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Article ; Online: Synthesis and biological evaluation of novel

Saito, Haruka / Watanabe, Hiroyuki / Ono, Masahiro

Bioorganic & medicinal chemistry letters

2024 Volume 99, Page(s) 129625

Abstract: The ghrelin receptor (GHSR) is known to regulate various physiological processes including appetite, food intake, and growth hormone release. Its expression is mainly observed in the brain, pancreas, stomach, and intestine. However, the functions of the ... ...

Abstract	The ghrelin receptor (GHSR) is known to regulate various physiological processes including appetite, food intake, and growth hormone release. Its expression is mainly observed in the brain, pancreas, stomach, and intestine. However, the functions of the receptor have not been fully elucidated. GHSR imaging with positron emission tomography (PET) is expected to further understanding of the functions and pathologies of the receptor. In this study, we newly designed and synthesized diaminopyrimidine derivatives ([
MeSH term(s)	Animals ; Mice ; Brain/diagnostic imaging ; Brain/metabolism ; Positron-Emission Tomography/methods ; Pyrimidines ; Receptors, Ghrelin/metabolism ; Tissue Distribution ; Fluorine Radioisotopes/chemistry
Chemical Substances	2,4-diaminopyrimidine (156-81-0) ; Pyrimidines ; Receptors, Ghrelin ; Fluorine Radioisotopes
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2024.129625
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Article ; Online: The effect of native language and bilingualism on multimodal perception in speech: A study of audio-aerotactile integrationa).

Saito, Haruka / Tiede, Mark / Whalen, D H / Ménard, Lucie

The Journal of the Acoustical Society of America

2024 Volume 155, Issue 3, Page(s) 2209–2220

Abstract: Previous studies of speech perception revealed that tactile sensation can be integrated into the perception of stop consonants. It remains uncertain whether such multisensory integration can be shaped by linguistic experience, such as the listener's ... ...

Abstract	Previous studies of speech perception revealed that tactile sensation can be integrated into the perception of stop consonants. It remains uncertain whether such multisensory integration can be shaped by linguistic experience, such as the listener's native language(s). This study investigates audio-aerotactile integration in phoneme perception for English and French monolinguals as well as English-French bilingual listeners. Six step voice onset time continua of alveolar (/da/-/ta/) and labial (/ba/-/pa/) stops constructed from both English and French end points were presented to listeners who performed a forced-choice identification task. Air puffs were synchronized to syllable onset and randomly applied to the back of the hand. Results show that stimuli with an air puff elicited more "voiceless" responses for the /da/-/ta/ continuum by both English and French listeners. This suggests that audio-aerotactile integration can occur even though the French listeners did not have an aspiration/non-aspiration contrast in their native language. Furthermore, bilingual speakers showed larger air puff effects compared to monolinguals in both languages, perhaps due to bilinguals' heightened receptiveness to multimodal information in speech.
MeSH term(s)	Language ; Linguistics ; Multilingualism ; Speech ; Speech Perception/physiology ; Humans
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0025381
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Article ; Online: Lip Movements for an Unfamiliar Vowel: Mandarin Front Rounded Vowel Produced by Japanese Speakers.

Saito, Haruka

Journal of speech, language, and hearing research : JSLHR

2016 Volume 59, Issue 6, Page(s) S1558–S1565

Abstract: Purpose: The study was aimed at investigating what kind of lip positions are selected by Japanese adult participants for an unfamiliar Mandarin rounded vowel /y/ and if their lip positions are related to and/or differentiated from those for their native ...

Abstract	Purpose: The study was aimed at investigating what kind of lip positions are selected by Japanese adult participants for an unfamiliar Mandarin rounded vowel /y/ and if their lip positions are related to and/or differentiated from those for their native vowels. Method: Videotaping and post hoc tracking measurements for lip positions, namely protrusion and vertical aperture, and acoustic analysis of vowel formants were conducted on participants' production in a repetition task. Results: First, 31.2% of all productions of /y/ were produced with either protruded or compressed rounding. Second, the lip positions for /y/ were differentiated from those for the perceived nearest native vowel; although they correlated with them in terms of vertical aperture, they did not in terms of protrusion/retraction. Conclusions: Lip positions for a novel rounded vowel seemed to be produced as a modification of existing lip positions from the native repertoire. Moreover, the degree of vertical aperture might be easily transferred, and the degree of protrusion is less likely to be retained in the new lip positions.
MeSH term(s)	Adolescent ; Biomechanical Phenomena ; Female ; Humans ; Lip/physiology ; Male ; Motor Activity/physiology ; Motor Skills/physiology ; Movement/physiology ; Phonetics ; Speech/physiology ; Uncertainty ; Video Recording ; Young Adult
Language	English
Publishing date	2016-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1364086-0
ISSN	1558-9102 ; 1092-4388
ISSN (online)	1558-9102
ISSN	1092-4388
DOI	10.1044/2015_JSLHR-S-15-0033
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Article: Efficacy of RNA-spray-induced silencing of Phakopsora pachyrhizi chitin synthase genes to control soybean rust

