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  1. Article ; Online: Dimension reduction of microbiome data linked Bifidobacterium and Prevotella to allergic rhinitis.

    Komaki, Shohei / Sahoyama, Yukari / Hachiya, Tsuyoshi / Koseki, Keita / Ogata, Yusuke / Hamazato, Fumiaki / Shiozawa, Manabu / Nakagawa, Tohru / Suda, Wataru / Hattori, Masahira / Kawakami, Eiryo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7983

    Abstract: Dimension reduction has been used to visualise the distribution of multidimensional microbiome data, but the composite variables calculated by the dimension reduction methods have not been widely used to investigate the relationship of the human gut ... ...

    Abstract Dimension reduction has been used to visualise the distribution of multidimensional microbiome data, but the composite variables calculated by the dimension reduction methods have not been widely used to investigate the relationship of the human gut microbiome with lifestyle and disease. In the present study, we applied several dimension reduction methods, including principal component analysis, principal coordinate analysis (PCoA), non-metric multidimensional scaling (NMDS), and non-negative matrix factorization, to a microbiome dataset from 186 subjects with symptoms of  allergic rhinitis (AR) and 106 controls. All the dimension reduction methods supported that the distribution of microbial data points appeared to be continuous rather than discrete. Comparison of the composite variables calculated from the different dimension reduction methods showed that the characteristics of the composite variables differed depending on the distance matrices and the dimension reduction methods. The first composite variables calculated from PCoA and NMDS with the UniFrac distance were strongly associated with AR (FDR adjusted P = 2.4 × 10
    MeSH term(s) Humans ; Bifidobacterium ; Prevotella ; Gastrointestinal Microbiome ; Multidimensional Scaling Analysis ; Rhinitis, Allergic
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57934-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiple nutritional and gut microbial factors associated with allergic rhinitis: the Hitachi Health Study.

    Sahoyama, Yukari / Hamazato, Fumiaki / Shiozawa, Manabu / Nakagawa, Tohru / Suda, Wataru / Ogata, Yusuke / Hachiya, Tsuyoshi / Kawakami, Eiryo / Hattori, Masahira

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3359

    Abstract: Several studies suggest the involvement of dietary habits and gut microbiome in allergic diseases. However, little is known about the nutritional and gut microbial factors associated with the risk of allergic rhinitis (AR). We recruited 186 participants ... ...

    Abstract Several studies suggest the involvement of dietary habits and gut microbiome in allergic diseases. However, little is known about the nutritional and gut microbial factors associated with the risk of allergic rhinitis (AR). We recruited 186 participants with symptoms of AR and 106 control subjects without symptoms of AR at the Hitachi Health Care Center, Japan. The habitual consumption of 42 selected nutrients were examined using the brief-type self-administered diet history questionnaire. Faecal samples were collected and subjected to amplicon sequencing of the 16S ribosomal RNA gene hypervariable regions. Association analysis revealed that four nutrients (retinol, vitamin A, cryptoxanthin, and copper) were negatively associated with AR. Among 40 genera examined, relative abundance of Prevotella and Escherichia were associated with AR. Furthermore, significant statistical interactions were observed between retinol and Prevotella. The age- and sex-adjusted odds of AR were 25-fold lower in subjects with high retinol intake and high Prevotella abundance compared to subjects with low retinol intake and low Prevotella abundance. Our data provide insights into complex interplay between dietary nutrients, gut microbiome, and the development of AR.
    MeSH term(s) Feces ; Gastrointestinal Microbiome ; Humans ; Prevotella/genetics ; RNA, Ribosomal, 16S/genetics ; Rhinitis, Allergic/complications ; Rhinitis, Allergic/epidemiology ; Vitamin A
    Chemical Substances RNA, Ribosomal, 16S ; Vitamin A (11103-57-4)
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07398-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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