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  1. Article ; Online: Optimal Intermittent Administration Interval of Abaloparatide for Bone Morphogenetic Protein-Induced Bone Formation in a Rat Spinal Fusion Model.

    Abe, Tetsutaro / Miyazaki, Masashi / Sako, Noriaki / Kanezaki, Shozo / Tsubouchi, Yuta / Kaku, Nobuhiro

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Both bone morphogenetic protein 2 (BMP-2) and abaloparatide are used to promote bone formation. However, there is no consensus about their optimal administration. We investigated the optimal administration theory for the pairing of BMP-2 and ... ...

    Abstract Both bone morphogenetic protein 2 (BMP-2) and abaloparatide are used to promote bone formation. However, there is no consensus about their optimal administration. We investigated the optimal administration theory for the pairing of BMP-2 and abaloparatide in a rat spinal fusion model. Group I was only implanted in carriers and saline. Carriers with 3 µg of recombinant human BMP-2 (rhBMP-2) were implanted in other groups. Abaloparatide injections were administered three times a week for group III (for a total amount of 120 µg/kg in a week) and six times a week for group IV (for a total amount of 120 µg/kg in a week) after surgery. They were euthanized 8 weeks after the surgery, and we explanted their spines at that time. We assessed them using manual palpation tests, radiography, high-resolution micro-computed tomography (micro-CT), and histological analysis. We also analyzed serum bone metabolism markers. The fusion rate in Groups III and IV was higher than in Group I, referring to the manual palpation tests. Groups III and IV recorded greater radiographic scores than those in Groups I and II, too. Micro-CT analysis showed that Tbs. Sp in Groups III and IV was significantly lower than in Group I. Tb. N in Group IV was significantly higher than in Group I. Serum marker analysis showed that bone formation markers were higher in Groups III and IV than in Group I. On the other hand, bone resorption markers were lower in Group IV than in Group I. A histological analysis showed enhanced trabecular bone osteogenesis in Group IV. Frequent administration of abaloparatide may be suitable for the thickening of trabecular bone structure and the enhancement of osteogenesis in a rat spinal fusion model using BMP-2 in insufficient doses.
    MeSH term(s) Humans ; Animals ; Rats ; Osteogenesis ; Spinal Fusion ; X-Ray Microtomography ; Bone Morphogenetic Proteins ; Parathyroid Hormone-Related Protein
    Chemical Substances abaloparatide (AVK0I6HY2U) ; Bone Morphogenetic Proteins ; Parathyroid Hormone-Related Protein
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of accuracy of pedicle screw placement in dysplastic pedicles in adolescent idiopathic scoliosis using the pedicle expansion technique with CT-based navigation.

    Miyazaki, Masashi / Abe, Tetsutaro / Sako, Noriaki / Kanezaki, Shozo / Tsumura, Hiroshi

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

    2023  

    Abstract: Background: This study aimed to study the accuracy of pedicle screw (PS) insertion into dysplastic pedicles in adolescent idiopathic scoliosis (AIS) comparing cannulated screw using the pedicle expansion technique (PET) versus conventional technique.: ...

