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  1. Article ; Online: Docosahexaenoic Acid Plus Piracetam Versus Piracetam Alone for Treatment of Breath-Holding Spells in Children: A Randomized Clinical Trial.

    Salamah, Abeer / Darwish, Amira Hamed

    Pediatric neurology

    2023  Volume 148, Page(s) 32–36

    Abstract: Background: Piracetam is the most widely used drug in breath-holding spells (BHS); however, its efficacy might not be satisfying to parents. This study aimed to compare the efficacy of docosahexaenoic acid (DHA) plus piracetam with piracetam alone in ... ...

    Abstract Background: Piracetam is the most widely used drug in breath-holding spells (BHS); however, its efficacy might not be satisfying to parents. This study aimed to compare the efficacy of docosahexaenoic acid (DHA) plus piracetam with piracetam alone in reducing the frequency and severity of BHS in infants and preschool children.
    Methods: This randomized clinical trial included two groups diagnosed with BHS. Group I included 50 patients who received DHA plus piracetam. Group II (control group) included 50 children who were managed with piracetam plus a placebo. Children were re-evaluated at one, three, and six months after treatment. Occurrences of BHS and drug side effects were recorded. The primary outcome was to evaluate the effect of the combined treatment of piracetam and DHA on the frequency and severity of spells.
    Results: BHS were reported in only 16% of children six months after treatment with piracetam and DHA compared with 50% of those treated with piracetam only (P value = 0.001).
    Conclusion: DHA plus piracetam is more effective than piracetam alone in decreasing the frequency and severity of BHS in children.
    MeSH term(s) Infant ; Child, Preschool ; Humans ; Piracetam/pharmacology ; Piracetam/therapeutic use ; Docosahexaenoic Acids/pharmacology ; Breath Holding ; Seizures/drug therapy ; Combined Modality Therapy
    Chemical Substances Piracetam (ZH516LNZ10) ; Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2023.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2260: Show issues Location:
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  2. Article ; Online: Bumetanide, a Diuretic That Can Help Children with Autism Spectrum Disorder.

    Shaker, Esraa / El Agami, Osama / Salamah, Abeer

    CNS & neurological disorders drug targets

    2023  Volume 23, Issue 4, Page(s) 536–542

    Abstract: Background: Autism Spectrum Disorder (ASD) is a common child neurodevelopmental disorder, whose pathogenesis is not completely understood. Until now, there is no proven treatment for the core symptoms of ASD. However, some evidence indicates a crucial ... ...

    Abstract Background: Autism Spectrum Disorder (ASD) is a common child neurodevelopmental disorder, whose pathogenesis is not completely understood. Until now, there is no proven treatment for the core symptoms of ASD. However, some evidence indicates a crucial link between this disorder and GABAergic signals which are altered in ASD. Bumetanide is a diuretic that reduces chloride, shifts gamma-amino-butyric acid (GABA) from excitation to inhibition, and may play a significant role in the treatment of ASD.
    Objective: The objective of this study is to assess the safety and efficacy of bumetanide as a treatment for ASD.
    Methods: Eighty children, aged 3-12 years, with ASD diagnosed by Childhood Autism Rating Scale (CARS), ⩾ 30 were included in this double-blind, randomized, and controlled study. Group 1 received Bumetanide, Group 2 received a placebo for 6 months. Follow-up by CARS rating scale was performed before and after 1, 3, and 6 months of treatment.
    Results: The use of bumetanide in group 1 improved the core symptoms of ASD in a shorter time with minimal and tolerable adverse effects. There was a statistically significant decrease in CARS and most of its fifteen items in group 1
    Conclusion: Bumetanide has an important role in the treatment of core symptoms of ASD.
    MeSH term(s) Child ; Humans ; Bumetanide/therapeutic use ; Diuretics/therapeutic use ; Autism Spectrum Disorder/drug therapy ; Autistic Disorder ; Double-Blind Method
    Chemical Substances Bumetanide (0Y2S3XUQ5H) ; Diuretics
    Language English
    Publishing date 2023-04-03
    Publishing country United Arab Emirates
    Document type Randomized Controlled Trial ; Clinical Trial
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/1871527322666230404114911
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    Zs.A 5892: Show issues Location:
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  3. Article ; Online: Citicoline in hypoxic ischemic encephalopathy in neonates: a randomized controlled trial.

