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Artikel ; Online: Fatty Acid Esterification as a NASH Therapeutic Target.

Sakuma, Ikki / Vatner, Daniel F

Cellular and molecular gastroenterology and hepatology

2023 Band 17, Heft 2, Seite(n) 311–312

Mesh-Begriff(e)	Humans ; Fatty Acids ; Esterification ; Non-alcoholic Fatty Liver Disease/drug therapy
Chemische Substanzen	Fatty Acids
Sprache	Englisch
Erscheinungsdatum	2023-11-17
Erscheinungsland	United States
Dokumenttyp	Editorial ; Comment
ZDB-ID	2819778-1
ISSN	2352-345X ; 2352-345X
ISSN (online)	2352-345X
ISSN	2352-345X
DOI	10.1016/j.jcmgh.2023.10.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: iPSCs and aging.

Sakuma, Ikki / Tanaka, Tomoaki

Nihon rinsho. Japanese journal of clinical medicine

2018 Band 74, Heft 9, Seite(n) 1560–1564

Abstract: In addition to the discovery that mature cells can be reprogrammed to become pluripotent stem cells(iPS cells), the technical innovations of big-data analyses as well as the cutting- edge technologies such as nuclear reprogramming technique and genome- ... ...

Abstract	In addition to the discovery that mature cells can be reprogrammed to become pluripotent stem cells(iPS cells), the technical innovations of big-data analyses as well as the cutting- edge technologies such as nuclear reprogramming technique and genome-editing system are emerging a big paradigm shift in the field of regenerative medicine and aging. This is bonafide a kind of the molecular biological movement of the Renaissance to answer the question of 120 years ago "D'ofi Venons Nous Que Sommes Nous Oi Allons Nous", a testament of Paul Gauguin. These technologies enable us, particularly inexhaustible researchers with challenging spirits, not only to dynamically, qualitatively and visually systematically understand underling mechanisms of single gene, single molecule, single cell and their complicated networks in vivo with broadly combining them from cells to organs and individuals', but also to pursue the mechanistic insight into "Life, Aging, Disease, and Death" and thereby con- trol them. We herein review about recent hot topic findings focused on regenerative medicine, cellular senescence & aging as well as aging-related disease, and then discuss the functional interconnection between reprogramming process and senescence signal.
Mesh-Begriff(e)	Aging/genetics ; Animals ; Cellular Reprogramming ; Cellular Senescence ; Humans ; Induced Pluripotent Stem Cells ; Regenerative Medicine
Sprache	Japanisch
Erscheinungsdatum	2018-12-17
Erscheinungsland	Japan
Dokumenttyp	Journal Article ; Review
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.

Sakuma, Ikki / Gaspar, Rafael C / Luukkonen, Panu K / Kahn, Mario / Zhang, Dongyan / Zhang, Xuchen / Murray, Sue / Golla, Jaya Prakash / Vatner, Daniel F / Samuel, Varman T / Petersen, Kitt Falk / Shulman, Gerald I

Proceedings of the National Academy of Sciences of the United States of America

2023 Band 120, Heft 52, Seite(n) e2312666120

Abstract: AGPAT2 (1-acyl-sn-glycerol-3-phosphate-acyltransferase-2) converts lysophosphatidic acid (LPA) into phosphatidic acid (PA), and mutations of ... ...

Abstract	AGPAT2 (1-acyl-sn-glycerol-3-phosphate-acyltransferase-2) converts lysophosphatidic acid (LPA) into phosphatidic acid (PA), and mutations of the
Mesh-Begriff(e)	Male ; Rats ; Animals ; Acyltransferases/metabolism ; Glycerol ; 1-Acylglycerol-3-Phosphate O-Acyltransferase/genetics ; 1-Acylglycerol-3-Phosphate O-Acyltransferase/metabolism ; Rats, Sprague-Dawley ; Lipodystrophy/genetics ; Fatty Liver ; Adipose Tissue, White/metabolism ; Phosphatidic Acids ; Inflammation ; Overnutrition ; Phosphates
Chemische Substanzen	Acyltransferases (EC 2.3.-) ; lysophosphatidic acid (PG6M3969SG) ; Glycerol (PDC6A3C0OX) ; 1-Acylglycerol-3-Phosphate O-Acyltransferase (EC 2.3.1.51) ; Phosphatidic Acids ; Phosphates
Sprache	Englisch
Erscheinungsdatum	2023-12-21
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2312666120
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: O

Nakamoto, Akiko / Ohashi, Natsuko / Sugawara, Lucia / Morino, Katsutaro / Ida, Shogo / Perry, Rachel J / Sakuma, Ikki / Yanagimachi, Tsuyoshi / Fujita, Yukihiro / Ugi, Satoshi / Kume, Shinji / Shulman, Gerald I / Maegawa, Hiroshi

American journal of physiology. Endocrinology and metabolism

2023 Band 325, Heft 1, Seite(n) E46–E61

Abstract: Adipose tissues accumulate excess energy as fat and heavily influence metabolic homeostasis. ...

