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Article ; Online: Facile process of

Saha, Ishita / Ghosh, Sourav / Roy, Shubham / Basu, Tarakdas / Karmakar, Parimal

2024 Volume 19, Issue 3

Abstract: Mucilage is a sticky substance found in various plants and microorganisms and is made up of proteins and polysaccharides. Mucilage ... ...

Abstract	Mucilage is a sticky substance found in various plants and microorganisms and is made up of proteins and polysaccharides. Mucilage from
MeSH term(s)	Mice ; Animals ; Humans ; Wound Healing ; Rosa ; Plant Extracts/chemistry ; Bromodeoxyuridine ; Reactive Oxygen Species ; Burns/therapy ; Skin Diseases
Chemical Substances	Plant Extracts ; Bromodeoxyuridine (G34N38R2N1) ; Reactive Oxygen Species
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ad2c1d
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Article ; Online: Corrigendum: Topical effect of polyherbal flowers extract on xanthan gum hydrogel patch-induced wound healing activity in human cell lines and male BALB/c mice (2023

Saha, Ishita / Roy, Shubham / Das, Deepak / Das, Sukhen / Karmakar, Parimal

Biomedical materials (Bristol, England)

2023 Volume 18, Issue 6

Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Published Erratum
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/acf663
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Article ; Online: Topical effect of polyherbal flowers extract on xanthan gum hydrogel patch-induced wound healing activity in human cell lines and male BALB/c mice.

Saha, Ishita / Roy, Shubham / Das, Deepak / Das, Sukhen / Karmakar, Parimal

Biomedical materials (Bristol, England)

2023 Volume 18, Issue 3

Abstract: Wound or injury is a breakdown in the skin's protective function as well as damage to the normal tissues. Wound healing is a dynamic and complex phenomenon of replacing injured skin or body tissues. In ancient times ... ...

Abstract	Wound or injury is a breakdown in the skin's protective function as well as damage to the normal tissues. Wound healing is a dynamic and complex phenomenon of replacing injured skin or body tissues. In ancient times the
MeSH term(s)	Animals ; Mice ; Humans ; Male ; Hydrogels/chemistry ; Wound Healing ; Cell Line ; Plants, Medicinal ; Flowers ; Plant Extracts/chemistry
Chemical Substances	Hydrogels ; xanthan gum (TTV12P4NEE) ; Plant Extracts
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/acce89
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Article ; Online: Contrasting effects of molecular crowding on the membrane-perturbing and chaperone-like activities of major bovine seminal plasma protein, PDC-109.

Singh, Bhanu Pratap / Cheppali, Sudheer K / Saha, Ishita / Swamy, Musti J

International journal of biological macromolecules

2023 Volume 254, Issue Pt 2, Page(s) 127573

Abstract: Crowded environments inside cells and biological fluids greatly affect protein stability and activity. PDC-109, a polydisperse oligomeric protein of the bovine seminal plasma selectively binds choline phospholipids on the sperm cell surface and causes ... ...

Abstract	Crowded environments inside cells and biological fluids greatly affect protein stability and activity. PDC-109, a polydisperse oligomeric protein of the bovine seminal plasma selectively binds choline phospholipids on the sperm cell surface and causes membrane destabilization and lipid efflux, leading to acrosome reaction. PDC-109 also exhibits chaperone-like activity (CLA) and protects client proteins against various kinds of stress, such as high temperature and low pH. In the present work, we have investigated the effect of molecular crowding on these two different activities of PDC-109 employing Dextran 70 (D70) - a widely used polymeric dextran - as the crowding agent. The results obtained show that presence of D70 markedly increases membrane destabilization by PDC-109. Isothermal titration calorimetric studies revealed that under crowded condition the binding affinity of PDC-109 for choline phospholipids increases approximately 3-fold, which could in turn facilitate membrane destabilization. In contrast, under identical conditions, its CLA was reduced significantly. The decreased CLA could be correlated to reduced surface hydrophobicity, which was due to stabilization of the protein oligomers. These results establish that molecular crowding exhibits contrasting effects on two different functional activities of PDC-109 and highlight the importance of microenvironment of proteins in modulating their functional activities.
MeSH term(s)	Humans ; Male ; Cattle ; Animals ; Seminal Plasma Proteins/metabolism ; Semen/metabolism ; Seminal Vesicle Secretory Proteins/analysis ; Seminal Vesicle Secretory Proteins/chemistry ; Seminal Vesicle Secretory Proteins/metabolism ; Spermatozoa/metabolism ; Phospholipids/metabolism ; Choline/analysis
Chemical Substances	Seminal Plasma Proteins ; Seminal Vesicle Secretory Proteins ; Phospholipids ; Choline (N91BDP6H0X)
Language	English
Publishing date	2023-11-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127573
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Article ; Online: Contributions and Limitations of Mitochondria-Targeted and Non-Targeted Antioxidants in the Treatment of Parkinsonism: an Updated Review.