Saito, Haruka / Sakata, Nanami / Ishiga, Takako / Ishiga, Yasuhiro

Journal of general plant pathology. 2022 May, v. 88, no. 3

2022

Abstract: Asian soybean rust caused by Phakopsora pachyrhizi is mainly controlled by synthetic fungicides; however, fungicide tolerance has emerged in P. pachyrhizi. In tests of spray-induced gene silencing (SIGS) using dsRNAs of P. pachyrhizi chitin synthase ... ...

Abstract	Asian soybean rust caused by Phakopsora pachyrhizi is mainly controlled by synthetic fungicides; however, fungicide tolerance has emerged in P. pachyrhizi. In tests of spray-induced gene silencing (SIGS) using dsRNAs of P. pachyrhizi chitin synthase genes (dsCHS), which are important for the differentiation of appressoria that are needed for infection, soybean rust lesion formation was reduced. Further, treatment with dsCHS suppressed appressoria formation. These results suggest that SIGS of fungal CHS genes will provide an additional tool to control soybean rust.
Keywords	Phakopsora pachyrhizi ; appressoria ; chitin synthase ; fungi ; fungicide resistance ; genes ; plant pathology ; soybean rust
Language	English
Dates of publication	2022-05
Size	p. 203-206.
Publishing place	Springer Nature Singapore
Document type	Article
ZDB-ID	2016032-X
ISSN	1345-2630
ISSN	1345-2630
DOI	10.1007/s10327-022-01061-w
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Article ; Online: Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma.

Sripodok, Pawat / Saito, Haruka / Kouketsu, Atsumu / Takahashi, Tetsu / Kumamoto, Hiroyuki

Odontology

2023 Volume 112, Issue 1, Page(s) 221–229

Abstract: Sirtuins (SIRTs) are a family of proteins involved in the metabolic process responsible for extending the lifespan. The role of SIRT1, 6, and 7 in oral squamous cell carcinoma (OSCC) and oral leukoplakia (OLP), one of its precursors, is still elusive. In ...

Abstract	Sirtuins (SIRTs) are a family of proteins involved in the metabolic process responsible for extending the lifespan. The role of SIRT1, 6, and 7 in oral squamous cell carcinoma (OSCC) and oral leukoplakia (OLP), one of its precursors, is still elusive. In this study, 82 OLP and 77 OSCC were immunohistochemically examined for SIRT1, 6, and 7. Stained sections were thoroughly scanned and evaluated using a digital image analysis program. The SIRT1, 6, and 7 expressions were detected in the nuclei of epithelial and carcinoma cells in various degrees. Afterward, any correlations among SIRTs, including associations with clinicopathological features and the Kaplan-Meier curves were analyzed. OSCC demonstrated significantly higher SIRT1 expression than OLP, while non-dysplastic lesions showed significantly higher SIRT6 expression than other lesions. A strong correlation was observed between SIRT6 and 7 in OLP, SIRT1 and 6 in in OSCC and in SIRT6 and 7 when all lesion types were considered. There were no significant differences between SIRTs reactivity and the clinical features in OLP. For OSCC, SIRT1 and 6 was found to be directly associated with site of the lesion, while SIRT7 showed a direct relationship between gender, stromal lymphocytic infiltration, and depth of the invasion. OSCC with high SIRT7 expression revealed a slightly lower survival probability, although not statistically significant (p = 0.1019). Our findings suggest that SIRT1, 6, and 7 may play correlated and diverse roles in the development and advancement of OSCC.
MeSH term(s)	Humans ; Mouth Neoplasms ; Carcinoma, Squamous Cell ; Squamous Cell Carcinoma of Head and Neck ; Sirtuin 1 ; Leukoplakia, Oral/pathology ; Head and Neck Neoplasms ; Sirtuins
Chemical Substances	Sirtuin 1 (EC 3.5.1.-) ; SIRT1 protein, human (EC 3.5.1.-) ; SIRT6 protein, human (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2023-05-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2092085-4
ISSN	1618-1255 ; 1618-1247
ISSN (online)	1618-1255
ISSN	1618-1247
DOI	10.1007/s10266-023-00816-x
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Article ; Online: Correction to: Immunoexpression of SIRT1, 6, and 7 in oral leukoplakia and oral squamous cell carcinoma.

