5%]) and presentation of data on the risk of bias of each study (item 19; 14 articles [18%]). Compliance was the highest for description of rationale (item 3; 78 articles [99%]), sources of funding and other support (item 27; 75 articles [95%]), and inclusion of a structured summary in the abstract (item 2; 75 articles [95%]). Conclusions and relevance: The reporting quality of systematic reviews in plastic surgery requires improvement. Enforcement of compliance through journal submission systems, as well as improved education, awareness, and a cohesive strategy among all stakeholders, is called for. Level of evidence: NA.
MeSH term(s)	Meta-Analysis as Topic ; Review Literature as Topic ; Surgery, Plastic
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2702062-9
ISSN	2168-6092 ; 2168-6076
ISSN (online)	2168-6092
ISSN	2168-6076
DOI	10.1001/jamafacial.2015.1726
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of the mandatory implementation of reporting guidelines on reporting quality in a surgical journal: A before and after study.

Agha, Riaz Ahmed / Fowler, Alexander J / Limb, Christopher / Whitehurst, Katharine / Coe, Robert / Sagoo, Harkiran / Jafree, Daniyal J / Chandrakumar, Charmilie / Gundogan, Buket

International journal of surgery (London, England)

2016 Volume 30, Page(s) 169–172

Abstract: Background: Journals are an important conduit for the publication of research. However, the reporting quality of research has been shown to be lacking. We sought to determine if reporting quality could be improved by mandating compliance with the ... ...

Abstract	Background: Journals are an important conduit for the publication of research. However, the reporting quality of research has been shown to be lacking. We sought to determine if reporting quality could be improved by mandating compliance with the relevant reporting guidelines during the submission process to a single surgical journal. Methods: The policy above was implemented in the International Journal of Surgery (IJS) in March 2013. This involved requiring all authors submitting observational studies, randomised controlled trials (RCTs) and systematic reviews to submit completed STROBE, CONSORT and PRISMA Statement checklists respectively along with their paper, making them available to the editor and peer-reviewers. Articles were analysed in three distinct periods from 2012 to 2014, before and after guideline implementation by two independent teams. Results: Our results show that overall STROBE compliance following implementation of the policy increased by a statistically significant 12% (68%-77%, p = 0.00018). Similarly CONSORT compliance increased (50%-70%) as did PRISMA compliance (48%-76%). The items that improved the most were those providing detail on study design, outcome definitions as well as measurement, how patients and quantitative variables were handled during the analyses and discussing limitations and detailing potential sources of bias. Conclusion: Implementing a policy mandating the submission of a completed reporting guideline checklist for observational studies, RCTs and systematic reviews can increase compliance. We advocate this measure for other journals and for other study types.
MeSH term(s)	Biomedical Research/standards ; Clinical Studies as Topic/standards ; Guideline Adherence/standards ; Guidelines as Topic/standards ; Humans ; Mandatory Reporting ; Publications/standards ; Publishing/standards ; Research Design/standards
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2016.04.032
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Article: The Academic Surgical Collaborative: Launching a new trainee research collaborative.

Pidgeon, Thomas E / Fowler, Alexander J / Whitehurst, Katharine / Wellstead, Georgina / Gundogan, Buket / Sagoo, Harkiran K / Lee, Seon Young / Agha, Riaz

Annals of medicine and surgery (2012)

2015 Volume 4, Issue 2, Page(s) 133–135

Language	English
Publishing date	2015-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2015.04.020
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Article ; Online: Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies.

Wulaningsih, Wahyu / Sagoo, Harkiran K / Hamza, Mustafa / Melvin, Jennifer / Holmberg, Lars / Garmo, Hans / Malmström, Håkan / Lambe, Mats / Hammar, Niklas / Walldius, Göran / Jungner, Ingmar / Van Hemelrijck, Mieke

International journal of molecular sciences

2016 Volume 17, Issue 9

Abstract: To investigate the association between serum calcium and risk of breast cancer using a large cohort and a systematic review with meta-analysis. From the Swedish Apolipoprotein Mortality Risk (AMORIS) Study we included 229,674 women who had baseline ... ...

