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Article ; Online: A feasibility study comparing gel immersion endoscopic resection and underwater endoscopic mucosal resection for superficial nonampullary duodenal epithelial tumors.

Miyakawa, Akihiro / Kuwai, Toshio / Sakuma, Yukie / Kubota, Manabu / Nakamura, Akira / Itobayashi, Ei / Shimura, Haruhisa / Suzuki, Yoshio / Shimura, Kenji

Endoscopy

2022 Volume 55, Issue 3, Page(s) 261–266

Abstract: Background: Although gel immersion endoscopic resection (GIER) is a potential alternative to underwater endoscopic mucosal resection (UEMR) for superficial nonampullary duodenal epithelial tumors (SNADETs), comparisons between the two are currently ... ...

Abstract	Background: Although gel immersion endoscopic resection (GIER) is a potential alternative to underwater endoscopic mucosal resection (UEMR) for superficial nonampullary duodenal epithelial tumors (SNADETs), comparisons between the two are currently insufficient. Methods: 40 consecutive procedures performed in 35 patients were retrospectively reviewed; the primary outcome was procedure time, and the secondary outcomes were en bloc and R0 resection rates, tumor and specimen size, and adverse events. Results: Lesions were divided into GIER (n = 22) and UEMR groups (n = 18). The median (range) procedure time was significantly shorter in the GIER group than in the UEMR group (2.75 [1-3.5] minutes vs. 3 2 3 4 5 6 7 8 9 10 minutes; Conclusions: GIER is efficacious and safe to treat SNADETs, although additional studies are needed.
MeSH term(s)	Humans ; Endoscopic Mucosal Resection/adverse effects ; Endoscopic Mucosal Resection/methods ; Feasibility Studies ; Retrospective Studies ; Immersion ; Duodenal Neoplasms/surgery ; Duodenal Neoplasms/pathology ; Carcinoma ; Treatment Outcome
Language	English
Publishing date	2022-08-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1924-4711
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: The efficacy of prophylactic clip closure of mucosal defects after colorectal endoscopic submucosal dissection on delayed bleeding.

Miyakawa, Akihiro / Kuwai, Toshio / Sakuma, Yukie / Kubota, Manabu / Nakamura, Akira / Itobayashi, Ei / Shimura, Haruhisa / Suzuki, Yoshio / Shimura, Kenji

Scandinavian journal of gastroenterology

2021 Volume 56, Issue 10, Page(s) 1236–1242

Abstract: Objective: Although prophylactic clip closure after endoscopic mucosal resection may prevent delayed bleeding, information regarding colorectal endoscopic submucosal dissection (CR-ESD) is lacking. Therefore, this study evaluated the effect of ... ...

Abstract	Objective: Although prophylactic clip closure after endoscopic mucosal resection may prevent delayed bleeding, information regarding colorectal endoscopic submucosal dissection (CR-ESD) is lacking. Therefore, this study evaluated the effect of prophylactic clip closure on delayed bleeding rate after CR-ESD. Materials and methods: A total of 614 CR-ESD procedures performed in 561 patients were retrospectively reviewed. The primary outcome, which was delayed bleeding rate, was analyzed between the prophylactic clip closure and non-closure groups. Furthermore, the predictors of delayed bleeding were also evaluated. Results: The patients were divided into the clip closure group ( Conclusions: Prophylactic clip closure after CR-ESD is associated with low delayed bleeding rate. LST-G-Mix promotes delayed bleeding, and performing prophylactic clip closure may be advisable.
MeSH term(s)	Colorectal Neoplasms/surgery ; Endoscopic Mucosal Resection/adverse effects ; Humans ; Intestinal Mucosa/surgery ; Postoperative Hemorrhage/epidemiology ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/prevention & control ; Retrospective Studies ; Surgical Instruments ; Treatment Outcome
Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2021.1953129
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Article: A feasibility study comparing gel immersion endoscopic resection and underwater endoscopic mucosal resection for superficial nonampullary duodenal epithelial tumors

Miyakawa, Akihiro / Kuwai, Toshio / Sakuma, Yukie / Kubota, Manabu / Nakamura, Akira / Itobayashi, Ei / Shimura, Haruhisa / Suzuki, Yoshio / Shimura, Kenji

