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  1. Article ; Online: Effect of transversus abdominis plane block with or without buprenorphine after inguinal hernia surgery on postoperative pain.

    Elshalakany, Nirvana Ahmed / Salah, Asmaa Mohamed

    Anaesthesiology intensive therapy

    2023  Volume 55, Issue 4, Page(s) 277–284

    Abstract: Introduction: Transversus abdominis plane (TAP) has been mentioned as having bene-ficial effects on chronic pain after hernioplasty. This study assessed the effects of TAP block on acute and persistent postoperative pain after inguinal hernia surgery, ... ...

    Abstract Introduction: Transversus abdominis plane (TAP) has been mentioned as having bene-ficial effects on chronic pain after hernioplasty. This study assessed the effects of TAP block on acute and persistent postoperative pain after inguinal hernia surgery, with or without buprenorphine.
    Material and methods: 64 patients were allocated to group R ( n = 32) and received 20 mL of 0.25% ropivacaine for TAP block; group RB ( n = 32) received 20 mL of 0.25% ropivacaine containing 300 µg of buprenorphine for TAP block. The primary outcome was the analgesic and antihyperalgesic effect of buprenorphine. The duration of analgesia, analgesic consumption, postoperative pain scores at rest and sitting up to 48 hours, and the effect on wound hyperalgesia were evaluated. Secondary outcomes included the incidence of side effects and complications.
    Results: The median (IQR) duration of analgesia in group R was 386.5 (37.25) minutes vs. 868 (41.3) minutes in the RB group. Median pain scores on sitting were found to be significantly better in group RB than in group R at 6, 12, and 24 hours ( P < 0.001). The wound hyperalgesia index showed a significant difference between groups ( P < 0.001). The incidence of persistent postoperative pain was 6.25% in the R group, as compared to 0% in the RB group. Otherwise, the patients did not have any further complications associated with the block.
    Conclusions: The results demonstrated that TAP block with buprenorphine reduced acute postoperative pain severity, but we did not find a difference between groups in persistent pain.
    MeSH term(s) Humans ; Ropivacaine/pharmacology ; Buprenorphine/therapeutic use ; Buprenorphine/pharmacology ; Hernia, Inguinal/surgery ; Hernia, Inguinal/complications ; Hernia, Inguinal/drug therapy ; Hyperalgesia/complications ; Hyperalgesia/drug therapy ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Abdominal Muscles ; Analgesics/therapeutic use ; Analgesics, Opioid/therapeutic use
    Chemical Substances Ropivacaine (7IO5LYA57N) ; Buprenorphine (40D3SCR4GZ) ; Analgesics ; Analgesics, Opioid
    Language English
    Publishing date 2023-12-12
    Publishing country Poland
    Document type Journal Article
    ISSN 1731-2531
    ISSN (online) 1731-2531
    DOI 10.5114/ait.2023.132837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The impact of clinical pharmacists' medication reconciliation upon patients' admission to reduce medication discrepancies in the emergency department: a prospective quasi-interventional study.

    Shaker, Heba Othman / Sabry, Ahmed Abdel Fattah / Salah, Asmaa / Ragab, Gilan Mohamed / Sedik, Nahla Ahmed / Ali, Zahraa / Magdy, Doha / Alkafafy, Asmaa Mohamed

    International journal of emergency medicine

    2023  Volume 16, Issue 1, Page(s) 89

    Abstract: Background: The role of the clinical pharmacist in medication reconciliation is well established. Upon patients' admission, the reconciliation service mainly focuses on achieving an accurate and full drug history. This will achieve the best treatment ... ...

