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  1. Article: Editorial: Advances in the therapeutic targeting of human matrix metalloproteinases in health and disease.

    Bharadwaj, Shiv / Sahoo, Amaresh Kumar / Yadava, Umesh

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1150474

    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1150474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparative assessment of nanosized intracanal medicaments on penetration and fracture resistance of root dentin - An

    Prashanth, B R / Revankar, Bhoomika / Karale, Rupali / Moogi, Prashant P / Mangala, M G / Sahoo, Amaresh Kumar

    Journal of conservative dentistry and endodontics

    2024  Volume 27, Issue 1, Page(s) 17–23

    Abstract: Context: The antimicrobial potential of conventional medicaments is reduced due to their limited permeability. The use of calcium hydroxide (CH) is known to reduce the root strength. Nano intracanal medicaments have the following advantages over ... ...

    Abstract Context: The antimicrobial potential of conventional medicaments is reduced due to their limited permeability. The use of calcium hydroxide (CH) is known to reduce the root strength. Nano intracanal medicaments have the following advantages over conventional such as higher surface area and chemical reactivity, and due to its nanosize, have better penetrability, supporting its possible use as an intracanal medicament. Nano versions of CH, chitosan (CS), CS + CH, curcumin (T), and its conventional forms are used in our study.
    Aim: The aim of this study was to evaluate and compare the depth of penetration of nanosized intracanal medicaments and their effect on fracture resistance of root dentin.
    Materials and methods: Eighty extracted single-rooted teeth were used after decoronation. Canals were enlarged up to size 30 (0.04° taper) using Neoendo instruments (Orikam, India). Teeth were randomly assigned to two broad groups based on the type of intracanal medicament used; Group A: control (conventional) (
    Results: The highest fracture resistance was seen with NCS and the maximum depth of penetration with nano calcium hydroxide (NCH).
    Conclusion: The fracture resistance and depth of penetration at a 4-week interval were higher in nano forms compared to their micro-sized counterparts with all groups. The coronal section presented the highest depth of penetration of intracanal medicaments followed by the middle and least in the apical section of root dentin with all groups.
    Language English
    Publishing date 2024-01-13
    Publishing country India
    Document type Journal Article
    ISSN 2950-4708
    ISSN (online) 2950-4708
    DOI 10.4103/JCDE.JCDE_138_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring plant-derived small molecules as inhibitors of Marburg virus RNA binding protein activity.

    Bajrai, Leena Hussein / Almalki, Abdulrahman Abdullah / Sahoo, Amaresh Kumar / Dwivedi, Vivek Dhar / Azhar, Esam Ibraheem

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–11

    Abstract: The search for antiviral medications is greatly influenced by the hunt for potent inhibitors of viral proteins. To find possible inhibitors of the RNA binding activity of the Marburg virus VP35 protein, we used a thorough in silico drug discovery ... ...

    Abstract The search for antiviral medications is greatly influenced by the hunt for potent inhibitors of viral proteins. To find possible inhibitors of the RNA binding activity of the Marburg virus VP35 protein, we used a thorough in silico drug discovery approach in this investigation. A comprehensive virtual screening process, followed by a detailed MMGBSA analysis, led to the discovery of four potential inhibitory compounds viz. Kudzuisoflavone A, Miquelianin, Rutin, and Protopseudohypericin. They were identified from an extensive library of phytomolecules derived from three medicinal plants:
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2306500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2093: Show issues Location:
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  4. Article ; Online: Correction to "Visible Light-Mediated Photoactivated Sulfur Quantum Dots as Heightened Antibacterial Agents".

    Shivalkar, Saurabh / Arshad, Farwa / Sahoo, Amaresh Kumar / Sk, Md Palashuddin

    ACS omega

    2023  Volume 8, Issue 5, Page(s) 5138

    Abstract: This corrects the article DOI: 10.1021/acsomega.2c03968.]. ...

    Abstract [This corrects the article DOI: 10.1021/acsomega.2c03968.].
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Published Erratum
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c08216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Visible Light-Mediated Photoactivated Sulfur Quantum Dots as Heightened Antibacterial Agents.

    Shivalkar, Saurabh / Arshad, Farwa / Sahoo, Amaresh Kumar / Sk, Md Palashuddin

    ACS omega

    2022  Volume 7, Issue 37, Page(s) 33358–33364

    Abstract: The need for antimicrobial or antibacterial fabric has increased exponentially in recent past years, especially after the outbreak of the SARS-CoV-2 pandemic. Several studies have been conducted, and the primary focus is the development of simple, ... ...

