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Article ; Online: Successful resection of bilateral parafalcine meningioma with unilateral interhemispheric and contralateral transfalcine approach under nonintubated spontaneous breathing conditions: illustrative case.

Hirono, Seiichiro / Kawano, Keisuke / Ito, Masato / Saito, Kana / Hayashida, Taiichiro / Higuchi, Yoshinori

Journal of neurosurgery. Case lessons

2024 Volume 7, Issue 15

Abstract: Background: The best surgical approach for resecting bilateral parafalcine meningioma, as well as the optimal anesthesia and airway management for craniotomy in patients with interstitial pneumonia (IP) for preventing postsurgical exacerbation, remains ... ...

Abstract	Background: The best surgical approach for resecting bilateral parafalcine meningioma, as well as the optimal anesthesia and airway management for craniotomy in patients with interstitial pneumonia (IP) for preventing postsurgical exacerbation, remains unclear. Observations: A 66-year-old female with a history of multiple relapses of IP underwent craniotomy for resection of a 4.5-cm bilateral parafalcine meningioma located just beneath the inferior sagittal sinus. To avoid mechanical ventilation or high-concentration oxygenation, the entire procedure was performed under nonintubated spontaneous breathing conditions with a supraglottic airway/laryngeal mask airway (SGA/LMA) device. Half of the tumor was resected using the ipsilateral interhemispheric approach, while the remaining half was resected using the contralateral transfalcine approach (CTA). No brain retractors were required. Preoperative embolization contributed toward reducing blood loss and surgery duration. During most of the operation, additional oxygen administration was not required. The postoperative course was uneventful, without exacerbation of the IP. Lessons: This case demonstrated the utility and feasibility of a unilateral interhemispheric approach combined with CTA for resection of a bilateral parafalcine meningioma. Additionally, this case provides an alternative method of airway and anesthesia management with an SGA/LMA device and nonintubated spontaneous breathing for the prevention of postoperative acute exacerbation of IP.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ISSN	2694-1902
ISSN (online)	2694-1902
DOI	10.3171/CASE2424
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Article ; Online: Handling of human milk to prevent acquired cytomegalovirus infection in Japanese neonatal intensive care units: The first nationwide survey.

Saito, Kana / Tanaka, Kosuke / Nakagawa, Ryota / Ozawa, Junichi / Haga, Mitsuhiro / Miyahara, Naoyuki / Kabe, Kazuhiko / Namba, Fumihiko

Pediatrics international : official journal of the Japan Pediatric Society

2024 Volume 66, Issue 1, Page(s) e15728

Abstract: Background: Human milk (HM) has been proven to provide immunological and nutritional advantages to neonates; however, acquired cytomegalovirus (CMV) infection can be associated with raw HM. In Japan, there are no standardized guidelines concerning HM ... ...

Abstract	Background: Human milk (HM) has been proven to provide immunological and nutritional advantages to neonates; however, acquired cytomegalovirus (CMV) infection can be associated with raw HM. In Japan, there are no standardized guidelines concerning HM handling. This cross-sectional survey was performed to reveal specific trends in HM handling in neonatal intensive care units (NICUs) in Japan. Methods: A questionnaire was sent to 255 NICUs participating in the Japanese Neonatologist Association in May 2020. It involved HM handling practices, such as maternal screening, pasteurization, storage, and the workforce. Results: Of 255 NICUs, 174 (67.8%) responded to the survey. Maternal CMV screening was carried out in 37 units (22.2%), and CMV inactivation in HM was performed in 44 units (26.5%). For CMV inactivation, a freeze-thawing method was employed in about 90% of units. In 70% of units providing CMV inactivation, CMV inactivation was conducted regardless of bodyweight and corrected gestational age of infants until the infants' discharge. Acquired CMV infection in preterm neonates was observed in 43 units (25.7%) in the survey period. Conclusion: A wide range of HM handling practices are used in Japanese NICUs. A national guideline for handling HM in NICUs should be created to promote the infection control of CMV.
MeSH term(s)	Infant, Newborn ; Infant ; Humans ; Milk, Human ; Infant, Premature ; Japan/epidemiology ; Intensive Care Units, Neonatal ; Cross-Sectional Studies ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/prevention & control ; Surveys and Questionnaires
Language	English
Publishing date	2024-03-04
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15728
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Zs.A 848: Show issues

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Article ; Online: A Small-for-Gestational-Age Infant with MIRAGE Syndrome Who Developed Heat Stroke and Rhabdomyolysis due to Severe Temperature Instability.

