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Artikel ; Online: An observational study on variation in the relations and branches of recurrent laryngeal nerve

Sailaja K.

International Journal of Research in Medical Sciences, Vol 4, Iss 6, Pp 2328-

2016 Band 2331

Abstract: Background: Recurrent laryngeal nerve is one of the most important nerves because; it is subjected too much variation in its site, branches and relation with the branches of inferior thyroid artery and to thyroid gland. Therefore, the present study was ... ...

Abstract	Background: Recurrent laryngeal nerve is one of the most important nerves because; it is subjected too much variation in its site, branches and relation with the branches of inferior thyroid artery and to thyroid gland. Therefore, the present study was undertaken to study the variation in the relations and branches of recurrent laryngeal nerve. Methods: The present study was undertaken in postmortem specimen from Forensic department and cadavers in the dissection hall after the ethical clearance. The specimens were collected enbloc including tongue, oesophagus and trachea. Also, the specimens were used for modified Sihler's technique. Specimen was dissected and recurrent laryngeal nerve was identified. Its relation and branches were noted. The data regarding the number of branches, level of branching, anastomoses were expressed as percentages. Results: Recurrent laryngeal nerve does not always lie in the trachea-oesophageal sulcus. It lies lateral to trachea. This relation is found more on the right side than on the left side. The relation of the nerve to inferior thyroid artery was considered. It was found that, the nerve was lying posterior to the artery more commonly. There is no significant difference between right and left sides. The division of the nerve into anterior and posterior branches before entering the larynx was observed in half of the specimens, nerve divided before entry into the larynx. In most cases, the level of division was 1 cm below the cricothyroid joint. In few specimens, it varied from 2 to 4 cm. Conclusions: The variation in the position is more common on the right side. Branches may arise from the nerve about 4cm below the cricothyroid joint. It lies posterior to the inferior thyroid artery more frequently. [Int J Res Med Sci 2016; 4(6.000): 2328-2331]
Schlagwörter	Recurrent laryngeal nerve ; Relations ; Branches ; Anastamosis ; Cricothyroid joints ; Medicine (General) ; R5-920 ; Medicine ; R
Thema/Rubrik (Code)	410
Sprache	Englisch
Erscheinungsdatum	2016-06-01T00:00:00Z
Verlag	Medip Academy
Dokumenttyp	Artikel ; Online
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Artikel ; Online: A study on internal laryngeal nerve-its variation in the course, branching, anastamosis and relation to inferior thyroid artery

Sailaja K.

International Journal of Research in Medical Sciences, Vol 4, Iss 10, Pp 4602-

2016 Band 4606

Abstract: Background: Recurrent laryngeal nerves sometimes may not follow the classically describe course. It does not always lie in the tracheo-oesophageal groove. The relations of the nerve to inferior thyroid artery may vary. Therefore, the present study was ... ...

Abstract	Background: Recurrent laryngeal nerves sometimes may not follow the classically describe course. It does not always lie in the tracheo-oesophageal groove. The relations of the nerve to inferior thyroid artery may vary. Therefore, the present study was undertaken to study the variation in the relations and branches of recurrent laryngeal nerve. Methods: The present study was undertaken in postmortem specimen from Forensic department and cadavers in the dissection hall after the ethical clearance. The specimens were collected enbloc including tongue, oesophagus and trachea. Also, the specimens were used for modified Sihler's technique. Specimen was dissected and recurrent laryngeal nerve was identified. Its relation and branches were noted. The data regarding the number of branches, level of branching, anastomoses were expressed as percentages. Results: The nerve was seen passing posterior to the cricothyroid joint to enter the larynx. In 56% of specimens, artery was anterior to the nerve on both sides, nerve was anterior to the artery on both sides in 19%, nerve and artery was found to be ascending in the same plane side artery lateral and nerve medial in 6%, nerve divides before entry into the larynx on both sides in 68%, nerve does not divide in 75%, Division of the nerve was observed about 4cm below the joint in 6% of specimen, 3cms below the joint in 19% of specimens, 2cm below the in 19% of specimens and 1cm below the joint in 38% of specimens. Conclusions: It was found that, the nerve was lying posterior to the artery more commonly. There no significant difference between right and left sides. The division of the nerve into anterior and posterior branches before entering the larynx was observed. In half of the specimens, nerve divided before entry into the larynx. [Int J Res Med Sci 2016; 4(10.000): 4602-4606]
Schlagwörter	Anastamosis ; Branches ; Cricothyroid ; Recurrent laryngeal nerve ; Relations ; Medicine (General) ; R5-920 ; Medicine ; R
Thema/Rubrik (Code)	410
Sprache	Englisch
Erscheinungsdatum	2016-10-01T00:00:00Z
Verlag	Medip Academy
Dokumenttyp	Artikel ; Online
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Artikel: Critically Ill Obstetric Admissions to an Intensive Care Unit: A Prospective Analysis from a Tertiary Care University Hospital in South India.

