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  1. Article ; Online: The Effect of Benson's Relaxation Technique on Coping Strategies Among Informal Caregivers of Cancer Patients: A Randomized Controlled Trial Study.

    Barghbani, Hamid / Heshmatifar, Narjes / Mahdavifar, Neda / Ansari, Mojgan / Sahebkar, Mohammad

    Cancer nursing

    2024  

    Abstract: Background: Informal caregivers of cancer patients often experience high levels of stress and burden, leading to the adoption of ineffective coping strategies. This can result in psychological problems for the caregivers and inadequate care provision.!## ...

    Abstract Background: Informal caregivers of cancer patients often experience high levels of stress and burden, leading to the adoption of ineffective coping strategies. This can result in psychological problems for the caregivers and inadequate care provision.
    Objective: This study aimed to investigate the impact of Benson's relaxation technique (BRT) on coping strategies among informal caregivers of cancer patients.
    Interventions/methods: This open-label randomized clinical trial enrolled 113 caregivers visiting the radiotherapy and chemotherapy departments of Vasei Hospital in Sabzevar, Iran, who scored ≥48 on the Novak and Guest Caregiver Burden Inventory. The participants were randomly allocated to either the intervention group or the control group. The intervention group received BRT, with participants performing the technique twice a day for 20 minutes each time over a 1-month period. The control group did not receive any intervention. Coping strategies were assessed using Endler and Parker's coping strategies inventory.
    Results: The findings of the study revealed that the intervention group showed an increase in the utilization of problem-oriented coping strategies (P = .076) and a decrease in the utilization of emotion-oriented coping strategies (P < .001) and avoidance-oriented coping strategies in the intervention group compared with the control group (P = .004).
    Conclusions: Findings suggest that BRT, as a cost-effective and nonpharmacological intervention, effectively reduces the reliance on emotion-oriented and avoidance-oriented coping strategies among informal caregivers of cancer patients.
    Implications for practice: Healthcare professionals working in oncology settings are encouraged to incorporate BRT into their care practices.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391995-x
    ISSN 1538-9804 ; 0162-220X
    ISSN (online) 1538-9804
    ISSN 0162-220X
    DOI 10.1097/NCC.0000000000001318
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  2. Article: Comparison of the effect of ursodeoxycholic acid and multistrain synbiotic on indirect hyperbilirubinemia among neonates treated with phototherapy: A double-blind, randomized, placebo-controlled clinical trial study.

    Babaie, Elahe / Hassanpour, Kazem / Aldaghi, Mitra / Sahebkar, Mohammad

    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

    2023  Volume 28, Page(s) 40

    Abstract: Background: This study was aimed at evaluating the effect of ursodeoxycholic acid (UDCA) and multistrain synbiotic on indirect hyperbilirubinemia among neonates treated with phototherapy.: Materials and methods: This double-blind, randomized clinical ...

    Abstract Background: This study was aimed at evaluating the effect of ursodeoxycholic acid (UDCA) and multistrain synbiotic on indirect hyperbilirubinemia among neonates treated with phototherapy.
    Materials and methods: This double-blind, randomized clinical trial was conducted on 120 subjects presenting with indirect hyperbilirubinemia in 2019. Subjects were randomly divided into three groups of synbiotic, UDCA, and control. The synbiotic group received five drops/day of synbiotic in addition to phototherapy. UDCA group received 10 mg/kg/day of Ursobil divided every 12 h in addition to phototherapy. The Control group received a placebo (water) in addition to phototherapy. Phototherapy was discontinued when the bilirubin levels reached <10 mg/dL. Total bilirubin levels were measured using the diazo method at 12, 24, and 36 h after hospitalization. This study used repeated measure analysis of variance and post hoc tests.
    Results: The mean total of bilirubin was substantially decreased in both synbiotic and UDCA groups as compared to the control group at 24 h after hospitalization (P < 0.001). Moreover, the Bonferroni post hoc test showed significant differences regarding the mean total of bilirubin between the three groups (P < 0.05) except for the association between UDCA and synbiotic at 24 h after hospitalization (P > 0.99).
    Conclusion: Findings suggest that UDCA and synbiotic administration alongside phototherapy are more effective in reducing bilirubin levels as compared to phototherapy alone.
    Language English
    Publishing date 2023-04-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 2513029-8
    ISSN 1735-7136 ; 1735-1995
    ISSN (online) 1735-7136
    ISSN 1735-1995
    DOI 10.4103/jrms.jrms_894_21
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  3. Article ; Online: Antinociceptive effect of N-acetyl glucosamine in a rat model of neuropathic pain.