Saito, Kana / Nakagawa, Ryota / Narumi, Satoshi / Ohashi, Hirofumi / Ishiguro, Akiko / Kabe, Kazuhiko

Neonatology

2023 Volume 120, Issue 3, Page(s) 390–394

Abstract: MIRAGE syndrome is characterized by myelodysplasia, infection, restriction of growth, adrenal hypoplasia, genital phenotypes, and enteropathy. This report describes heat stroke and rhabdomyolysis caused by anhidrosis as a symptom of MIRAGE syndrome in a ... ...

Abstract	MIRAGE syndrome is characterized by myelodysplasia, infection, restriction of growth, adrenal hypoplasia, genital phenotypes, and enteropathy. This report describes heat stroke and rhabdomyolysis caused by anhidrosis as a symptom of MIRAGE syndrome in a small-for-gestational-age (SGA) female neonate born at 32 weeks of gestation (birth weight, 911 g [-3.8 SD]). She developed severe temperature instability with anhidrosis, growth failure, mild developmental delay, hypothyroidism, and intractable enteropathy. On day 156, her temperature reached 42.0°C; her fever persisted for 2 h with prolonged irritability. Her serum creatine kinase level increased to a peak value of 12,716 (normal range, 43-321) IU/L. The clinical feature was diagnosed as rhabdomyolysis caused by heat stroke, which resulted from physical exertion with anhidrosis. Her SAMD9 variant was c.2945G>A, p. (Arg982His). Neonatologists should be aware of MIRAGE syndrome as a differential diagnosis of SGA with temperature instability.
MeSH term(s)	Humans ; Infant, Newborn ; Female ; Hypohidrosis ; Temperature ; Adrenal Insufficiency/genetics ; Infant, Small for Gestational Age ; Fetal Growth Retardation ; Heat Stroke ; Rhabdomyolysis/complications ; Rhabdomyolysis/diagnosis ; Intracellular Signaling Peptides and Proteins
Chemical Substances	SAMD9 protein, human ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-04-12
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000529762
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Zs.A 391: Show issues

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Article ; Online: Dataset for reproducing absorption spectra of methyl orange from the RGB values of microscopic images.

Inagawa, Arinori / Saito, Kana / Sasaki, Asuka / Uehara, Nobuo

Data in brief

2020 Volume 31, Page(s) 105998

Abstract: The present dataset is related to the research paper entitled "Reproducing Absorption Spectra of pH Indicators from RGB Values of Microscopic Images" (Inagawa et al., 2020). The dataset contains microscopic images of aqueous methyl orange (MO), ... ...

Abstract	The present dataset is related to the research paper entitled "Reproducing Absorption Spectra of pH Indicators from RGB Values of Microscopic Images" (Inagawa et al., 2020). The dataset contains microscopic images of aqueous methyl orange (MO), absorption spectra acquired with a spectrophotometer, loading spectra and calculation sheets for reproducing absorption spectra of aqueous MO from their RGB values of the microscopic images. The microscopic transmission images of the standard MO solutions at various pH conditions were acquired with a CMOS camera equipped with an invert microscope. Meanwhile, the loading spectra were obtained by principle component analysis of a series of absorption spectra of the standard solutions. The conversion matrix from RGB values in a region of interests (ROI) to score values were linear-algebraically determined from the RGB values and score values of the standard solutions. The absorption spectra of the sample solutions of which pH conditions are unknown were then reproduced by calculating the linear combination of the loading spectra with the score values obtained from the conversion process. Herein, the absorption spectra of MO are reproduced at various pH and ROI conditions.
Language	English
Publishing date	2020-07-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2020.105998
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Article: Dataset for reproducing absorption spectra of methyl orange from the RGB values of microscopic images

Inagawa, Arinori / Saito, Kana / Sasaki, Asuka / Uehara, Nobuo

Data in Brief. 2020 Aug., v. 31

2020

Abstract: The present dataset is related to the research paper entitled “Reproducing Absorption Spectra of pH Indicators from RGB Values of Microscopic Images” (Inagawa et al., 2020). The dataset contains microscopic images of aqueous methyl orange (MO), ... ...

