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  1. Article ; Online: Association between the controlling nutritional status score and outcomes in ischemic stroke patients with active cancer.

    Sakurai, Rei / Gon, Yasufumi / Shimada, Yuki / Okazaki, Shuhei / Todo, Kenichi / Sasaki, Tsutomu / Mochizuki, Hideki

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2024  Volume 120, Page(s) 170–174

    Abstract: Background: The effect of nutritional status on survival in ischemic stroke patients with active cancer remains unclear.: Methods: This study retrospectively evaluated ischemic stroke patients with active cancer admitted to a university hospital in ... ...

    Abstract Background: The effect of nutritional status on survival in ischemic stroke patients with active cancer remains unclear.
    Methods: This study retrospectively evaluated ischemic stroke patients with active cancer admitted to a university hospital in Japan between 2006 and 2016. Patients were followed for 2 years after stroke. The controlling nutritional status (CONUT) score was used to classify undernutrition degree into 4 groups: normal, light, moderate, and severe. Survival rates were compared using the Kaplan-Meier method. Hazard ratio (HR) and 95 % confidence intervals (CIs) for mortality were calculated using Cox regression models.
    Results: A total of 158 patients (31 % women; median age: 71 years) were analyzed. Of these, 47 % had distant metastasis. The median (interquartile range) National Institute of Health Stroke Scale and CONUT scores were 4 (1-10) and 5 (3-7), respectively. Kaplan-Meier curve indicated that patients with poorer nutritional status had worse outcomes (overall log-rank test, p < 0.001). The univariable Cox regression analysis showed that the HR (95 % CI) for the light, moderate, and severe groups were 1.14 (0.45-2.86), 3.01 (1.27-7.12), and 2.94 (1.10-7.84), respectively. This statistical significance did not persist after adjustment for potential confounders (HR [95 % CI] for the light, moderate, and severe groups were 0.95 [0.36-2.49], 1.56 [0.57-4.28], and 1.34 [0.37-4.92], respectively). Past stroke, distant metastasis, and plasma D-dimer levels on admission were independent predictors of prognosis.
    Conclusions: This single-center, retrospective study suggests that nutritional status serves as a prognostic indicator for ischemic stroke patients with active cancer. However, the effect is not statistically independent.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Nutritional Status ; Retrospective Studies ; Ischemic Stroke ; Malnutrition ; Prognosis ; Neoplasms ; Stroke
    Language English
    Publishing date 2024-01-20
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2024.01.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3999: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Ischemic Stroke Due to Heparin-induced Thrombocytopenia during Severe COVID-19 Infection.

    Murakami, Yasutaka / Okazaki, Shuhei / Yamamoto, Makoto / Sakurai, Rei / Jinno, Jyunki / Ozono, Tatsuhiko / Ikenaka, Kensuke / Gon, Yasufumi / Todo, Kenichi / Sasaki, Tsutomu / Hirata, Haruhiko / Uchiyama, Akinori / Mochizuki, Hideki

    Internal medicine (Tokyo, Japan)

    2022  Volume 61, Issue 18, Page(s) 2797–2801

    Abstract: A 53-year-old woman with severe coronavirus disease 2019 (COVID-19) pneumonia was admitted and treated with intravenous unfractionated heparin for thromboprophylaxis under general anesthesia with mechanical ventilation. She developed right hemiparesis ... ...

    Abstract A 53-year-old woman with severe coronavirus disease 2019 (COVID-19) pneumonia was admitted and treated with intravenous unfractionated heparin for thromboprophylaxis under general anesthesia with mechanical ventilation. She developed right hemiparesis after hospitalization due to a large hemorrhagic infarction. Her platelet count decreased from 243,000/μL at administration to 121,000/μL. Anti-platelet factor 4-heparin antibody testing was positive according to a latex immunoturbidimetric assay. She was therefore diagnosed with heparin-induced thrombocytopenia. We immediately stopped the heparin and started argatroban; the platelet count recovered, and thrombosis did not relapse. Physicians should consider heparin-induced thrombocytopenia as a cause of ischemic stroke in patients with COVID-19 infection.
    MeSH term(s) Anticoagulants/adverse effects ; COVID-19/complications ; Female ; Heparin/adverse effects ; Humans ; Ischemic Stroke/etiology ; Middle Aged ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Venous Thromboembolism/drug therapy
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2022-07-05
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.9531-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Pyrazolo pyrimidine-type inhibitors of SRC family tyrosine kinases promote ovarian steroid-induced differentiation of human endometrial stromal cells in vitro.