    Abstract Background: The role of the clinical pharmacist in medication reconciliation is well established. Upon patients' admission, the reconciliation service mainly focuses on achieving an accurate and full drug history. This will achieve the best treatment plan and reduce medication discrepancies. Upon the recent implementation of clinical pharmacy services in the emergency department at Alexandria Main University Hospital, medication reconciliation was one of the most important duties that needed to be focused on. We hypothesized that clinical pharmacists are able to achieve patients' drug history lists with higher accuracy than emergency physicians.
    Results: A total number of 161 patients were included. Age was 58.59 ± (13.78) years, number of comorbidities was 2.39 ± (1.22) and number of home medications was 4.51 ± (2.72). Clinical pharmacists' fulfillment of patients' drug history was significantly more accurate than the emergency physicians (75.16% and 50.3% of the total number of revised patients' profiles respectively). The clinical pharmacists could put a written copy of the accurate patients' drug history list in only 50.93% of the revised patients' profiles. Five hundred eighty-five medication discrepancies were detected which represent an average of 3.63 discrepancies/medication sheet. Medications at Transitions and Clinical Handoffs (MATCH) Toolkit for medication reconciliation and the National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) index were used to categorize discrepancies. Categories A, B, and C represented (66.5%), while categories D, E, and F represented (33.5%) of the total discrepancies. There was a significant direct relationship between the total number of discrepancies and both the number of comorbidities and the number of drugs administered before hospital admission.
    Conclusion: The clinical pharmacists are the main members of the emergency health care team. One of their fundamental services is medication reconciliation. The establishment of a complete drug history list and physicians' discussion about the current treatment plan can obviously detect and reduce medication errors.
    Trial registration: NCT04395443. Registered 16 May 2020.
    Language English
    Publishing date 2023-12-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411462-5
    ISSN 1865-1380 ; 1865-1372
    ISSN (online) 1865-1380
    ISSN 1865-1372
    DOI 10.1186/s12245-023-00568-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cellulose-based CoFe LDH composite as a nano-adsorbent for sulfamethoxazole and cefixime residues: Evaluation of performance, green metrics and cytotoxicity.

    Kotp, Amna A / Allam, Ahmed A / Salah, Asmaa M / Kamal, W / Essam, Doaa / Mahgoub, Samar M / Mohamed, Mahmoud A / Eldin, Zienab E / Alfassam, Haifa E / Rudayni, Hassan A / Alawam, Abdullah S / Nasr, Fahd A / Mahmoud, Rehab

    Journal of contaminant hydrology

    2024  Volume 264, Page(s) 104364

    Abstract: The increase in antibiotic residues poses a serious threat to ecological and aquatic environments, necessitating the development of cost-effective, convenient, and recyclable adsorbents. In our study, we used cellulose-based layered double hydroxide (LDH) ...

    Abstract The increase in antibiotic residues poses a serious threat to ecological and aquatic environments, necessitating the development of cost-effective, convenient, and recyclable adsorbents. In our study, we used cellulose-based layered double hydroxide (LDH) as an efficient adsorbent and nanocarrier for both sulfamethoxazole (SMX) and cefixime (CFX) residues due to their biodegradability and biocompatibility. Chemical processes are measured according to green chemistry metrics to identify which features adhere to the principles. A GREEnness Assessment (ESA), Analytical GREEnness Preparation (AGREEprep), and Analytical Eco-Scale Assessments (ESA) were used to assess the suitability of the proposed analytical method. We extensively analyzed the synthesized CoFe LDH/cellulose before and after the adsorption processes using XRD, FTIR, and SEM. We investigated the factors affecting the adsorption process, such as pH, adsorbent dose, concentrations of SMX and CFX and time. We studied six nonlinear adsorption isotherm models at pH 5 using CoFe LDH, which showed maximum adsorption capacities (qmax) of 272.13 mg/g for SMX and 208.00 mg/g for CFX. Kinetic studies were also conducted. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was performed on Vero cells in direct contact with LDH nanocomposites to evaluate the cytotoxicity and side effects of cellulose-based CoFe LDH. The cellulose-based CoFe LDH nanocomposite demonstrated excellent cytocompatibility and less cytotoxic effects on the tested cell line. These results validate the potential use of these unique LDH-based cellulose cytocompatible biomaterials for water treatment applications. The cost of the prepared adsorbents was investigated.
    Language English
    Publishing date 2024-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1494766-3
    ISSN 1873-6009 ; 0169-7722
    ISSN (online) 1873-6009
    ISSN 0169-7722
    DOI 10.1016/j.jconhyd.2024.104364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Senior interventional cardiologists are exposed to higher effective doses than other staff members.

    Ghany, H A Abdel / Diab, H M / Salah, Asmaa / Taha, Ahmed A

    Radiation and environmental biophysics

    2020  Volume 59, Issue 4, Page(s) 743–748

    Abstract: Those working in interventional cardiology are exposed to varying radiation doses during diagnostic and interventional procedures. The work presented in this paper aimed to monitor the effective doses received by different categories of medical staff ... ...