    Abstract The need for antimicrobial or antibacterial fabric has increased exponentially in recent past years, especially after the outbreak of the SARS-CoV-2 pandemic. Several studies have been conducted, and the primary focus is the development of simple, automated, performance efficient and cost-efficient fabric for disposable and frequent-use items such as personal protective materials. In this regard, we have explored the light-driven antibacterial activity of water-soluble Sdots for the first time. Sdots are a new class of non-metallic quantum dots of the nanosulfur family having a polymeric sulfur core. These Sdots exhibited excellent antibacterial activity by generating reactive oxygen species under sunlight or visible light. Under 6 h of sunlight irradiation, it was observed that >90% of the bacterial growth was inhibited in the presence of Sdots. Furthermore, low toxic Sdots were employed to develop antibacterial fabric for efficiently cleaning the bacterial infection. The prominent zone of inhibition of up to 9 mm was observed post 12 h incubation of Sdots treated fabric with
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c03968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Manganese Doping in Biomass Derived Carbon Dots Amplifies White Light-Induced Antibacterial Activity.

    Tariq, Mohammad / Shivalkar, Saurabh / Hasan, Hammad / Sahoo, Amaresh Kumar / Sk, Md Palashuddin

    ACS omega

    2023  Volume 8, Issue 51, Page(s) 49460–49466

    Abstract: The prevalence of antibiotic-resistant bacterial infections demands effective alternative therapeutics of antibiotics, whereas biocompatible zero-dimensional nanomaterials are an excellent option due to their small size. In this study, we report the one- ... ...

    Abstract The prevalence of antibiotic-resistant bacterial infections demands effective alternative therapeutics of antibiotics, whereas biocompatible zero-dimensional nanomaterials are an excellent option due to their small size. In this study, we report the one-step hydrothermal approach that was used to synthesize luminescent manganese doped carbon dots (Mn-Cdots) with an efficient quantum yield of 9.2% by employing green
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A comprehensive guide on screening and selection of a suitable AMP against biofilm-forming bacteria.

    Anurag Anand, Ananya / Amod, Ayush / Anwar, Sarfraz / Sahoo, Amaresh Kumar / Sethi, Gautam / Samanta, Sintu Kumar

    Critical reviews in microbiology

    2023  , Page(s) 1–20

    Abstract: Lately, antimicrobial resistance (AMR) is increasing at an exponential rate making it important to search alternatives to antibiotics in order to combat multi-drug resistant (MDR) bacterial infections. Out of the several antibacterial and antibiofilm ... ...

    Abstract Lately, antimicrobial resistance (AMR) is increasing at an exponential rate making it important to search alternatives to antibiotics in order to combat multi-drug resistant (MDR) bacterial infections. Out of the several antibacterial and antibiofilm strategies being tested, antimicrobial peptides (AMPs) have shown to give better hopes in terms of a long-lasting solution to the problem. To select a desired AMP, it is important to make right use of available tools and databases that aid in identification, classification, and analysis of the physiochemical properties of AMPs. To identify the targets of these AMPs, it becomes crucial to understand their mode-of-action. AMPs can also be used in combination with other antibacterial and antibiofilm agents so as to achieve enhanced efficacy against bacteria and their biofilms. Due to concerns regarding toxicity, stability, and bioavailability, strategizing drug formulation at an early-stage becomes crucial. Although there are few concerns regarding development of bacterial resistance to AMPs, the evolution of resistance to AMPs occurs extremely slowly. This comprehensive review gives a deep insight into the selection of the right AMP, deciding the right target and combination strategy along with the type of formulation needed, and the possible resistance that bacteria can develop to these AMPs.
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1053620-6
    ISSN 1549-7828 ; 1040-841X
    ISSN (online) 1549-7828
    ISSN 1040-841X
    DOI 10.1080/1040841X.2023.2293019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1025: Show issues Location:
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  8. Article ; Online: In Silico

    Singh, Vishal / Verma, Suman / Fatima, Fiza / Samanta, Sintu Kumar / Varadwaj, Pritish Kumar / Sahoo, Amaresh Kumar

    ACS omega

    2023  Volume 8, Issue 41, Page(s) 38025–38037

    Abstract: Treatment of triple-negative breast cancer (TNBC) is very challenging as only few therapeutic options are available, including chemotherapy. Thus, a constant search for new and effective approaches of therapy that could potentially fight against TNBC and ...