    Maruyama, Tetsuo / Yamamoto, Yurie / Shimizu, Aki / Masuda, Hirotaka / Sakai, Nozomi / Sakurai, Rei / Asada, Hironori / Yoshimura, Yasunori

    Biology of reproduction

    2004  Volume 70, Issue 1, Page(s) 214–221

    Abstract: Reversible protein tyrosine phosphorylation, coordinately controlled by protein tyrosine kinases and phosphatases, is a critical element in signal transduction pathways regulating a wide variety of biological processes, including cell growth, ... ...

    Abstract Reversible protein tyrosine phosphorylation, coordinately controlled by protein tyrosine kinases and phosphatases, is a critical element in signal transduction pathways regulating a wide variety of biological processes, including cell growth, differentiation, and tumorigenesis. We have previously reported that c-Src belonging to the Src family tyrosine kinase (SFK) becomes dephosphorylated at tyrosine 530 (Y530) and thereby activated during progestin-induced differentiation of human endometrial stromal cells (i.e., decidualization). In this study, to elucidate the role of decidual c-Src activation, we examined whether 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1) and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2), both potent and selective SFK inhibitors, affected the ovarian steroid-induced decidualization in vitro. Unexpectedly, PP1 paradoxically increased the kinase activity of decidual c-Src together with dephosphorylation of Y530 in the presence of ovarian steroids. Concomitantly, PP1 enhanced morphological and functional decidualization, as determined by induction of decidualization markers, such as insulin-like growth factor binding protein-1 and prolactin. PP2 also advanced decidualization along with up-regulation of the active form of c-Src whose Y-530 was dephosphorylated. In contrast to PP1 and PP2, herbimycin A, a tyrosine kinase inhibitor with less specificity for SFKs, showed little enhancing effect on the expression of both IGFBP-1 and active c-Src. These results suggest that SFKs, including c-Src, may play a significant role in stromal cell differentiation, providing a clue for a possible therapeutic strategy to modulate endometrial function by targeting signaling pathway(s) involving SFKs.
    MeSH term(s) Animals ; Benzoquinones ; Biomarkers ; Cell Differentiation ; Decidua/cytology ; Decidua/metabolism ; Endometrium/cytology ; Endometrium/metabolism ; Enzyme Inhibitors/pharmacology ; Estrogens/pharmacology ; Female ; Humans ; Insulin-Like Growth Factor Binding Protein 1/genetics ; Lactams, Macrocyclic ; Mice ; Mitogen-Activated Protein Kinases/metabolism ; NIH 3T3 Cells ; Phosphorylation/drug effects ; Platelet-Derived Growth Factor/pharmacology ; Progesterone/pharmacology ; Prolactin/genetics ; Proto-Oncogene Proteins c-sis ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Quinones/pharmacology ; Rifabutin/analogs & derivatives ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Stromal Cells/cytology ; Stromal Cells/drug effects ; Stromal Cells/metabolism ; src-Family Kinases/antagonists & inhibitors ; src-Family Kinases/metabolism
    Chemical Substances 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine ; AG 1879 ; Benzoquinones ; Biomarkers ; Enzyme Inhibitors ; Estrogens ; Insulin-Like Growth Factor Binding Protein 1 ; Lactams, Macrocyclic ; Platelet-Derived Growth Factor ; Proto-Oncogene Proteins c-sis ; Pyrazoles ; Pyrimidines ; Quinones ; becaplermin (1B56C968OA) ; Rifabutin (1W306TDA6S) ; Progesterone (4G7DS2Q64Y) ; herbimycin (70563-58-5) ; Prolactin (9002-62-4) ; src-Family Kinases (EC 2.7.10.2) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2004-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1095/biolreprod.103.021527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 551: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Involvement of histone acetylation in ovarian steroid-induced decidualization of human endometrial stromal cells.

    Sakai, Nozomi / Maruyama, Tetsuo / Sakurai, Rei / Masuda, Hirotaka / Yamamoto, Yurie / Shimizu, Aki / Kishi, Ikuko / Asada, Hironori / Yamagoe, Satoshi / Yoshimura, Yasunori

    The Journal of biological chemistry

    2003  Volume 278, Issue 19, Page(s) 16675–16682

    Abstract: Histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones, regulating gene transcription. Decidualization is the progestin-induced differentiation of estrogen-primed endometrial stromal cells (ESCs), which ... ...