    Abstract Those working in interventional cardiology are exposed to varying radiation doses during diagnostic and interventional procedures. The work presented in this paper aimed to monitor the effective doses received by different categories of medical staff members practicing interventional cardiology procedures including senior cardiologists, junior cardiologists, anesthetists and nurses. Thermo-luminescence dosimeter (TLD) badges that consisted of lithium fluoride doped with magnesium and titanium were used to quantify radiation doses. Measurements were performed with the dosimeters mounted under and above leaded aprons worn by medical staff. The results revealed that the effective doses to senior cardiologists were the highest compared to those to other participating staff members, due to their position close to the X-ray tube. The average daily effective doses for senior cardiologists, junior cardiologists, anesthetists and nurses were higher for dosimeters located above the aprons than those for dosimeters located under the aprons. Above the apron, the average effective doses accumulated during the study period were 0.44 ± 0.06, 0.34 ± 0.05, 0.29 ± 0.03 and 0.29 ± 0.04 mSv, respectively; whereas, under the apron, they were 0.20 ± 0.02, 0.18 ± 0.02, 0.17 ± 0.02 and 0.18 ± 0.02, respectively. Also, the fluoroscopy time was correlated with the dose acquired, especially for senior cardiologists. It is concluded that doses to senior cardiologists are quite high, and that many variables can affect staff exposure such as distance, direction, procedure and skills.
    MeSH term(s) Anesthesiologists ; Cardiologists ; Fluoroscopy ; Hospitals, University ; Humans ; Nurses ; Occupational Exposure/analysis ; Professional Role ; Radiation Dosage ; Thermoluminescent Dosimetry ; X-Rays
    Language English
    Publishing date 2020-07-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124987-3
    ISSN 1432-2099 ; 0301-634X
    ISSN (online) 1432-2099
    ISSN 0301-634X
    DOI 10.1007/s00411-020-00862-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Safe, Efficient and Environmentally Friendly Fungicide Against Aflatoxin-producing Fungi in Nourishment Cereal (P04-133-19)

    Awney, Hala / Amin, Ghada / El-Naggar, El-Moatazbellah / Salah, Asmaa

    Current developments in nutrition. 2019 June 13, v. 3, no. Supplement_1

    2019  

    Abstract: Aflatoxins are highly toxic, carcinogenic, mutagenic and teratogenic metabolites produced by some Aspergillus species that contaminate a wide range of nourishment cereal and pose serious health problems for human and livestock with nanograms limits of ... ...

    Abstract Aflatoxins are highly toxic, carcinogenic, mutagenic and teratogenic metabolites produced by some Aspergillus species that contaminate a wide range of nourishment cereal and pose serious health problems for human and livestock with nanograms limits of acceptability in foods. This study aimed to extract, identify and assess essential oils extracted from ginger rhizomes (Zingiber officinale Rose) (EOG) and flower head of Chamomile (Chamomilla recutita L.) (EOC) against aflatoxin producing fungi. Toxicity evaluation was conducted to ensure their safety. Essential oils were extracted by hydrodistillation using Clevenger apparatus and identified by Gas Chromatography-Mass Spectrometry (GCMS). The fungicidal effect was assessed against penicillium chrysogenum, Aspergillus niger and Aspergillus flavus isolated from bean, corn and rice using agar disc diffusion method to determine maximum inhibition zone (MIZ) and minimum inhibitory concentration (MIC) for each extract. Toxicity evaluation was conducted on two groups of 10 male rats treated with EOG or EOC at a dose of 0.1 g/kg (1/50 LD) for 28 consecutive days against control group. Serum biochemical analysis, hematological parameters and liver histological investigations were considered. The phytochemical analysis identified 20 compounds in EOG and 26 compounds in EOC. The most common compounds were monoterpenes and sesquiterpenes in EOG and EOC respectively. The highest MIZ showed by EOC (5.15 ± 0.07 cm) and EOG (4.15 ± 0.07 cm) against P. chrysogenum. The MIC showed that EOG has greater inhibitory effect against P. chrysogenum (2.5 μg/ml) whereas EOC exhibit strong inhibitory effect against all tested fungi with lower MIC values ranged from 1.25 to 2.5 μg/ml. Serum biochemical analysis and hematological parameters indicated minor changes in EOC and EOC group while liver histological features showed marked improvement in hepatic tissues of EOC and EOG groups compared with control. Promising fungicidal effects of both EOC and EOG against aflatoxin producing fungi have been demonstrated, however further evaluation is needed concerning its safety. College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia.
    Keywords aflatoxins ; agar ; antifungal properties ; Aspergillus flavus ; Aspergillus niger ; beans ; blood serum ; carcinogenicity ; chamomile ; corn ; essential oils ; flowers ; foods ; fungi ; fungicides ; gas chromatography-mass spectrometry ; ginger ; hematologic tests ; histology ; hydrodistillation ; liver ; livestock ; males ; Matricaria chamomilla ; metabolites ; minimum inhibitory concentration ; monoterpenoids ; mutagens ; Penicillium chrysogenum ; rats ; rhizomes ; rice ; sesquiterpenoids ; teratogenicity ; tissues ; Zingiber officinale
    Language English
    Dates of publication 2019-0613
    Publishing place Oxford University Press
    Document type Article
    ISSN 2475-2991
    DOI 10.1093/cdn/nzz051.P04-133-19
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Ewing sarcoma outcomes in a country with limited resources: Egypt as an example.