Banerjee, Priyajit / Saha, Ishita / Sarkar, Diptendu / Maiti, Arpan Kumar

Neurotoxicity research

2022 Volume 40, Issue 3, Page(s) 847–873

Abstract: As conventional therapeutics can only treat the symptoms of Parkinson's disease (PD), major focus of research in recent times is to slow down or prevent the progression of neuronal degeneration in PD. Non-targeted antioxidants have been an integral part ... ...

Abstract	As conventional therapeutics can only treat the symptoms of Parkinson's disease (PD), major focus of research in recent times is to slow down or prevent the progression of neuronal degeneration in PD. Non-targeted antioxidants have been an integral part of the conventional therapeutics regimen; however, their importance have lessened over time because of their controversial outcomes in clinical PD trials. Inability to permeate and localize within the mitochondria remains the main drawback on the part of non-targeted antioxidants inspite of possessing free radical scavenging properties. In contrast, mitochondrial-targeted antioxidants (MTAs), a special class of compounds have emerged having high advantages over non-targeted antioxidants by virtue of efficient pharmacokinetics and better absorption rate with capability to localize many fold inside the mitochondrial matrix. Preclinical experimentations indicate that MTAs have the potential to act as better alternatives compared to conventional non-targeted antioxidants in treating PD; however, sufficient clinical trials have not been conducted to investigate the efficacies of MTAs in treating PD. Controversial clinical outcomes on the part of non-targeted antioxidants and lack of clinical trials involving MTAs have made it difficult to go ahead with a direct comparison and in turn have slowed down the progress of development of safer and better alternate strategies in treating PD. This review provides an insight on the roles MTAs and non-targeted antioxidants have played in the treatment of PD till date in preclinical and clinical settings and discusses about the limitations of mitochondria-targeted and non-targeted antioxidants that can be resolved for developing effective strategies in treating Parkinsonism.
MeSH term(s)	Antioxidants/therapeutic use ; Humans ; Mitochondria/physiology ; Parkinson Disease/drug therapy ; Parkinsonian Disorders/drug therapy
Chemical Substances	Antioxidants
Language	English
Publishing date	2022-04-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-022-00501-x
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Article ; Online: Fabrication and Therapeutic Process of a Green Silver-Nanoparticle-Embedded Mucilage Microsphere for Pathogenic-Bacteria-Infected Second-Degree Burn and Excision Wounds.

Saha, Ishita / Ghosh, Sourav / Mondal, Arunima / Roy, Shubham / Basu, Tarakdas / Sengupta, Arunima / Das, Deepak / Karmakar, Parimal

ACS applied bio materials

2024 Volume 7, Issue 4, Page(s) 2554–2568

Abstract: Multidrug-resistant bacteria are a serious problem in biomedical applications that decrease the wound healing process and increase the mortality rate. Therefore, in this study, we have prepared a green-synthesized silver-nanoparticle-encapsulated ... ...

Abstract	Multidrug-resistant bacteria are a serious problem in biomedical applications that decrease the wound healing process and increase the mortality rate. Therefore, in this study, we have prepared a green-synthesized silver-nanoparticle-encapsulated mucilage microsphere (HMMS@GSNP) from
MeSH term(s)	Male ; Mice ; Animals ; Silver ; Methicillin-Resistant Staphylococcus aureus ; Microspheres ; Burns/drug therapy ; Nanoparticles
Chemical Substances	colloidal silver ; Silver (3M4G523W1G)
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.4c00177
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Article ; Online: Melatonin ameliorates lipopolysaccharide induced brain inflammation through modulation of oxidative status and diminution of cytokine rush in Danio rerio.