Abstract	Adipose tissues accumulate excess energy as fat and heavily influence metabolic homeostasis.
Mesh-Begriff(e)	Animals ; Mice ; Acetylglucosamine/metabolism ; Fatty Acids, Nonesterified ; Obesity/genetics ; Obesity/metabolism ; Adipose Tissue/metabolism ; Body Weight/genetics ; Weight Gain ; N-Acetylglucosaminyltransferases/genetics ; N-Acetylglucosaminyltransferases/metabolism
Chemische Substanzen	Acetylglucosamine (V956696549) ; Fatty Acids, Nonesterified ; N-Acetylglucosaminyltransferases (EC 2.4.1.-)
Sprache	Englisch
Erscheinungsdatum	2023-05-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00263.2022
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ceritinib Aggravates Glycemic Control in Insulin-treated Patients with Diabetes and Metastatic ALK-positive Lung Cancer.

Sakuma, Ikki / Nagano, Hidekazu / Yoshino, Ichiro / Yokote, Koutaro / Tanaka, Tomoaki

Internal medicine (Tokyo, Japan)

2018 Band 58, Heft 6, Seite(n) 817–820

Abstract: We herein report a 75-year-old woman with insulin-treated diabetes and metastatic anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer who received ceritinib, a second-generation ALK inhibitor, and achieved dramatic tumor reduction. ... ...

Abstract	We herein report a 75-year-old woman with insulin-treated diabetes and metastatic anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer who received ceritinib, a second-generation ALK inhibitor, and achieved dramatic tumor reduction. However, her fasting blood glucose increased, particularly markedly in the first two weeks after ceritinib administration, and did not normalize even increasing the total insulin dose. After discontinuing ceritinib, her glucose levels rapidly reduced. Ceritinib can aggravate hyperglycemia in patients with diabetes who lack compensatory insulin secretion, due to its inhibitory effects on the insulin receptor. Careful monitoring for ceritinib-induced hyperglycemia should be performed, especially in the first two weeks after ceritinib administration.
Mesh-Begriff(e)	Aged ; Anaplastic Lymphoma Kinase/metabolism ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Biomarkers/blood ; Biomarkers, Tumor/metabolism ; Blood Glucose/metabolism ; Carcinoma, Non-Small-Cell Lung/complications ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Female ; Humans ; Hyperglycemia/blood ; Hyperglycemia/chemically induced ; Hyperglycemia/diagnosis ; Hypoglycemic Agents/therapeutic use ; Insulins/therapeutic use ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Neoplasm Metastasis ; Pyrimidines/adverse effects ; Pyrimidines/therapeutic use ; Sulfones/adverse effects ; Sulfones/therapeutic use
Chemische Substanzen	Antineoplastic Agents ; Biomarkers ; Biomarkers, Tumor ; Blood Glucose ; Hypoglycemic Agents ; Insulins ; Pyrimidines ; Sulfones ; ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; ceritinib (K418KG2GET)
Sprache	Englisch
Erscheinungsdatum	2018-11-19
Erscheinungsland	Japan
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1870-18
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Cyclothymic Temperament is Associated with Poor Medication Adherence and Disordered Eating in Type 2 Diabetes Patients: A Case-Control Study.

Yamamoto, Tetsuya / Sakurai, Kenichi / Watanabe, Masahiro / Sakuma, Ikki / Kanahara, Nobuhisa / Shiina, Akihiro / Hasegawa, Tadashi / Watanabe, Hiroyuki / Iyo, Masaomi / Ishibashi, Ryoichi

Diabetes therapy : research, treatment and education of diabetes and related disorders

2021 Band 12, Heft 9, Seite(n) 2611–2624

Abstract: Introduction: Poor medication adherence and disordered eating are major self-care problems in patients with type 2 diabetes that worsen glycemic control and increase the risk of developing severe diabetes complications. Affective temperament, which ... ...

