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  1. Article ; Online: Determining the threshold for azathioprine use in recurrent diffuse alveolar hemorrhage in idiopathic pulmonary hemosiderosis.

    Saha, Biplab K

    The American journal of the medical sciences

    2023  Volume 366, Issue 2, Page(s) 155–156

    MeSH term(s) Humans ; Azathioprine/therapeutic use ; Lung Diseases/complications ; Lung Diseases/diagnostic imaging ; Lung Diseases/drug therapy ; Hemorrhage/drug therapy ; Hemorrhage/etiology ; Hemosiderosis/complications ; Hemosiderosis/drug therapy
    Chemical Substances Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2023-05-07
    Publishing country United States
    Document type Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2023.03.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pneumomediastinum: A Rare Complication of Endobronchial Ultrasound Guided Fine Needle Aspiration.

    Saha, Biplab K

    Prague medical report

    2022  Volume 123, Issue 1, Page(s) 43–47

    Abstract: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is a commonly performed outpatient procedure used for the diagnosis, staging of lung cancer, and the evaluation of thoracic lymphadenopathy of unknown origin. With the advent of ...

    Abstract Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is a commonly performed outpatient procedure used for the diagnosis, staging of lung cancer, and the evaluation of thoracic lymphadenopathy of unknown origin. With the advent of this minimally invasive technology, mediastinoscopy, once the gold standard, has fallen out of favour. Pneumomediastinum is a rare complication of EBUS-TBNA and can often be managed conservatively. We present a case of a 52-year-old female who developed pneumomediastinum following EBUS-TBNA and improved with expectant management in the emergency department. We discuss the proposed pathophysiology of this rare occurrence that usually follows a benign course. Severe complications, such as mediastinitis and tracheal tear, need to be excluded promptly.
    MeSH term(s) Endoscopic Ultrasound-Guided Fine Needle Aspiration/adverse effects ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Endosonography/methods ; Female ; Humans ; Lung Neoplasms/diagnosis ; Mediastinal Emphysema/diagnosis ; Mediastinal Emphysema/etiology ; Mediastinoscopy ; Middle Aged
    Language English
    Publishing date 2022-03-05
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 2148569-0
    ISSN 1214-6994
    ISSN 1214-6994
    DOI 10.14712/23362936.2022.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Deadly Thrombotic Microangiopathy Syndrome without Schistocytosis.

    Saha, Biplab K

    Southern medical journal

    2021  Volume 114, Issue 7, Page(s) 416–418

    MeSH term(s) Diagnosis, Differential ; Humans ; Thrombotic Microangiopathies/etiology ; Thrombotic Microangiopathies/physiopathology
    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.14423/SMJ.0000000000001265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is It Time to Call Idiopathic Pulmonary Hemosiderosis by the Correct Name: Immune-Mediated Pulmonary Hemosiderosis?

    Saha, Biplab K

    The American journal of the medical sciences

    2021  Volume 361, Issue 6, Page(s) 809–811

    MeSH term(s) Autoimmune Diseases/classification ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/physiopathology ; Hemosiderosis/classification ; Hemosiderosis/diagnosis ; Hemosiderosis/physiopathology ; Humans ; Lung Diseases/classification ; Lung Diseases/diagnosis ; Lung Diseases/physiopathology ; Hemosiderosis, Pulmonary
    Language English
    Publishing date 2021-01-09
    Publishing country United States
    Document type Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2021.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Etiology of Hemoptysis in Children.

    Bonnier, Alyssa / Saha, Biplab K

    Indian pediatrics

    2023  Volume 60, Issue 4, Page(s) 265–266

    MeSH term(s) Child ; Humans ; Hemoptysis/etiology
    Language English
    Publishing date 2023-03-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Young Female With a Hyperlucent and Hyperinflated Lung Segment.