    Mohebbi, Ehsan / Molavi, Mehdi / Amin, Mohamadreza / Amin, Bahareh / Sahebkar, Mohammad

    Acta neuropsychiatrica

    2022  Volume 34, Issue 5, Page(s) 260–268

    Abstract: Objective: This study was aimed at evaluating the efficacy of glucosamine and potential mechanisms of actions in a neuropathic pain model in rats.: Methods: Glucosamine (500, 1000 and 2000 mg/kg) was administered via gavage route, 1 day before the ... ...

    Abstract Objective: This study was aimed at evaluating the efficacy of glucosamine and potential mechanisms of actions in a neuropathic pain model in rats.
    Methods: Glucosamine (500, 1000 and 2000 mg/kg) was administered via gavage route, 1 day before the chronic constriction injury (CCI) of sciatic nerve and daily for 14 days (prophylactic regimen), or from days 5 to 14 post-injury (therapeutic regimen), as the indicators of neuropathic pain, mechanical allodynia, cold allodynia and thermal hyperalgesia were assessed on days 0, 3, 5, 7, 10 and 14 after ligation. Inducible nitric oxide synthase (iNOS) and tumour necrosis factor alpha (TNF-α) gene expressions were measured by real-time polymerase chain reaction. TNF-α protein content was measured using the enzyme-linked immunosorbent assay method.
    Results: Three days after nerve injury, the threshold of pain was declined among animals subjected to neuropathic pain. Mechanical and cold allodynia, as well as thermal hyperalgesia were attenuated by glucosamine (500, 1000, 2000 mg/kg) in the prophylactic regimen. However, existing pain was not decreased by this drug. Increased mRNA expression of iNOS and TNF-α was significantly reduced in the spinal cord of CCI animals by glucosamine (500, 1000, 2000 mg/kg) in the prophylactic regimen. The overall expression of spinal TNF-α was increased by CCI, but this increase was reduced in animals receiving glucosamine prophylactic treatment.
    Conclusion: Findings suggest that glucosamine as a safe supplement may be a useful candidate in preventing neuropathic pain following nerve injury. Antioxidant and anti-inflammatory effects may be at least in part responsible for the antinociceptive effects of this drug.
    MeSH term(s) Rats ; Animals ; Hyperalgesia/drug therapy ; Hyperalgesia/metabolism ; Tumor Necrosis Factor-alpha ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type II/therapeutic use ; Antioxidants ; Neuralgia/drug therapy ; Analgesics/pharmacology ; Analgesics/therapeutic use ; Glucosamine/pharmacology ; Glucosamine/therapeutic use ; Anti-Inflammatory Agents/therapeutic use ; RNA, Messenger
    Chemical Substances Tumor Necrosis Factor-alpha ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Antioxidants ; Analgesics ; Glucosamine (N08U5BOQ1K) ; Anti-Inflammatory Agents ; RNA, Messenger
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154361-9
    ISSN 1601-5215 ; 0924-2708
    ISSN (online) 1601-5215
    ISSN 0924-2708
    DOI 10.1017/neu.2022.3
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  4. Article: Comparison of the effect of 40 and 80 mg/day doses of atorvastatin on changes in lipid profiles among acute coronary syndrome patients: A randomized clinical trial study.