    Abstract Background: This study aimed to study the accuracy of pedicle screw (PS) insertion into dysplastic pedicles in adolescent idiopathic scoliosis (AIS) comparing cannulated screw using the pedicle expansion technique (PET) versus conventional technique.
    Methods: Forty-two AIS patients with 766 PSs were evaluated. In total, 236 screws were inserted into dysplastic pedicles: 138 and 98 screws were inserted using the PET (PET group) and standard technique (conventional group), respectively. Both methods used CT-based navigation to determine the insertion point. In the PET, a rigid ball tip feeler was tapped with a mallet to create an insertion route, a guide wire was passed through the tap, the pedicle was enlarged, and then a cannulated PS with a diameter of 4.35 mm was inserted. Postoperative CT was used to compare the accuracy of PS insertion.
    Results: In total, 23/236 (9.7%) perforations occurred. Regarding overall perforation, there were six (4.3%) and 17 (17.3%) cases in the PET and conventional group, respectively (P = 0.008). In terms of medial perforation, the PET group (n = 2, 1.4%) was significantly better than the conventional group (n = 7, 7.1%) (P = 0.021). In terms of lateral perforation, the PET group (n = 4, 2.9%) was significantly better than conventional group (n = 10, 10.2%) (P = 0.030). Only grade 1 perforation had occurred in the PET group, whereas grades 2 and 3 perforation occurred in the conventional group.
    Conclusion: Use of the PET with CT-based navigation significantly increased the accuracy and safety of PS insertion in dysplastic pedicles in AIS.
    Language English
    Publishing date 2023-04-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1314243-4
    ISSN 1436-2023 ; 0949-2658
    ISSN (online) 1436-2023
    ISSN 0949-2658
    DOI 10.1016/j.jos.2023.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4484: Show issues Location:
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  3. Article ; Online: Efficacy of gelatin-thrombin matrix sealants for blood loss in single-level transforaminal lumbar interbody fusion.

    Abe, Tetsutaro / Miyazaki, Masashi / Sako, Noriaki / Kanezaki, Shozo / Hirakawa, Masashi / Kawano, Masanori / Kaku, Nobuhiro

    Medicine

    2023  Volume 102, Issue 36, Page(s) e34667

    Abstract: Although gelatin-thrombin matrix sealants have been used successfully in other surgery types, their effect on reducing blood loss during single-level transforaminal lumbar interbody fusion is unclear. We thus examined the efficacy of gelatin-thrombin ... ...

    Abstract Although gelatin-thrombin matrix sealants have been used successfully in other surgery types, their effect on reducing blood loss during single-level transforaminal lumbar interbody fusion is unclear. We thus examined the efficacy of gelatin-thrombin matrix sealants for reducing blood loss during such surgery. We analyzed 102 patients who underwent single-level transforaminal lumbar interbody fusion for lumbar degenerative disease. We compared body mass index, surgical time, intraoperative blood loss, postoperative blood loss, true total blood loss, hidden blood loss, the proportion of blood transfusion, blood pressure pre- and post-surgery (systolic and diastolic), and pre-and post-surgery laboratory data (hemoglobin, hematocrit, platelets, prothrombin time, activated partial thromboplastin time, and D-dimer) between patients in whom gelatin-thrombin matrix sealants were (GTMS group) or were not (control group) used during surgery. One-week postoperative epidural hematoma size was measured using magnetic resonance imaging. The GTMS and control groups included 54 (24 males and 30 females) and 48 patients (19 males and 29 females). Intraoperative, true total, and hidden blood loss; epidural hematoma size; and hospitalization duration were significantly lower in the GTMS than in the control group. Intraoperative blood loss correlated with surgical time (R = 0.523, P = .001), body mass index (R = 0.221, P = .036), and the amount of gelatin-thrombin matrix sealant used (r = -0.313, P = .002). In multivariate linear regression analysis using intraoperative blood loss as the dependent variable, surgical time (standardization coefficient 0.516, P = .001) and amount of gelatin-thrombin matrix sealant used (standardization coefficient -0.220, P = .032) were independently related factors. In our study, the GTMS group had significantly less intraoperative true total and hidden blood loss than did the control group. Thus, use of gelatin-thrombin matrix sealants reduce perioperative blood loss in transforaminal lumbar interbody fusion.
    MeSH term(s) Female ; Male ; Humans ; Thrombin/therapeutic use ; Gelatin/therapeutic use ; Blood Loss, Surgical/prevention & control ; Hematoma, Epidural, Cranial ; Postoperative Hemorrhage ; Disease Progression ; Hematoma, Epidural, Spinal
    Chemical Substances Thrombin (EC 3.4.21.5) ; Gelatin (9000-70-8)
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000034667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dome impaction classification in acetabular fractures: Identifying atypical dome impactions with absence of the gull sign: A retrospective descriptive study.