Abstract	Introduction: Poor medication adherence and disordered eating are major self-care problems in patients with type 2 diabetes that worsen glycemic control and increase the risk of developing severe diabetes complications. Affective temperament, which remains mostly unchanged throughout life, is speculated to predict poor treatment response and high comorbidity. The aim of this study was to explore the link between affective temperament and poor glycemic control due to insufficient self-care. Methods: This single-center case-control study involved 77 outpatients divided into the 'poor glycemic control' group (n = 52) and the 'better glycemic control' group (n = 25) based on their mean glycated hemoglobin (HbA1c) levels over the past 12 months. All participants underwent one-on-one interviews during which they completed the following psychometric questionnaires: (1) the Mini-International Neuropsychiatric Interview 5.0.0; (2) the Temperament Evaluation of Memphis, Pisa, and San Diego Auto-questionnaire; (3) a researcher-designed single question for assessing subclinical stress-induced overeating; and (4) the Morisky Medication Adherence Scale. The difference between two continuous independent variables was determined using Student's t test. Discrete variables were compared using the Chi-square (χ Results: Those outpatients in the poor glycemic control group exhibited significantly more stress-induced overeating (χ Conclusion: Cyclothymic temperament is significantly associated with disordered eating and/or poor medication adherence in patients with type 2 diabetes and is possibly linked to poor glycemic control.
Sprache	Englisch
Erscheinungsdatum	2021-07-31
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-021-01121-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Identification of genotype-biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency.

Communications biology

2023 Band 6, Heft 1, Seite(n) 787

Abstract: Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is an autosomal recessive disorder characterized by hypoglycemic lactic acidosis. Due to the rarity of FBPase deficiency, the mechanism by which the mutations cause enzyme ... ...

Abstract	Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is an autosomal recessive disorder characterized by hypoglycemic lactic acidosis. Due to the rarity of FBPase deficiency, the mechanism by which the mutations cause enzyme activity loss still remains unclear. Here we identify compound heterozygous missense mutations of FBP1, c.491G>A (p.G164D) and c.581T>C (p.F194S), in an adult patient with hypoglycemic lactic acidosis. The G164D and F194S FBP1 mutants exhibit decreased FBP1 protein expression and a loss of FBPase enzyme activity. The biochemical phenotypes of all previously reported FBP1 missense mutations in addition to G164D and F194S are classified into three functional categories. Type 1 mutations are located at pivotal residues in enzyme activity motifs and have no effects on protein expression. Type 2 mutations structurally cluster around the substrate binding pocket and are associated with decreased protein expression due to protein misfolding. Type 3 mutations are likely nonpathogenic. These findings demonstrate a key role of protein misfolding in mediating the pathogenesis of FBPase deficiency, particularly for Type 2 mutations. This study provides important insights that certain patients with Type 2 mutations may respond to chaperone molecules.
Mesh-Begriff(e)	Humans ; Fructose-1,6-Diphosphatase Deficiency/genetics ; Fructose-1,6-Diphosphatase Deficiency/complications ; Fructose-Bisphosphatase/genetics ; Fructose-Bisphosphatase/metabolism ; Fructose ; Acidosis, Lactic/complications ; Acidosis, Lactic/genetics ; Phenotype ; Genotype ; Hypoglycemic Agents
Chemische Substanzen	Fructose-Bisphosphatase (EC 3.1.3.11) ; Fructose (30237-26-4) ; Hypoglycemic Agents
Sprache	Englisch
Erscheinungsdatum	2023-07-28
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05160-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Inhibition of

Luukkonen, Panu K / Sakuma, Ikki / Gaspar, Rafael C / Mooring, Meghan / Nasiri, Ali / Kahn, Mario / Zhang, Xian-Man / Zhang, Dongyan / Sammalkorpi, Henna / Penttilä, Anne K / Orho-Melander, Marju / Arola, Johanna / Juuti, Anne / Zhang, Xuchen / Yimlamai, Dean / Yki-Järvinen, Hannele / Petersen, Kitt Falk / Shulman, Gerald I

Proceedings of the National Academy of Sciences of the United States of America

2023 Band 120, Heft 4, Seite(n) e2217543120

Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which prognosis is determined by liver fibrosis. A common variant in hydroxysteroid 17-beta dehydrogenase 13 ( ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which prognosis is determined by liver fibrosis. A common variant in hydroxysteroid 17-beta dehydrogenase 13 (
Mesh-Begriff(e)	Animals ; Humans ; Mice ; Liver/metabolism ; Liver Cirrhosis/pathology ; Non-alcoholic Fatty Liver Disease/pathology ; Pyrimidines/pharmacology ; Pyrimidines/metabolism
Chemische Substanzen	pyrimidine (K8CXK5Q32L) ; Pyrimidines ; HSD17B13 protein, human (EC 1.1.-.-)
Sprache	Englisch
Erscheinungsdatum	2023-01-20
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2217543120
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Unique Case of Renovascular Hypertension due to Fibromuscular Dysplasia in an Extra-renal Artery.