    Salamah, Abeer / El Amrousy, Doaa / Elsheikh, Mai / Mehrez, Mostafa

    Italian journal of pediatrics

    2023  Volume 49, Issue 1, Page(s) 55

    Abstract: Background: Hypoxic-ischemic encephalopathy (HIE) is one of the major complications that can lead to death or disability in neonates. We assessed the effect of citicoline as a neuroprotector in neonates with moderate and severe HIE.: Methods: This ... ...

    Abstract Background: Hypoxic-ischemic encephalopathy (HIE) is one of the major complications that can lead to death or disability in neonates. We assessed the effect of citicoline as a neuroprotector in neonates with moderate and severe HIE.
    Methods: This clinical trial was carried on 80 neonates with moderate to severe HIE who were not candidates for therapeutic cooling. They were subdivided randomly into two groups; citicoline treatment group which included 40 neonates who received citicoline 10 mg / kg /12 h IV for 4 weeks plus other supportive measures and the control group which included 40 neonates who were managed with placebo and the same supportive measures. All patients were evaluated for duration of mechanical ventilation (MV), need for inotropes, seizures (type, frequency, and duration), and duration of NICU. Cranial ultrasounds and brain magnetic resonance image (MRI) were performed for all included neonates after 4 weeks of treatment. Follow- ups of all neonates for the neurodevelopmental outcomes were done at 3, 6, 9, and 12 months.
    Results: There was a significant reduction in the number of neonates having seizures after discharge in the citicoline-treated group (2 neonates) compared to the control group (11 neonates). Cranial ultrasound and MRI findings at 4 weeks were significantly better in the treatment group compared to the control group. Moreover, neurodevelopmental outcome showed significant improvement at 9 and 12 months in the citicoline treated neonates compared to the control group. There was statistically significant reduction in the duration of seizures, NICU stay, inotrope use, and MV in the treatment group compared to the control group. Citicoline was well tolerated with no remarkable side effects.
    Conclusion: Citicoline could be a promising neuroprotector drug in neonates with HIE.
    Trial registration: The study was registered at ClinicalTrials.gov (NCT03949049). Registered at 14 May 2019, https://clinicaltrials.gov/ct2/show/NCT03949049.
    MeSH term(s) Infant, Newborn ; Humans ; Hypoxia-Ischemia, Brain/complications ; Cytidine Diphosphate Choline/therapeutic use ; Brain/pathology ; Seizures/therapy ; Hypothermia, Induced ; Magnetic Resonance Imaging
    Chemical Substances Cytidine Diphosphate Choline (536BQ2JVC7)
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-023-01452-5
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    Zs.A 1961: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Coenzyme Q10 in the Treatment of Attention Deficit Hyperactivity Disorder in Children: A Randomized Controlled Trial.

    Gamal, Fatma / El Agami, Osama / Salamah, Abeer

    CNS & neurological disorders drug targets

    2022  Volume 21, Issue 8, Page(s) 717–723

    Abstract: Background: Attention Deficit Hyperactivity Disorder is a common child neurobehavioral disorder whose pathogenesis is not completely understood. However, some evidence indicates a crucial link between this disorder and the degree of oxidative stress. ... ...