Sripodok, Pawat / Saito, Haruka / Kouketsu, Atsumu / Takahashi, Tetsu / Kumamoto, Hiroyuki

Odontology

2023 Volume 112, Issue 1, Page(s) 230–231

Language	English
Publishing date	2023-06-14
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	2092085-4
ISSN	1618-1255 ; 1618-1247
ISSN (online)	1618-1255
ISSN	1618-1247
DOI	10.1007/s10266-023-00825-w
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Article ; Online: Identification, characterization, and application of a d-cysteine desulfhydrase from rice seed (Oryza sativa L.).

Yamasawa, Ryosuke / Saito, Haruka / Yashima, Yoshiki / Ito, Hiroyuki / Hamada, Shigeki

Protein expression and purification

2023 Volume 211, Page(s) 106341

Abstract: Cysteine desulfhydrases decompose cysteine to produce pyruvate, ammonium, and hydrogen sulfide. Using d-cysteine (D-cys) as a substrate, an enzyme with this activity was purified from rice seeds and identified at the native protein level. MALDI-TOF-MS ... ...

Abstract	Cysteine desulfhydrases decompose cysteine to produce pyruvate, ammonium, and hydrogen sulfide. Using d-cysteine (D-cys) as a substrate, an enzyme with this activity was purified from rice seeds and identified at the native protein level. MALDI-TOF-MS analysis of its tryptic peptides revealed a 426 amino acid protein encoded by the OsDCD1 gene (Os02g0773300). Recombinant OsDCD1 (rOsDCD1) was expressed in Escherichia coli cells and purified as a single protein by column chromatography. Gel filtration column chromatography indicated that the native enzyme was a homodimer. The enzyme exhibited maximum catalytic activity at approximately pH 7.5 and 40 °C and was stable at pH 5.5-7.5 and < 37 °C. Kinetics analysis indicated K
MeSH term(s)	Cystathionine gamma-Lyase/genetics ; Cystathionine gamma-Lyase/metabolism ; Oryza/genetics ; Cysteine/metabolism
Chemical Substances	Cystathionine gamma-Lyase (EC 4.4.1.1) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1055455-5
ISSN	1096-0279 ; 1046-5928
ISSN (online)	1096-0279
ISSN	1046-5928
DOI	10.1016/j.pep.2023.106341
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Article ; Online: Relation between stockperson behavior toward cows in a holding area and milk yields.

Saito, Haruka / Seo, Tetsuya

Animal science journal = Nihon chikusan Gakkaiho

2020 Volume 91, Issue 1, Page(s) e13334

Abstract: To assess the effects of negative and positive behaviors on milk yields, this study examined the attitudes and behaviors of stockpersons toward their cows and milk yields at a farm where 15 workers milked 67 cows as rotating shift work. At a holding area ...

Abstract	To assess the effects of negative and positive behaviors on milk yields, this study examined the attitudes and behaviors of stockpersons toward their cows and milk yields at a farm where 15 workers milked 67 cows as rotating shift work. At a holding area when moving cows to the parlor, stockperson behaviors were observed at 34 milkings. Behaviors were classified as negative (NEG) or positive (POS): NEG were attempts to move cows using touching (NT), vocalization (NV), and gestures (NG); POS were communications without attempting to move cows, consisting of touch (PT) or vocalization (PV). Numbers of NV and NEG were negatively correlated with milk yields of first parity (p < .05). Average milk yields of first parity and all cows were higher when PT were observed (p < .001, p < .0001) and POS were observed (p < .001 and p < .0001). Numbers of PT were positively correlated with milk yields of first parity (p < .05). Average milk yields of second parity were higher when PV was observed (p < .01). Positive behaviors, especially touching, are related to higher herd milk yields. Negative behaviors such as negative vocalizations are related to lower yields of younger cows.
MeSH term(s)	Animal Husbandry ; Animal Welfare ; Animals ; Behavior/physiology ; Cattle/physiology ; Cattle/psychology ; Human-Animal Bond ; Humans ; Lactation/physiology ; Lactation/psychology ; Milk/metabolism
Language	English
Publishing date	2020-04-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13334
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Article ; Online: Covering cabbage leaves with cellulose nanofiber confers resistance against Pseudomonas cannabina pv. alisalensis

Sakata, Nanami / Shiraishi, Nanami / Saito, Haruka / Komoto, Haruka / Ishiga, Takako / Usuki, Giyu / Yamashita, Yūji / Ishiga, Yasuhiro

J Gen Plant Pathol. 2023 Jan., v. 89, no. 1 p.53-60

2023

Abstract: Cellulose nanofiber (CNF) is produced from cellulose, which is one of the most abundant and renewable biomasses in nature. We previously demonstrated that covering soybean leaves with CNF changed leaf surface hydrophobicity and confers resistance against ...

