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Article ; Online: Relationship between age-related hearing loss and consumption of coffee and tea.

Watarai, Gosuke / Suzuki, Jun / Motoike, Ikuko N / Sakurai, Miyuki / Ikeda, Ryoukichi / Kawase, Tetsuaki / Kinoshita, Kengo / Hozawa, Atsushi / Kuriyama, Shinichi / Fuse, Nobuo / Yamamoto, Masayuki / Katori, Yukio

Geriatrics & gerontology international

2023 Volume 23, Issue 6, Page(s) 453–456

MeSH term(s)	Humans ; Coffee/adverse effects ; Tea/adverse effects ; Hearing Loss/epidemiology ; Risk Factors
Chemical Substances	Coffee ; Tea
Language	English
Publishing date	2023-05-03
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14589
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Article ; Online: Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection.

Takahashi, Yuta / Ueki, Masao / Yamada, Makoto / Tamiya, Gen / Motoike, Ikuko N / Saigusa, Daisuke / Sakurai, Miyuki / Nagami, Fuji / Ogishima, Soichi / Koshiba, Seizo / Kinoshita, Kengo / Yamamoto, Masayuki / Tomita, Hiroaki

Translational psychiatry

2020 Volume 10, Issue 1, Page(s) 157

Abstract: To solve major limitations in algorithms for the metabolite-based prediction of psychiatric phenotypes, a novel prediction model for depressive symptoms based on nonlinear feature selection machine learning, the Hilbert-Schmidt independence criterion ... ...

Abstract	To solve major limitations in algorithms for the metabolite-based prediction of psychiatric phenotypes, a novel prediction model for depressive symptoms based on nonlinear feature selection machine learning, the Hilbert-Schmidt independence criterion least absolute shrinkage and selection operator (HSIC Lasso) algorithm, was developed and applied to a metabolomic dataset with the largest sample size to date. In total, 897 population-based subjects were recruited from the communities affected by the Great East Japan Earthquake; 306 metabolite features (37 metabolites identified by nuclear magnetic resonance measurements and 269 characterized metabolites based on the intensities from mass spectrometry) were utilized to build prediction models for depressive symptoms as evaluated by the Center for Epidemiologic Studies-Depression Scale (CES-D). The nested fivefold cross-validation was used for developing and evaluating the prediction models. The HSIC Lasso-based prediction model showed better predictive power than the other prediction models, including Lasso, support vector machine, partial least squares, random forest, and neural network. L-leucine, 3-hydroxyisobutyrate, and gamma-linolenyl carnitine frequently contributed to the prediction. We have demonstrated that the HSIC Lasso-based prediction model integrating nonlinear feature selection showed improved predictive power for depressive symptoms based on metabolome data as well as on risk metabolites based on nonlinear statistics in the Japanese population. Further studies should use HSIC Lasso-based prediction models with different ethnicities to investigate the generality of each risk metabolite for predicting depressive symptoms.
MeSH term(s)	Algorithms ; Databases, Factual ; Depression ; Japan ; Machine Learning
Language	English
Publishing date	2020-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-020-0831-9
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Article ; Online: Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background.

Taira, Makiko / Mugikura, Shunji / Mori, Naoko / Hozawa, Atsushi / Saito, Tomo / Nakamura, Tomohiro / Kiyomoto, Hideyasu / Kobayashi, Tadao / Ogishima, Soichi / Nagami, Fuji / Uruno, Akira / Shimizu, Ritsuko / Kobayashi, Tomoko / Yasuda, Jun / Kure, Shigeo / Sakurai, Miyuki / Motoike, Ikuko N / Kumada, Kazuki / Nakaya, Naoki /

Obara, Taku / Oba, Kentaro / Sekiguchi, Atsushi / Thyreau, Benjamin / Mutoh, Tatsushi / Takano, Yuji / Abe, Mitsunari / Maikusa, Norihide / Tatewaki, Yasuko / Taki, Yasuyuki / Yaegashi, Nobuo / Tomita, Hiroaki / Kinoshita, Kengo / Kuriyama, Shinichi / Fuse, Nobuo / Yamamoto, Masayuki

JMA journal

2023 Volume 6, Issue 3, Page(s) 246–264

Abstract: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of ... ...