    Abstract Background: Attention Deficit Hyperactivity Disorder is a common child neurobehavioral disorder whose pathogenesis is not completely understood. However, some evidence indicates a crucial link between this disorder and the degree of oxidative stress. Coenzyme Q10 (ubiquinol) is an antioxidant that may play a significant role in the treatment of Attention Deficit Hyperactivity Disorder.
    Objective: To assess the safety and efficacy of coenzyme Q10 as an add-on drug treatment for attention deficit hyperactivity disorder.
    Methods: Sixty children, aged 6-16 years, with attention deficit hyperactivity disorder, non-responders to atomoxetine treatment for 6 months, were included in this double-blind, randomized, and controlled study. Group 1 received atomoxetine plus coenzyme Q10, and group 2 received atomoxetine plus placebo for 6 months. Follow-up by CONNERS parent rating scale questionnaire (CPRS-48) was performed before and after 1, 3, and 6 months of treatment, and any drug-related side effects were reported.
    Results: The addition of coenzyme Q10 to atomoxetine in group 1 improved symptoms in a shorter time with minimal adverse effects. Group 1 showed improvement of about 33.87% in CPRS-48 total score versus 18.24% in group 2. There was a statistically significant decrease in CPRS-48 total score and its three subscales (learning problems, impulsive hyperactive subscale, and 10-items hyperactivity index) in group 1 versus group 2 after six months of treatment (p-value <0.001).
    Conclusion: Coenzyme Q10 has an important role as an add-on drug treatment for attention deficit hyperactivity disorder by improving symptoms, particularly hyperactivity, and in minimizing atomoxetine adverse effects.
    MeSH term(s) Atomoxetine Hydrochloride/therapeutic use ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Child ; Double-Blind Method ; Humans ; Propylamines/adverse effects ; Propylamines/therapeutic use ; Treatment Outcome ; Ubiquinone/analogs & derivatives
    Chemical Substances Propylamines ; Ubiquinone (1339-63-5) ; Atomoxetine Hydrochloride (57WVB6I2W0) ; coenzyme Q10 (EJ27X76M46)
    Language English
    Publishing date 2022-05-18
    Publishing country United Arab Emirates
    Document type Clinical Trial ; Randomized Controlled Trial
    ZDB-ID 2228394-8
    ISSN 1996-3181 ; 1871-5273
    ISSN (online) 1996-3181
    ISSN 1871-5273
    DOI 10.2174/1871527320666211124093345
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    Zs.A 5892: Show issues Location:
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  5. Article: Physical Activity Limitations In Children With Severe Haemophilia A. Does Emicizumab Make A Difference?

    Hassan, Ahmed Sobhi / Sherief, Laila Metwally / Hamdy, Mona / Salamah, Abeer / El-Agamy, Osama A

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73Suppl 4, Issue 4, Page(s) S31–S33

    Abstract: Objectives: To assess the effect of emicizumab on physical activity in children with severe haemophilia A.: Methods: The prospective cohortstudy was conducted from October 2021 to April 2022 at the Paediatric Department of Kafrelsheikh University ... ...

    Abstract Objectives: To assess the effect of emicizumab on physical activity in children with severe haemophilia A.
    Methods: The prospective cohortstudy was conducted from October 2021 to April 2022 at the Paediatric Department of Kafrelsheikh University Hospital, Egypt, in collaboration with the Haematology out-patient clinic of the Paediatric Department, Zagazig University, Egypt, and the Paediatric Department of Cairo University Hospital, Egypt, and comprised children aged 4-18 years with severe haemophilia A who received emicizumab prophylaxis. Paediatric Haemophilia Activities List was used to assess physical activity at baseline and aftersix months of regular emicizumab prophylaxis. Data was analysed using SPSS 26.
    Results: There were 29 children, all (100%) boys, with mean age 8.7±3.51 years(range 4-15 years. Of them, 17(58.62%) patients were negative for inhibitors. Median Paediatric Haemophilia Activities Listsum score was 59.54 (interquartile range: 50.15-62.05) at baseline which moved up to 84 (interquartile range: 79.05-86.35) post-intervention (p<0.001).
    Conclusions: Emicizumab prophylaxis improved the level of physical activity in children with severe haemophilia A.
    MeSH term(s) Male ; Humans ; Child ; Child, Preschool ; Adolescent ; Female ; Hemophilia A/drug therapy ; Prospective Studies ; Antibodies, Bispecific/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances emicizumab (7NL2E3F6K3) ; Antibodies, Bispecific ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-07-23
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.EGY-S4-10
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  6. Article ; Online: Insight into magnesium ions effect on chromosome banding and ultrastructure.

    Dwiranti, Astari / Mualifah, Mualifah / Kartapradja, Raden Hannie Dewi Hadyani / Abinawanto, Abinawanto / Salamah, Andi / Fukui, Kiichi

    Microscopy research and technique

    2022  Volume 85, Issue 10, Page(s) 3356–3364

    Abstract: Magnesium ion ( ... ...

