LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article: Systematic Review on the Correlation Between SARS-CoV-2 Real-Time PCR Cycle Threshold Values and Epidemiological Trends.

    Sala, Ester / Shah, Isheeta S / Manissero, Davide / Juanola-Falgarona, Marti / Quirke, Anne-Marie / Rao, Sonia N

    Infectious diseases and therapy

    2023  Volume 12, Issue 3, Page(s) 749–775

    Abstract: Background: The ability to proactively predict the epidemiological dynamics of infectious diseases such as coronavirus disease 2019 (COVID-19) would facilitate efficient public health responses and may help guide patient management. Viral loads of ... ...

    Abstract Background: The ability to proactively predict the epidemiological dynamics of infectious diseases such as coronavirus disease 2019 (COVID-19) would facilitate efficient public health responses and may help guide patient management. Viral loads of infected people correlate with infectiousness and, therefore, could be used to predict future case rates.
    Aim: In this systematic review, we determine whether there is a correlation between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) real-time reverse-transcription polymerase chain reaction (RT-PCR) cycle threshold (Ct) values (a proxy for viral load) and epidemiological trends in patients diagnosed with COVID-19, and whether Ct values are predictive of future cases.
    Methods: A PubMed search was conducted on August 22 2022, based on a search strategy of studies reporting correlations between SARS-CoV-2 Ct values and epidemiological trends.
    Results: Data from 16 studies were relevant for inclusion. RT-PCR Ct values were measured from national (n = 3), local (n = 7), single-unit (n = 5), or closed single-unit (n = 1) samples. All studies retrospectively examined the correlation between Ct values and epidemiological trends, and seven evaluated their prediction model prospectively. Five studies used the temporal reproduction number (R
    Conclusion: Ct values are negatively correlated with epidemiological trends and may be useful in predicting subsequent peaks in variant waves of COVID-19 and other circulating pathogens.
    Language English
    Publishing date 2023-02-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-023-00772-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: The Power of Wild Plants in Feeding Humanity: A Meta-Analytic Ethnobotanical Approach in the Catalan Linguistic Area

    Gras, Airy / Garnatje, Teresa / Marín, Jon / Parada, Montse / Sala, Ester / Talavera, Marc / Vallès, Joan

    Foods. 2020 Dec. 29, v. 10, no. 1

    2020  

    Abstract: Wild food plants (WFP) have always been present in our kitchen, although they have not always been given the same importance as crops. In the Catalan linguistic area (CLA), covered in this paper, WFP were of great importance as a subsistence food not ... ...

    Abstract Wild food plants (WFP) have always been present in our kitchen, although they have not always been given the same importance as crops. In the Catalan linguistic area (CLA), covered in this paper, WFP were of great importance as a subsistence food not only during the years of the Spanish civil war (1936–1939) and World War II (1939–1945), but also long before these periods and in the years thereafter. The CLA has been well studied at the level of traditional knowledge on plant biodiversity, and much of this information is collected in a database by the EtnoBioFiC research group. The aim of this work is to carry out a meta-analysis of the WFP dataset of the CLA (only regarding edible uses, drinks excluded) and to identify the most quoted plants, and the information associated with them. With data from 1659 informants, we recorded 10,078 use reports of 291 taxa (278 of which at specific or subspecific levels and 13 only determined at generic level) belonging to 67 families. The most reported taxa, also with highest cultural importance indexes, are Thymus vulgaris, Foeniculum vulgare subsp. piperitum, Laurus nobilis, Rubus ulmifolius and Mentha spicata. The ethnobotanicity index for food plants is 6.62% and the informant consensus factor, also for food uses, is a very high 0.97, supporting the robustness of the information. The results provided and discussed in this work concern a significant part of the edible resources in the territory considered, which is, often and mainly, underestimated and underutilised. Its consideration could be an opportunity to promote closer and more sustainable agriculture. From the state-of-the-art of this question, it is possible to propose old, in some cases forgotten foods that could be newly introduced onto the market, first, but not only, at a local level, which could be interesting for new crop development in the frame of a valorisation of territorial identity.
    Keywords Foeniculum vulgare ; Laurus nobilis ; Mentha spicata ; Rubus inermis ; Thymus vulgaris ; area ; beverages ; biodiversity ; crops ; data collection ; databases ; ethnobotany ; food plants ; indigenous knowledge ; information ; markets ; meta-analysis ; paper ; research ; sustainable agriculture ; wild plants
    Language English
    Dates of publication 2020-1229
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10010061
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: The Power of Wild Plants in Feeding Humanity: A Meta-Analytic Ethnobotanical Approach in the Catalan Linguistic Area.

