Article ; Online: The Design of a Participatory Peptide Nucleic Acid Duplex Crosslinker to Enhance the Stiffness of Self-Assembled Peptide Gels.
Angewandte Chemie (International ed. in English)
2023 Volume 63, Issue 4, Page(s) e202313507
Abstract: Herein, peptide nucleic acids (PNAs) are employed in the design of a participatory duplex PNA-peptide crosslinking agent. Biophysical and mechanical studies show that crosslinkers present during peptide assembly leading to hydrogelation participate in ... ...
| Abstract | Herein, peptide nucleic acids (PNAs) are employed in the design of a participatory duplex PNA-peptide crosslinking agent. Biophysical and mechanical studies show that crosslinkers present during peptide assembly leading to hydrogelation participate in the formation of fibrils while simultaneously installing crosslinks into the higher-order network that constitutes the peptide gel. The addition of 2 mol % crosslinker into the assembling system results in a ~100 % increase in mechanical stiffness without affecting the rate of peptide assembly or the local morphology of fibrils within the gel network. Stiffness enhancement is realized by only affecting change in the elastic component of the viscoelastic gel. A synthesis of the PNA-peptide duplex crosslinkers is provided that allows facile variation in peptide composition and addresses the notorious hydrophobic content of PNAs. This crosslinking system represents a new tool for modulating the mechanical properties of peptide-based hydrogels. |
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| MeSH term(s) | Peptide Nucleic Acids/chemistry ; Peptides/chemistry ; Hydrogels/chemistry |
| Chemical Substances | Peptide Nucleic Acids ; Peptides ; Hydrogels |
| Language | English |
| Publishing date | 2023-12-20 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2011836-3 |
| ISSN | 1521-3773 ; 1433-7851 |
| ISSN (online) | 1521-3773 |
| ISSN | 1433-7851 |
| DOI | 10.1002/anie.202313507 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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