Artikel ; Online: Longitudinal monitoring of SARS-CoV-2 spike protein-specific antibody responses in Lower Austria.
2022 Band 17, Heft 7, Seite(n) e0271382
Abstract: The Lower Austrian Wachau region was an early COVID-19 hotspot of infection. As previously reported, in June 2020, after the first peak of infections, we determined that 8.5% and 9.0% of the participants in Weißenkirchen and surrounding communities in ... ...
| Abstract | The Lower Austrian Wachau region was an early COVID-19 hotspot of infection. As previously reported, in June 2020, after the first peak of infections, we determined that 8.5% and 9.0% of the participants in Weißenkirchen and surrounding communities in the Wachau region were positive for immunoglobulin G (IgG) and immunoglobulin A (IgA) antibodies against the receptor-binding domain of the spike protein of SARS-CoV-2, respectively. Here, we present novel data obtained eight months later (February 2021) from Weißenkirchen, after the second peak of infection, with 25.0% (138/552) and 23.6% (130/552) of participants that are positive for IgG and IgA, respectively. In participants with previous IgG/IgA positivity (June 2020), we observed a 24% reduction in IgG levels, whereas the IgA levels remained stable in February 2021. This subgroup was further analyzed for SARS-CoV-2 induced T cell activities. Although 76% (34/45) and 76% (34/45) of IgG positive and IgA positive participants, respectively, showed specific T cell activities (upon exposure to SARS-CoV-2 spike protein-derived peptides), those were not significantly correlated with the levels of IgG or IgA. Thus, the analyses of antibodies cannot surrogate the measurement of T cell activities. For a comprehensive view on SARS-CoV-2-triggered immune responses, the measurement of different classes of antibodies should be complemented with the determination of T cell activities. |
|---|---|
| Mesh-Begriff(e) | Antibodies, Viral ; Antibody Formation ; Austria/epidemiology ; COVID-19/epidemiology ; COVID-19/immunology ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/immunology |
| Chemische Substanzen | Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 |
| Sprache | Englisch |
| Erscheinungsdatum | 2022-07-27 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2267670-3 |
| ISSN | 1932-6203 ; 1932-6203 |
| ISSN (online) | 1932-6203 |
| ISSN | 1932-6203 |
| DOI | 10.1371/journal.pone.0271382 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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