Article ; Online: t
2022 Volume 12, Issue 9
Abstract: SARS-CoV-2 infection alters cellular RNA content. Cellular RNAs are chemically modified and eventually degraded, depositing modified nucleosides into extracellular fluids such as serum and urine. Here we searched for COVID-19-specific changes in modified ...
| Abstract | SARS-CoV-2 infection alters cellular RNA content. Cellular RNAs are chemically modified and eventually degraded, depositing modified nucleosides into extracellular fluids such as serum and urine. Here we searched for COVID-19-specific changes in modified nucleoside levels contained in serum and urine of 308 COVID-19 patients using liquid chromatography-mass spectrometry (LC-MS). We found that two modified nucleosides, |
|---|---|
| MeSH term(s) | Adenosine/analogs & derivatives ; Biomarkers ; COVID-19/diagnosis ; Humans ; Nucleosides/chemistry ; RNA ; SARS-CoV-2 ; Threonine/analogs & derivatives |
| Chemical Substances | 2-methylthio-N6-threonylcarbamoyladenosine ; Biomarkers ; Nucleosides ; N(6)-(N-threonylcarbonyl)adenosine (24719-82-2) ; Threonine (2ZD004190S) ; RNA (63231-63-0) ; Adenosine (K72T3FS567) |
| Language | English |
| Publishing date | 2022-09-03 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2701262-1 |
| ISSN | 2218-273X ; 2218-273X |
| ISSN (online) | 2218-273X |
| ISSN | 2218-273X |
| DOI | 10.3390/biom12091233 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.