    Sahebkar, Mohammad / Khalilzadeh, Nafiseh / Movahedzadeh, Javad / Neamatshahi, Mahboubeh / Rad, Mostafa / Gholami, Omid

    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

    2023  Volume 28, Page(s) 24

    Abstract: Background: Statins play a vital role in the management of high-risk patients with atherosclerotic cardiovascular disease. The aim of this study was to evaluate the effect of two doses of 40 and 80 mg of atorvastatin on lipid profiles and inflammatory ... ...

    Abstract Background: Statins play a vital role in the management of high-risk patients with atherosclerotic cardiovascular disease. The aim of this study was to evaluate the effect of two doses of 40 and 80 mg of atorvastatin on lipid profiles and inflammatory markers among patients with acute coronary syndrome (ACS).
    Materials and methods: This single-blind, randomized clinical trial was conducted on 60 patients with ACS referred to Heshmatiyeh Hospital, Sabzevar, Iran. Eligible subjects were randomly assigned to either 80 mg/day (atorvastatin, 80 mg/day) or 40 mg/day intervention (atorvastatin, 40 mg/day) groups. Serum lipid profiles (low-density lipoprotein [LDL], high-density lipoprotein [HDL], triglyceride [TG], and total cholesterol), an inflammatory marker (creatine phosphokinase [CPK]), and liver function biomarkers (alanine aminotransferase, aspartate aminotransferase) were assessed before starting treatment and 3 months later.
    Results: According to the paired
    Conclusion: Findings suggest that increasing the dose of atorvastatin decreases the mean serum levels of LDL and CPK but has no effect on the mean serum HDL levels and liver function biomarkers.
    Language English
    Publishing date 2023-04-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2513029-8
    ISSN 1735-7136 ; 1735-1995
    ISSN (online) 1735-7136
    ISSN 1735-1995
    DOI 10.4103/jrms.jrms_1060_21
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  5. Article: Evaluating the effect of acupuncture on symptoms of diabetic peripheral neuropathy (DPN) among individuals with diabetic neuropathy: A single-blind, randomized trial study.

    Zardosht, Roghayeh / Arabi, Akram / Akhlaghi, Maedeh / Javan, Roghayeh / Khosrojerdi, Maryam / Sahebkar, Mohammad

    Journal of diabetes and metabolic disorders

    2023  Volume 22, Issue 2, Page(s) 1769–1778

    Abstract: Purpose: This study aimed to investigate the impact of acupuncture on Diabetic peripheral neuropathy (DPN) symptoms among individuals with diabetic neuropathy.: Methods: In a single-blind, randomized trial conducted between 2019 and 2020, 60 patients ...

    Abstract Purpose: This study aimed to investigate the impact of acupuncture on Diabetic peripheral neuropathy (DPN) symptoms among individuals with diabetic neuropathy.
    Methods: In a single-blind, randomized trial conducted between 2019 and 2020, 60 patients diagnosed with diabetic neuropathy were enrolled. These participants were randomly assigned to either the intervention or control group. The intervention group received real acupuncture alongside routine treatment once a week for seven sessions, each lasting 20 min. Meanwhile, the control group received sham acupuncture as an adjunct to their routine treatment, following the same schedule. To evaluate treatment efficacy, the study assessed primary outcomes, such as pain intensity measured using the Visual Analogue Scale (VAS). Secondary outcomes included evaluating fatigue severity and diabetic peripheral neuropathy (DPN) side effects, measured using the multidimensional fatigue inventory (MFI-20) and a standard questionnaire after each session.
    Results: No statistically significant differences in pain and fatigue scores were observed between the two groups throughout all visits, even after adjusting for baseline characteristics, age, sex, type of diabetes, discopathy, and carpal tunnel syndrome parameters (
    Conclusion: Findings suggest that using acupuncture as an adjunctive therapy alongside routine treatment may not lead to a significant reduction in the symptoms of peripheral neuropathy and fatigue severity among individuals with diabetic neuropathy.
    Supplementary information: The online version contains supplementary material available at 10.1007/s40200-023-01314-1.
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680289-2
    ISSN 2251-6581
    ISSN 2251-6581
    DOI 10.1007/s40200-023-01314-1
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  6. Article: Comparison of the efficacy of sublingual, oral, and vaginal administration of misoprostol in the medical treatment of missed abortion during first trimester of pregnancy: A randomized clinical trial study.