Abstract	Cellulose nanofiber (CNF) is produced from cellulose, which is one of the most abundant and renewable biomasses in nature. We previously demonstrated that covering soybean leaves with CNF changed leaf surface hydrophobicity and confers resistance against Phakopsora pachyrhizi, causal fungi of Asian soybean rust. However, whether CNF also suppresses bacterial disease has not been investigated. Therefore, we here investigated CNF application on management of bacterial blight disease caused by Pseudomonas cannabina pv. alisalensis (Pcal), which is one of the problematic bacterial diseases. CNF-treated leaves showed reduced disease symptoms and bacterial populations after spray-inoculation, but not after syringe-inoculation. These results indicate that covering cabbage leaves with CNF confers resistance before Pcal enters plants. We also demonstrated that bacterial virulence-related genes, including type three effectors-encoding, coronatine biosynthesis, and flagellin-related genes, were down-regulated on the CNF-treated leaf surfaces. Moreover, bacterial entry on CNF-treated leaves was significantly reduced. We also showed that flagellin (FliC) contributes to motility, bacterial entry, and disease development during Pcal infection. These results indicate that covering with CNF decreases flagellar motility and bacterial entry, leading to reduction of disease development. Thus, altering the leaf surface properties can change bacterial behaviors. Together, CNF has a potential to be a novel and efficient agent for controlling bacterial disease.
Keywords	Phakopsora pachyrhizi ; Pseudomonas ; biosynthesis ; blight ; cabbage ; cellulose ; flagellin ; hydrophobicity ; leaves ; nanofibers ; soybean rust ; soybeans
Language	English
Dates of publication	2023-01
Size	p. 53-60.
Publishing place	Springer Nature Singapore
Document type	Article ; Online
ZDB-ID	2016032-X
ISSN	1345-2630
ISSN	1345-2630
DOI	10.1007/s10327-022-01105-1
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Article ; Online: Antagonistic interactions between odorants alter human odor perception.

Fukutani, Yosuke / Abe, Masashi / Saito, Haruka / Eguchi, Ryo / Tazawa, Toshiaki / de March, Claire A / Yohda, Masafumi / Matsunami, Hiroaki

Current biology : CB

2023 Volume 33, Issue 11, Page(s) 2235–2245.e4

Abstract: The olfactory system uses hundreds of odorant receptors (ORs), the largest group of the G-protein-coupled receptor (GPCR) superfamily, to detect a vast array of odorants. Each OR is activated by specific odorous ligands, and like other GPCRs, antagonism ... ...

Abstract	The olfactory system uses hundreds of odorant receptors (ORs), the largest group of the G-protein-coupled receptor (GPCR) superfamily, to detect a vast array of odorants. Each OR is activated by specific odorous ligands, and like other GPCRs, antagonism can block activation of ORs. Recent studies suggest that odorant antagonisms in mixtures influence olfactory neuron activities, but it is unclear how this affects perception of odor mixtures. In this study, we identified a set of human ORs activated by methanethiol and hydrogen sulfide, two potent volatile sulfur malodors, through large-scale heterologous expression. Screening odorants that block OR activation in heterologous cells identified a set of antagonists, including β-ionone. Sensory evaluation in humans revealed that β-ionone reduced the odor intensity and unpleasantness of methanethiol. Additionally, suppression was not observed when methanethiol and β-ionone were introduced simultaneously to different nostrils. Our study supports the hypothesis that odor sensation is altered through antagonistic interactions at the OR level.
MeSH term(s)	Humans ; Odorants ; Receptors, Odorant/metabolism ; Smell/physiology ; Perception ; Olfactory Receptor Neurons/physiology ; Olfactory Perception/physiology
Chemical Substances	beta-ionone (A7NRR1HLH6) ; methylmercaptan (2X8406WW9I) ; Receptors, Odorant
Language	English
Publishing date	2023-05-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2023.04.072
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