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  1. Article ; Online: Bioactive Sialoglycosphingolipids (Gangliosides): Potent Differentiation-Inducers for Human Myelogenous Leukemia Cells: (glycosphingolipids/bioactive gangliosides/myelogenous leukemia/hematopoietic cells/human).

    Saito, Masaki

    Development, growth & differentiation

    2023  Volume 31, Issue 6, Page(s) 509–522

    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/j.1440-169X.1989.00509.x
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    Zs.A 194: Show issues Location:
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  2. Article: [Symptomatic Epilepsy].

    Saito, Masanori

    Brain and nerve = Shinkei kenkyu no shinpo

    2023  Volume 75, Issue 4, Page(s) 317–321

    Abstract: The notion of symptomatic epilepsy was historically reviewed. The structural etiologies of epilepsy include cerebrovascular diseases, neurodegenerative diseases, neoplasms, and traumatic brain injuries. Infections are the most common etiology worldwide. ... ...

    Abstract The notion of symptomatic epilepsy was historically reviewed. The structural etiologies of epilepsy include cerebrovascular diseases, neurodegenerative diseases, neoplasms, and traumatic brain injuries. Infections are the most common etiology worldwide. Metabolic epilepsy directly results from a known or presumed metabolic disorder. Immune epilepsy occurs because of autoimmune-mediated central nervous system inflammation.
    MeSH term(s) Humans ; Epilepsy/etiology ; Cerebrovascular Disorders ; Central Nervous System ; Brain Injuries, Traumatic/complications
    Language Japanese
    Publishing date 2023-04-10
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 398: Show issues Location:
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  3. Article ; Online: MRI-based quantification of carbon and oxygen concentrations in human soft tissues for range verification in proton therapy.

    Saito, Masatoshi

    Medical physics

    2023  Volume 50, Issue 9, Page(s) 5671–5681

    Abstract: Background: In-situ range verification of particle therapy based on the detection of secondary emitted radiation requires highly accurate assignment of elemental concentrations (particularly carbon and oxygen) in the human body.: Purpose: A method ... ...

    Abstract Background: In-situ range verification of particle therapy based on the detection of secondary emitted radiation requires highly accurate assignment of elemental concentrations (particularly carbon and oxygen) in the human body.
    Purpose: A method for quantitatively predicting carbon and oxygen concentrations in human soft tissues is proposed. This method relies on an empirical one-to-one correspondence between the mass fraction and water content (WC), which is a measurable tissue quantity based on magnetic resonance (MR) imaging (referred to as "MRWC-based method").
    Methods: A numerical analysis of the MRWC-based method was performed for 47 standard human soft tissues tabulated in the literature as objects of interest with unknown mass fractions of the four main elements-C, O, H, and N. Thereafter, the method was evaluated in terms of the mass-fraction quantification accuracy by comparing it with the gold-standard CT-based method developed by Schneider et al. The MRWC-based method was also applied to the MR imaging data of a virtual head phantom obtained from a three-dimensional MRI-simulated brain database.
    Results: The predicted mass fractions in a range of human soft tissues were in better agreement with the reference values than those predicted by the CT-based method. The mean absolute errors of the predicted mass% values for the overall standard soft tissues could be reduced from 4.8 percentage points (pp) (CT-based) to 0.5 pp (MRWC-based) for carbon and from 5.2 pp (CT-based) to 0.4 pp (MRWC-based) for oxygen. The application to the simulated MRI data confirmed the capability of the sufficient recognition of the boundaries between the white matter and gray matter in the brain that could not be realized by the CT-based method. Thus, the MRWC-based method exhibits superior performance in the prediction of carbon and oxygen concentrations in soft tissues.
    Conclusions: This study is limited to a proof-of-concept scope but demonstrates the feasibility of the MRWC-based method for the generation of elemental images of human soft tissues from MRI-derived water-content images.
    MeSH term(s) Humans ; Proton Therapy/methods ; Tomography, X-Ray Computed/methods ; Carbon ; Magnetic Resonance Imaging/methods ; Oxygen
    Chemical Substances Carbon (7440-44-0) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.16353
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    Zs.A 1210: Show issues Location:
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  4. Article ; Online: Novel Roles of Nanog in Cancer Cells and Their Extracellular Vesicles.

    Saito, Mikako

    Cells

    2022  Volume 11, Issue 23

    Abstract: The use of extracellular vesicle (EV)-based vaccines is a strategically promising way to prevent cancer metastasis. The effective roles of immune cell-derived EVs have been well understood in the literature. In the present paper, we focus on cancer cell- ... ...

    Abstract The use of extracellular vesicle (EV)-based vaccines is a strategically promising way to prevent cancer metastasis. The effective roles of immune cell-derived EVs have been well understood in the literature. In the present paper, we focus on cancer cell-derived EVs to enforce, more thoroughly, the use of EV-based vaccines against unexpected malignant cells that might appear in poor prognostic patients. As a model of such a cancer cell with high malignancy,
    Language English
    Publishing date 2022-12-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11233881
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  5. Article: Assertiveness of psychiatric day care users in Japan.

    Saito, Miyuki

    Journal of rural medicine : JRM

    2021  Volume 16, Issue 1, Page(s) 29–34

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2021-01-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2768933-5
    ISSN 1880-4888 ; 1880-487X
    ISSN (online) 1880-4888
    ISSN 1880-487X
    DOI 10.2185/jrm.2020-009
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  6. Article: [Mechanisms of bone formation by primary cilia].

    Saito, Masaki / Atsumi, Gen-Ichi

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2024  

    Abstract: Primary cilia are immotile cilia assembled from the centriole-derived basal body, and they protrude on the cell surface in almost all cell types during the cell cycle ... ...

    Abstract Primary cilia are immotile cilia assembled from the centriole-derived basal body, and they protrude on the cell surface in almost all cell types during the cell cycle G
    Language Japanese
    Publishing date 2024-04-26
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23113
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    Zs.A 439: Show issues Location:
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  7. Article ; Online: [Improvement of Medication Adherence in Psychiatry and Mental Health Literacy Education].

    Saito, Moemi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2021  Volume 141, Issue 4, Page(s) 541–555

    Abstract: In Japan, the number of patients with mental illness is increasing; therefore, the need for national measures, such as suicide prevention measures and measures against alcohol health disorders, and multiple social concerns and needs, such as depression ... ...

    Abstract In Japan, the number of patients with mental illness is increasing; therefore, the need for national measures, such as suicide prevention measures and measures against alcohol health disorders, and multiple social concerns and needs, such as depression and dementia problems, are increasing. As such, measures for mental health are emphasized. Mental health is a common issue; however, there is still prejudice regarding mental illness, and its understanding and awareness by local residents and medical staff need to be improved. The author introduced a medication self-management module in the psychiatric ward to improve medication adherence, and constructed a program for mental health literacy education in the faculty of pharmacy. This paper outlines these studies.
    MeSH term(s) Adolescent ; Adult ; Aged ; Education, Pharmacy ; Faculty, Pharmacy/education ; Female ; Health Literacy ; Humans ; Japan ; Male ; Medication Adherence ; Mental Disorders/psychology ; Mental Health/education ; Middle Aged ; Patient Participation ; Patients/psychology ; Pharmacists/psychology ; Psychiatry/education ; Smoking Cessation/psychology ; Students, Pharmacy/psychology ; Surveys and Questionnaires ; Young Adult
    Language Japanese
    Publishing date 2021-02-25
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.20-00218
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 643: Show issues Location:
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  8. Article ; Online: Quadratic relation for mass density calibration in human body using dual-energy CT data.

    Saito, Masatoshi

    Medical physics

    2021  Volume 48, Issue 6, Page(s) 3065–3073

    Abstract: Purpose: To derive the mass density (ρ) from dual-energy computed tomography (DECT) data by calibrating electron density (ρ: Methods: We propose the DEEDZ-MD method, in which a single polynomial parameterization covers the entire human-tissue range ... ...

    Abstract Purpose: To derive the mass density (ρ) from dual-energy computed tomography (DECT) data by calibrating electron density (ρ
    Methods: We propose the DEEDZ-MD method, in which a single polynomial parameterization covers the entire human-tissue range to establish an empirical quadratic relation between the atomic number-to-mass ratio and Z
    Results: The numerical analysis of the DEEDZ-MD method reveals a single quadratic relation between the atomic number-to-mass ratio and Z
    Conclusions: The DEEDZ-MD method can facilitate the generation of ρ images from dual-energy CT data without relying on the nontrivial segmentation of different tissues.
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.14899
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  9. Article ; Online: Editorial Comment to Muscarinic receptor binding activity in rat tissues by vibegron and prediction of its receptor occupancy levels in the human bladder.

    Saito, Motoaki

    International journal of urology : official journal of the Japanese Urological Association

    2021  Volume 28, Issue 12, Page(s) 1303

    MeSH term(s) Adrenergic beta-3 Receptor Agonists ; Animals ; Humans ; Pyrimidinones ; Pyrrolidines ; Rats ; Receptors, Muscarinic ; Urinary Bladder/diagnostic imaging
    Chemical Substances Adrenergic beta-3 Receptor Agonists ; N-(4-((5-(hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo(1,2-a)pyrimidine-6-carboxamide ; Pyrimidinones ; Pyrrolidines ; Receptors, Muscarinic
    Language English
    Publishing date 2021-09-27
    Publishing country Australia
    Document type Journal Article ; Comment
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.14714
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    Zs.MO 278: Show issues

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  10. Article: [Simulation of photon-counting detectors for conversion of dual-energy-subtracted computed tomography number to electron density].

    Saito, Masatoshi

    Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics

    2020  Volume 40, Issue 3, Page(s) 107

    MeSH term(s) Computer Simulation ; Electrons ; Humans ; Phantoms, Imaging ; Photons ; Subtraction Technique ; Tomography, X-Ray Computed
    Language Japanese
    Publishing date 2020-09-29
    Publishing country Japan
    Document type Journal Article
    ISSN 1345-5354
    ISSN 1345-5354
    DOI 10.11323/jjmp.40.3_107
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