Endoscopy

2022 Volume 55, Issue 03, Page(s) 261–266

Abstract	Background: Although gel immersion endoscopic resection (GIER) is a potential alternative to underwater endoscopic mucosal resection (UEMR) for superficial nonampullary duodenal epithelial tumors (SNADETs), comparisons between the two are currently insufficient. Methods: 40 consecutive procedures performed in 35 patients were retrospectively reviewed; the primary outcome was procedure time, and the secondary outcomes were en bloc and R0 resection rates, tumor and specimen size, and adverse events. Results: Lesions were divided into GIER (n = 22) and UEMR groups (n = 18). The median (range) procedure time was significantly shorter in the GIER group than in the UEMR group (2.75 [1–3.5] minutes vs. 3 2345678910 minutes; P = 0.01). The en bloc resection rate was 100 % in the GIER group, but only 83.3 % in the UEMR group. The R0 resection rate was significantly higher in the GIER group than in the UEMR group (95.5 % vs. 66.7 %; P = 0.03). The median specimen size was larger in the GIER group than in the UEMR group (14 mm vs. 7.5 mm; P < 0.001). The tumor size was not significantly different between the groups and no adverse events were observed. Conclusions: GIER is efficacious and safe to treat SNADETs, although additional studies are needed.
Language	English
Publishing date	2022-08-15
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1924-4711
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Sex differences in predictive factors for onset of type 2 diabetes in Japanese individuals: A 15-year follow-up study.

Yoshimoto, Mei / Sakuma, Yukie / Ogino, Jun / Iwai, Rie / Watanabe, Saburo / Inoue, Takeshi / Takahashi, Haruo / Suzuki, Yoshifumi / Kinoshita, Daisuke / Takemura, Koji / Takahashi, Hidenori / Shimura, Haruhisa / Babazono, Tetsuya / Yoshida, Shouji / Hashimoto, Naotake

Journal of diabetes investigation

2022

Abstract: Aims/introduction: The increase in the number of patients with type 2 diabetes mellitus is an important concern worldwide. The goal of this study was to investigate factors involved in the onset of type 2 diabetes mellitus, and sex differences in long- ... ...

Abstract	Aims/introduction: The increase in the number of patients with type 2 diabetes mellitus is an important concern worldwide. The goal of this study was to investigate factors involved in the onset of type 2 diabetes mellitus, and sex differences in long-term follow up of people with normal glucose tolerance. Materials and methods: Of 1,309 individuals who underwent screening at our facility in 2004, 748 individuals without diabetes were enrolled. Correlations of metabolic markers including serum adiponectin (APN) with onset of type 2 diabetes mellitus were examined over 15 years in these individuals. Results: The Kaplan-Meier curve for onset of type 2 diabetes mellitus for 15 years in the decreased APN group was examined. Hazard ratios for the APN concentration for onset of diabetes were 1.78 (95% confidence interval [CI] 1.20-2.63, P = 0.004) in all participants, 1.48 (95% CI 0.96-2.29, P = 0.078) for men and 3.01 (95% CI 1.37-6.59, P = 0.006) for women. During the follow-up period of 15 years, body mass index, estimated glomerular filtration rate, fatty liver, C-reactive protein and alanine aminotransferase in men were significant in univariate analysis, but only estimated glomerular filtration rate and fatty liver were significantly related to onset of type 2 diabetes mellitus in multivariate analysis. In women, body mass index, systolic blood pressure, triglyceride, fatty liver and APN were significant in univariate analysis, and APN was the only significant risk factor in multivariate analysis (P < 0.05). Conclusions: There are differences between men and women with regard to targets for intervention to prevent the onset of type 2 diabetes mellitus. Individuals requiring intensive intervention should be selected with this finding to maximize the use of limited social and economic resources.
Language	English
Publishing date	2022-10-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.13918
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Article ; Online: Learning curve for endoscopic submucosal dissection of early colorectal neoplasms with a monopolar scissor-type knife: use of the cumulative sum method.

Miyakawa, Akihiro / Kuwai, Toshio / Sakuma, Yukie / Kubota, Manabu / Nakamura, Akira / Itobayashi, Ei / Shimura, Haruhisa / Suzuki, Yoshio / Shimura, Kenji

Scandinavian journal of gastroenterology

2020 Volume 55, Issue 10, Page(s) 1234–1242

Abstract: Objective: Although scissor-type knives such as the Stag-Beetle (SB) Knife Jr are expected to result in a safe and easy colorectal endoscopic submucosal dissection (CR-ESD), information regarding the learning curve is lacking. Therefore, this study ... ...