Moniruzzaman, Mahammed / Maiti, Arpan Kumar / Chakraborty, Suman Bhusan / Saha, Ishita / Saha, Nimai Chandra

Environmental toxicology and pharmacology

2022 Volume 96, Page(s) 103983

Abstract: Lipopolysaccharide (LPS) is known to induce inﬂammation and immunonomodulation in a piscine model of Danio rerio. Present study aimed to explore the ability of melatonin in attenuating LPS-induced oxidative damages using this model. In LPS-exposed fish, ... ...

Abstract	Lipopolysaccharide (LPS) is known to induce inﬂammation and immunonomodulation in a piscine model of Danio rerio. Present study aimed to explore the ability of melatonin in attenuating LPS-induced oxidative damages using this model. In LPS-exposed fish, activation of stress marker MDA was observed in brain with corresponding augmentation of multiple pro-inflammatory cytokines (IL1β, IL6, IL10 and TNFα). In addition, it also showed marked increase in the levels of heat shock factor (HSF) and heat shock proteins (HSPs) in association with transcription factors (NF-kB and NRF2) and mitogen-activated protein kinases (MAPKs). The changes in the levels of these mediators are highly correlated with the induction of pro-inflammatory cytokines. In melatonin-treated fishes, significant amelioration of oxidative stress was observed with reduced levels of MDA and pro-inflammatory cytokines. Melatonin also modulated expression of HSPs that facilitated the brain to overcome inflammation-induced stress by directly initiating NFkB/NRF2 translocation. In summary, melatonin effectively functions to reduce stress induced inflammatory signalling through modulation of oxidative stress and protects the brain from the neuropathological insult.
MeSH term(s)	Animals ; Lipopolysaccharides/toxicity ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Cytokines/metabolism ; NF-E2-Related Factor 2/metabolism ; Zebrafish/metabolism ; Oxidative Stress ; NF-kappa B/metabolism ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/pathology ; Encephalitis
Chemical Substances	Lipopolysaccharides ; Melatonin (JL5DK93RCL) ; Cytokines ; NF-E2-Related Factor 2 ; NF-kappa B
Language	English
Publishing date	2022-09-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2022.103983
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Article ; Online: In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India.

Ganai, Indranil / Saha, Ishita / Banerjee, Priyajit / Laha, Arghya / Sultana, Saheen / Sultana, Nasima / Biswas, Himani / Moitra, Saibal / Podder, Sanjoy

Frontiers in immunology

2023 Volume 14, Page(s) 1089514

Abstract: Introduction: Prevalence of asthma is increasing steadily among general population in developing countries over past two decades. One of the causative agents of broncho-constriction in asthma is thromboxane A2 receptor (TBXA2R). However few studies of ... ...

Abstract	Introduction: Prevalence of asthma is increasing steadily among general population in developing countries over past two decades. One of the causative agents of broncho-constriction in asthma is thromboxane A2 receptor (TBXA2R). However few studies of TBXA2R polymorphism were performed so far. The present study aimed to assess potential association of TBXA2R rs34377097 polymorphism causing missense substitution of Arginine to Leucine (R60L) among 482 patients diagnosed with pollen-induced asthma and 122 control participants from West Bengal, India. Also we performed in-silico analysis of mutated TBXA2R protein (R60L) using homology modeling. Methods: Clinical parameters like Forced expiratory volume in 1 second (FEV Results: Genotype frequencies differed significantly between the study groups (P=0.03). There was no significant deviation from Hardy-Weinberg equilibrium in control population (χ2=1.56). Asthmatic patients have significantly higher frequency of rs34377097TT genotype than control subjects (P=0.03). SPT of patients showed maximum sensitivity in Discussion: The present in-silico study is the first one to report association of TBXA2R rs34377097 polymorphism in an Indian population. It may be used as prognostic marker of clinical response to asthma in West Bengal and possible target of therapeutics in future.
MeSH term(s)	Adolescent ; Humans ; Young Adult ; Asthma/genetics ; Asthma/epidemiology ; Genotype ; Pollen ; Polymorphism, Single Nucleotide ; Receptors, Thromboxane A2, Prostaglandin H2/genetics ; Receptors, Thromboxane A2, Prostaglandin H2/metabolism
Chemical Substances	Receptors, Thromboxane A2, Prostaglandin H2
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1089514
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Article: Substance P failed to reverse dextran sulfate sodium-induced murine colitis mediated by mitochondrial dysfunction: implications in ulcerative colitis.