    Abstract Treatment of triple-negative breast cancer (TNBC) is very challenging as only few therapeutic options are available, including chemotherapy. Thus, a constant search for new and effective approaches of therapy that could potentially fight against TNBC and mitigate side effects is "turn-on". Recently, multitarget therapy has come up with huge possibilities, and it may possibly be useful to overcome several concurrent challenges in cancer therapy. Herein, we proposed the inhibition of both Topoisomerase II enzyme and p53-MDM2 (p53 cavity in MDM2) protein complex by the same bioactive molecules for multitarget therapy. RNA-seq analysis was performed to get a network of essential proteins involved in the apoptosis pathway by considering the triple-negative breast cancer cell line (MDA-MB-231). All of the untreated duplicate sample data were retrieved from NCBI (GSC149768). Further, via
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c03640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Finding Novel AMPs Secreted from the Human Microbiome as Potent Antibacterial and Antibiofilm Agents and Studying Their Synergistic Activity with Ag NCs.

    Singh, Anirudh / Amod, Ayush / Mulpuru, Viswajit / Mishra, Nidhi / Sahoo, Amaresh Kumar / Samanta, Sintu Kumar

    ACS applied bio materials

    2023  Volume 6, Issue 9, Page(s) 3674–3682

    Abstract: Due to the enhanced resistance of bacteria to antibiotics, researchers always try to find effective alternatives to treat drug-resistant bacterial infections. In this context, we have explored antimicrobial peptides (AMPs), which are a broad class of ... ...

    Abstract Due to the enhanced resistance of bacteria to antibiotics, researchers always try to find effective alternatives to treat drug-resistant bacterial infections. In this context, we have explored antimicrobial peptides (AMPs), which are a broad class of small peptide molecules, and investigated their efficacy as potent antibacterial and antibiofilm agents. AMPs can cause cell death either through disruption of the cell membrane or by inhibiting vital intracellular functions, by binding to RNA, DNA, or intracellular components upon transversion through the cell membrane. We attempted to find potent intracellular cationic AMPs that can demonstrate antibacterial activity through interaction with DNA. As a source of AMPs, we have utilized those that are secreted from the human microbiome with the anticipation that these will be non-toxic in nature. Out of the total 1087 AMPs, 27 were screened on the basis of amino acid length and efficacy to cross the cell membrane barrier. From the list of 27 peptides, 4 candidates were selected through the docking score of these peptides with the DNA binding domain of H2A proteins. Further, the molecular dynamics simulation analysis demonstrated that 2 AMPs, i.e., peptides 7 and 25, are having considerable membrane permeation and DNA binding ability. Further, the in vitro analysis indicated that both peptides 7 and 25 could exhibit potent antibacterial and antibiofilm activities. In order to further enhance the antibiofilm potency, the above AMPs were used as supplements to silver nanoclusters (Ag NCs) to get synergistic activity. The synergistic activity of Ag NCs was found to be significantly increased with both the above AMPs.
    MeSH term(s) Humans ; Antimicrobial Peptides ; Biological Transport ; Anti-Bacterial Agents/pharmacology ; Microbiota ; Biofilms
    Chemical Substances Antimicrobial Peptides ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Strategies in design of self-propelling hybrid micro/nanobots for bioengineering applications.

    Shivalkar, Saurabh / Roy, Anwesha / Chaudhary, Shrutika / Samanta, Sintu Kumar / Chowdhary, Pallabi / Sahoo, Amaresh Kumar

    Biomedical materials (Bristol, England)

    2023  Volume 18, Issue 6

    Abstract: Micro/nanobots are integrated devices developed from engineered nanomaterials that have evolved significantly over the past decades. They can potentially be pre-programmed to operate robustly at numerous hard-to-reach organ/tissues/cellular sites for ... ...

    Abstract Micro/nanobots are integrated devices developed from engineered nanomaterials that have evolved significantly over the past decades. They can potentially be pre-programmed to operate robustly at numerous hard-to-reach organ/tissues/cellular sites for multiple bioengineering applications such as early disease diagnosis, precision surgeries, targeted drug delivery, cancer therapeutics, bio-imaging, biomolecules isolation, detoxification, bio-sensing, and clearing up clogged arteries with high soaring effectiveness and minimal exhaustion of power. Several techniques have been introduced in recent years to develop programmable, biocompatible, and energy-efficient micro/nanobots. Therefore, the primary focus of most of these techniques is to develop hybrid micro/nanobots that are an optimized combination of purely synthetic or biodegradable bots suitable for the execution of user-defined tasks more precisely and efficiently. Recent progress has been illustrated here as an overview of a few of the achievable construction principles to be used to make biomedical micro/nanobots and explores the pivotal ventures of nanotechnology-moderated development of catalytic autonomous bots. Furthermore, it is also foregrounding their advancement offering an insight into the recent trends and subsequent prospects, opportunities, and challenges involved in the accomplishments of the effective multifarious bioengineering applications.
    MeSH term(s) Nanotechnology/methods ; Biomedical Engineering ; Nanostructures ; Drug Delivery Systems/methods ; Bioengineering
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/acf975
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    Zs.A 6626: Show issues Location:
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