LIVIVO - Search results -

Search results

Result 1 - 10 of total 16

Search options

Article ; Online: Non-Haemodynamic Mechanisms Underlying Hypertension-Associated Damage in Target Kidney Components.

Russo, Elisa / Bussalino, Elisabetta / Macciò, Lucia / Verzola, Daniela / Saio, Michela / Esposito, Pasquale / Leoncini, Giovanna / Pontremoli, Roberto / Viazzi, Francesca

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: Arterial hypertension (AH) is a global challenge that greatly impacts cardiovascular morbidity and mortality worldwide. AH is a major risk factor for the development and progression of kidney disease. Several antihypertensive treatment options are ... ...

Abstract	Arterial hypertension (AH) is a global challenge that greatly impacts cardiovascular morbidity and mortality worldwide. AH is a major risk factor for the development and progression of kidney disease. Several antihypertensive treatment options are already available to counteract the progression of kidney disease. Despite the implementation of the clinical use of renin-angiotensin aldosterone system (RAAS) inhibitors, gliflozins, endothelin receptor antagonists, and their combination, the kidney damage associated with AH is far from being resolved. Fortunately, recent studies on the molecular mechanisms of AH-induced kidney damage have identified novel potential therapeutic targets. Several pathophysiologic pathways have been shown to play a key role in AH-induced kidney damage, including inappropriate tissue activation of the RAAS and immunity system, leading to oxidative stress and inflammation. Moreover, the intracellular effects of increased uric acid and cell phenotype transition showed their link with changes in kidney structure in the early phase of AH. Emerging therapies targeting novel disease mechanisms could provide powerful approaches for hypertensive nephropathy management in the future. In this review, we would like to focus on the interactions of pathways linking the molecular consequences of AH to kidney damage, suggesting how old and new therapies could aim to protect the kidney.
MeSH term(s)	Humans ; Hypertension ; Kidney/metabolism ; Renin-Angiotensin System ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Antihypertensive Agents/metabolism ; Hypertension, Renal/metabolism
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2023-05-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119422
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Homocysteine exchange across skeletal muscle in patients with chronic kidney disease.

Garibotto, Giacomo / Picciotto, Daniela / Verzola, Daniela / Valli, Alessando / Sofia, Antonella / Costigliolo, Francesca / Saio, Michela / Viazzi, Francesca / Esposito, Pasquale

Physiological reports

2023 Volume 11, Issue 6, Page(s) e15573

Abstract: Sites and mechanisms regulating the supply of homocysteine (Hcy) to the circulation are unexplored in humans. We studied the exchange of Hcy across the forearm in CKD patients (n = 17, eGFR 20 ± 2 ml/min), in hemodialysis (HD)-treated patients (n = 14) ... ...

Abstract	Sites and mechanisms regulating the supply of homocysteine (Hcy) to the circulation are unexplored in humans. We studied the exchange of Hcy across the forearm in CKD patients (n = 17, eGFR 20 ± 2 ml/min), in hemodialysis (HD)-treated patients (n = 14) and controls (n = 9). Arterial Hcy was ~ 2.5 folds increased in CKD and HD patients (p < 0.05-0.03 vs. controls). Both in controls and in patients Hcy levels in the deep forearm vein were consistently greater (+~7%, p < 0.05-0.01) than the corresponding arterial levels, indicating the occurrence of Hcy release from muscle. The release of Hcy from the forearm was similar among groups. In all groups arterial Hcy varied with its release from muscle (p < 0.03-0.02), suggesting that muscle plays an important role on plasma Hcy levels. Forearm Hcy release was inversely related to folate plasma level in all study groups but neither to vitamin B12 and IL-6 levels nor to muscle protein net balance. These data indicate that the release of Hcy from peripheral tissue metabolism plays a major role in influencing its Hcy plasma levels in humans and patients with CKD, and that folate is a major determinant of Hcy release.
MeSH term(s)	Humans ; Renal Insufficiency, Chronic/therapy ; Renal Dialysis ; Folic Acid ; Vitamin B 12 ; Muscle, Skeletal ; Homocysteine
Chemical Substances	Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204) ; Homocysteine (0LVT1QZ0BA)
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15573
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Contribution of Muscle Innate Immunity to Uremic Cachexia.