Sailaja K, Baby / Mk, Renuka

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2019 Band 23, Heft 2, Seite(n) 78–82

Abstract: Background: Critically ill obstetric patients represent a small proportion of intensive care unit (ICU) admissions. Physiological changes of pregnancy along with pregnancy specific diseases may lead to rapid deterioration of the health status of the ... ...

Abstract	Background: Critically ill obstetric patients represent a small proportion of intensive care unit (ICU) admissions. Physiological changes of pregnancy along with pregnancy specific diseases may lead to rapid deterioration of the health status of the parturient warranting ICU care. The present study aims to study the clinical profile and outcomes of the obstetric patients requiring ICU care. Study design and settings: Prospective observational study in the multidisciplinary ICU of a tertiary care teaching hospital conducted for a period of 2 years. Materials and methods: Demographic details, indication for ICU admission, severity of illness scores, interventions, complications and outcomes of the consecutive obstetric patients transferred to ICU were studied. Results: Ninety-one patients were admitted (26 per 1000 deliveries) to the ICU. Majority of them were postpartum (84.6%) and unbooked or referred (63.8%). Hypertensive disorders (24.2%) and obstetric hemorrhage (23.1%) were the major cause for admission to ICU. Forty three patients (47.3%) underwent cesarean delivery. Mechanical ventilation (54.9%), blood transfusion (46%), vasopressor therapy (22%) and dialysis (9.9%) were the various interventions provided in the ICU. Patients with sepsis had high mortality accounting for one third of ICU mortality. The ICU mortality rate was 9.9%. Conclusion: The present study showed a clinical profile and outcomes similar to the current scenario of critically ill obstetric patients nationwide. Further studies with a larger sample size may provide a better insight in this population. How to cite this article: Sailaja B, Renuka MK,
Sprache	Englisch
Erscheinungsdatum	2019-05-07
Erscheinungsland	India
Dokumenttyp	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-237121
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Preparation of Ibuprofen-loaded Eudragit S100 nanoparticles by Solvent evaporation technique.

VINEELA CH / KRISHNA SAILAJA K

International Journal of Pharma Sciences and Research , Vol 5, Iss 7, Pp 375-

2014 Band 384

Abstract: Aim The aim of the present study is to prepare Ibuprofen loaded Eudragit-S100 nanoparticles by means of Solvent evaporation method. Span 80 is used as surfactant. The model drug, Ibuprofen is a non-steroidal antiinflammatory drug (NSAID) commonly used ... ...

Abstract	Aim The aim of the present study is to prepare Ibuprofen loaded Eudragit-S100 nanoparticles by means of Solvent evaporation method. Span 80 is used as surfactant. The model drug, Ibuprofen is a non-steroidal antiinflammatory drug (NSAID) commonly used for the relief of symptoms of arthritis, primary dysmenorrheal, alleviating fever and reducing inflammation. It also has an analgesic effect, anti-platelet effect and vasodilation effect. Ibuprofen is available in the form of extended release tablets, chewable tablets, sustained release capsules, liquid filled capsules, syrup and suspension. Methodology Solvent evaporation technique was adapted for the preparation of Ibuprofen loaded Eudragit S100 nanoparticles. Preformed polymeric and drug solution was used as internal phase and mineral oil with 1% span 80 is used as external phase and allowed for stirring resulting in the formation of nanoparticles. Parameters like stirring rate, polymer to drug concentration and organic solvent quantity were optimized. Results and Conclusion In order to optimize the concentration of drug, polymer and organic solvent, three formulations were prepared by varying the concentration of polymer and solvents. The results obtained were compared. On comparision formulation 3(1:2) was showing particles in nanorange (345nm), higher stability (-26.9mV) and better entrapment efficiency (96.47). Invitro drug release studies were performed for a period of 10hrs and 46.02% of the drug has been released from the formulation. Conclusion It was observed that as the polymer ratio increases the release rate is sustained and encapsulation efficiency also increased.
Schlagwörter	Solvent evaporation ; Ibuprofen ; Eudragit S-100 ; drug content ; encapsulation efficiency ; invitro drug release. ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R
Thema/Rubrik (Code)	660
Sprache	Englisch
Erscheinungsdatum	2014-07-01T00:00:00Z
Verlag	KEJA Publications
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Genetic Variability Studies of Yellow Mosaic Virus Infecting Blackgram [Vigna mungo (L.) Hepper] from Andhra Pradesh, India