Abstract	The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study (TMM Brain MRI Study) was established to collect multimodal information through neuroimaging and neuropsychological assessments to evaluate the cognitive function and mental health of residents who experienced the Great East Japan Earthquake (GEJE) and associated tsunami. The study also aimed to promote advances in personalized healthcare and medicine related to mental health and cognitive function among the general population. We recruited participants for the first (baseline) survey starting in July 2014, enrolling individuals who were participating in either the TMM Community-Based Cohort Study (TMM CommCohort Study) or the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). We collected multiple magnetic resonance imaging (MRI) sequences, including 3D T1-weighted sequences, magnetic resonance angiography (MRA), diffusion tensor imaging (DTI), pseudo-continuous arterial spin labeling (pCASL), and three-dimensional fluid-attenuated inversion recovery (FLAIR) sequences. To assess neuropsychological status, we used both questionnaire- and interview-based rating scales. The former assessments included the Tri-axial Coping Scale, Impact of Event Scale in Japanese, Profile of Mood States, and 15-item Depression, Anxiety, and Stress Scale, whereas the latter assessments included the Mini-Mental State Examination, Japanese version. A total of 12,164 individuals were recruited for the first (baseline) survey, including those unable to complete all assessments. In parallel, we returned the MRI results to the participants and subsequently shared the MRI data through the TMM Biobank. At present, the second (first follow-up) survey of the study started in October 2019 is underway. In this study, we established a large and comprehensive database that included robust neuroimaging data as well as psychological and cognitive assessment data. In combination with genomic and omics data already contained in the TMM Biobank database, these data could provide new insights into the relationships of pathological processes with neuropsychological disorders, including age-related cognitive impairment.
Language	English
Publishing date	2023-06-30
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2022-0220
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Article: [A case of toxicity caused by drug interaction between capecitabine and phenytoin in patient with colorectal cancer].

Sakurai, Miyuki / Kawahara, Kaori / Ueda, Rie / Fukui, Eiji / Yamada, Ryuhei

Gan to kagaku ryoho. Cancer & chemotherapy

2011 Volume 38, Issue 5, Page(s) 841–843

Abstract: We present a case of toxicity caused by a drug interaction between capecitabine and phenytoin (PHT). The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer. Our patient was a 44-year-old ...

Abstract	We present a case of toxicity caused by a drug interaction between capecitabine and phenytoin (PHT). The drug combination elevated the plasma level of PHT in a patient on chemotherapy with capecitabine for colorectal cancer. Our patient was a 44-year-old woman diagnosed with epilepsy in her 20's, being treated with valproic acid (VPA) and PHT. Adjuvant chemotherapy with capecitabine began following surgery for colorectal cancer. Seven weeks later, she developed numbness, dizziness, dysarthria and difficulty walking, and was hospitalized for investigation. Her serum PHT level was elevated at 35. 1 μg/ mL. This case suggests that when capecitabine and PHT are coadministered, PHT levels should be monitored frequently, and that PHT dosage should be adjusted accordingly if it cannot be replaced by an alternative anticonvulsant.
MeSH term(s)	Adult ; Anticonvulsants/adverse effects ; Anticonvulsants/blood ; Anticonvulsants/therapeutic use ; Antimetabolites, Antineoplastic/adverse effects ; Antimetabolites, Antineoplastic/blood ; Antimetabolites, Antineoplastic/therapeutic use ; Capecitabine ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/drug therapy ; Deoxycytidine/adverse effects ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/blood ; Deoxycytidine/therapeutic use ; Drug Interactions ; Epilepsy/blood ; Epilepsy/complications ; Epilepsy/drug therapy ; Female ; Fluorouracil/adverse effects ; Fluorouracil/analogs & derivatives ; Fluorouracil/blood ; Fluorouracil/therapeutic use ; Humans ; Phenytoin/adverse effects ; Phenytoin/blood ; Phenytoin/therapeutic use
Chemical Substances	Anticonvulsants ; Antimetabolites, Antineoplastic ; Deoxycytidine (0W860991D6) ; Phenytoin (6158TKW0C5) ; Capecitabine (6804DJ8Z9U) ; Fluorouracil (U3P01618RT)
Language	Japanese
Publishing date	2011-05
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: Evaluation of zero-order controlled release preparations of nifedipine tablet on dissolution test, together with cost benefit point of view.

Sakurai, Miyuki / Naruto, Ikue / Matsuyama, Kenji

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2008 Volume 128, Issue 5, Page(s) 819–826

Abstract: Many generic drugs have been released to decrease medical expenses, but some problems have been reported with regard to bioavailability and safety. In this study, we compared three once-a-day controlled-release preparations of nifedipine by the ... ...