Sakuma, Ikki / Saito, Jun / Matsuzawa, Yoko / Omura, Masao / Matsui, Seiji / Nishikawa, Tetsuo

Internal medicine (Tokyo, Japan)

2018 Band 57, Heft 18, Seite(n) 2689–2694

Abstract: A 33-year-old man was admitted to our hospital to undergo an evaluation to determine the cause of secondary hypertension. Computerized tomography angiography (CTA) showed bilateral multiple renal arteries with significant stenosis of the right extra- ... ...

Abstract	A 33-year-old man was admitted to our hospital to undergo an evaluation to determine the cause of secondary hypertension. Computerized tomography angiography (CTA) showed bilateral multiple renal arteries with significant stenosis of the right extra-renal artery due to fibromuscular dysplasia and segmental impairment of renal perfusion. Although the plasma aldosterone concentration and plasma renin activity were within the normal ranges, percutaneous balloon dilatation of the stenotic lesion resolved his hypertension, leading to a diagnosis of renovascular hypertension caused by segmental renal ischemia due to extra-renal artery stenosis. CTA should be considered during the examination of patients with early-age hypertension, even if the plasma renin activity is not sufficiently elevated.
Mesh-Begriff(e)	Adult ; Aldosterone/blood ; Angioplasty, Balloon ; Computed Tomography Angiography ; Fibromuscular Dysplasia/blood ; Fibromuscular Dysplasia/complications ; Fibromuscular Dysplasia/diagnostic imaging ; Fibromuscular Dysplasia/therapy ; Humans ; Hypertension, Renovascular/blood ; Hypertension, Renovascular/diagnostic imaging ; Hypertension, Renovascular/etiology ; Male ; Renal Artery Obstruction/blood ; Renal Artery Obstruction/diagnostic imaging ; Renal Artery Obstruction/etiology ; Renal Artery Obstruction/therapy ; Renin/blood
Chemische Substanzen	Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
Sprache	Englisch
Erscheinungsdatum	2018-04-27
Erscheinungsland	Japan
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0023-17
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway.

Aersilan, Alimasi / Hashimoto, Naoko / Yamagata, Kazuyuki / Yokoyama, Masataka / Nakayama, Akitoshi / Shi, Xiaoyan / Nagano, Hidekazu / Sakuma, Ikki / Nohata, Nijiro / Kinoshita, Takashi / Seki, Naohiko / Rahmutulla, Bahityar / Kaneda, Atsushi / Zhahara, Siti Nurul / Gong, Yingbo / Nishimura, Motoi / Kawauchi, Shoichiro / Kawakami, Eiryo / Tanaka, Tomoaki

Scientific reports

2022 Band 12, Heft 1, Seite(n) 18443

Abstract: The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer. However, the relationship between the mevalonate ... ...

Abstract	The microRNA (miR) miR-874, a potential tumour suppressor, causes cell death via target gene suppression in various cancer types. Mevalonate pathway inhibition also causes cell death in breast cancer. However, the relationship between the mevalonate pathway and miR-874-induced apoptosis or its association with the tumour suppressor p53 has not been elucidated. We identified phosphomevalonate kinase (PMVK), a key mevalonate pathway enzyme, and sterol regulatory element-binding factor 2 (SREBF2), the master cholesterol biosynthesis regulator, as direct miR‑874 targets. Next-generation sequencing analysis revealed a significant miR-874-mediated downregulation of PMVK and SREBF2 gene expression and p53 pathway enrichment. Luciferase reporter assays showed that miR-874 directly regulated PMVK and SREBF2. miR-874-induced apoptosis was p53 dependent, and single-cell RNA sequencing analysis demonstrated that miR-874 transfection resulted in apoptosis and p53 pathway activation. Downregulation of PMVK expression also caused cell cycle arrest and p53 pathway activation, which was rescued by geranylgeranyl pyrophosphate (GGPP) supplementation. Analysis of The Cancer Genome Atlas (TCGA) database indicated a negative correlation between miR-874 and PMVK expression and between miR-874 and SREBF2 expression. These findings suggest that miR-874 suppresses the mevalonate pathway by targeting SREBF2 and PMVK, resulting in GGPP depletion, which activates the p53 pathway and promotes cycle arrest or apoptosis.
Mesh-Begriff(e)	Humans ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Mevalonic Acid/metabolism ; Cell Line, Tumor ; MicroRNAs/metabolism ; Apoptosis/genetics ; Cell Transformation, Neoplastic/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic
Chemische Substanzen	MIRN874 microRNA, mouse ; Tumor Suppressor Protein p53 ; Mevalonic Acid (S5UOB36OCZ) ; phosphomevalonate kinase (EC 2.7.4.2) ; MicroRNAs ; MIRN874 microRNA, human
Sprache	Englisch
Erscheinungsdatum	2022-11-02
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-23205-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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