Vijay Kumar Naik, D. / Bhaskara Reddy, B. V. / Sarada Jayalakshmi Devi, R. / Prasanthi, L. / Lakshminarayana Vemireddy, R. / Srividhya, Akkari / Chaithanya, B. H. / Hemalatha, T. M. / Sailaja, K.

Legume research

2022 Band 45, Heft 7, Seite(n) 907

Dokumenttyp	Artikel
ZDB-ID	407856-1
ISSN	0250-5371
Datenquelle	Current Contents Ernährung, Umwelt, Agrar

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Artikel ; Online: Theoretical study on cyclophane amide molecular receptors and its complexation behavior with TCNQ.

Meenakshi Sundaram, Soma Sundaram / Karthick, Selvam / Sailaja, Krishnamurty / Karkuzhali, Rajendran / Gopu, Gopalakrishnan

Journal of photochemistry and photobiology. B, Biology

2019 Band 203, Seite(n) 111735

Abstract: Complexation behavior of cyclophane amide molecular receptors towards 7,7,8,8-tetracyanoquinodimethane (TCNQ) studied. TD-B3LYP/6-31 + G(d,p) based density functional theory was employed to investigate the photophysical characteristics of the complexes ... ...

Abstract	Complexation behavior of cyclophane amide molecular receptors towards 7,7,8,8-tetracyanoquinodimethane (TCNQ) studied. TD-B3LYP/6-31 + G(d,p) based density functional theory was employed to investigate the photophysical characteristics of the complexes obtained. Syn isomers of cyclophane amide molecular hosts show preferred conformation over other conformations. Molecular Orbital analysis indicates the electronic structure change, which reflects in the absorption spectra of the cyclophane amide-1@TCNQ, and cyclophane amide-2@TCNQ charge-transfer (CT) complexes. Binding energy studies with B3LYP-D3/6-31 + G (d,p) theory demonstrated that the more effective binding of the pyridine-2,6-dicarboxamide macrocycles than for their isophthalamide analogs. Both the CT complexes show intermolecular bifurcated hydrogen bonding (N-H
Mesh-Begriff(e)	Density Functional Theory ; Ethers, Cyclic/chemistry ; Hydrogen Bonding ; Molecular Conformation ; Nitriles/chemistry ; Piperidines/chemistry ; Static Electricity
Chemische Substanzen	Ethers, Cyclic ; Nitriles ; Piperidines ; cyclophane 1 ; cyclophane 2 ; tetracyanoquinodimethane (1518-16-7)
Sprache	Englisch
Erscheinungsdatum	2019-12-09
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	623022-2
ISSN	1873-2682 ; 1011-1344
ISSN (online)	1873-2682
ISSN	1011-1344
DOI	10.1016/j.jphotobiol.2019.111735
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Dissertation / Habilitation ; Online: Effect of glycine betaine in the alleviation of abiotic stresses in groundnut genotypes

Sailaja, K

1998

Abstract: Many of the biotic and abiotic stresses faced by grain legumes contributr to the large yield gap between potential and realzed yields. Abiotic stresses occurring at critical growth stages in groundnut affect productivity by reducing the total dry matter, ...