    Souizi, Behnaz / Akrami, Rahim / Borzoee, Fateme / Sahebkar, Mohammad

    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

    2020  Volume 25, Page(s) 72

    Abstract: Background: This study was aimed at comparing the efficacy of different routes of misoprostol administration, including sublingual, oral, and vaginal, on the induction of medical abortion in the first trimester of pregnancy.: Materials and methods: ... ...

    Abstract Background: This study was aimed at comparing the efficacy of different routes of misoprostol administration, including sublingual, oral, and vaginal, on the induction of medical abortion in the first trimester of pregnancy.
    Materials and methods: This open-label, randomized clinical trial study was performed on 172 individuals in three parallel groups of vaginal, sublingual, and oral administration of misoprostol. The participants were randomized using permuted blocks of six. A dose of 600 μg of misoprostol every 6 h (maximum of 4 doses) was administrated to each group. Higham chart and demographic questionnaires were completed by the investigator. Data were analyzed using Stata software version 12.
    Results: The mean age of the participants was 29.81 ± 6.7 years, and the mean gestational age was 8.45 ± 2.32 weeks. We found a significant difference regarding the abortion success rate and the time interval between the administration of the drug among three groups (
    Conclusion: The findings suggest that vaginal administration of misoprostol is more successful than the sublingual and oral route for complete abortion; vaginal administration of misoprostol is an appropriate alternative to curettage.
    Language English
    Publishing date 2020-07-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2513029-8
    ISSN 1735-7136 ; 1735-1995
    ISSN (online) 1735-7136
    ISSN 1735-1995
    DOI 10.4103/jrms.JRMS_393_19
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  7. Article ; Online: Clinical evaluation of efficacy, safety and tolerability of cysteamine 5% cream in comparison with modified Kligman's formula in subjects with epidermal melasma: A randomized, double-blind clinical trial study.

    Karrabi, Maryam / David, Jennifer / Sahebkar, Mohammad

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2020  Volume 27, Issue 1, Page(s) 24–31

    Abstract: Background: Kligman's formula (KF) remains to date the dermatologists' treatment of choice for melasma. This study was aimed at the evaluation of the effectiveness of Modified Kligman's formula (MKF) in comparison with cysteamine 5% cream on the ... ...

    Abstract Background: Kligman's formula (KF) remains to date the dermatologists' treatment of choice for melasma. This study was aimed at the evaluation of the effectiveness of Modified Kligman's formula (MKF) in comparison with cysteamine 5% cream on the severity of epidermal melasma.
    Materials and methods: A total of 50 subjects with epidermal melasma were included in this double-blind, randomized trial study. Subjects received either cysteamine 5% cream or an MKF (4% hydroquinone, 0.05% retinoic acid and 0.1% betamethasone). Cysteamine cream (applied once daily, 15 minutes exposure) or MKF (applied once daily, whole night exposure) were used by the subjects over four consecutive months. The efficacy of the treatments was determined through the modified Melasma Area Severity Index (mMASI) score, the Investigator's Global Assessment (IGA) and patient questionnaires.
    Results: The mean (SD) age of the subjects was 34.96 (6.17) and 35.76 (5.23) years for cysteamine and MKF group, respectively. The mean mMASI score after 4 months was 7.04 (2.23) in the MKF group and 6.09 (2.01) in the cysteamine group. At both prospective evaluation points (2 months, 4 months), the percentage reduction in mMASI score was approximately 9% greater by cysteamine cream as compared to MKF, and these differences were statistically significant (P = .005 and .001 respectively).
    Conclusion: Cysteamine 5% cream showed greater efficacy as compared to MKF. It is thus proposed that cysteamine 5% cream is more effective than MKF in the treatment of melasma, with the advantage of being significantly better tolerated.
    MeSH term(s) Cysteamine/adverse effects ; Double-Blind Method ; Humans ; Melanosis/drug therapy ; Ointments ; Treatment Outcome
    Chemical Substances Ointments ; Cysteamine (5UX2SD1KE2)
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/srt.12901
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    Zs.A 4278: Show issues Location:
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  8. Article ; Online: Comparison of 40% trichloroacetic acid and cryotherapy for the treatment of plantar warts: A single-blind, randomized clinical trial.