Abstract	To investigate the association between serum calcium and risk of breast cancer using a large cohort and a systematic review with meta-analysis. From the Swedish Apolipoprotein Mortality Risk (AMORIS) Study we included 229,674 women who had baseline measurements of serum total calcium and albumin. Multivariable Cox regression was used to assess the association between total and albumin-corrected calcium and breast cancer risk. For the systematic review, an electronic search of MEDLINE and EMBASE databases was performed to identify other prospective cohorts assessing the relationship between serum calcium and breast cancer risk. We pooled the results of our AMORIS cohort with other eligible studies in a meta-analysis using a random effects model. I² test was used to assess heterogeneity. In the AMORIS study, 10,863 women were diagnosed with breast cancer (mean follow-up: 19 years). We found an inverse association between total serum calcium and breast cancer when comparing the fourth quartile to the first quartile (HR: 0.94, 95% CI: 0.88-0.99, p value for trend 0.04) and similar results using albumin-corrected calcium. In the systematic review, we identified another two prospective cohorts evaluating pre-diagnostic serum total calcium and breast cancer. Combining these studies and our findings in AMORIS in a meta-analysis showed a protective effect of serum calcium against breast cancer, with a summary RR of 0.80 (95% CI: 0.66-0.97). No substantial heterogeneity was observed. Our findings in AMORIS and the meta-analysis support an inverse association between serum calcium and breast cancer risk, which warrants mechanistic investigations.
MeSH term(s)	Adult ; Biomarkers, Tumor/blood ; Breast Neoplasms/blood ; Breast Neoplasms/epidemiology ; Calcium/blood ; Female ; Humans ; Middle Aged ; Prospective Studies ; Sweden
Chemical Substances	Biomarkers, Tumor ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-09-06
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms17091487
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Article ; Online: Nipple sparing versus skin sparing mastectomy: a systematic review protocol.

Agha, Riaz A / Wellstead, Georgina / Sagoo, Harkiran / Al Omran, Yasser / Barai, Ishani / Rajmohan, Shivanchan / Fowler, Alexander J / Orgill, Dennis P / Rusby, Jennifer E

BMJ open

2016 Volume 6, Issue 5, Page(s) e010151

Abstract: Introduction: Breast cancer has a lifetime incidence of one in eight women. Over the past three decades there has been a move towards breast conservation and a focus on aesthetic outcomes while maintaining oncological safety. For some patients, ... ...

Abstract	Introduction: Breast cancer has a lifetime incidence of one in eight women. Over the past three decades there has been a move towards breast conservation and a focus on aesthetic outcomes while maintaining oncological safety. For some patients, mastectomy is the preferred option. There is growing interest in the potential use of nipple sparing mastectomy (NSM). However, oncological safety remains unproven, and the benefits and indications have not been clearly identified. The objective of this systematic review will be to determine the safety and efficacy of NSM as compared with skin sparing mastectomy (SSM). Methods and analysis: All original comparative studies including; randomised controlled trials, cohort studies and case-control studies involving women undergoing either NSM or SSM for breast cancer will be included. Outcomes are primary-relating to oncological outcomes and secondary-relating to clinical, aesthetic, patient reported and quality of life outcomes. A comprehensive electronic literature search, designed by a search specialist, will be undertaken. Grey literature searches will also be conducted. Eligibility assessment will occur in two stages; title and abstract screening and then full text assessment. Each step will be conducted by two trained teams acting independently. Data will then be extracted and stored in a database with standardised extraction fields to facilitate easy and consistent data entry. Data analysis will be undertaken to explore the relationship between NSM or SSM and preselected outcomes, heterogeneity will be assessed using the Cochrane tests. Ethics and dissemination: This systematic review requires no ethical approval. It will be published in a peer-reviewed journal. It will also be presented at national and international conferences. Updates of the review will be conducted to inform and guide healthcare practice and policy.
MeSH term(s)	Breast Neoplasms/surgery ; Humans ; Mastectomy, Segmental/adverse effects ; Mastectomy, Segmental/methods ; Nipples/surgery ; Organ Sparing Treatments ; Research Design ; Skin ; Systematic Reviews as Topic
Language	English
Publishing date	2016-05-20
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2747269-3
ISSN	2044-6055 ; 2044-6055 ; 2053-3624
ISSN (online)	2044-6055
ISSN	2044-6055 ; 2053-3624
DOI	10.1136/bmjopen-2015-010151
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Article: The First 500 Registrations to the Research Registry

Agha, Riaz / Fowler, Alexander J / Limb, Christopher / Al Omran, Yasser / Sagoo, Harkiran / Koshy, Kiron / Jafree, Daniyal J / Anwar, Mohammed Omer / McCullogh, Peter / Orgill, Dennis Paul

Frontiers in surgery

2016 Volume 3, Page(s) 50

Abstract: Introduction: The Declaration of Helsinki 2013 encourages the registration of all research studies involving human participants. However, emphasis has been placed on prospective clinical trials, and it is estimated that only 10% of observational studies ...

Abstract	Introduction: The Declaration of Helsinki 2013 encourages the registration of all research studies involving human participants. However, emphasis has been placed on prospective clinical trials, and it is estimated that only 10% of observational studies are registered. In response, Research Registry Methods: Since the launch of Research Registry Results: A total of 500 studies were registered on Research Registry Conclusions: Since its conception in February 2015, Research Registry
Language	English
Publishing date	2016-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2016.00050
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