Esposito, Pasquale / Verzola, Daniela / Saio, Michela / Picciotto, Daniela / Frascio, Marco / Laudon, Alessandro / Zanetti, Valentina / Brunori, Giuliano / Garibotto, Giacomo / Viazzi, Francesca

Nutrients

2023 Volume 15, Issue 13

Abstract: Protein energy wasting (PEW) is a common complication both in chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Of note, PEW is one of the stronger predictors of morbidity and mortality in this patient population. The pathogenesis of PEW ... ...

Abstract	Protein energy wasting (PEW) is a common complication both in chronic kidney disease (CKD) and end-stage kidney disease (ESKD). Of note, PEW is one of the stronger predictors of morbidity and mortality in this patient population. The pathogenesis of PEW involves several mechanisms, including anorexia, insulin resistance, acidosis and low-grade inflammation. In addition, "sterile" muscle inflammation contributes to PEW at an advanced CKD stage. Both immune and resident muscle cells can activate innate immunity; thus, they have critical roles in triggering "sterile" tissue inflammation. Toll-like receptor 4 (TLR4) can detect endogenous danger-associated molecular patterns generated or retained in blood in uremia and induce a sterile muscle inflammatory response via NF-κB in myocytes. In addition, TLR4, though the activation of the NLRP3 inflammasome, links the sensing of metabolic uremic stress in muscle to the activation of pro-inflammatory cascades, which lead to the production of IL-1β and IL-18. Finally, uremia-induced accelerated cell senescence is associated with a secretory phenotype that favors fibrosis in muscle. Targeting these innate immune pathways could lead to novel therapies for CKD-related PEW.
MeSH term(s)	Humans ; Cachexia/complications ; Toll-Like Receptor 4/metabolism ; Immunity, Innate ; Renal Insufficiency, Chronic/therapy ; Inflammation/complications ; Uremia/complications ; Muscles/metabolism
Chemical Substances	Toll-Like Receptor 4
Language	English
Publishing date	2023-06-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15132832
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Altered adiponectin regulation in skeletal muscle of patients with chronic kidney disease.

Verzola, Daniela / Saio, Michela / Milanesi, Samantha / Picciotto, Daniela / Frascio, Marco / Brunori, Giuliano / Laudon, Alessandro / La Porta, Edoardo / Rumeo, Noemi / Zanetti, Valentina / Russo, Elisa / Garibotto, Giacomo / Viazzi, Francesca / Esposito, Pasquale

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2024

Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfae051
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: SA-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease.

Esposito, Pasquale / Picciotto, Daniela / Verzola, Daniela / Garibotto, Giacomo / Parodi, Emanuele Luigi / Sofia, Antonella / Costigliolo, Francesca / Gaggero, Gabriele / Zanetti, Valentina / Saio, Michela / Viazzi, Francesca

Journal of clinical medicine

2024 Volume 13, Issue 2

Abstract: Cellular senescence has emerged as an important driver of aging and age-related disease in the kidney. The activity of β-galactosidase at pH 6 (SA-β-Gal) is a classic maker of senescence in cellular biology; however, the predictive role of kidney tissue ... ...

Abstract	Cellular senescence has emerged as an important driver of aging and age-related disease in the kidney. The activity of β-galactosidase at pH 6 (SA-β-Gal) is a classic maker of senescence in cellular biology; however, the predictive role of kidney tissue SA-β-Gal on eGFR loss in chronic kidney disease (CKD) is still not understood. We retrospectively studied the expression of SA-β-Gal in kidney biopsies obtained in a cohort [
Language	English
Publishing date	2024-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13020322
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Muscle protein turnover and low-protein diets in patients with chronic kidney disease.

Garibotto, Giacomo / Picciotto, Daniela / Saio, Michela / Esposito, Pasquale / Verzola, Daniela

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2020 Volume 35, Issue 5, Page(s) 741–751

Abstract: Adaptation to a low-protein diet (LPD) involves a reduction in the rate of amino acid (AA) flux and oxidation, leading to more efficient use of dietary AA and reduced ureagenesis. Of note, the concept of 'adaptation' to low-protein intakes has been ... ...