    Morsy, Ahmed Mohammed / Abdel-Hadi, Salah / Rezk, Khalid Mohammed / Amira, Gamal / Ahmed, Badawy Mohammed / Hussien, Marwa Tammam / Ameen, Mahmoud Gamal / Kamel, Hosam Eldein Mostafa / Fouad, Doaa Mohamed / Attia, Alia Mohamed / Salah, Asmaa / Abd Elbadee, Osama Mostafa / Yousseif, Ayatallah Ali / Abdelgawad, Marwa Ismail / Fathy, Asmaa Hussein / Elwany, Yasmine Nagy / Ramadan, Islam Karam-Allah / Mosallam, Khaled Hassan / Abd Elwahab, Ahmed Ibrahim /
    Mahmoud, Khaled Hashim / Amine, Maged Abdel Fattah / Abd Elzaher, Ahmed Refaat / Eltyb, Hanan Ahmed / Hefni, Ahmed Mubarak

    American journal of cancer research

    2021  Volume 11, Issue 6, Page(s) 3212–3226

    Abstract: As the scarcity of published research that comprehensively and meticulously analyzed the patient, disease, and treatment factors of prognostic significance in Ewing sarcoma (EWS) in Egypt; This study aimed at assessing survival outcomes of EWS in Upper ... ...

    Abstract As the scarcity of published research that comprehensively and meticulously analyzed the patient, disease, and treatment factors of prognostic significance in Ewing sarcoma (EWS) in Egypt; This study aimed at assessing survival outcomes of EWS in Upper Egypt, delineating factors of prognostic significance in comparison to other leading oncology centers in Egypt and internationally. By retrospectively reviewing medical records of 85 patients with a verified diagnosis of EWS in the period from 2001 to 2015 at Pediatric and Medical Oncology Departments at South Egypt Cancer Institute; We gathered data relevant to the patient, disease, and treatment variables of the study. Survival was estimated using the Kaplan Meier method and differences between various groups were determined by log rank test. Univariable and multivariable analyses were performed using Cox regression. With a median follow-up period of 62.7 months (95% CI 52.2-73.2, SE=5.4) for the study patients, the estimates of event-free survival (EFS) and overall survival (OS) at 3 and 5 years were 42.1% and 50.6%, and 40.8% and 48.5%, respectively. Metastatic disease at initial presentation (HR=8.91, 95% CI, 4.00-19.9; P<0.0001) stood as the most powerful predictor of OS in the multivariable analysis, followed by surgery used as a local modality (HR=0.16, 95% CI, 0.06-0.44; P=0.0004). Response to neoadjuvant chemotherapy (HR=2.61, 95% CI, 1.11-6.13; P=0.028), primary tumor size (HR=2.49, 95% CI, 1.03-6.03; P=0.044) were also shown to be significantly associated with OS. Radiotherapy as a local modality, whose effect, apparently shown to increase the hazard of events occurrence in the univariable analysis, an effect that was reversed to reveal EFS advantage (HR=0.41, 95% CI, 0.18-0.95; P=0.036) after control of other variables. With 5-year OS of 48.5%, our survival results were comparable to those previously published from Egypt; however, differences still exist between centers due to varied representative study samples. However, outcomes in Egypt in general are still inferior to internationally published studies.
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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