LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 54

Search options

  1. Article: Evidence for Two Modes of Binding of the Negative Allosteric Modulator SB269,652 to the Dopamine D

    Ågren, Richard / Sahlholm, Kristoffer

    Biomedicines

    2021  Volume 10, Issue 1

    Abstract: SB269,652 has been described as the first negative allosteric modulator (NAM) of the dopamine ... ...

    Abstract SB269,652 has been described as the first negative allosteric modulator (NAM) of the dopamine D
    Language English
    Publishing date 2021-12-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10010022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: G protein-coupled receptor kinase-2 confers isoform-specific calcium sensitivity to dopamine D

    Ågren, Richard / Sahlholm, Kristoffer

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2021  Volume 35, Issue 11, Page(s) e22013

    Abstract: The dopamine ... ...

    Abstract The dopamine D
    MeSH term(s) Animals ; Calcium/metabolism ; Cells, Cultured ; Female ; G-Protein-Coupled Receptor Kinase 2/metabolism ; Oocytes/cytology ; Oocytes/metabolism ; Receptors, Dopamine D2/metabolism ; Xenopus laevis ; beta-Arrestin 2/metabolism
    Chemical Substances Receptors, Dopamine D2 ; beta-Arrestin 2 ; G-Protein-Coupled Receptor Kinase 2 (EC 2.7.11.16) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202100704RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Voltage-Dependent Dopamine Potency at D

    Ågren, Richard / Sahlholm, Kristoffer

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 581151

    Abstract: In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the ... ...

    Abstract In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gα
    Language English
    Publishing date 2020-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.581151
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Synthetic corticosteroids as tryptophan hydroxylase stabilizers.

    Betari, Nibal / Teigen, Knut / Sahlholm, Kristoffer / Haavik, Jan

    Future medicinal chemistry

    2021  Volume 13, Issue 17, Page(s) 1465–1474

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adrenal Cortex Hormones/chemical synthesis ; Adrenal Cortex Hormones/chemistry ; Adrenal Cortex Hormones/pharmacology ; Catalytic Domain/drug effects ; Enzyme Stability ; Humans ; Molecular Conformation ; Molecular Docking Simulation ; Tryptophan Hydroxylase/metabolism
    Chemical Substances Adrenal Cortex Hormones ; Tryptophan Hydroxylase (EC 1.14.16.4)
    Language English
    Publishing date 2021-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2021-0068
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals.

    Ågren, Richard / Patil, Snehal / Zhou, Xiang / Sahlholm, Kristoffer / Pääbo, Svante / Zeberg, Hugo

    Molecular biology and evolution

    2023  Volume 40, Issue 6

    Abstract: Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. ...

    Abstract Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. Here, we meta-analyze 3 biobanks comprising 7,871 cases and 645,880 controls and find 61 genome-wide significant variants associated with Dupuytren's disease. We show that 3 of the 61 loci harbor alleles of Neandertal origin, including the second and third most strongly associated ones (P = 6.4 × 10-132 and P = 9.2 × 10-69, respectively). For the most strongly associated Neandertal variant, we identify EPDR1 as the causal gene. Dupuytren's disease is an example of how admixture with Neandertals has shaped regional differences in disease prevalence.
    MeSH term(s) Animals ; Humans ; Male ; Alleles ; Dupuytren Contracture/genetics ; Neanderthals/genetics ; Risk Factors
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998579-7
    ISSN 1537-1719 ; 0737-4038
    ISSN (online) 1537-1719
    ISSN 0737-4038
    DOI 10.1093/molbev/msad130
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2137: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: An E280K Missense Variant in

    Ågren, Richard / Geerdink, Niels / Brunner, Han G / Paucar, Martin / Kamsteeg, Erik-Jan / Sahlholm, Kristoffer

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: A five-year-old girl presented with headache attacks, clumsiness, and a history of transient gait disturbances. She and her father, mother, twin sister, and brother underwent neurological evaluation, neuroimaging, and exome sequencing covering 357 genes ... ...

    Abstract A five-year-old girl presented with headache attacks, clumsiness, and a history of transient gait disturbances. She and her father, mother, twin sister, and brother underwent neurological evaluation, neuroimaging, and exome sequencing covering 357 genes associated with movement disorders. Sequencing revealed the new variant
    MeSH term(s) Male ; Female ; Humans ; Spinocerebellar Degenerations/genetics ; Shal Potassium Channels/genetics ; Mutation, Missense ; Mutation ; Cerebellar Ataxia ; Ataxia
    Chemical Substances Shal Potassium Channels ; KCND3 protein, human
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310924
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: In Vitro Comparison of Ulotaront (SEP-363856) and Ralmitaront (RO6889450): Two TAAR1 Agonist Candidate Antipsychotics.