Abstract	The present dataset is related to the research paper entitled “Reproducing Absorption Spectra of pH Indicators from RGB Values of Microscopic Images” (Inagawa et al., 2020). The dataset contains microscopic images of aqueous methyl orange (MO), absorption spectra acquired with a spectrophotometer, loading spectra and calculation sheets for reproducing absorption spectra of aqueous MO from their RGB values of the microscopic images. The microscopic transmission images of the standard MO solutions at various pH conditions were acquired with a CMOS camera equipped with an invert microscope. Meanwhile, the loading spectra were obtained by principle component analysis of a series of absorption spectra of the standard solutions. The conversion matrix from RGB values in a region of interests (ROI) to score values were linear-algebraically determined from the RGB values and score values of the standard solutions. The absorption spectra of the sample solutions of which pH conditions are unknown were then reproduced by calculating the linear combination of the loading spectra with the score values obtained from the conversion process. Herein, the absorption spectra of MO are reproduced at various pH and ROI conditions.
Keywords	absorption ; cameras ; data collection ; methyl orange ; pH ; principal component analysis ; spectrophotometers
Language	English
Dates of publication	2020-08
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2020.105998
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ibudilast Suppresses MUC5AC Mucus Production through Inhibition of ERK1/2 Phosphorylation.

Ishibashi, Jumpei / Saito, Kana / Ishizaki, Takako / Horie, Ichiro / Isohama, Yoichiro

Biological & pharmaceutical bulletin

2021 Volume 44, Issue 3, Page(s) 404–409

Abstract: Mucus hypersecretion is a hallmark of respiratory diseases, and excess airway mucus can worsen these conditions. Therefore, it is important to control the production of airway mucus in the treatment of respiratory diseases. The phosphodiesterase ... ...

Abstract	Mucus hypersecretion is a hallmark of respiratory diseases, and excess airway mucus can worsen these conditions. Therefore, it is important to control the production of airway mucus in the treatment of respiratory diseases. The phosphodiesterase inhibitor ibudilast has been reported to be effective in treating sputum and postnasal drip in patients with chronic airway inflammation. On the basis of the hypothesis that ibudilast could inhibit mucus production in the airway, in the present study, we examined the effects of ibudilast on the production of MUC5AC, a major protein component of mucus. In in vitro studies using NCI-H292 cells, ibudilast suppressed MUC5AC production induced by various stimuli. In addition, ibudilast inhibited extracellular signal-regulated kinase (ERK)1/2 phosphorylation and MUC5AC gene transcription. Furthermore, it attenuated MUC5AC production and Muc5ac mRNA expression in lipopolysaccharide-treated mice in vivo. Collectively, these findings demonstrate that ibudilast has an inhibitory effect on mucus production, which could at least partly be attributed to the inhibition of ERK1/2 phosphorylation and the repression of MUC5AC gene transcription.
MeSH term(s)	Animals ; Cell Line ; Humans ; Hydrogen Peroxide/pharmacology ; Lipopolysaccharides/pharmacology ; Male ; Mice, Inbred ICR ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Mucin 5AC/antagonists & inhibitors ; Mucin 5AC/genetics ; Mucin 5AC/metabolism ; Mucus/metabolism ; Phosphodiesterase Inhibitors/pharmacology ; Phosphorylation/drug effects ; Pyridines/pharmacology ; Smoke ; Nicotiana ; Mice
Chemical Substances	Lipopolysaccharides ; Mucin 5AC ; Phosphodiesterase Inhibitors ; Pyridines ; Smoke ; Hydrogen Peroxide (BBX060AN9V) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; ibudilast (M0TTH61XC5)
Language	English
Publishing date	2021-02-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b20-00798
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Zs.A 1474: Show issues

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Article ; Online: Geometrical pH mapping of Microfluids by principal-component-analysis-based xyz-spectrum conversion method.

Inagawa, Arinori / Saito, Kana / Fukuyama, Mao / Numata, Munenori / Uehara, Nobuo

Analytica chimica acta

2021 Volume 1182, Page(s) 338952

Abstract: The absorption spectra of bromothymol blue (BTB) solution introduced in microfluidic devices were reproduced by principal component analysis (PCA)-based xyz-spectrum conversion methods for geometric mapping of the pH values of fluids. We fabricated PDMS- ... ...