Abstract	Adaptation to a low-protein diet (LPD) involves a reduction in the rate of amino acid (AA) flux and oxidation, leading to more efficient use of dietary AA and reduced ureagenesis. Of note, the concept of 'adaptation' to low-protein intakes has been separated from the concept of 'accommodation', the latter term implying a decrease in protein synthesis, with development of wasting, when dietary protein intake becomes inadequate, i.e. beyond the limits of the adaptive mechanisms. Acidosis, insulin resistance and inflammation are recognized mechanisms that can increase protein degradation and can impair the ability to activate an adaptive response when an LPD is prescribed in a chronic kidney disease (CKD) patient. Current evidence shows that, in the short term, clinically stable patients with CKD Stages 3-5 can efficiently adapt their muscle protein turnover to an LPD containing 0.55-0.6 g protein/kg or a supplemented very-low-protein diet (VLPD) by decreasing muscle protein degradation and increasing the efficiency of muscle protein turnover. Recent long-term randomized clinical trials on supplemented VLPDs in patients with CKD have shown a very good safety profile, suggesting that observations shown by short-term studies on muscle protein turnover can be extrapolated to the long-term period.
MeSH term(s)	Diet, Protein-Restricted/methods ; Dietary Supplements ; Humans ; Muscle Proteins/metabolism ; Nutritional Status ; Proteolysis ; Renal Insufficiency, Chronic/diet therapy ; Renal Insufficiency, Chronic/metabolism
Chemical Substances	Muscle Proteins
Language	English
Publishing date	2020-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfaa072
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: How to Overcome Anabolic Resistance in Dialysis-Treated Patients?

Garibotto, Giacomo / Saio, Michela / Aimasso, Francesca / Russo, Elisa / Picciotto, Daniela / Viazzi, Francesca / Verzola, Daniela / Laudon, Alessandro / Esposito, Pasquale / Brunori, Giuliano

Frontiers in nutrition

2021 Volume 8, Page(s) 701386

Abstract: A current hypothesis is that dialysis-treated patients are "anabolic resistant" i. e., their muscle protein synthesis (MPS) response to anabolic stimuli is blunted, an effect which leads to muscle wasting and poor physical performance in aging and in ... ...

Abstract	A current hypothesis is that dialysis-treated patients are "anabolic resistant" i. e., their muscle protein synthesis (MPS) response to anabolic stimuli is blunted, an effect which leads to muscle wasting and poor physical performance in aging and in several chronic diseases. The importance of maintaining muscle mass and MPS is often neglected in dialysis-treated patients; better than to describe mechanisms leading to energy-protein wasting, the aim of this narrative review is to suggest possible strategies to overcome anabolic resistance in this patient's category. Food intake, in particular dietary protein, and physical activity, are the two major anabolic stimuli. Unfortunately, dialysis patients are often aged and have a sedentary behavior, all conditions which
Language	English
Publishing date	2021-08-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2021.701386
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: New Treatment Options for Hyperkalemia in Patients with Chronic Kidney Disease.

Esposito, Pasquale / Conti, Novella Evelina / Falqui, Valeria / Cipriani, Leda / Picciotto, Daniela / Costigliolo, Francesca / Garibotto, Giacomo / Saio, Michela / Viazzi, Francesca

Journal of clinical medicine

2020 Volume 9, Issue 8

Abstract: Hyperkalemia may cause life-threatening cardiac and neuromuscular alterations, and it is associated with high mortality rates. Its treatment includes a multifaceted approach, guided by potassium levels and clinical presentation. In general, treatment of ... ...

Abstract	Hyperkalemia may cause life-threatening cardiac and neuromuscular alterations, and it is associated with high mortality rates. Its treatment includes a multifaceted approach, guided by potassium levels and clinical presentation. In general, treatment of hyperkalemia may be directed towards stabilizing cell membrane potential, promoting transcellular potassium shift and lowering total K
Language	English
Publishing date	2020-07-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9082337
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cellular Senescence Is Associated with Faster Progression of Focal Segmental Glomerulosclerosis.

