LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 47

Search options

  1. Article ; Online: Artificial intelligence for automated detection of large mammals creates path to upscale drone surveys.

    Lenzi, Javier / Barnas, Andrew F / ElSaid, Abdelrahman A / Desell, Travis / Rockwell, Robert F / Ellis-Felege, Susan N

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 947

    Abstract: Imagery from drones is becoming common in wildlife research and management, but processing data efficiently remains a challenge. We developed a methodology for training a convolutional neural network model on large-scale mosaic imagery to detect and ... ...

    Abstract Imagery from drones is becoming common in wildlife research and management, but processing data efficiently remains a challenge. We developed a methodology for training a convolutional neural network model on large-scale mosaic imagery to detect and count caribou (Rangifer tarandus), compare model performance with an experienced observer and a group of naïve observers, and discuss the use of aerial imagery and automated methods for large mammal surveys. Combining images taken at 75 m and 120 m above ground level, a faster region-based convolutional neural network (Faster-RCNN) model was trained in using annotated imagery with the labels: "adult caribou", "calf caribou", and "ghost caribou" (animals moving between images, producing blurring individuals during the photogrammetry processing). Accuracy, precision, and recall of the model were 80%, 90%, and 88%, respectively. Detections between the model and experienced observer were highly correlated (Pearson: 0.96-0.99, P value < 0.05). The model was generally more effective in detecting adults, calves, and ghosts than naïve observers at both altitudes. We also discuss the need to improve consistency of observers' annotations if manual review will be used to train models accurately. Generalization of automated methods for large mammal detections will be necessary for large-scale studies with diverse platforms, airspace restrictions, and sensor capabilities.
    MeSH term(s) Animals ; Cattle ; Artificial Intelligence ; Unmanned Aerial Devices ; Reindeer ; Software ; Neural Networks, Computer
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28240-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Pseudomonas putida infection induces immune-antioxidant, hepato-renal, ethological, and histopathological/immunohistochemical disruptions in Oreochromis niloticus: the palliative role of titanium dioxide nanogel.

    Rahman, Afaf N Abdel / Mahboub, Heba H / Elshopakey, Gehad E / Darwish, Mahmoud I M / Gharib, Heba Said Abdel-Rahman / Shaalan, Mohamed / Fahmy, Esraa M / Abdel-Ghany, Heba M / Ismail, Sameh H / Elsheshtawy, Hassnaa Mahmoud

    BMC veterinary research

    2024  Volume 20, Issue 1, Page(s) 127

    Abstract: Background: Pseudomonas putida is a pathogenic bacterium that induces great losses in fishes, including Nile tilapia (Oreochromis niloticus). Currently, the application of nanomaterials in aquaculture practices has gained more success as it endows ... ...

    Abstract Background: Pseudomonas putida is a pathogenic bacterium that induces great losses in fishes, including Nile tilapia (Oreochromis niloticus). Currently, the application of nanomaterials in aquaculture practices has gained more success as it endows promising results in therapies compared to traditional protocols.
    Objective: Therefore, the current perspective is considered the first report to assess the anti-bacterial efficacy of titanium dioxide nanogel (TDNG) against Pseudomonas putida (P. putida) in Nile tilapia.
    Methods: The fish (n = 200; average body weight: 47.50±1.32 g) were allocated into four random groups (control, TDNG, P. putida, and TDNG + P. putida), where 0.9 mg/L of TDNG was applied as bath treatment for ten days.
    Results: Outcomes revealed that P. putida infection caused ethological alterations (surfacing, abnormal movement, and aggression) and depression of immune-antioxidant variables (complement 3, lysozyme activity, total antioxidant capacity, superoxide dismutase, and reduced glutathione content). Additionally, a substantial elevation in hepatorenal biomarkers (aspartate and alanine aminotransferases and creatinine) with clear histopathological changes and immuno-histochemical alterations (very weak BCL-2 and potent caspase-3 immuno-expressions) were seen. Surprisingly, treating P. putida-infected fish with TDNG improved these variables and obvious restoration of the tissue architectures.
    Conclusion: Overall, this report encompasses the key role of TDNG as an anti-bacterial agent for controlling P. putida infection and improving the health status of Nile tilapia.
    MeSH term(s) Animals ; Antioxidants ; Pseudomonas putida ; Cichlids ; Nanogels ; Diet ; Dietary Supplements ; Animal Feed/analysis ; Fish Diseases/drug therapy ; Fish Diseases/microbiology ; Polyethylene Glycols ; Polyethyleneimine ; Titanium
    Chemical Substances Antioxidants ; titanium dioxide (15FIX9V2JP) ; polyethylene glycol polyethyleneimine nanogel ; Nanogels ; Polyethylene Glycols (3WJQ0SDW1A) ; Polyethyleneimine (9002-98-6) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191675-5
    ISSN 1746-6148 ; 1746-6148
    ISSN (online) 1746-6148
    ISSN 1746-6148
    DOI 10.1186/s12917-024-03972-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Myosin inhibitor reverses hypertrophic cardiomyopathy in genotypically diverse pediatric iPSC-cardiomyocytes to mirror variant correction.