Chandraiah, Spoorthi B / Ghosh, Shashwati / Saha, Ishita / More, Sunil S / Annappa, Gautham S / Maiti, Arpan K

3 Biotech

2021 Volume 11, Issue 4, Page(s) 199

Abstract: As controversy exists about the efficacy of substance P (SP) in treating ulcerative colitis (UC) with no previous study highlighting the impact of SP on mitochondrial dysfunction in this diseased condition, it became logical to perform the present study. ...

Abstract	As controversy exists about the efficacy of substance P (SP) in treating ulcerative colitis (UC) with no previous study highlighting the impact of SP on mitochondrial dysfunction in this diseased condition, it became logical to perform the present study. C57BL/6 J mice were administered with DSS @ 3.5%/gm body weight for 3 cycles of 5 days each followed by i.v. dose of SP @ 5nmole per kg for consecutive 7 days. Histopathological features were noticed in the affected colon along with colonic mitochondrial dysfunction, alterations in mitochondrial stress variables and enhanced colonic cell death. Interestingly, SP failed to reverse colitic features and proved ineffective in inhibiting mitochondrial dysfunction. Unexpectedly SP alone seemed to impart detrimental effects on some of the mitochondrial functions, enhanced lipid peroxidation and increased staining intensities for caspases 3 and 9 in the normal colon. To substantiate in vivo findings and to assess free radical scavenging property of SP, Caco-2 cells were exposed to DSS with or without SP in the presence and absence of specific free radical scavengers and antioxidants. Interestingly, in vitro treatment with SP failed to restore mitochondrial functions and its efficacy proved below par compared to SOD and DMSO indicating involvement of O
Language	English
Publishing date	2021-03-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-021-02755-2
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Article ; Online: Biocompatible Carbon Dot Decorated α-FeOOH Nanohybrid for an Effective Fluorometric Sensing of Cr (VI) in Wastewater and Living Cells.

Ghosh, Bidisha / Roy, Shubham / Bardhan, Souravi / Mondal, Dhananjoy / Saha, Ishita / Ghosh, Saheli / Basu, Ruma / Karmakar, Parimal / Das, Kaustuv / Das, Sukhen

Journal of fluorescence

2022 Volume 32, Issue 4, Page(s) 1489–1500

Abstract: This article reports the fluorometric detection of toxic hexavalent chromium Cr (VI)) in wastewater and Cr (VI) contaminated living cells using in-situ grown carbon quantum dots into the goethite (α-FeOOH) nano-matrix. The synthesized nano-hybrid shows ... ...

Abstract	This article reports the fluorometric detection of toxic hexavalent chromium Cr (VI)) in wastewater and Cr (VI) contaminated living cells using in-situ grown carbon quantum dots into the goethite (α-FeOOH) nano-matrix. The synthesized nano-hybrid shows enormous potential in determining the chromium contamination levels in various types of water samples. This selective fluorometric probe is enormously sensitive (LOD 81 nM) toward hexavalent chromium, which makes it a dedicated chromium sensor. Moreover, the sensing mechanism has been assessed using Stern-Volmer's equation and fluorescence lifetime experiments showing the simultaneous occurrence of photoinduced electron transfer and the inner filter effect. This chromium sensor has also been employed to assess the contamination level in real-life industrial wastewater. The performance of this probe in a real-life wastewater sample is quite commendable. Further, this biocompatible fluorometric probe has been used to demonstrate the in-vitro sensing of Cr (VI) in HeLa cells. The rapid detection mechanism of hexavalent chromium in living cells has been validated using theoretical docking simulations. Henceforth, this fluorometric sensor material could open new avenues not only in wastewater monitoring but also in biomedical applications.
MeSH term(s)	Carbon ; Chromium/analysis ; HeLa Cells ; Humans ; Iron Compounds ; Minerals ; Wastewater ; Water Pollutants, Chemical/analysis
Chemical Substances	Iron Compounds ; Minerals ; Waste Water ; Water Pollutants, Chemical ; Chromium (0R0008Q3JB) ; goethite (1310-14-1) ; Carbon (7440-44-0)
Language	English
Publishing date	2022-05-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-022-02962-x
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