Abstract	The absorption spectra of bromothymol blue (BTB) solution introduced in microfluidic devices were reproduced by principal component analysis (PCA)-based xyz-spectrum conversion methods for geometric mapping of the pH values of fluids. We fabricated PDMS-made microfluidic devices with a channel depth of 1 mm to overcome the lower detection limits of transmittance image acquisition. Aqueous solutions of pH indicators under various pH conditions were hydrodynamically introduced into the channel, and RGB values of the region of interest (ROI) were obtained via image analysis. The xyz values were then converted into absorption spectral data of the pH indicator using the PCA-based spectral reproduction previously proposed by the authors. The high reproducibility of the spectra was confirmed to be comparable to that of the conventional method using a spectrophotometer. We applied the present method to elucidate the pH gradient at an aqueous biphasic interface in the microfluidic channels generated by contacting multiple laminar flows of two or three buffered solutions. We confirmed that the pH gradient ranged from approximately 70 to 140 μm, which is consistent with the results reported using other approaches. The results demonstrate the applicability of the present method to the fluctuation field in micro/nanospaces to acquire spectrophotometric information in the order of milliseconds without monochromating equipment.
MeSH term(s)	Hydrogen-Ion Concentration ; Lab-On-A-Chip Devices ; Microfluidics ; Principal Component Analysis ; Reproducibility of Results
Language	English
Publishing date	2021-08-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2021.338952
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Article ; Online: Antenatal corticosteroids in specific groups at risk of preterm birth: a systematic review.

Saito, Kana / Nishimura, Etsuko / Ota, Erika / Namba, Fumihiko / Swa, Toshiyuki / Ramson, Jenny / Lavin, Tina / Cao, Jenny / Vogel, Joshua Peter

BMJ open

2023 Volume 13, Issue 9, Page(s) e065070

Abstract: Objective: This study aimed to synthesise available evidence on the efficacy of antenatal corticosteroid (ACS) therapy among women at risk of imminent preterm birth with pregestational/gestational diabetes, chorioamnionitis or fetal growth restriction ( ... ...

Abstract	Objective: This study aimed to synthesise available evidence on the efficacy of antenatal corticosteroid (ACS) therapy among women at risk of imminent preterm birth with pregestational/gestational diabetes, chorioamnionitis or fetal growth restriction (FGR), or planned caesarean section (CS) in the late preterm period. Methods: A systematic search of MEDLINE, EMBASE, CINAHL, Cochrane Library, Web of Science and Global Index Medicus was conducted for all comparative randomised or non-randomised interventional studies in the four subpopulations on 6 June 2021. Risk of Bias Assessment tool for Non-randomised Studies and the Cochrane Risk of Bias tool were used to assess the risk of bias. Grading of Recommendations Assessment, Development and Evaluations tool assessed the certainty of evidence. Results: Thirty-two studies involving 5018 pregnant women and 10 819 neonates were included. Data on women with diabetes were limited, and evidence on women undergoing planned CS was inconclusive. ACS use was associated with possibly reduced odds of neonatal death (pooled OR: 0.51; 95% CI: 0.31 to 0.85, low certainty), intraventricular haemorrhage (pooled OR: 0.41; 95% CI: 0.23 to 0.72, low certainty) and respiratory distress syndrome (pooled OR: 0.59; 95% CI: 0.45 to 0.77, low certainty) in women with chorioamnionitis. Among women with FGR, the rates of surfactant use (pooled OR: 0.38; 95% CI: 0.23 to 0.62, moderate certainty), mechanical ventilation (pooled OR: 0.42; 95% CI: 0.26 to 0.66, moderate certainty) and oxygen therapy (pooled OR: 0.48; 95% CI: 0.30 to 0.77, moderate certainty) were probably reduced; however, the rate of hypoglycaemia probably increased (pooled OR: 2.06; 95% CI: 1.27 to 3.32, moderate certainty). Conclusions: There is a paucity of evidence on ACS for women who have diabetes. ACS therapy may have benefits in women with chorioamnionitis and is probably beneficial in FGR. There is limited direct trial evidence on ACS efficacy in women undergoing planned CS in the late preterm period, though the totality of evidence suggests it is probably beneficial. Prospero registration number: CRD42021267816.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Humans ; Female ; Cesarean Section ; Chorioamnionitis ; Premature Birth/prevention & control ; Diabetes, Gestational/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Fetal Growth Retardation
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-065070
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Article ; Online: Predictability of the neurodevelopmental assessment based on the Kyoto Scale of Psychological Development 2001 at 18-24 months of corrected age and 3 years of age in identifying cognitive impairment at 6 years of age in very preterm infants: A retrospective study at a Japanese tertiary center.