    Karrabi, Maryam / Kheirkhah, Maryam / Shahrestanaki, Ehsan / Thomas, Smitha / Sahebkar, Mohammad

    Dermatologic therapy

    2020  Volume 33, Issue 4, Page(s) e13559

    Abstract: Plantar warts can cause pain near the toes and the sole of the foot and may result in referral for treatment. This study was aimed at comparing 40% trichloroacetic acid (TCA) and cryotherapy (Cryo) for the treatment of plantar warts. This single-blind, ... ...

    Abstract Plantar warts can cause pain near the toes and the sole of the foot and may result in referral for treatment. This study was aimed at comparing 40% trichloroacetic acid (TCA) and cryotherapy (Cryo) for the treatment of plantar warts. This single-blind, randomized clinical trial was performed on 60 subjects presenting with plantar wart in Sabzevar, Iran in 2018. The first intervention group was treated with 40% TCA in four sessions within 4 weeks. The second intervention group was treated with Cryo using liquid nitrogen in four sessions within 8 weeks. The mean (SD) age of subjects was 20.16 ± 5.96 years and 68.33% (n = 41) were male. Although the resolution rate of warts in the TCA 40% group was greater than the Cryo group, there was no statistical association found between the two groups by adjusting age, sex, and basal time (P = .648). Findings suggest that although 40% TCA was almost as effective as Cryo in the treatment of plantar warts, considering the lower adverse effects of TCA 40% group as compared to the Cryo group, it could be a proper alternative.
    MeSH term(s) Adolescent ; Adult ; Cryotherapy ; Female ; Humans ; Iran ; Male ; Single-Blind Method ; Treatment Outcome ; Trichloroacetic Acid/adverse effects ; Warts/diagnosis ; Warts/therapy ; Young Adult
    Chemical Substances Trichloroacetic Acid (5V2JDO056X)
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13559
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  9. Article ; Online: Evaluation of the effect of selecting gluteal injection site on the pain injection based on anthropometric indices and body shape pattern: A randomised controlled trial study.

    Sahebkar, Mohammad / Khosrojerdi, Azam / Rad, Mostafa / Stewart, Jacqueline J / Rastaghi, Sedighe / Assarroudi, Abdolghader

    Journal of clinical nursing

    2021  Volume 30, Issue 11-12, Page(s) 1556–1563

    Abstract: Aims and objectives: This study was aimed at comparing the effect of injection site selection based on anthropometric indices and body shape pattern on pain injection.: Background: Pain is one of the common complications of intramuscular injection. ... ...