    Kanezaki, Shozo / Miyazaki, Masashi / Sakamoto, Tomonori / Hino, Akihiro / Abe, Tetsutaro / Sako, Noriaki / Tsumura, Hiroshi

    Medicine

    2023  Volume 102, Issue 42, Page(s) e35523

    Abstract: We aimed to describe variations of dome impaction fractures and their characteristics using a new classification system, to explore the relationship between dome impaction and the gull sign. The present study was a retrospective descriptive study. All ... ...

    Abstract We aimed to describe variations of dome impaction fractures and their characteristics using a new classification system, to explore the relationship between dome impaction and the gull sign. The present study was a retrospective descriptive study. All 104 cases of acetabular fracture that were treated in our institution from 2013 to 2022 were enrolled. Of these, 22 had dome impaction fractures. The primary outcome variable was to describe the variations and characteristics of dome impaction fractures. They were classified into 3 major subgroups based on reconstructed axial, coronal, and sagittal computed tomography findings: anteromedial, superomedial (SM), and posteromedial. The secondary outcome variable was to explore the relationship between dome impaction on computed tomography findings and the gull sign on plain radiographs. There were 4 cases of anteromedial (18.2%), 13 of SM (59.1%), and 5 of posteromedial (22.7%). There were 15 cases (68.2%) with the gull sign and 7 cases (31.8%) without the gull sign on plain radiographs. Twelve of fifteen cases (80.0%) with the gull sign had dome impaction fractures of the SM type. We found a variety of patterns of dome impaction fracture. Surgeons should be aware of atypical dome impactions not showing the gull sign.
    MeSH term(s) Humans ; Animals ; Charadriiformes ; Retrospective Studies ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/surgery ; Hip Fractures ; Spinal Fractures ; Radiography ; Acetabulum/surgery ; Gastrointestinal Diseases
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000035523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: Is the Iliac Wing Curved Inward in Patients with Developmental Dysplasia of the Hip?

    Sako, Noriaki / Kaku, Nobuhiro / Tagomori, Hiroaki / Tsumura, Hiroshi

    Clinics in orthopedic surgery

    2021  Volume 13, Issue 4, Page(s) 461–467

    Abstract: Background: There is a paucity of studies on the iliac curvature in developmental dysplasia of the hip (DDH). Here, we examined the iliac curvature in DDH using three-dimensional computed tomography.: Methods: We allocated cases with a center-edge ... ...

    Abstract Background: There is a paucity of studies on the iliac curvature in developmental dysplasia of the hip (DDH). Here, we examined the iliac curvature in DDH using three-dimensional computed tomography.
    Methods: We allocated cases with a center-edge angle of < 20° to the DDH group (55 cases) and cases with a center-edge angle of > 25° to the control group (57 cases) and measured the straight line (line A) between the anterior and posterior superior iliac spines. We examined which part of the iliac bone line A passes through and classified the results into 4 categories (type A, inside the iliac bone; type B, through the iliac bone; type C, outside the iliac bone; and type D, both inside and outside the iliac bone) to evaluate the iliac wing curvature. After measuring the area and internal surface of the iliac wing using line A, we examined the correlation between these values, the interspinous distance, the superior iliac angle, and the center-edge angle.
    Results: Distributions of the four types were compared between the two groups; there was no significant difference. The length of the portion of line A inside the ilium and the area formed by line A and the iliac wing, which shows the degree of iliac wing curvature, were not significantly different between the groups. There were no correlations between these values and the center-edge angle; however, there were weak positive correlations among the interspinous distance, the superior iliac angle, and the center-edge angle.
    Conclusions: The inward nature of the iliac bone in patients with DDH is mainly due to the internal rotation of the entire iliac bone and less likely due to the curvature of the iliac bone.
    MeSH term(s) Acetabulum ; Developmental Dysplasia of the Hip ; Hip Dislocation, Congenital/diagnostic imaging ; Humans ; Ilium/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-11-15
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2502788-8
    ISSN 2005-4408 ; 2005-291X
    ISSN (online) 2005-4408
    ISSN 2005-291X
    DOI 10.4055/cios20230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6807: Show issues Location:
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  6. Article ; Online: Three-Dimensional Evaluation of Innominate Bone Rotation in Female Patients with Developmental Dysplasia of the Hip.