    Ågren, Richard / Betari, Nibal / Saarinen, Marcus / Zeberg, Hugo / Svenningsson, Per / Sahlholm, Kristoffer

    The international journal of neuropsychopharmacology

    2023  Volume 26, Issue 9, Page(s) 599–606

    Abstract: Background: Trace amine-associated receptor-1 (TAAR1) agonists have been proposed as potential antipsychotics, with ulotaront and ralmitaront having reached clinical trials. While ulotaront demonstrated efficacy in a recent Phase II trial, a ... ...

    Abstract Background: Trace amine-associated receptor-1 (TAAR1) agonists have been proposed as potential antipsychotics, with ulotaront and ralmitaront having reached clinical trials. While ulotaront demonstrated efficacy in a recent Phase II trial, a corresponding study studies of ralmitaront failed to show efficacy as a monotherapy or as an adjunct to atypical antipsychotics. In addition to TAAR1 agonism, ulotaront is a partial agonist at the serotonin 1A receptor (5-HT1AR). However, little is known about ralmitaront.
    Methods: We compared ulotaront and ralmitaront at TAAR1, 5-HT1AR, and dopamine D2 using luciferase complementation-based G protein recruitment, cAMP accumulation, and G protein-coupled inward rectifier potassium channel activation assays.
    Results: Ralmitaront showed lower efficacy at TAAR1 in G protein recruitment, cAMP accumulation, and GIRK activation assays. Moreover, ralmitaront lacked detectable activity at 5-HT1AR and dopamine D2.
    Conclusions: Compared with ulotaront, ralmitaront shows lower efficacy and slower kinetics at TAAR1 and lacks efficacy at 5-HT1AR. These data may be relevant to understanding differences in clinical profiles of these 2 compounds.
    MeSH term(s) Dopamine/metabolism ; Antipsychotic Agents/pharmacology ; Receptors, G-Protein-Coupled/agonists ; Pyrans
    Chemical Substances SEP-363856 ; Dopamine (VTD58H1Z2X) ; Antipsychotic Agents ; Receptors, G-Protein-Coupled ; Pyrans
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440129-0
    ISSN 1469-5111 ; 1461-1457
    ISSN (online) 1469-5111
    ISSN 1461-1457
    DOI 10.1093/ijnp/pyad049
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5187: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Antipsychotics with similar association kinetics at dopamine D

    Zeberg, Hugo / Sahlholm, Kristoffer

    Nature communications

    2018  Volume 9, Issue 1, Page(s) 3577

    MeSH term(s) Antipsychotic Agents ; Dopamine ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Kinetics ; Receptors, Dopamine D2
    Chemical Substances Antipsychotic Agents ; Receptors, Dopamine D2 ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2018-09-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-04489-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes.

    Sahlholm, Kristoffer

    Biochemical and biophysical research communications

    2011  Volume 415, Issue 3, Page(s) 509–514

    Abstract: G protein coupled inward rectifier K(+) channels (GIRK) are activated by the G(βγ) subunits of G proteins upon activation of G protein coupled receptors (GPCRs). Receptor-stimulated GIRK currents are known to possess a curious property, termed "agonist- ... ...

    Abstract G protein coupled inward rectifier K(+) channels (GIRK) are activated by the G(βγ) subunits of G proteins upon activation of G protein coupled receptors (GPCRs). Receptor-stimulated GIRK currents are known to possess a curious property, termed "agonist-dependent relaxation," denoting a slow current increase upon stepping the membrane voltage from positive to negative potentials. Regulators of G protein signaling (RGS) proteins have earlier been implicated in this phenomenon since RGS coexpression was required for relaxation to be observed in heterologous expression systems. However, a recent study presented contrasting evidence that GIRK current relaxation reflects voltage sensitive agonist binding to the GPCR. The present study re-examined the role of RGS protein in agonist-dependent relaxation and found that RGS coexpression is not necessary for the relaxation phenomenon. However, RGS4 speeds up relaxation kinetics, allowing the phenomenon to be observed using shorter voltage steps. These findings resolve the controversy regarding the role of RGS protein vs. GPCR voltage sensitivity in mediating agonist-dependent relaxation of GIRK currents.
    MeSH term(s) Animals ; Binding Sites/genetics ; Calcium/metabolism ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/agonists ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/metabolism ; Humans ; Mutation ; Oocytes ; RGS Proteins/metabolism ; Xenopus laevis
    Chemical Substances G Protein-Coupled Inwardly-Rectifying Potassium Channels ; RGS Proteins ; RGS4 protein (175335-35-0) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2011-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2011.10.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2.

    Burström, Viktor / Ågren, Richard / Betari, Nibal / Valle-León, Marta / Garro-Martínez, Emilio / Ciruela, Francisco / Sahlholm, Kristoffer

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1087171

    Abstract: The dopamine ... ...

    Abstract The dopamine D
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1087171
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top