    Saha, Biplab K

    The American journal of the medical sciences

    2020  Volume 361, Issue 2, Page(s) e13–e14

    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Female ; Humans ; Lung/abnormalities ; Lung/diagnostic imaging ; Lung, Hyperlucent/diagnostic imaging ; Lung, Hyperlucent/drug therapy ; Pulmonary Emphysema/congenital ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/drug therapy ; Smoking ; Steroids/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Steroids
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2020.07.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Few and Far Between: A Case of Aortoesophageal Fistula in Locally Advanced Esophageal Cancer.

    Saha, Biplab K

    The American journal of the medical sciences

    2020  Volume 361, Issue 1, Page(s) e3–e4

    MeSH term(s) Aortic Diseases/diagnosis ; Aortic Diseases/diagnostic imaging ; Esophageal Fistula/diagnosis ; Esophageal Fistula/diagnostic imaging ; Esophageal Neoplasms/etiology ; Fatal Outcome ; Hematemesis/diagnosis ; Hematemesis/diagnostic imaging ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2020-06-10
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2020.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Idiopathic pulmonary hemosiderosis: A state of the art review.

    Saha, Biplab K

    Respiratory medicine

    2020  Volume 176, Page(s) 106234

    Abstract: Idiopathic pulmonary hemosiderosis (IPH) is an uncommon cause of diffuse alveolar hemorrhage (DAH). Patients with IPH usually present with hemoptysis, and the diagnosis is often delayed by years. Patients often present with intermittent episodes of ... ...

    Abstract Idiopathic pulmonary hemosiderosis (IPH) is an uncommon cause of diffuse alveolar hemorrhage (DAH). Patients with IPH usually present with hemoptysis, and the diagnosis is often delayed by years. Patients often present with intermittent episodes of hemoptysis interspersed between periods of relative normalcy. However, massive hemorrhage resulting in acute respiratory failure and non-remitting hemoptysis have also been described. The classic triad includes hemoptysis, radiologic lung infiltrate, and iron deficiency anemia. Several hypotheses regarding the pathogenesis of IPH have been proposed. These risk factors include an autoimmune, allergic or genetic predisposition, and possible environmental exposure. Since IPH appears to be responsive to corticosteroids, the autoimmune hypothesis is considered to play a crucial role. A diagnosis of IPH requires exclusion of other etiologies of DAH, including infection, medications, toxic inhalation, vasculitis, and anti-glomerular basement membrane disease, among others. Histologically, IPH is characterized by the presence of hemosiderin-laden macrophages in the alveolar space without any evidence of vasculitis or immunocomplex deposition. Corticosteroid therapy represents the primary modality of treatment. Other immunosuppressive medications have also been used with varying success, especially in the setting of steroid-refractory disease. The prognosis of IPH in adults is somewhat better compared to the pediatric population. The severity of the initial presentation does not predict future outcomes. Which risk factors and patient characteristics are associated with a poor outcome are also unknown. More research is necessary to elucidate the pathophysiology and appropriate treatment.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Anemia, Iron-Deficiency/etiology ; Autoimmunity ; Child ; Delayed Diagnosis/prevention & control ; Female ; Genetic Predisposition to Disease ; Hemoptysis/etiology ; Hemosiderosis/diagnosis ; Hemosiderosis/drug therapy ; Hemosiderosis/etiology ; Hemosiderosis/pathology ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung/diagnostic imaging ; Lung/pathology ; Lung Diseases/diagnosis ; Lung Diseases/drug therapy ; Lung Diseases/etiology ; Lung Diseases/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prognosis ; Radiography, Thoracic ; Risk Factors ; Severity of Illness Index ; Hemosiderosis, Pulmonary
    Chemical Substances Adrenal Cortex Hormones ; Immunosuppressive Agents
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2020.106234
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Liposteroid Therapy for Idiopathic Pulmonary Hemosiderosis: A Scoping Review of the Literature.

    Saha, Biplab K / Milman, Nils T

    Prague medical report

    2022  Volume 123, Issue 2, Page(s) 65–81

    Abstract: Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage (DAH). Glucocorticosteroids (CS) represent the first line therapy for IPH. Although most patients respond to CS, steroid refractoriness is seen in an appreciable ... ...