Abstract	Many of the biotic and abiotic stresses faced by grain legumes contributr to the large yield gap between potential and realzed yields. Abiotic stresses occurring at critical growth stages in groundnut affect productivity by reducing the total dry matter, pod yield and quality. Present study investigates thc role of glycine bctninc in nllevintiny cll'ccts of the three major abiotic stresses i, e., drought, heat and salinity on selected groundnut genotypes. The investigation was conducted in 3 phases (a) effect of betaine on tolerance of groundnut seedlings to heat and salinity stress conditions, (b) effect of betaine on isolated plants growing in pots subjected to drought, heat and salinity, and ( c) effect of betaine on tolerance of groundnut genotypes to simulated drought under field conditions. The experiments were conducted during 1996- 98 period at ICRISAT centre, Patancheru in laboratory, glass house, growth chamber and field. (a) The seedlings were subjected to high temperature and salinity stress conditions in laboratory with and without glycine betaine trcatmcnt, under high temperature stress conditions, the seedlings with betaine treatment are able to produce root and shoot lengths (34 and 40%) than seedlings without betaine treatment, in the non induced treatments, there was a 122% greater growth in betaine treated seedlings compared to untreated ones, correspondingly the gel electrophoresis results indicated that betaine treatment was able to produce four new proteins with molecular weights of 76.4, 60.6, 54.6 and 16.5 kDa. Similarly under salinity stress conditions, the betaine treatment was able to produce 30 and 32% more root and shoot growths. The protein profiles indicated that betaine treatment was able to produce four new proteins with molecular weights of 65.4, 37.8, 35.4 and 16.5 kDa. These stress shock proteins which are produced under high temperature and.
Schlagwörter	Groundnut
Thema/Rubrik (Code)	580
Sprache	Englisch
Erscheinungsland	in
Dokumenttyp	Dissertation / Habilitation ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Dissertation / Habilitation ; Online: Effect of glycine betaine in the alleviation of abiotic stresses in groundnut genotypes

Sailaja, K

1998

Abstract	Many of the biotic and abiotic stresses faced by grain legumes contributr to the large yield gap between potential and realzed yields. Abiotic stresses occurring at critical growth stages in groundnut affect productivity by reducing the total dry matter, pod yield and quality. Present study investigates thc role of glycine bctninc in nllevintiny cll'ccts of the three major abiotic stresses i, e., drought, heat and salinity on selected groundnut genotypes. The investigation was conducted in 3 phases (a) effect of betaine on tolerance of groundnut seedlings to heat and salinity stress conditions, (b) effect of betaine on isolated plants growing in pots subjected to drought, heat and salinity, and ( c) effect of betaine on tolerance of groundnut genotypes to simulated drought under field conditions. The experiments were conducted during 1996- 98 period at ICRISAT centre, Patancheru in laboratory, glass house, growth chamber and field. (a) The seedlings were subjected to high temperature and salinity stress conditions in laboratory with and without glycine betaine trcatmcnt, under high temperature stress conditions, the seedlings with betaine treatment are able to produce root and shoot lengths (34 and 40%) than seedlings without betaine treatment, in the non induced treatments, there was a 122% greater growth in betaine treated seedlings compared to untreated ones, correspondingly the gel electrophoresis results indicated that betaine treatment was able to produce four new proteins with molecular weights of 76.4, 60.6, 54.6 and 16.5 kDa. Similarly under salinity stress conditions, the betaine treatment was able to produce 30 and 32% more root and shoot growths. The protein profiles indicated that betaine treatment was able to produce four new proteins with molecular weights of 65.4, 37.8, 35.4 and 16.5 kDa. These stress shock proteins which are produced under high temperature and.
Schlagwörter	Groundnut
Thema/Rubrik (Code)	580
Sprache	Englisch
Erscheinungsland	in
Dokumenttyp	Dissertation / Habilitation ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Genetic Variability Studies of Yellow Mosaic Virus Infecting Blackgram [Vigna mungo (L.) Hepper] from Andhra Pradesh, India

Naik, D. Vijay Kumar / Reddy, B.V. Bhaskara / Devi, R. Sarada Jayalakshmi / Prasanthi, L. / Vemireddy, R. Lakshminarayana / Srividhya, Akkari / Chaithanya, B.H. / Hemalatha, T.M. / Sailaja, K.

Legume research. 2022 July, v. 45, no. 7

2022

Abstract: The productivity of blackgram is affected by many biotic and abiotic stresses. Among the biotic stresses, yellow mosaic disease (YMD) cause severe yield loss and it is caused by four distinct viruses (belongs to genus begomovirus) collectively known as ... ...