    Sako, Noriaki / Kaku, Nobuhiro / Kitahara, Yoshiki / Kubota, Yuta / Tagomori, Hiroaki / Tsumura, Hiroshi

    Clinics in orthopedic surgery

    2022  Volume 14, Issue 2, Page(s) 196–204

    Abstract: Background: Patients with developmental dysplasia of the hip (DDH) are known to have abnormal pelvic morphologies; however, rotation of innominate bone features remains unclear. Thus, we investigated innominate bone rotation in patients with DDH by ... ...

    Abstract Background: Patients with developmental dysplasia of the hip (DDH) are known to have abnormal pelvic morphologies; however, rotation of innominate bone features remains unclear. Thus, we investigated innominate bone rotation in patients with DDH by measuring the associated angles and distances using three-dimensional (3D) computed tomography.
    Methods: We defined four straight lines in pelvic 3D models: from the anterior superior iliac spine to the posterior superior iliac spine, from the anterior inferior iliac spine to the posterior inferior iliac spine, from the pubic tubercle to the ischial spine, and from the pubic tubercle to the ischial tuberosity. Similarly, we measured the angles formed by these lines using the vertical axis of the anterior pelvic plane on the horizontal plane and the horizontal axis on the sagittal plane. Additionally, we measured the distances between the femoral head centers and the acetabular centers in the coronal plane.
    Results: The difference in internal rotation angle between the superior and inferior parts of the iliac bone was significantly lower, by approximately 1.7°, in the DDH group than in the control group (
    Conclusions: Patients with DDH had a more internally rotated ilium and ischiopubic bone than normal individuals; however, it should be emphasized that internal rotation was reduced near the acetabulum, and the acetabulum was shifted laterally. Similarly, it was shown that patients with DDH had different rotations of the ilium and ischiopubic bone in the sagittal plane.
    MeSH term(s) Acetabulum ; Developmental Dysplasia of the Hip ; Female ; Femur Head ; Hip Dislocation, Congenital/diagnostic imaging ; Humans ; Ischium/diagnostic imaging ; Pelvis
    Language English
    Publishing date 2022-04-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2502788-8
    ISSN 2005-4408 ; 2005-291X
    ISSN (online) 2005-4408
    ISSN 2005-291X
    DOI 10.4055/cios21032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6807: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Iliac anatomy in women with developmental dysplasia of the hip: Measurements using three-dimensional computed tomography.

    Sako, Noriaki / Kaku, Nobuhiro / Kubota, Yuta / Kitahara, Yoshiki / Tagomori, Hiroaki / Tsumura, Hiroshi

    Journal of orthopaedics

    2021  Volume 25, Page(s) 1–5

    Abstract: Background: We aimed to clarify the iliac anatomy in developmental dysplasia of the hip using three-dimensional computed tomography.: Methods: The distance between two points along each anatomical portion of the ilium, including the acetabular center, ...

    Abstract Background: We aimed to clarify the iliac anatomy in developmental dysplasia of the hip using three-dimensional computed tomography.
    Methods: The distance between two points along each anatomical portion of the ilium, including the acetabular center, were compared between patients in the dysplasia and control groups.
    Results: There were no significant differences in the upper part of the ilium between the groups. However, three distances that included the acetabular center were significantly shorter in the dysplasia group than in the control group.
    Conclusions: Our study suggests that bone dysplasia occurs in the ilium near the acetabulum, not in the iliac wings.
    Language English
    Publishing date 2021-04-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240839-3
    ISSN 0972-978X
    ISSN 0972-978X
    DOI 10.1016/j.jor.2021.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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