Abstract	Many generic drugs have been released to decrease medical expenses, but some problems have been reported with regard to bioavailability and safety. In this study, we compared three once-a-day controlled-release preparations of nifedipine by the dissolution test (one branded and two generic preparations). Although the two generic drugs were equivalent to the branded drug according to the criteria listed in the Japanese "Guideline for Bioequivalence Studies of Generic Products", there was still a possibility of problems arising. For example, side effects could be caused by a rapid increase in the blood level of nifedipine with one generic drug, while bioavailability might be inadequate with the other due to its small area under the concentration vs. time curve. When each drug was prescribed at a dosage of 20 mg once daily for two weeks, the difference in the copayment for the patient was only 10 yen. Accordingly, it is important for doctors and pharmacists to carefully consider whether such a slight difference in price is really a benefit for the patient.
MeSH term(s)	Biological Availability ; Cost-Benefit Analysis/economics ; Delayed-Action Preparations ; Drugs, Generic ; Nifedipine/administration & dosage ; Nifedipine/adverse effects ; Nifedipine/economics ; Nifedipine/pharmacokinetics ; Safety ; Solubility ; Tablets ; Therapeutic Equivalency
Chemical Substances	Delayed-Action Preparations ; Drugs, Generic ; Tablets ; Nifedipine (I9ZF7L6G2L)
Language	English
Publishing date	2008-03-13
Publishing country	Japan
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.128.819
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Article ; Online: Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator.

Yamada, Mitsuhiro / Motoike, Ikuko N / Kojima, Kaname / Fuse, Nobuo / Hozawa, Atsushi / Kuriyama, Shinichi / Katsuoka, Fumiki / Tadaka, Shu / Shirota, Matsuyuki / Sakurai, Miyuki / Nakamura, Tomohiro / Hamanaka, Yohei / Suzuki, Kichiya / Sugawara, Junichi / Ogishima, Soichi / Uruno, Akira / Kodama, Eiichi N / Fujino, Naoya / Numakura, Tadahisa /

Ichikawa, Tomohiro / Mitsune, Ayumi / Ohe, Takashi / Kinoshita, Kengo / Ichinose, Masakazu / Sugiura, Hisatoshi / Yamamoto, Masayuki

Communications biology

2021 Volume 4, Issue 1, Page(s) 1288

Abstract: Lung function reflects the ability of the respiratory system and is utilized for the assessment of respiratory diseases. Because type 2 airway inflammation influences lung function, genome wide association studies (GWAS) for lung function would be ... ...

Abstract	Lung function reflects the ability of the respiratory system and is utilized for the assessment of respiratory diseases. Because type 2 airway inflammation influences lung function, genome wide association studies (GWAS) for lung function would be improved by adjustment with an indicator of the inflammation. Here, we performed a GWAS for lung function with adjustment for exhaled nitric oxide (FeNO) levels in two independent Japanese populations. Our GWAS with genotype imputations revealed that the RNF5/AGER locus including AGER rs2070600 SNP, which introduces a G82S substitution of AGER, was the most significantly associated with FEV
MeSH term(s)	Adult ; Aged ; Biomarkers ; Exhalation ; Female ; Genetic Loci ; Genome-Wide Association Study ; Genotype ; Humans ; Japan ; Lung/immunology ; Male ; Middle Aged ; Nitric Oxide/metabolism ; Pneumonia/genetics ; Respiratory Function Tests
Chemical Substances	Biomarkers ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2021-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-021-02813-8
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Article ; Online: Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study.

Fuse, Nobuo / Sakurai, Miyuki / Motoike, Ikuko N / Kojima, Kaname / Takai-Igarashi, Takako / Nakaya, Naoki / Tsuchiya, Naho / Nakamura, Tomohiro / Ishikuro, Mami / Obara, Taku / Miyazawa, Akiko / Homma, Kei / Ido, Keisuke / Taira, Makiko / Kobayashi, Tomoko / Shimizu, Ritsuko / Uruno, Akira / Kodama, Eiichi N / Suzuki, Kichiya /

Hamanaka, Yohei / Tomita, Hiroaki / Sugawara, Junichi / Suzuki, Yoichi / Nagami, Fuji / Ogishima, Soichi / Katsuoka, Fumiki / Minegishi, Naoko / Hozawa, Atsushi / Kuriyama, Shinichi / Yaegashi, Nobuo / Kure, Shigeo / Kinoshita, Kengo / Yamamoto, Masayuki

Ophthalmology science

2022 Volume 2, Issue 1, Page(s) 100113

Abstract: Purpose: To elucidate the differences in ocular biometric parameters by generation and gender and to identify axial length (AL)-associated genetic variants in Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data.! ...