    Kinnear, Caroline / Said, Abdelrahman / Meng, Guoliang / Zhao, Yimu / Wang, Erika Y / Rafatian, Naimeh / Parmar, Neha / Wei, Wei / Billia, Filio / Simmons, Craig A / Radisic, Milica / Ellis, James / Mital, Seema

    Cell reports. Medicine

    2024  , Page(s) 101520

    Abstract: Pathogenic variants in MYH7 and MYBPC3 account for the majority of hypertrophic cardiomyopathy (HCM). Targeted drugs like myosin ATPase inhibitors have not been evaluated in children. We generate patient and variant-corrected iPSC-cardiomyocytes (CMs) ... ...

    Abstract Pathogenic variants in MYH7 and MYBPC3 account for the majority of hypertrophic cardiomyopathy (HCM). Targeted drugs like myosin ATPase inhibitors have not been evaluated in children. We generate patient and variant-corrected iPSC-cardiomyocytes (CMs) from pediatric HCM patients harboring single variants in MYH7 (V606M; R453C), MYBPC3 (G148R) or digenic variants (MYBPC3 P955fs, TNNI3 A157V). We also generate CMs harboring MYBPC3 mono- and biallelic variants using CRISPR editing of a healthy control. Compared with isogenic and healthy controls, variant-positive CMs show sarcomere disorganization, higher contractility, calcium transients, and ATPase activity. However, only MYH7 and biallelic MYBPC3 variant-positive CMs show stronger myosin-actin binding. Targeted myosin ATPase inhibitors show complete rescue of the phenotype in variant-positive CMs and in cardiac Biowires to mirror isogenic controls. The response is superior to verapamil or metoprolol. Myosin inhibitors can be effective in genotypically diverse HCM highlighting the need for myosin inhibitor drug trials in pediatric HCM.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2024.101520
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Book ; Online: Backpropagation-Free 4D Continuous Ant-Based Neural Topology Search

    ElSaid, AbdElRahman / Ricanek, Karl / Lyu, Zeming / Ororbia, Alexander / Desell, Travis

    2023  

    Abstract: Continuous Ant-based Topology Search (CANTS) is a previously introduced novel nature-inspired neural architecture search (NAS) algorithm that is based on ant colony optimization (ACO). CANTS utilizes a continuous search space to indirectly-encode a ... ...

    Abstract Continuous Ant-based Topology Search (CANTS) is a previously introduced novel nature-inspired neural architecture search (NAS) algorithm that is based on ant colony optimization (ACO). CANTS utilizes a continuous search space to indirectly-encode a neural architecture search space. Synthetic ant agents explore CANTS' continuous search space based on the density and distribution of pheromones, strongly inspired by how ants move in the real world. This continuous search space allows CANTS to automate the design of artificial neural networks (ANNs) of any size, removing a key limitation inherent to many current NAS algorithms that must operate within structures of a size that is predetermined by the user. This work expands CANTS by adding a fourth dimension to its search space representing potential neural synaptic weights. Adding this extra dimension allows CANTS agents to optimize both the architecture as well as the weights of an ANN without applying backpropagation (BP), which leads to a significant reduction in the time consumed in the optimization process: at least an average of 96% less time consumption with very competitive optimization performance, if not better. The experiments of this study - using real-world data - demonstrate that the BP-Free CANTS algorithm exhibits highly competitive performance compared to both CANTS and ANTS while requiring significantly less operation time.