    Abstract Histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones, regulating gene transcription. Decidualization is the progestin-induced differentiation of estrogen-primed endometrial stromal cells (ESCs), which is crucial for implantation and maintenance of pregnancy. We here show that trichostatin A (TSA), a specific HDAC inhibitor, enhances the up-regulation of decidualization markers such as insulin-like growth factor binding protein-1 (IGFBP-1) and prolactin in a dose-dependent manner that is directed by 17beta-estradiol (E(2)) plus progesterone (P(4)) in cultured ESCs, but not glandular cells, both isolated from human endometrium. Morphological changes resembling decidual transformation were also augmented by co-addition of TSA. Acid urea triton gel analysis and immunoblot using acetylated histone type-specific antibodies demonstrated that treatment with E(2) plus P(4) significantly increased the levels of acetylated H3 and H4 whose increment was augmented by co-treatment with TSA. Chromatin immunoprecipitation assay revealed that treatment with E(2) plus P(4) increased the amount of proximal progesterone-responsive region of IGFBP-1 promoter associated with acetylated H4, which was dramatically enhanced by co-addition of TSA. Taken together, our results suggest that histone acetylation is deeply involved in differentiation of human ESCs and that TSA has a potential as an enhancer of decidualization through promotion of progesterone action.
    MeSH term(s) Acetylation ; Acetyltransferases/antagonists & inhibitors ; Acetyltransferases/metabolism ; Cell Line ; Decidua/cytology ; Decidua/drug effects ; Decidua/physiology ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Estradiol/pharmacology ; Female ; Histone Acetyltransferases ; Histone Deacetylase Inhibitors ; Histone Deacetylases/metabolism ; Histones/metabolism ; Humans ; Hydroxamic Acids/pharmacology ; Insulin-Like Growth Factor Binding Protein 1/metabolism ; Pregnancy ; Progesterone/pharmacology ; Prolactin/metabolism ; Saccharomyces cerevisiae Proteins/antagonists & inhibitors ; Saccharomyces cerevisiae Proteins/metabolism ; Stromal Cells/cytology ; Stromal Cells/physiology ; Up-Regulation/drug effects
    Chemical Substances Enzyme Inhibitors ; Histone Deacetylase Inhibitors ; Histones ; Hydroxamic Acids ; Insulin-Like Growth Factor Binding Protein 1 ; Saccharomyces cerevisiae Proteins ; trichostatin A (3X2S926L3Z) ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E) ; Prolactin (9002-62-4) ; Acetyltransferases (EC 2.3.1.-) ; Histone Acetyltransferases (EC 2.3.1.48) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2003-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M211715200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells.

    Yamamoto, Yurie / Maruyama, Tetsuo / Sakai, Nozomi / Sakurai, Rei / Shimizu, Aki / Hamatani, Toshio / Masuda, Hirotaka / Uchida, Hiroshi / Sabe, Hisataka / Yoshimura, Yasunori

    Molecular human reproduction

    2002  Volume 8, Issue 12, Page(s) 1117–1124

    Abstract: Decidual growth factors and locally produced cytokines are thought to activate specific phosphorylation signalling pathway(s), thereby eliciting a variety of decidual functions. We have previously reported the activation of c-Src tyrosine kinase during ... ...

    Abstract Decidual growth factors and locally produced cytokines are thought to activate specific phosphorylation signalling pathway(s), thereby eliciting a variety of decidual functions. We have previously reported the activation of c-Src tyrosine kinase during ovarian steroid-induced decidualization of cultured human endometrial stromal cells. As chicken c-Src is known to be activated upon dephosphorylation of tyrosine 527 (Y527, corresponding to Y530 in human), we here employed a monoclonal antibody, clone 28, directed against the active form of human c-Src whose Y530 is dephosphorylated, and investigated whether c-Src became dephosphorylated at Y530 and thereby activated during decidualization. We found that the active form of c-Src was up-regulated and demonstrated increased kinase activity during in-vitro decidualization. Immunohistochemistry revealed that decidual cells in early pregnancy decidua were intensely stained with clone 28 when compared with the stromal cells in the non-pregnant endometrium. Moreover, the active form of c-Src translocated from a perinuclear region to the cytoplasm upon decidualization. Thus, the Y530 dephosphorylation, kinase activation, and subcellular translocation of c-Src may be intracellular signalling events associated with decidualization in vivo as well as in vitro.
    MeSH term(s) Cell Differentiation/physiology ; Decidua/cytology ; Decidua/growth & development ; Endometrium/cytology ; Endometrium/growth & development ; Female ; Humans ; Phosphorylation ; Pregnancy ; Protein-Tyrosine Kinases/biosynthesis ; Protein-Tyrosine Kinases/genetics ; Stromal Cells/metabolism ; src-Family Kinases
    Chemical Substances Protein-Tyrosine Kinases (EC 2.7.10.1) ; CSK tyrosine-protein kinase (EC 2.7.10.2) ; src-Family Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2002-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1324348-2
    ISSN 1460-2407 ; 1360-9947
    ISSN (online) 1460-2407
    ISSN 1360-9947
    DOI 10.1093/molehr/8.12.1117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4482: Show issues Location:
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