Verzola, Daniela / Saio, Michela / Picciotto, Daniela / Viazzi, Francesca / Russo, Elisa / Cipriani, Leda / Carta, Annalisa / Costigliolo, Francesca / Gaggero, Gabriele / Salvidio, Gennaro / Esposito, Pasquale / Garibotto, Giacomo / Poggi, Laura

American journal of nephrology

2021 Volume 51, Issue 12, Page(s) 950–958

Abstract: Background: A current, albeit unproven, hypothesis is that an acceleration of cellular senescence is involved in impaired renal repair and progression of glomerular diseases. Focal segmental glomerulosclerosis (FSGS) is a glomerular disease with a ... ...

Abstract	Background: A current, albeit unproven, hypothesis is that an acceleration of cellular senescence is involved in impaired renal repair and progression of glomerular diseases. Focal segmental glomerulosclerosis (FSGS) is a glomerular disease with a substantial risk for progression to ESRD. However, if and to what extent cell senescence predicts a negative outcome in FSGS is still unknown. Methods: The hypothesis that cell senescence represents a proximate mechanism by which the kidney is damaged in FSGS (NOS phenotype) was investigated in 26 consecutive kidney biopsies from adult FSGS cases (eGFR 72 ± 4 mL/min, proteinuria 2.3 ± 0.6 g/day) who were incident for 2 years in a Northern Italian nephrology center and had a 6-year clinical follow-up. Results: Cell senescence (p16INK4A, SA-β-galactosidase [SA-β-Gal]) was upregulated by ∼3- to 4-fold in both glomerular and tubular cells in kidney biopsies of FSGS as compared to age-matched controls (p < 0.05-0.01). Tubular SA-β-Gal correlated with proteinuria and glomerulosclerosis, while only as a trend, tubular p16INK4A was directly associated with interstitial fibrosis. At univariate analysis, basal eGFR, proteinuria, and tubular expression of SA-β-Gal and p16INK4A were significantly directly related to the annual loss of eGFR. No correlation was observed between glomerular p16INK4A and eGFR loss. However, at multivariate analysis, eGFR, proteinuria, and tubular p16INK4A, but not SA-β-Gal, contributed significantly to the prediction of eGFR loss. Conclusions: The results indicate that an elevated cell senescence rate, expressed by an upregulation of p16INK4A in tubules at the time of initial biopsy, represents an independent predictor of progression to ESRD in adult patients with FSGS.
MeSH term(s)	Adult ; Aged ; Cellular Senescence ; Disease Progression ; Female ; Glomerulosclerosis, Focal Segmental/complications ; Glomerulosclerosis, Focal Segmental/pathology ; Glomerulosclerosis, Focal Segmental/physiopathology ; Humans ; Kidney Failure, Chronic/etiology ; Male ; Middle Aged ; Time Factors
Language	English
Publishing date	2021-01-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000511560
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1635: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway.

Milanesi, Samantha / Garibaldi, Silvano / Saio, Michela / Ghigliotti, Giorgio / Picciotto, Daniela / Ameri, Pietro / Garibotto, Giacomo / Barisione, Chiara / Verzola, Daniela

Oxidative medicine and cellular longevity

2019 Volume 2019, Page(s) 2050183

Abstract: Indoxyl sulfate (IS) accumulation occurs early during chronic kidney disease (CKD) progression and contributes to renal dysfunction by inducing fibrosis, inflammation, oxidative stress, and tissue remodeling. Renal toxicity of high IS concentrations ( ... ...

Abstract	Indoxyl sulfate (IS) accumulation occurs early during chronic kidney disease (CKD) progression and contributes to renal dysfunction by inducing fibrosis, inflammation, oxidative stress, and tissue remodeling. Renal toxicity of high IS concentrations (250
MeSH term(s)	Animals ; Disease Models, Animal ; Fibroblasts/metabolism ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Indican/metabolism ; Kidney/pathology ; Mice ; Rats
Chemical Substances	HSP90 Heat-Shock Proteins ; Indican (N187WK1Y1J)
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Journal Article
ISSN	1942-0994
ISSN (online)	1942-0994
DOI	10.1155/2019/2050183
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED