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  1. Article ; Online: Low-pressure, knee-length compression stockings provide most comfort with no effect on thrombosis risk.

    Sajid, Muhammad Shafique

    Evidence-based nursing

    2016  Volume 19, Issue 3, Page(s) 89

    MeSH term(s) Humans ; Knee ; Knee Joint ; Stockings, Compression ; Thrombosis
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1425988-6
    ISSN 1468-9618 ; 1367-6539
    ISSN (online) 1468-9618
    ISSN 1367-6539
    DOI 10.1136/eb-2015-102165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Alcohol-Containing Versus Aqueous-Based Solutions for Skin Preparation in Abdominal Surgery: A Systematic Review and Meta-analysis.

    Peristeri, Dimitra V / Nour, Hussameldin M / Ahsan, Amiya / Abogabal, Sameh / Singh, Krishna K / Sajid, Muhammad Shafique

    The Journal of surgical research

    2023  Volume 291, Page(s) 734–741

    Abstract: Introduction: The use of optimal skin antiseptic agents for the prevention of surgical site infection (SSI) is of critical importance, especially during abdominal surgical procedures. Alcohol-based chlorhexidine gluconate (CHG) and aqueous-based ... ...

    Abstract Introduction: The use of optimal skin antiseptic agents for the prevention of surgical site infection (SSI) is of critical importance, especially during abdominal surgical procedures. Alcohol-based chlorhexidine gluconate (CHG) and aqueous-based povidone-iodine (PVI) are the two most common skin antiseptics used nowadays. The objective of this article is to evaluate the effectiveness of alcohol-based CHG versus aqueous-based PVI used for skin preparation before abdominal surgery to reduce SSIs.
    Methods: Standard medical databases such as MEDLINE, Embase, Pubmed, and Cochrane Library were searched to find randomized, controlled trials comparing alcohol-based CHG skin preparation versus aqueous-based PVI in patients undergoing abdominal surgery. The combined outcomes of SSIs were calculated using odds ratio with 95% confidence intervals. All data were analyzed using Review Manager Software 5.4, and the meta-analysis was performed with a random effect model analysis.
    Results: A total of 11 studies, all randomized, controlled trials, were included (n = 12,072 participants), recruiting adult patients undergoing abdominal surgery. In the random effect model analysis, the use of alcohol-based CHG in patients undergoing abdominal surgery was associated with a reduced risk of SSI compared to aqueous-based PVI (odds ratio: 0.84; 95% confidence interval [0.74, 0.96], z = 2.61, P = 0.009).
    Conclusions: Alcohol-based CHG may be more effective for preventing the risk of SSI compared to aqueous-based PVI agents in abdominal surgery. The conclusion of this meta-analysis may add a guiding value to reinforce current clinical practice guidelines.
    MeSH term(s) Adult ; Humans ; Preoperative Care/methods ; Anti-Infective Agents, Local/therapeutic use ; Povidone-Iodine/therapeutic use ; Ethanol/therapeutic use ; Chlorhexidine/therapeutic use ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Surgical Wound Infection/prevention & control
    Chemical Substances Anti-Infective Agents, Local ; Povidone-Iodine (85H0HZU99M) ; Ethanol (3K9958V90M) ; chlorhexidine gluconate (MOR84MUD8E) ; Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of laparoscopic cholecystectomy in the management of chronic right upper quadrant pain due to biliary dyskinesia: a systematic review and meta-analysis.

    Rehman, Saad / Singh, Krishna Kumar / Sajid, Muhammad Shafique

    Translational gastroenterology and hepatology

    2019  Volume 4, Page(s) 71

    Abstract: Background: The objective of this study was to evaluate the surgical outcomes and feasibility of performing laparoscopic cholecystectomy (LC) in patients with longstanding right upper quadrant pain secondary to biliary dyskinesia.: Methods: A ... ...

    Abstract Background: The objective of this study was to evaluate the surgical outcomes and feasibility of performing laparoscopic cholecystectomy (LC) in patients with longstanding right upper quadrant pain secondary to biliary dyskinesia.
    Methods: A systematic review of the literature including published randomized, controlled trials, non-randomized trials and comparative trials of any type, reporting outcomes of LC in the management of chronic right upper quadrant pain in patients with biliary dyskinesia, using the principles of meta-analysis on RevMan 5.3 statistical software, was undertaken.
    Results: Thirteen studies including 740 patients evaluating the symptomatic improvement following LC in patients with biliary dyskinesia presenting as chronic right upper quadrant pain were included. There were 542 patients in LC group and 198 patients in Non-LC group. Successful complete resolution of symptoms was more likely to be achieved in LC group [risk ratio (RR), 0.21; 95% confidence interval (CI), 0.09-0.50, P=0.00001]. In addition, the risk of failure to resolve symptoms (risk ratio, 0.15; 95% CI, 0.05-0.39, P=0.00001) was lower in LC group.
    Conclusions: LC may be considered as an acceptable surgical intervention in patients with biliary dyskinesia presenting with chronic right upper quadrant pain. Currently there is insufficient evidence to recommend the routine use of LC in every patient with biliary dyskinesia. Paucity of high power randomised, controlled trials is the major reason for this lack of evidence which should be addressed soon and until then current study may be used to provide the basis for offering LC in selected group of patients.
    Language English
    Publishing date 2019-09-23
    Publishing country China
    Document type Journal Article
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh.2019.08.10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Meta-Analysis of Randomized Controlled Trials Comparing the Efficacy of Radioactive Iodine Monotherapy versus Radioactive Iodine Therapy and Adjunctive Lithium for the Treatment of Hyperthyroidism.

    Ahmed, Fahad Wali / Kirresh, Omar Zuhair / Majeed, Muhammad Shakeel / Iftikhar, Mawara / Sajid, Muhammad Shafique

    Endocrine research

    2021  Volume 46, Issue 4, Page(s) 160–169

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Graves Disease ; Humans ; Hyperthyroidism/drug therapy ; Hyperthyroidism/radiotherapy ; Iodine Radioisotopes/therapeutic use ; Lithium ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Iodine Radioisotopes ; Lithium (9FN79X2M3F)
    Language English
    Publishing date 2021-05-24
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 605823-1
    ISSN 1532-4206 ; 0743-5800
    ISSN (online) 1532-4206
    ISSN 0743-5800
    DOI 10.1080/07435800.2021.1924769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Minimally invasive surgery for gastric cancer in UK: current status and future perspectives.

    Sajid, Muhammad Shafique / Hebbar, Madhusoodhana / Sayegh, Mazin E

    Translational gastroenterology and hepatology

    2017  Volume 2, Page(s) 44

    Abstract: The aim of this study is to review the literature and report the various minimally invasive methods used to treat gastric cancer in the UK and compare it with worldwide practice. Published randomised studies, non-randomised studies and case series ... ...

    Abstract The aim of this study is to review the literature and report the various minimally invasive methods used to treat gastric cancer in the UK and compare it with worldwide practice. Published randomised studies, non-randomised studies and case series reporting the use of minimal invasive approach to treat gastric cancer were retrieved from the search of standard medical electronic databases and their outcomes were highlighted suggesting their effectiveness. Several randomised, controlled trials and meta-analyses have proven the clinical and oncological safety of the laparoscopic gastrectomy for gastric cancer. Similarly, robot-assisted gastrectomy, EMR (endoscopic mucosal resection) and ESD (endoscopic sub-mucosal dissection) have also been proven feasible and safe to treat gastric cancer of various stages in prospective and retrospective comparative studies. However, UK based studies on minimally invasive surgery to treat gastric cancer is scarce and the paucity of trials led to uncertain outcomes. Laparoscopic gastrectomy, robot-assisted gastrectomy, EMR and ESD are feasible procedures in terms of clinical and oncological safety but mainly being practiced in Asian countries with high prevalence of stomach cancer. The UK based practice is still small and limited but the introduction of MIGOCS and STOMACH trial might help to widen the application of this technique.
    Keywords covid19
    Language English
    Publishing date 2017-05-09
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN 2415-1289
    DOI 10.21037/tgh.2017.04.06
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Improving the mucosal visualization at gastroscopy: a systematic review and meta-analysis of randomized, controlled trials reporting the role of Simethicone ± N-acetylcysteine.

    Sajid, Muhammad Shafique / Rehman, Saad / Chedgy, Fergus / Singh, Krishna K

    Translational gastroenterology and hepatology

    2018  Volume 3, Page(s) 29

    Abstract: Background: The objective of this article is to study the role of Simethicone ± N-acetylcysteine in improving the mucosal visualization during oesophago-gastro-duodenoscopy (OGD).: Methods: The data retrieved from the published randomized controlled ... ...

    Abstract Background: The objective of this article is to study the role of Simethicone ± N-acetylcysteine in improving the mucosal visualization during oesophago-gastro-duodenoscopy (OGD).
    Methods: The data retrieved from the published randomized controlled trials (RCTs) reporting the role of Simethicone ± N-acetylcysteine during OGD was analysed using the principles of meta-analysis. The summated outcome of continuous variables was expressed as standardized mean difference (SMD) and dichotomous data was presented in odds ratio (OR).
    Results: Three RCTs on 654 patients reported OGD with and without pre-procedure oral administration of Simethicone ± N-acetylcysteine evaluating visibility as good or excellent in number during the procedure. In the random effects model analysis using the statistical software Review Manager 5.3, the use of Simethicone ± N-acetylcysteine was associated with improved (OR, 0.43; 95% CI, 0.28, 0.68; z=3.65; P=0.0003) mucosal visibility. Four RCTs on 364 patients reported OGD with and without pre-procedure oral administration of Simethicone ± N-acetylcysteine evaluating visibility score in study group. In the random effects model analysis using the statistical software Review Manager 5.3, the use of Simethicone ± N-acetylcysteine was associated with improved (SMD, -1.66; 95% CI, -1.93, -1.40; z=12.25; P=0.00001) mucosal visibility score compared to no-Simethicone group.
    Conclusions: The findings of current study on 1,099 patients successfully demonstrate that the pre-procedure oral administration of Simethicone ± N-acetylcysteine improves mucosal visualization and mucosal visualization score during OGD.
    Language English
    Publishing date 2018-05-19
    Publishing country China
    Document type Journal Article
    ISSN 2415-1289
    ISSN 2415-1289
    DOI 10.21037/tgh.2018.05.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Milligan-Morgan (Open) Versus Ferguson Haemorrhoidectomy (Closed): A Systematic Review and Meta-Analysis of Published Randomized, Controlled Trials.

    Bhatti, Muhammad I / Sajid, Muhammad Shafique / Baig, Mirza K

    World journal of surgery

    2016  Volume 40, Issue 6, Page(s) 1509–1519

    Abstract: Objective: The purpose of this article is to systematically analyse the randomized, controlled trials (RCTs) comparing Ferguson or closed haemorrhoidectomy (CH) versus open haemorrhoidectomy (OH) or Milligan-Morgan haemorrhoidectomy in the management of ...

    Abstract Objective: The purpose of this article is to systematically analyse the randomized, controlled trials (RCTs) comparing Ferguson or closed haemorrhoidectomy (CH) versus open haemorrhoidectomy (OH) or Milligan-Morgan haemorrhoidectomy in the management of haemorrhoidal disease (HD).
    Methods: RCTs on the effectiveness of CH and OH in the management of HD were analysed systematically using RevMan(®), and combined outcome was expressed as odds ratio (OR) and standardized mean difference.
    Results: Eleven CRTs encompassing 1326 patients were analysed systematically. There was significant heterogeneity among included trials. Therefore, in the random effects model, CH was associated with a reduced post-operative pain (SMD, -0.36; 95 % CI, -0.64, -0.07; z = 2.45; p = 0.01), faster wound healing (OR, 0.08; 95 % CI, 0.02, 0.24; z = 4.33; p < 0.0001), lesser risk of post-operative bleeding (OR, 0.50; 95 % CI, 0.27, 0.91; z = 2.27; p < 0.02) and prolonged duration of operation (SMD, 6.10; 95 % CI, 3.21, 8.98; z = 4.13; p < 0.0001). But the variables such as pain on defecation (SMD, -0.33; 95 % CI, -0.68, 0.03; z = 1.82; p = 0.07), length of hospital stay, post-operative complications, HD recurrence and risk of surgical site infection were similar in both groups.
    Conclusion: CH has clinically measurable advantages over OH in terms of reduced post-operative pain, lower risk of post-operative bleeding and faster wound healing.
    MeSH term(s) Defecation ; Hemorrhoidectomy/adverse effects ; Hemorrhoidectomy/methods ; Hemorrhoids/surgery ; Humans ; Length of Stay ; Operative Time ; Pain, Postoperative/etiology ; Postoperative Hemorrhage/etiology ; Randomized Controlled Trials as Topic ; Recurrence ; Surgical Wound Infection/etiology ; Treatment Outcome ; Wound Healing
    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Review
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-016-3419-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A systematic review of clinical effectiveness of wound edge protector devices in reducing surgical site infections in patients undergoing abdominal surgery.

    Sajid, Muhammad Shafique / Rathore, M A / Sains, P / Singh, K K

    Updates in surgery

    2017  Volume 69, Issue 1, Page(s) 21–28

    Abstract: This article highlights the clinical effectiveness of wound edge protector devices (WEPD) in preventing the post-operative surgical site infections (SSI) in patients undergoing abdominal surgery. Using the principles of meta-analysis and systematic ... ...

    Abstract This article highlights the clinical effectiveness of wound edge protector devices (WEPD) in preventing the post-operative surgical site infections (SSI) in patients undergoing abdominal surgery. Using the principles of meta-analysis and systematic review as recommended by the Cochrane Collaboration, the data from selected randomized, controlled trials (RCTs) were analysed to generate summated outcome and presented in the form of odds ratio (OR). Eighteen RCTs on 3808 reported the effectiveness of WEPD in patients undergoing abdominal surgery. The use of WEPD was associated with the reduced incidence of overall SSI (OR 0.59; 95% CI 0.43-0.81; z = 3.30; p < 0.001) and superficial SSI (OR 0.42; 95% CI 0.18-0.95; z = 2.09; p < 0.04). In addition, WEPD also successfully reduced the risk of SSI in clean-contaminated wounds (OR 0.67; 95% CI 0.46-0.98; z = 2.06; p < 0.04) as well as in contaminated wounds (OR 0.24; 95% CI 0.12-0.49; z = 3.96; p < 0.0001). WEPD seems to be an effective intervention to reduce the risk of post-operative SSI in patients undergoing abdominal surgery.
    Language English
    Publishing date 2017-03
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-017-0415-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A critical appraisal of the cost effectiveness of laparoscopic colorectal surgery for oncological and non-oncological resections.

    Sajid, Muhammad Shafique / Rathore, Munir Ahmad / Baig, Mirza Khurrum / Sains, Parv

    Updates in surgery

    2017  Volume 69, Issue 3, Page(s) 339–344

    Abstract: The aim of this study was to critically appraise the cost effectiveness of the laparoscopic colorectal (LCRS) surgery using published randomised, control trials (RCTs). Published RCTs comparing the cost effectiveness of LCRS with conventional open ... ...

    Abstract The aim of this study was to critically appraise the cost effectiveness of the laparoscopic colorectal (LCRS) surgery using published randomised, control trials (RCTs). Published RCTs comparing the cost effectiveness of LCRS with conventional open surgery were selected from the search of standard electronic databases and the extracted data were analysed using the statistical software RevMan 5.3. Seven RCTs on 2197 patients reported the cost effectiveness of the LCRS. There was significant heterogeneity (τ
    MeSH term(s) Colectomy/economics ; Colectomy/methods ; Colorectal Neoplasms/economics ; Colorectal Neoplasms/surgery ; Cost-Benefit Analysis ; Humans ; Laparoscopy/economics ; Models, Statistical ; Rectum/surgery ; United Kingdom
    Language English
    Publishing date 2017-09
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-017-0458-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Laparoscopic Versus Open Preperitoneal Mesh Repair of Inguinal Hernia: an Integrated Systematic Review and Meta-analysis of Published Randomized Controlled Trials.

    Sajid, Muhammad Shafique / Caswell, Jennifer / Singh, Krishna K

    The Indian journal of surgery

    2015  Volume 77, Issue Suppl 3, Page(s) 1258–1269

    Abstract: The objective of this article is to systematically analyse the randomized, controlled trials comparing open (OPPR) versus laparoscopic (LPPR) preperitoneal mesh repair of inguinal hernia. Randomized, controlled trials comparing OPPR versus LPPR of ... ...

    Abstract The objective of this article is to systematically analyse the randomized, controlled trials comparing open (OPPR) versus laparoscopic (LPPR) preperitoneal mesh repair of inguinal hernia. Randomized, controlled trials comparing OPPR versus LPPR of inguinal hernia were analysed systematically using RevMan®, and combined outcomes were expressed as odds ratio (OR) and standardized mean difference (SMD). Ten randomized trials evaluating 1286 patients were retrieved from the electronic databases. There were 606 patients in the OPPR repair group and 680 patients in the LPPR group. There was significant heterogeneity among trials (p < 0.0001). Therefore, in the random effects model, LPPR was associated with longer operative time and relatively lesser postoperative pain in the case of the trans-abdominal preperitoneal approach. Statistically, both OPPR and LPPR were equivalent in terms of developing chronic groin pain, recurrence and postoperative complications. OPPR of inguinal hernia is associated with shorter operative time and comparable with LPPR (both total extraperitoneal and trans-abdominal preperitoneal approaches) in terms of risk of chronic groin pain, recurrence and complications.
    Language English
    Publishing date 2015-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 138063-1
    ISSN 0972-2068 ; 0019-5650
    ISSN 0972-2068 ; 0019-5650
    DOI 10.1007/s12262-015-1271-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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