    Gras, Airy / Garnatje, Teresa / Marín, Jon / Parada, Montse / Sala, Ester / Talavera, Marc / Vallès, Joan

    Foods (Basel, Switzerland)

    2020  Volume 10, Issue 1

    Abstract: Wild food plants (WFP) have always been present in our kitchen, although they have not always been given the same importance as crops. In the Catalan linguistic area (CLA), covered in this paper, WFP were of great importance as a subsistence food not ... ...

    Abstract Wild food plants (WFP) have always been present in our kitchen, although they have not always been given the same importance as crops. In the Catalan linguistic area (CLA), covered in this paper, WFP were of great importance as a subsistence food not only during the years of the Spanish civil war (1936-1939) and World War II (1939-1945), but also long before these periods and in the years thereafter. The CLA has been well studied at the level of traditional knowledge on plant biodiversity, and much of this information is collected in a database by the EtnoBioFiC research group. The aim of this work is to carry out a meta-analysis of the WFP dataset of he CLA (only regarding edible uses, drinks excluded) and to identify the most quoted plants, and the information associated with them. With data from 1659 informants, we recorded 10,078 use reports of 291 taxa (278 of which at specific or subspecific levels and 13 only determined at generic level) belonging to 67 families. The most reported taxa, also with highest cultural importance indexes, are
    Language English
    Publishing date 2020-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10010061
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model.

    Sala, Ester / Vived, Celia / Luna, Júlia / Saavedra-Ávila, Noemí Alejandra / Sengupta, Upasana / Castaño, A Raúl / Villar-Pazos, Sabrina / Haba, Laura / Verdaguer, Joan / Ropero, Ana B / Stratmann, Thomas / Pizarro, Javier / Vázquez-Carrera, Manuel / Nadal, Angel / Lahti, Jill M / Mora, Conchi

    Frontiers in immunology

    2021  Volume 12, Page(s) 634797

    Abstract: Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the : Methods: We studied T1D pathogenesis in NOD mice hemideficient for ...

    Abstract Background: Pancreatic islets are exposed to strong pro-apoptotic stimuli: inflammation and hyperglycemia, during the progression of the autoimmune diabetes (T1D). We found that the
    Methods: We studied T1D pathogenesis in NOD mice hemideficient for CDK11 (N-HTZ), and, in N-HTZ deficient for Cyclin D3 (K11HTZ-D3KO), in comparison to their respective controls (N-WT and K11WT-D3KO). Moreover, we exposed pancreatic islets to either pro-inflammatory cytokines in the presence of increasing glucose concentrations, or Thapsigargin, an Endoplasmic Reticulum (ER)-stress inducing agent, and assessed apoptotic events. The expression of key ER-stress markers (
    Results: N-HTZ mice were significantly protected against T1D, and NS-HTZ pancreatic islets exhibited an impaired sensitivity to cytokine-induced apoptosis, regardless of glucose concentration. However, thapsigargin-induced apoptosis was not altered. Furthermore, CDK11 hemideficiency did not attenuate the exacerbation of T1D caused by Cyclin D3 deficiency.
    Conclusions: This study is the first to report that CDK11 is repressed in T1D as a protection mechanism against inflammation-induced apoptosis and suggests that CDK11 lies upstream Cyclin D3 signaling. We unveil the CDK11/Cyclin D3 tandem as a new potential intervention target in T1D.
    MeSH term(s) Activating Transcription Factor 4/metabolism ; Animals ; Apoptosis/drug effects ; Autoimmunity/drug effects ; Blood Glucose/metabolism ; Cyclin D3/genetics ; Cyclin D3/metabolism ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Cytokines/pharmacology ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/enzymology ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/pathology ; Disease Models, Animal ; Endoplasmic Reticulum Chaperone BiP ; Endoplasmic Reticulum Stress/drug effects ; Heat-Shock Proteins/metabolism ; Inflammation/blood ; Inflammation/enzymology ; Inflammation/genetics ; Inflammation/pathology ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/enzymology ; Insulin-Secreting Cells/pathology ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/physiology ; Thapsigargin/pharmacology ; Tissue Culture Techniques ; Transcription Factor CHOP/metabolism ; Mice
    Chemical Substances Atf4 protein, mouse ; Blood Glucose ; Ccnd3 protein, mouse ; Cyclin D3 ; Cytokines ; Ddit3 protein, mouse ; Endoplasmic Reticulum Chaperone BiP ; Heat-Shock Proteins ; Activating Transcription Factor 4 (145891-90-3) ; Transcription Factor CHOP (147336-12-7) ; Thapsigargin (67526-95-8) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Cdk11b protein, mouse (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22)
    Language English
    Publishing date 2021-02-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.634797
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Cyclin D3 promotes pancreatic β-cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes.