    Abstract Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage (DAH). Glucocorticosteroids (CS) represent the first line therapy for IPH. Although most patients respond to CS, steroid refractoriness is seen in an appreciable minority of patients. This paper reviews and evaluates the efficacy and safety profile of liposomal dexamethasone 21-palmitate (liposteroid) for the treatment of IPH. Medline, Embase and Web of Science biomedical databases were searched between 1980 and 2020 to identify papers describing patients with IPH, who were treated with liposteroid. A total of five articles were identified. Four in the form of case reports and one as a case series. A total of 12 pediatric patients (5 boys, 7 girls) were identified, with a median age of 2.3 years (range 0.5-8.6). Liposteroid therapy in intravenous doses ranging 0.06-0.1 mg/kg body weight appeared to be effective for both remission induction therapy, and maintenance therapy. There was no mortality among patients treated with liposteroid, either in the acute phase or during follow-up. The majority of patients for whom long-term follow-up data were available, were cured or in disease remission. No acute adverse events were reported, and long-term side effects were minimal and tolerable. Liposteroid represents a potential alternative or supplement to conventional CS therapy, as it appears to be more efficacious and associated with fewer side effects. Larger prospective, controlled trials are necessary to be able to define more precisely the therapeutic role of liposteroid in IPH.
    MeSH term(s) Child ; Child, Preschool ; Female ; Hemosiderosis/complications ; Hemosiderosis/diagnosis ; Hemosiderosis/drug therapy ; Humans ; Infant ; Lung Diseases/complications ; Lung Diseases/drug therapy ; Male ; Prospective Studies ; Hemosiderosis, Pulmonary
    Language English
    Publishing date 2022-05-12
    Publishing country Czech Republic
    Document type Journal Article ; Review
    ZDB-ID 2148569-0
    ISSN 1214-6994
    ISSN 1214-6994
    DOI 10.14712/23362936.2022.7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: An Unusual Etiology of Fluorodeoxyglucose Avid Intrathoracic Lymph Nodes.

    Bonnier, Alyssa / Saha, Santu / Austin, Adam / Saha, Biplab K

    Prague medical report

    2024  Volume 125, Issue 1, Page(s) 79–86

    Abstract: A middle-aged man in his 50s, active smoker, presented to the pulmonary office for lung cancer evaluation. On a low-dose computed tomography for lung cancer screening, he was found to have an 8 mm endobronchial lesion in the right main stem bronchus. A ... ...

    Abstract A middle-aged man in his 50s, active smoker, presented to the pulmonary office for lung cancer evaluation. On a low-dose computed tomography for lung cancer screening, he was found to have an 8 mm endobronchial lesion in the right main stem bronchus. A PET-CT revealed no endobronchial lesion, but incidentally, fluorodeoxyglucose (FDG) avidity was present in the right hilar (SUV 13.2) and paratracheal lymph nodes (LNs). He underwent bronchoscopy and EBUS-TBNA of station 7 and 10 R LNs. The fine needle aspiration (FNA) revealed necrotizing epithelioid granuloma. The acid-fast bacilli (AFB) and Grocott methenamine silver (GMS) stains were negative. He had suffered from pneumonic tularemia 13 months ago and immunohistochemical staining for Francisella tularensis on FNA samples at Center for Disease Control and Prevention was negative. The intense positron emission tomography (PET) avidity was attributed to prior tularemic intrathoracic lymphadenitis without active tularemia, a rare occurrence. To the best of our knowledge, PET-positive intrathoracic lymph node beyond one year without evidence of active tularemia has not been previously reported.
    MeSH term(s) Male ; Middle Aged ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Early Detection of Cancer ; Tularemia/diagnosis ; Tularemia/pathology ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Neoplasm Staging ; Retrospective Studies
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2024-02-21
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 2148569-0
    ISSN 1214-6994
    ISSN 1214-6994
    DOI 10.14712/23362936.2024.8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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