Abstract	Purpose: To elucidate the differences in ocular biometric parameters by generation and gender and to identify axial length (AL)-associated genetic variants in Japanese individuals, we analyzed Tohoku Medical Megabank Organization (ToMMo) Eye Study data. Design: We designed the ToMMo Eye Study, examined AL variations, and conducted genome-wide association studies (GWASs). Participants: In total, 33 483 participants aged > 18 years who were recruited into the community-based cohort (CommCohort) and the birth and three-generation cohort (BirThree Cohort) of the ToMMo Eye Study were examined. Methods: Each participant was screened with an interview, ophthalmic examinations, and a microarray analysis. The GWASs were performed in 22 379 participants in the CommCohort (discovery stage) and 11 104 participants in the BirThree Cohort (replication stage). We evaluated the associations of single nucleotide polymorphisms (SNPs) with AL using a genome-wide significance threshold (5 × 10 Main outcome measures: We identified the association of SNPs with AL and distributions of AL in right and left eyes and individuals of different sexes and ages. Results: In the discovery stage, the mean AL of the right eye (23.99 mm) was significantly greater than that of the left eye (23.95 mm). This difference was reproducible across sexes and ages. The GWASs revealed 703 and 215 AL-associated SNPs with genome-wide significance in the discovery and validation stages, respectively, and many of the SNPs in the discovery stage were replicated in the validation stage. Validated SNPs and their associated loci were meta-analyzed for statistical significance ( Conclusions: Our large-scale GWASs exploiting ToMMo Eye Study data identified 31 loci linked to variations in AL, 7 of which are newly reported in this article. The results revealed genetic heterogeneity and similarity in SNPs related to ethnic variations in AL.
Language	English
Publishing date	2022-01-22
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-9145
ISSN (online)	2666-9145
DOI	10.1016/j.xops.2022.100113
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Article: [Survey of nutrient and food-group intake of cancer outpatients given chemotherapy].

Torii, Takashi / Sakurai, Miyuki / Mikami, Chiaki / Ono, Mika / Hayashi, Yuriko / Katsuya, Masako / Usui, Junichi

Gan to kagaku ryoho. Cancer & chemotherapy

2010 Volume 37, Issue 1, Page(s) 93–98

Abstract: A survey of nutrient and food oral intake was undertaken to clarify problems in nourishment support of chemotherapy outpatients with cancer diseases. The ingestion frequency survey (Food Frequency Questionnaire Based on Food Groups: FFQg) of nutrient and ...

Abstract	A survey of nutrient and food oral intake was undertaken to clarify problems in nourishment support of chemotherapy outpatients with cancer diseases. The ingestion frequency survey (Food Frequency Questionnaire Based on Food Groups: FFQg) of nutrient and food intake was carried out in 54 patients, after chemotherapy at an outpatient clinic in Hyogo Prefectural Nishinomiya Hospital during three weeks from June 25,2007 to July 13,2007. Among them, 50 patients (92.6%) reported a valid response (14 breast, 13 colon, 6 stomach, 9 pancreas, and 8 other cancers). Body mass index (BMI; kg/m2, mean +/-SD) grouped by the type of the cancer was 22.3+/-3.1 in breast, 21.3+/-2.6 in colon, 17.9+/-2.0 stomach, 18.0+/-1.2 in pancreas and 22.6+/-1.8 in other cancers. BMIs in stomach or pancreas cancer patients were significantly low compared to those in patients with breast, colon, or other cancers. Each group's caloric intake per standard weight (kcal: mean+/-SD) was 31.4+/-5.3 in breast, 27.7+/-5.6 in colon, 34.2+/-10.3 in stomach, 29.1+/-5.0 in pancreas, and 26.8+/-6.4 in other cancers. No significant differences were recognized among them. In conclusion, oral intake in chemotherapy outpatients was secured from the result for each type of cancer; however, BMI was low in outpatients with stomach or pancreas cancer in spite of ingestion of food enough to maintain standard weight.
MeSH term(s)	Body Mass Index ; Diet ; Female ; Humans ; Male ; Neoplasms/drug therapy ; Nutrition Assessment ; Outpatients ; Pancreatic Neoplasms/drug therapy ; Stomach Neoplasms/drug therapy ; Surveys and Questionnaires
Language	Japanese
Publishing date	2010-01
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article: Hemagglutination and antigenic comparison of rabbit hemorrhagic disease virus.

Mizoguchi, Toru / Itou, Ken-ichi / Sakurai, Miyuki

The Journal of veterinary medical science

2003 Volume 65, Issue 1, Page(s) 95–97

Abstract: The hemagglutinating activity and serological properties of three strains of rabbit hemorrhagic disease virus, Chinese, Korean and Shizuoka, which was first isolated in Japan, were examined by hemagglutination (HA) and cross hemagglutination inhibition ( ... ...