Abstract	Objective: Although scissor-type knives such as the Stag-Beetle (SB) Knife Jr are expected to result in a safe and easy colorectal endoscopic submucosal dissection (CR-ESD), information regarding the learning curve is lacking. Therefore, this study evaluated the learning curve with using SB Knife Jr. Materials and methods: We retrospectively reviewed 507 CR-ESD procedures performed in 464 patients using SB Knife Jr. The primary endpoint was a learning curve to achieve a satisfactory complete resection rate. The secondary endpoints were learning curves to achieve a satisfactory Results: The complete, Conclusions: SB Knife Jr enables safe and easy CR-ESD during the introductory period compared to the conventional tip-type knife and has an acceptable learning curve. Therefore, using this knife will encourage the widespread adoption of CR-ESD in Asian general hospitals and non-Asian countries.
MeSH term(s)	Colorectal Neoplasms/surgery ; Endoscopic Mucosal Resection ; Humans ; Learning Curve ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2020-08-27
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2020.1807597
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Zs.A 567: Show issues

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Article ; Online: Characteristics and Prognosis of Patients with Immunoglobulin M Monoclonal Gammopathy.

Tanaka, Hiroaki / Sakuma, Yukie / Ikeda, Hideki / Shimizu, Ryo / Sugita, Yasumasa / Iwai, Rie

Journal of clinical and experimental hematopathology : JCEH

2017 Volume 57, Issue 2, Page(s) 47–53

Abstract: Many patients with immunoglobulin M (IgM) monoclonal gammopathy remain asymptomatic and, consequently, untreated; however, few studies have evaluated the clinical course and prognosis of these patients. Using the screening procedures at our hospital, 74 ... ...

Abstract	Many patients with immunoglobulin M (IgM) monoclonal gammopathy remain asymptomatic and, consequently, untreated; however, few studies have evaluated the clinical course and prognosis of these patients. Using the screening procedures at our hospital, 74 patients with IgM monoclonal gammopathy were selected. We excluded 11 patients in whom the treatment for lymphoid neoplasms had been initiated at the time of IgM monoclonal protein detection. The remaining 63 patients were considered to be the patient population with IgM MGUS and asymptomatic WM, and were analyzed. In these patients, the median overall survival was longer than 14 years. More than half of these patients died from causes other than lymphoid neoplasm. The cumulative incidence of lymphoid neoplasm requiring treatment was 17.5%. In five of eight patients requiring treatment for lymphoid neoplasms, the causes of death were related with these lymphoid neoplasms. Our study suggests that not all patients with IgM monoclonal gammopathy require uniform treatment for prolonged survival; however, most lymphoid neoplasms requiring treatment are refractory diseases. Our findings may help manage patients with macroglobulinemia.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Disease-Free Survival ; Female ; Humans ; Immunoglobulin M ; Infant ; Male ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance/blood ; Monoclonal Gammopathy of Undetermined Significance/mortality ; Monoclonal Gammopathy of Undetermined Significance/therapy ; Retrospective Studies ; Survival Rate ; Waldenstrom Macroglobulinemia/blood ; Waldenstrom Macroglobulinemia/mortality ; Waldenstrom Macroglobulinemia/therapy
Chemical Substances	Immunoglobulin M
Language	English
Publishing date	2017-10-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2395568-5
ISSN	1880-9952 ; 1346-4280
ISSN (online)	1880-9952
ISSN	1346-4280
DOI	10.3960/jslrt.17025
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Article: Hyperferritinemia Is a Predictor of Onset of Diabetes in Japanese Males Independently of Decreased Renal Function and Fatty Liver: A Fifteen-Year Follow-Up Study.

Sakuma, Yukie / Ogino, Jun / Iwai, Rie / Inoue, Takashi / Takahashi, Haruo / Suzuki, Yoshifumi / Kinoshita, Daisuke / Takemura, Koji / Takahashi, Hidenori / Shimura, Haruhisa / Sato, Yasunori / Yoshida, Shouji / Hashimoto, Naotake

Journal of clinical medicine research

2021 Volume 13, Issue 12, Page(s) 541–548

Abstract: Background: Type 2 diabetes is an important health concern worldwide. The disease etiology may depend on multiple environmental and genetic factors that cause insulin resistance, including dysregulation of iron storage. The goal of this study was to ... ...