    Saavedra-Ávila, Noemí Alejandra / Sengupta, Upasana / Sánchez, Begoña / Sala, Ester / Haba, Laura / Stratmann, Thomas / Verdaguer, Joan / Mauricio, Dídac / Mezquita, Belén / Ropero, Ana Belén / Nadal, Ángel / Mora, Conchi

    Proceedings of the National Academy of Sciences of the United States of America

    2014  Volume 111, Issue 33, Page(s) E3405–14

    Abstract: Type 1 diabetes is an autoimmune condition caused by the lymphocyte-mediated destruction of the insulin-producing β cells in pancreatic islets. We aimed to identify final molecular entities targeted by the autoimmune assault on pancreatic β cells that ... ...

    Abstract Type 1 diabetes is an autoimmune condition caused by the lymphocyte-mediated destruction of the insulin-producing β cells in pancreatic islets. We aimed to identify final molecular entities targeted by the autoimmune assault on pancreatic β cells that are causally related to β cell viability. Here, we show that cyclin D3 is targeted by the autoimmune attack on pancreatic β cells in vivo. Cyclin D3 is down-regulated in a dose-dependent manner in β cells by leukocyte infiltration into the islets of the nonobese diabetic (NOD) type 1 diabetes-prone mouse model. Furthermore, we established a direct in vivo causal link between cyclin D3 expression levels and β-cell fitness and viability in the NOD mice. We found that changes in cyclin D3 expression levels in vivo altered the β-cell apoptosis rates, β-cell area homeostasis, and β-cell sensitivity to glucose without affecting β-cell proliferation in the NOD mice. Cyclin D3-deficient NOD mice exhibited exacerbated diabetes and impaired glucose responsiveness; conversely, transgenic NOD mice overexpressing cyclin D3 in β cells exhibited mild diabetes and improved glucose responsiveness. Overexpression of cyclin D3 in β cells of cyclin D3-deficient mice rescued them from the exacerbated diabetes observed in transgene-negative littermates. Moreover, cyclin D3 overexpression protected the NOD-derived insulinoma NIT-1 cell line from cytokine-induced apoptosis. Here, for the first time to our knowledge, cyclin D3 is identified as a key molecule targeted by autoimmunity that plays a nonredundant, protective, and cell cycle-independent role in β cells against inflammation-induced apoptosis and confers metabolic fitness to these cells.
    MeSH term(s) Animals ; Apoptosis ; Cell Cycle ; Cyclin D3/physiology ; Cytokines/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/pathology ; Islets of Langerhans/pathology ; Mice ; Mice, Inbred NOD
    Chemical Substances Cyclin D3 ; Cytokines
    Language English
    Publishing date 2014-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1323236111
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Análisis de conglomerados de cancer. El caso del barrio de Campdorà, Girona.

    Lertxundi-Manterola, Aitana / Saez, Marc / Marcos-Gragera, Rafael / Izquierdo, Angel / Pibernat, Nuri / Sala, Ester / Camps, Neus

    Revista espanola de salud publica

    2006  Volume 79, Issue 4, Page(s) 443–452

    Abstract: A conglomerate of cases may be defined as the onset of a number of cases of a disease larger than would be expected for a certain population group, geographical area or a certain timeframe. In the case of cancer, the study of conglomerates entails a ... ...

    Title translation Cancer cluster analysis. The case of the Campdorà District in Girona, Spain.
    Abstract A conglomerate of cases may be defined as the onset of a number of cases of a disease larger than would be expected for a certain population group, geographical area or a certain timeframe. In the case of cancer, the study of conglomerates entails a number of specific characteristics as compared to other groups of diseases. This work is aimed at proposing a protocol affording the possibility of conducting the study of cancer conglomerates in time and/or space. This article is illustrated with a practical application in the case of the Campdorà District in Girona. Following a proposed protocol for the study of conglomerates, a description is provided of several statistical tools making it possible to draw a comparison among the existence of time-related groupings, as well as the related risk. During the period studied (1994-2002), no excessive statistically significant number of cancer cases seemed to have occurred in the Campdorà District in Girona.
    MeSH term(s) Cluster Analysis ; Humans ; Neoplasms/epidemiology ; Spain
    Language Spanish
    Publishing date 2006-02-02
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 1288657-9
    ISSN 2173-9110 ; 1135-5727 ; 0034-8899
    ISSN (online) 2173-9110
    ISSN 1135-5727 ; 0034-8899
    DOI 10.1590/s1135-57272005000400002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top