    Abstract Aims and objectives: This study was aimed at comparing the effect of injection site selection based on anthropometric indices and body shape pattern on pain injection.
    Background: Pain is one of the common complications of intramuscular injection. Selecting the right place for gluteal injection is one of the challenges of nursing which can increase the safety and success of the injection and thereby reduce the pain severity caused by it.
    Design: Open-label randomized controlled trial study.
    Methods: In this study, 162 eligible subjects referred to the emergency unit of Vasei Hospital of Sabzevar, Iran were randomly assigned to three groups of control, anthropometric indices and body shape pattern. Subjects in the control group received dorsogluteal injection (traditional way). In the anthropometric group, body mass index (BMI), waist circumference (WC) and anterior superior iliac spine to iliac tubercle (ASIS-IT), and in body shape pattern group, observed body shape indices (OBS), BMI and sex were used to select the gluteal injection site. Pain injection was assessed using the Visual Analogue Scale (VAS). The CONSORT checklist was used.
    Results: The mean age of the participant was 39.43 ± 13.16 and 43.21% (n = 70) were male. Based on multiple linear regression analysis, the mean pain injection was substantially lower in body shape pattern as compared to the control group (r
    Conclusions: Findings of this study suggest that the selection of a gluteal injection site based on body shape pattern in comparison with traditional dorsogluteal injection method has a significant effect on pain injection relief.
    Relevance to clinical practice: Nurses can choose the appropriate gluteal injection site based on the body shape pattern to reduce the pain of the intramuscular (IM) gluteal injections.
    MeSH term(s) Anthropometry ; Body Mass Index ; Humans ; Injections, Intramuscular ; Iran ; Male ; Pain ; Somatotypes
    Language English
    Publishing date 2021-02-25
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1159483-4
    ISSN 1365-2702 ; 0962-1067 ; 1752-9816
    ISSN (online) 1365-2702
    ISSN 0962-1067 ; 1752-9816
    DOI 10.1111/jocn.15703
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  10. Article ; Online: Evaluating the effects of telenursing on patients' activities of daily living and instrumental activities of daily living after myocardial infarction: A randomized controlled trial study.

    Sefidi, Narges / Assarroudi, Abdolghader / Zandi, Zahra / Malkemes, Susan J / Rakhshani, Mohammad Hassan / Abbaszade, Ali / Sahebkar, Mohammad

    Geriatrics & gerontology international

    2022  Volume 22, Issue 8, Page(s) 616–622

    Abstract: Aim: This study aimed to assess the effects of telenursing on patients' activities of daily living and instrumental activities of daily living (ADLs and IADLs) following a myocardial infarction (MI).: Methods: This randomized, parallel-group, ... ...

    Abstract Aim: This study aimed to assess the effects of telenursing on patients' activities of daily living and instrumental activities of daily living (ADLs and IADLs) following a myocardial infarction (MI).
    Methods: This randomized, parallel-group, controlled trial was conducted on 95 patients post-MI from 2018 to 2019. Patients were randomly assigned to the intervention (telenursing) and control groups using permuted block randomization. Through telephone calls, telenursing was performed twice a week during the first six consecutive weeks, then once a week until week 12. ADL and IADL questionnaires were completed by both groups before intervention and 12 weeks later. The CONSORT 2010 checklist was used to report the study protocol.
    Results: The mean age of patients was 56.8 ± 11.07 and 54.2 ± 9.8 years in the telenursing and control group, respectively. The mean ADL and IADL scores in the telenursing group were substantially greater than in the control group [4.57 (3.18, 5.97); P < 0.001 and 4.40 (3.06, 5.75); P < 0.001, respectively]. The odds of a higher degree of independence (no disabilities vs. mild disabilities and disability as well as no disabilities and mild disabilities vs. disability) regarding ADLs and IADLs were significantly greater in the telenursing group as compared with the control group (P < 0.001 and P < 0.001, respectively).
    Conclusions: Our findings suggest that the use of telenursing intervention may increase patients' ADLs and IADLs after an MI and may enhance their independence. Geriatr Gerontol Int 2022; 22: 616-622.
    MeSH term(s) Activities of Daily Living ; Aged ; Disabled Persons ; Humans ; Myocardial Infarction ; Surveys and Questionnaires ; Telenursing
    Language English
    Publishing date 2022-06-22
    Publishing country Japan
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2113849-7
    ISSN 1447-0594 ; 1444-1586
    ISSN (online) 1447-0594
    ISSN 1444-1586
    DOI 10.1111/ggi.14426
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