Abstract	The hemagglutinating activity and serological properties of three strains of rabbit hemorrhagic disease virus, Chinese, Korean and Shizuoka, which was first isolated in Japan, were examined by hemagglutination (HA) and cross hemagglutination inhibition (HI) test with human erythrocytes. Similar results were observed between the Chinese and Korean strains, both of which gave positive HA at 4 degrees C with O, A, B and AB, and at 22 degrees C with B and AB blood groups. In the Shizuoka strain, positive HA was observed at 4 degrees C with O, A, B and AB, at 22 degrees C with A, B And AB, and at 37 degrees C with B blood group. In experimentally infected rabbits, HI antibody in these animals showed a titer of 16,384 or 32,768 at 4 weeks after inoculation. No serological difference was observed in three strains by cross HI test.
MeSH term(s)	Animals ; Antigens, Viral/immunology ; China ; Erythrocytes/virology ; Hemagglutination Inhibition Tests ; Hemagglutination, Viral ; Hemorrhagic Disease Virus, Rabbit/classification ; Hemorrhagic Disease Virus, Rabbit/immunology ; Hemorrhagic Disease Virus, Rabbit/physiology ; Humans ; Japan ; Korea ; Rabbits/virology ; Temperature
Chemical Substances	Antigens, Viral
Language	English
Publishing date	2003-01-31
Publishing country	Japan
Document type	Comparative Study ; Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.65.95
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Article: Pharmacokinetic model analysis of interaction between phenytoin and capecitabine.

Miyazaki, Shohei / Satoh, Hiroki / Ikenishi, Masayuki / Sakurai, Miyuki / Ueda, Mutsuaki / Kawahara, Kaori / Ueda, Rie / Ohtori, Tohru / Matsuyama, Kenji / Miki, Akiko / Hori, Satoko / Fukui, Eiji / Nakatsuka, Eitaro / Sawada, Yasufumi

International journal of clinical pharmacology and therapeutics

2016 Volume 54, Issue 9, Page(s) 657–665

Abstract: Objective: Recent reports have shbown an increase in serum phenytoin levels resulting in phenytoin toxicity after initiation of luoropyrimidine chemotherapy. To prevent phenytoin intoxication, phenytoin dosage must be adjusted. We sought to develop a ... ...

Abstract	Objective: Recent reports have shbown an increase in serum phenytoin levels resulting in phenytoin toxicity after initiation of luoropyrimidine chemotherapy. To prevent phenytoin intoxication, phenytoin dosage must be adjusted. We sought to develop a pharmacokinetic model of the interaction between phenytoin and capecitabine. Methods: We developed the phenytoin-capecitabine interaction model on the assumption that fluorouracil (5-FU) inhibits cytochrome P450 (CYP) 2C9 synthesis in a concentration- dependent manner. The plasma 5-FU concentration after oral administration of capecitabine was estimated using a conventional compartment model. Nonlinear pharmacokinetics of phenytoin was modeled by incorporating the Michaelis-Menten equation to represent the saturation of phenytoin metabolism. The resulting model was fitted to data from our previously-reported cases. Results: The developed phenytoincapecitabine interaction model successfully described the profiles of serum phenytoin concentration in patients who received phenytoin and capecitabine concomitantly. The 50% inhibitory 5-FU concentration for CYP2C9 synthesis and the degradation rate constant of CYP2C9 were estimated to be 0.00310 ng/mL and 0.0768 day-1, respectively. This model and these parameters allow us to predict the appropriate phenytoin dosage schedule when capecitabine is administered concomitantly. Conclusions: This newly-developed model accurately describes changes in phenytoin concentration during concomitant capecitabine chemotherapy, and it may be clinically useful for predicting appropriate phenytoin dosage adjustments for maintaining serum phenytoin levels within the therapeutic range.
MeSH term(s)	Administration, Oral ; Anticonvulsants/administration & dosage ; Anticonvulsants/pharmacokinetics ; Antimetabolites, Antineoplastic/administration & dosage ; Antimetabolites, Antineoplastic/pharmacology ; Capecitabine/administration & dosage ; Capecitabine/pharmacokinetics ; Capecitabine/pharmacology ; Cytochrome P-450 CYP2C9/drug effects ; Cytochrome P-450 CYP2C9/metabolism ; Drug Interactions ; Fluorouracil/pharmacokinetics ; Fluorouracil/pharmacology ; Humans ; Models, Biological ; Nonlinear Dynamics ; Phenytoin/administration & dosage ; Phenytoin/pharmacokinetics
Chemical Substances	Anticonvulsants ; Antimetabolites, Antineoplastic ; Phenytoin (6158TKW0C5) ; Capecitabine (6804DJ8Z9U) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2016-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP202416
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