Abstract	The productivity of blackgram is affected by many biotic and abiotic stresses. Among the biotic stresses, yellow mosaic disease (YMD) cause severe yield loss and it is caused by four distinct viruses (belongs to genus begomovirus) collectively known as yellow mosaic virus (YMV). Hence there is need to characterize various YMV isolates associated with blackgram in Andhra Pradesh. YMV infected blackgram samples were collected from East Godavari, Kurnool and Prakasam districts of Andhra Pradesh. The Rolling Circle Amplification (RCA) based full length MYMIV DNA-A and MYMV DNA-B of three isolates were cloned and sequenced. Nucleotide sequence of full length DNA-A of MYMIV-East Godavari isolate showed >96% similarity at nucleotide and >90% at amino acid level with other MYMIV isolates in NCBI database. The complete DNA-A nucleotide sequence of MYMIV-Kurnool and MYMIV-Prakasam isolates shared >99% similarity at nucleotide and >98% at amino acid level with other MYMIV isolates. The complete nucleotide sequence of MYMV DNA-B of three isolates (East Godavari, Kurnool and Prakasam) had >97% homology with other MYMV DNA-B isolates from database. The predicted amino acid sequence of MYMV DNA-B of three isolates shared >96% homology with other MYMV-B isolates. The common region (CR) sequence similarity between MYMIV-As and MYMV-Bs of East Godavari and Kurnool isolates was 76.4% and 78.3% with Prakasam isolate. The divergence between the MYMIV-A and MYMV-B of present three isolates (East Godavari, Kurnool and Prakasam) under study were ranged from 22.2 to 22.6%.
Schlagwörter	Begomovirus ; Vigna mungo ; amino acid sequences ; amino acids ; black gram ; databases ; genetic variation ; nucleotide sequences ; research ; sequence homology ; viruses ; India
Sprache	Englisch
Erscheinungsverlauf	2022-07
Umfang	p. 907-913.
Erscheinungsort	Agricultural Research Communication Centre
Dokumenttyp	Artikel
ISSN	0976-0571
DOI	10.18805/LR-4800
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Analysis of CYP3A53 and CYP3A56 gene polymorphisms in Indian chronic myeloid leukemia patients.

Sailaja, K / Rao, D Nageswara / Rao, D Raghunadha / Vishnupriya, S

Asian Pacific journal of cancer prevention : APJCP

2010 Band 11, Heft 3, Seite(n) 781–784

Abstract: CYP3A5 is a member of the CYP3A gene family which metabolizes 50% of therapeutic drugs and steroid hormones. CYP3A5*3 and CYP3A5*6 polymorphisms exhibit inter-individual differences in CYP3A5 expression. The CYP3A5*3 allele (A6986G transition in intron 3) ...

Abstract	CYP3A5 is a member of the CYP3A gene family which metabolizes 50% of therapeutic drugs and steroid hormones. CYP3A53 and CYP3A56 polymorphisms exhibit inter-individual differences in CYP3A5 expression. The CYP3A53 allele (A6986G transition in intron 3) results in loss of CYP3A5 expression and the CYP3A56 allele (G14690A transition in exon 2, leading to the skipping of exon 7) is associated with lower CYP3A5 catalytic activity. The aim of the present study was to investigate their influence on susceptibility to chronic myeloid leukemia (CML). 265 CML cases and 241 age and sex matched healthy controls were analyzed by the PCR-RFLP technique. The frequencies of homozygous 3/3 genotype and CYP3A53 allele were elevated significantly in the CML group compared to controls (χ²=93.15, df=2, p=0.0001). With respect to clinical parameters, CYP3A53 allele frequency was increased in patients with advanced phase of the disease (0.71) as compared to those in chronic phase (0.65). Patients without hematological response (minor/poor) had higher frequency of 3/3 genotype (54.54%) as compared to those with major hematological response (41.2%). CYP3A56 allele was not observed in cases as well as in controls. Our study suggests that the CYP3A53 gene polymorphism is significantly associated with the risk of CML development and disease progression.
Mesh-Begriff(e)	Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Cytochrome P-450 CYP3A/genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Genetic/genetics ; Polymorphism, Restriction Fragment Length ; Prognosis ; Risk Factors ; Survival Rate ; Young Adult
Chemische Substanzen	CYP3A5 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1)
Sprache	Englisch
Erscheinungsdatum	2010
Erscheinungsland	Thailand
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2476-762X
ISSN (online)	2476-762X
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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