Haga, Mitsuhiro / Kanai, Masayo / Motojima, Yukiko / Saito, Kana / Itoh, Kanako / Saito, Takami / Ishiguro, Akio / Takada, Eiko / Kunikata, Tetsuya / Sobajima, Hisanori / Namba, Fumihiko / Kabe, Kazuhiko

Early human development

2024 Volume 193, Page(s) 106015

Abstract: Background: It is unknown how accurately the current Japanese classification system for neurodevelopmental delay based on the assessment with the Kyoto Scale of Psychological Development (KSPD) at toddlerhood and pre-school periods predicts cognitive ... ...

Abstract	Background: It is unknown how accurately the current Japanese classification system for neurodevelopmental delay based on the assessment with the Kyoto Scale of Psychological Development (KSPD) at toddlerhood and pre-school periods predicts cognitive impairment at school age. Methods: This single-center retrospective cohort study enrolled infants born at 22-29 weeks of gestational age. At 18-24 months of corrected age and 3 years of age, the patients were categorized according to the current Japanese criteria for neurodevelopmental delay based on their overall developmental quotient calculated using the KSPD-2001. Cognitive impairment at 6 years of age was classified according to the calculated or estimated full-scale intelligence quotient. The predictability of the current Japanese classification of neurodevelopmental delay for cognitive impairment at 6 years of age was investigated. Results: Of 566 eligible patients, 364 (64 %) completed the protocol. The current classification for the neurodevelopmental delay showed significant agreement with the severity of cognitive impairment at 6 years of age. The sensitivity and specificity of the KSPD-2001-based assessment for any cognitive impairment at 6 years of age were 0.64 and 0.74 at 18-24 months of corrected age and 0.83 and 0.70 at 3 years of age. The corresponding sensitivity and specificity for moderate/severe cognitive impairment were 0.51 and 0.96 at 18-24 months of corrected age and 0.68 and 0.95 at 3 years of age. Conclusion: The KSPD-2001 is a useful tool to predict the severity of cognitive impairment at school age.
Language	English
Publishing date	2024-04-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	752532-1
ISSN	1872-6232 ; 0378-3782
ISSN (online)	1872-6232
ISSN	0378-3782
DOI	10.1016/j.earlhumdev.2024.106015
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Zs.A 1373: Show issues

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Article: Tocolytic Therapy Inhibiting Preterm Birth in High-Risk Populations: A Systematic Review and Meta-Analysis.

Yamaji, Noyuri / Suzuki, Hitomi / Saito, Kana / Swa, Toshiyuki / Namba, Fumihiko / Vogel, Joshua P / Ramson, Jenny A / Cao, Jenny / Tina, Lavin / Ota, Erika

Children (Basel, Switzerland)

2023 Volume 10, Issue 3

Abstract: This systematic review aimed to identify the benefits and possible harms of tocolytic therapy for preterm labour management in the context of pregnant women with extremely preterm birth, multiple gestations, or growth-restricted foetuses. A comprehensive ...

Abstract	This systematic review aimed to identify the benefits and possible harms of tocolytic therapy for preterm labour management in the context of pregnant women with extremely preterm birth, multiple gestations, or growth-restricted foetuses. A comprehensive search using MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, CINAHL, and the WHO Global Index Medicus databases was conducted from 10 to 15 July 2021. We included randomized controlled trials and non-randomized studies that assessed the effects of tocolysis compared with placebo or no treatment. We found 744 reports and, finally, nine studies (three randomized controlled trials and six cohort studies) pertaining to women with <28 weeks of gestation were included. No eligible studies were identified among women with a multiple pregnancy or a growth-restricted foetus. A meta-analysis of the trial data showed that there were no clear differences in perinatal death nor for a delay in birth. Non-randomized evidence showed that tocolysis delayed birth by 7 days, though there was no clear difference for preterm birth. In summary, it remains unclear whether tocolytic therapy for inhibiting preterm labour is beneficial for these subgroups of women and their newborns. Further well-designed randomized controlled trials and observational studies are needed to address the lack of evidence regarding tocolytic agents in these populations.
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10030443
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