Abstract	Background: Type 2 diabetes is an important health concern worldwide. The disease etiology may depend on multiple environmental and genetic factors that cause insulin resistance, including dysregulation of iron storage. The goal of this study was to examine the relationship of the serum ferritin concentration with onset of diabetes over a long period. Methods: Correlations of serum ferritin and metabolic markers with onset of diabetes mellitus were examined over 15 years in 150 males participating in a health screening program. Results: HOMA-β showed a gradual significant decrease in the first 4 years in subjects with ferritin > 190 ng/mL (group H) compared to those with ferritin ≤ 190 ng/mL, but there was no difference in HOMA-R between these groups. A significant number of cases with onset of diabetes was observed over 15 years (hazard ratio (HR): 3.97), and obesity, fasting blood glucose level, hemoglobin A1c (HbA1c), HOMA-R, fasting immunoreactive insulin (IRI) and C-peptide immunoreactivity (CPR) were all significant in univariate comparison between non-diabetes and diabetes-onset groups. In multivariate analysis, ferritin in group H (HR: 3.25), fatty liver (HR: 3.38), estimated glomerular filtration rate (eGFR) < 70 mL/min/1.73 m Conclusions: These results suggest that the serum ferritin level is an important index for priority intervention in preventive medicine for reduction of onset of diabetes.
Language	English
Publishing date	2021-12-28
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr4635
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Article ; Online: Characteristics and prognosis of patients with non-immunoglobulin-M monoclonal gammopathy of undetermined significance: a retrospective study.

Kuwabara, Chihiro / Sakuma, Yukie / Kume, Ayaka / Tamura, Yuri / Shimizu, Ryo / Iwai, Rie / Ishii, Akihiro / Tanaka, Hiroaki

International journal of hematology

2018 Volume 109, Issue 2, Page(s) 154–161

Abstract: Non-immunoglobulin (Ig)-M monoclonal gammopathy of undetermined significance (MGUS) is a precursor lesion with the potential to evolve into a malignant plasma cell neoplasm. The prevalence of MGUS differs by ethnicity and is lower in the Japanese ... ...

Abstract	Non-immunoglobulin (Ig)-M monoclonal gammopathy of undetermined significance (MGUS) is a precursor lesion with the potential to evolve into a malignant plasma cell neoplasm. The prevalence of MGUS differs by ethnicity and is lower in the Japanese population than in the Western population. However, there is limited evidence about the clinical course of MGUS in Asian races. The present study aims at elucidating the clinical course and prognosis of Japanese patients with non-IgM MGUS in the clinical setting. We retrospectively examined 1009 patients with non-IgM MGUS identified by screening procedures. The median overall survival of these patients was > 20 years, and only one-fifth patients died of plasma cell neoplasms. The cumulative incidence of plasma cell neoplasms requiring treatment was 19%. Multivariate analysis revealed that immunoparesis and female gender were independent factors affecting treatment requirement. Although the characteristics and clinical course of patients with non-IgM MGUS obtained in this study were found to be essentially similar to those of previous studies, we report here for the first time that female gender is a significant independent factor for requiring treatment.
MeSH term(s)	Adult ; Aged ; Asian Continental Ancestry Group ; Disease Progression ; Female ; Humans ; Immunoglobulin M ; Male ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance/diagnosis ; Monoclonal Gammopathy of Undetermined Significance/epidemiology ; Monoclonal Gammopathy of Undetermined Significance/mortality ; Neoplasms, Plasma Cell/mortality ; Prognosis ; Retrospective Studies ; Sex Factors ; Survival Analysis
Chemical Substances	Immunoglobulin M
Language	English
Publishing date	2018-11-08
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-018-2555-7
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Zs.A 269: Show issues

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Article ; Online: Impact of Hematopoietic Progenitor Cell Count as an Indicator for Optimal Timing of Peripheral Stem Cell Harvest in Clinical Practice.

Tanaka, Hiroaki / Ishii, Akihiro / Sugita, Yasumasa / Shimizu, Ryo / Sato, Fumi / Sakuma, Yukie / Iwai, Rie / Kakuta, Shinichiro

Journal of clinical and experimental hematopathology : JCEH

2017 Volume 56, Issue 3, Page(s) 150–159

Abstract: For optimizing CD34+ cell collection, appropriately timing peripheral blood stem cell harvest (PBSCH) initiation is crucial. Automatic cell analyzers with the immature myeloid information channel provide hematopoietic progenitor cell (HPC) count, a ... ...