    Comment: arXiv admin note: text overlap with arXiv:2011.10831
    Keywords Computer Science - Neural and Evolutionary Computing
    Subject code 006
    Publishing date 2023-05-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article ; Online: Regions of bovine adenovirus-3 IVa2 involved in nuclear/nucleolar localization and interaction with pV.

    Woldemariam, Tekeleselassie / Wang, Wenxiu / Said, Abdelrahman / Tikoo, Suresh K

    Virology

    2020  Volume 546, Page(s) 25–37

    Abstract: Bovine adenovirus-3 (BAdV-3) is a non enveloped, icosahedral DNA virus containing a genome of 34446 bps. The intermediate region of BAdV-3 encodes pIX and IVa2 proteins. Here, we report the characterization of BAdV-3 IVa2. Anti-IVa2 serum detected a 50 ... ...

    Abstract Bovine adenovirus-3 (BAdV-3) is a non enveloped, icosahedral DNA virus containing a genome of 34446 bps. The intermediate region of BAdV-3 encodes pIX and IVa2 proteins. Here, we report the characterization of BAdV-3 IVa2. Anti-IVa2 serum detected a 50 kDa protein at 24-48 h post infection in BAdV-3 infected cells. The IVa2 localizes to nucleus and nucleolus of BAdV-3 infected cells. Analysis of mutant IVa2 demonstrated that amino acids 1-25 and 373-448 are required for nuclear and nucleolar localization of IVa2, respectively. The nuclear import of IVa2 utilize importin α -1 of importin nuclear import pathway. Although deletion/substitution of amino acids 4-18 is sufficient to abrogate the nuclear localization of IVa2, amino acids 1-25 are required for nuclear localization of a cytoplasmic protein. Furthermore, we demonstrate that amino acids 1-25 and 120-140 of IVa2 interact with importin α-1 and pV proteins, respectively in BAdV-3 infected cells.
    MeSH term(s) Active Transport, Cell Nucleus ; Adenoviridae Infections/genetics ; Adenoviridae Infections/metabolism ; Adenoviridae Infections/veterinary ; Adenoviridae Infections/virology ; Amino Acid Motifs ; Animals ; Cattle ; Cattle Diseases/genetics ; Cattle Diseases/metabolism ; Cattle Diseases/virology ; Cell Nucleolus/genetics ; Cell Nucleolus/metabolism ; Cell Nucleolus/virology ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; Genome, Viral ; Karyopherins/genetics ; Karyopherins/metabolism ; Mastadenovirus/chemistry ; Mastadenovirus/genetics ; Mastadenovirus/metabolism ; Protein Binding ; Protein Transport ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism
    Chemical Substances Karyopherins ; Viral Proteins ; iva2 protein, adenovirus
    Language English
    Publishing date 2020-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2020.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Nanostructured lipid carriers for enhanced

    Said, Abdelrahman R / Zoghroban, Hager S / Arafa, Mona F / Mahmoud, Soheir S / El Maghraby, Gamal M

    Drug development and industrial pharmacy

    2021  Volume 47, Issue 4, Page(s) 663–672

    Abstract: WHO considers praziquantel (PZQ) as the drug of choice for treatment ... ...

    Abstract WHO considers praziquantel (PZQ) as the drug of choice for treatment of
    MeSH term(s) Animals ; Drug Carriers ; Lipids ; Mice ; Nanostructures ; Praziquantel/pharmacology ; Schistosomicides/pharmacology
    Chemical Substances Drug Carriers ; Lipids ; Schistosomicides ; Praziquantel (6490C9U457)
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 751874-2
    ISSN 1520-5762 ; 0363-9045
    ISSN (online) 1520-5762
    ISSN 0363-9045
    DOI 10.1080/03639045.2021.1908339
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Porcine Adenovirus Type 3 E3 Encodes a Structural Protein Essential for Capsid Stability and Production of Infectious Progeny Virions.