Abstract	For optimizing CD34+ cell collection, appropriately timing peripheral blood stem cell harvest (PBSCH) initiation is crucial. Automatic cell analyzers with the immature myeloid information channel provide hematopoietic progenitor cell (HPC) count, a surrogate marker of CD34+ cells, which can be obtained within a few minutes without requiring monoclonal antibodies. The final decision on PBSCH initiation can be made using the HPC count obtained on the morning of the harvest day. Herein, we evaluated the impact of the HPC count as an indicator for the optimal timing of PBSCH in clinical practice over 9 years. One hundred and eighteen aphereses from 72 cases had a definite number of CD34+ cells/kg in the PBSC yield. A correlation was found between the HPC count in the PB and the CD34+ cell count (R = 0.563, p ＜ 0.001), whereas no correlation existed between the white blood cell and CD34+ cell counts (R = 0.0418, p = 0.65). We defined ＞ 2.0 × 10
MeSH term(s)	Adult ; Antigens, CD34/analysis ; Female ; Hematopoietic Stem Cell Mobilization/methods ; Hematopoietic Stem Cell Mobilization/standards ; Hematopoietic Stem Cells/cytology ; Humans ; Leukapheresis/methods ; Leukapheresis/standards ; Leukocyte Count ; Male ; Middle Aged ; Peripheral Blood Stem Cell Transplantation/methods ; Peripheral Blood Stem Cells/cytology ; Practice Patterns, Physicians'/standards ; Time Factors
Chemical Substances	Antigens, CD34
Language	English
Publishing date	2017-03-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2395568-5
ISSN	1880-9952 ; 1346-4280
ISSN (online)	1880-9952
ISSN	1346-4280
DOI	10.3960/jslrt.56.150
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Article ; Online: Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial.

Miyakawa, Akihiro / Kodera, Satoshi / Sakuma, Yukie / Shimada, Taro / Kubota, Manabu / Nakamura, Akira / Itobayashi, Ei / Shimura, Haruhisa / Suzuki, Yoshio / Sato, Yasunori / Shimura, Kenji

Digestion

2018 Volume 100, Issue 3, Page(s) 160–169

Abstract: Background/aims: Feeding recommendations after endoscopic submucosal dissection (ESD) for gastric neoplasms are not established and based on clinical experience.: Methods: This was a prospective pilot randomized controlled trial. Patients undergoing ... ...

Abstract	Background/aims: Feeding recommendations after endoscopic submucosal dissection (ESD) for gastric neoplasms are not established and based on clinical experience. Methods: This was a prospective pilot randomized controlled trial. Patients undergoing ESD for gastric neoplasms were randomly assigned to solid (n = 50) or liquid diet (n = 50) groups. Beginning the day after hemostasis confirmation until discharge, the solid diet group started on a diet of rice porridge, whereas the liquid diet group started on a liquid diet, with gradual transition to solid food. The primary endpoint was delayed bleeding rate. The secondary endpoints were quality of life (QOL), ulcer-stage, hospital fees, and post-ESD symptoms. Results: Delayed bleeding occurred in the solid diet group (2%) but not in the liquid diet group. The QOL evaluation using European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-STO22 showed better score in the solid diet group. The patients who felt dietary restriction at discharge was of a larger number in the liquid diet group (p = 0.019). More patients experienced appetite loss (p = 0.038), constipation (p = 0.022), and dietary restriction (p = 0.037) in the liquid diet group during hospitalization. The other endpoints were equivalent between the groups. Conclusion: Early initiation of solid foods after ESD is feasible and associated with higher QOL, potentially rendering conventional liquid diets unnecessary, although additional studies are needed (Trial registration number: UMIN000013297).
MeSH term(s)	Aged ; Aged, 80 and over ; Endoscopic Mucosal Resection/adverse effects ; Endoscopic Mucosal Resection/methods ; Endoscopic Mucosal Resection/rehabilitation ; Feasibility Studies ; Female ; Gastroscopy/adverse effects ; Gastroscopy/methods ; Gastroscopy/rehabilitation ; Humans ; Male ; Middle Aged ; Nutrition Therapy/adverse effects ; Nutrition Therapy/methods ; Pilot Projects ; Postoperative Care/adverse effects ; Postoperative Care/methods ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Prospective Studies ; Quality of Life ; Stomach Neoplasms/surgery ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2018-12-14
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1712-7
ISSN	1421-9867 ; 0012-2823
ISSN (online)	1421-9867
ISSN	0012-2823
DOI	10.1159/000494490
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