    Said, Abdelrahman / Woldemariam, Tekeleselassie A / Tikoo, Suresh K

    Journal of virology

    2018  Volume 92, Issue 20

    Abstract: The adenovirus E3 region encodes proteins that are not essential for viral ... ...

    Abstract The adenovirus E3 region encodes proteins that are not essential for viral replication
    MeSH term(s) Adenoviruses, Porcine/physiology ; Adenoviruses, Porcine/ultrastructure ; Animals ; Capsid/chemistry ; Capsid/ultrastructure ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Cell Line ; Humans ; Microbial Viability ; Microscopy, Electron, Transmission ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Protein Stability ; Swine
    Chemical Substances Capsid Proteins ; Mutant Proteins
    Language English
    Publishing date 2018-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00680-18
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Book ; Online ; Thesis: Molecular characterization of the gene products encoded by open reading frames 34 and 59 of equine herpesvirus type 1 (EHV-1)

    Said, Abdelrahman Fekry Abdelrahman [Verfasser]

    2016  

    Author's details Abdelrahman Fekry Abdelrahman Said
    Keywords Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
    Subject code sg630
    Language English
    Publisher Freie Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    More links

    Kategorien

  9. Book: Molecular characterization of the gene products encoded by open reading frames 34 and 59 of equine herpesvirus type 1 (EHV-1)

    Said, Abdelrahman Fekry Abdelrahman

    2016  

    Author's details vorgelegt von Abdelrahman Fekry Abdelrahman Said
    Language English
    Size IX, 86 Seiten, Diagramme, Illustrationen
    Publisher Mensch und Buch Verlag
    Publishing place Berlin
    Document type Book
    ISBN 9783863877279 ; 3863877276
    Database Special collection on veterinary medicine and general parasitology

    More links

    Kategorien

  10. Article ; Online: Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis.

    El-Dakroury, Walaa A / Zewail, Moataz B / Asaad, Gihan F / Abdallah, Heba M I / Shabana, Marwa E / Said, Abdelrahman R / Doghish, Ahmed S / Azab, Hadeer A / Amer, Dalia H / Hassan, Ahmed E / Sayed, Alaa S / Samra, Ghada M / Sallam, Al-Aliaa M

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2024  Volume 196, Page(s) 114205

    Abstract: The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a novel and potential oral therapeutic option for ulcerative colitis (UC) ... ...

    Abstract The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles (SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a novel and potential oral therapeutic option for ulcerative colitis (UC) treatment. Different FEX-CS-SLNs with varied molecular weights of CS were prepared and optimized. Optimized FEX-CS-SLNs exhibited 229 ± 6.08 nm nanometric size, 36.3 ± 3.18 mV zeta potential, 64.9 % EE, and a controlled release profile. FTIR, DSC, and TEM confirmed good drug entrapment and spherical particles. Mucoadhesive properties of FEX-CS-SLNs were investigated through mucin incubation and exhibited considerable mucoadhesion. The protective effect of FEX-pure, FEX-market, and FEX-CS-SLNs against acetic acid-induced ulcerative colitis in rats was examined. Oral administration of FEX-CS-SLNs for 14 days before ulcerative colitis induction reversed UC symptoms and almost restored the intestinal mucosa to normal integrity and inhibited Phosphatidylinositol-3 kinase (73.6 %), protein kinase B (73.28 %), and elevated nuclear factor erythroid 2-related factor 2 (185.9 %) in colonic tissue. Additionally, FEX-CS-SLNs inhibited tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) to (70.79 % & 72.99 %) in colonic tissue. The ameliorative potential of FEX-CS-SLNs outperformed that of FEX-pure and FEX-market. The exceptional protective effect of FEX-CS-SLNs makes it a potentially effective oral system for managing ulcerative colitis.
    MeSH term(s) Rats ; Animals ; Colitis, Ulcerative/drug therapy ; Chitosan ; Drug Carriers/adverse effects ; Nanoparticles ; Particle Size ; Liposomes ; Terfenadine/analogs & derivatives
    Chemical Substances Lipid Nanoparticles ; Chitosan (9012-76-4) ; Drug Carriers ; fexofenadine (E6582LOH6V) ; Liposomes ; Terfenadine (7BA5G9Y06Q)
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2024.114205
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top