    Abstract Magnesium ion (Mg
    MeSH term(s) Chelating Agents ; Chromosome Banding ; Edetic Acid ; Euchromatin ; HeLa Cells ; Heterochromatin ; Humans ; Ions ; Magnesium/pharmacology
    Chemical Substances Chelating Agents ; Euchromatin ; Heterochromatin ; Ions ; Edetic Acid (9G34HU7RV0) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099714-3
    ISSN 1097-0029 ; 1059-910X
    ISSN (online) 1097-0029
    ISSN 1059-910X
    DOI 10.1002/jemt.24190
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    Zs.A 2251: Show issues Location:
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  7. Article ; Online: Efficacy of Citicoline as a Neuroprotector in children with post cardiac arrest: a randomized controlled clinical trial.

    Salamah, Abeer / Mehrez, Mostafa / Faheem, Amany / El Amrousy, Doaa

    European journal of pediatrics

    2020  Volume 180, Issue 4, Page(s) 1249–1255

    Abstract: Brain hypoxia after cardiac arrest leads to damage of the neuronal cell membrane. Citicoline is necessary for the synthesis of cell membrane. We planned to assess the neuroprotective effect of citicoline in children after cardiac arrest. This randomized ... ...

    Abstract Brain hypoxia after cardiac arrest leads to damage of the neuronal cell membrane. Citicoline is necessary for the synthesis of cell membrane. We planned to assess the neuroprotective effect of citicoline in children after cardiac arrest. This randomized controlled trial was carried out at pediatric intensive care units (PICU) and surgical ICU at Tanta university hospital on 80 consecutive children surviving in-hospital cardiac arrest who were subdivided into two groups. Group I (citicoline group) included 40 children with post-cardiac arrest who received citicoline 10 mg /kg /12 h IV for 6 weeks plus other supportive measures and group II (control group) included 40 children with post-cardiac arrest who were managed with only supportive measures. All patients were evaluated for Glasgow coma score (GCS), modified Rankin scale (mRS) for children, seizures frequency, type and duration, and serum neuron-specific enolase (NSE) before and 3 months after the treatment. GCS and mRS significantly improved in citicholine group compared to the control group. Seizure frequency and duration, mortality, PICU and hospital stay significantly decreased in citicholine group compared to the control group. Serum NSE levels significantly decreased in citicholine group only. No side effects were recorded.Conclusion: Citicoline is a promising neuroprotective drug in children with post-cardiac arrest.Trial Registration: The study was registered at Pan African Clinical Trials Registry (PACTR) www.pactr.samrc.ac.za with trial number PACTR201907742119058. What is known? • Post-resuscitation brain injury is one of the major complications that can lead to death or disability. • CDP-choline has been studied for acute ischemic stroke in several adult studies because of its reparative effect. What is new? • Our study was the first in pediatrics that assessed the neuroprotective effect of CDP-choline on the brain in children after cardiac arrest. • We found that Citicoline is a promising neuroprotective drug in children with post-cardiac arrest.
    MeSH term(s) Adult ; Brain Injuries ; Brain Ischemia ; Child ; Cytidine Diphosphate Choline/therapeutic use ; Heart Arrest/complications ; Heart Arrest/drug therapy ; Humans ; Stroke
    Chemical Substances Cytidine Diphosphate Choline (536BQ2JVC7)
    Language English
    Publishing date 2020-11-10
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-020-03871-6
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    Um IV Zs.75: Show issues Location:
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  8. Article ; Online: Effect of varash oil to decrease menstrual pain in primary dysmenorrhea of senior high school student at Palu City.

    Negara, Ni Wayan Wirayanti Putri / Stang / Ansariad / Salamah, A Ummu / Seweng, Arifin / Nur, Rosmala / Syam, Aminuddin

    Gaceta sanitaria

    2021  Volume 35 Suppl 2, Page(s) S145–S147

    Abstract: Objective: menstrual pain is a common gynecological symptom at women on or near their menstrual period. Two third of them experienced moderate to severe pain. However, just several seek for medical help. This research aims to know the effect of ginger ... ...

    Abstract Objective: menstrual pain is a common gynecological symptom at women on or near their menstrual period. Two third of them experienced moderate to severe pain. However, just several seek for medical help. This research aims to know the effect of ginger oil used on decreasing menstrual pain scale.
    Materials and methods: this cross over experimental study was held from February until May 2020 on 64 grade XI high school students at Palu city. Participants were grouping cluster randomly into group A which applied 5ml ginger oil five days before until the second day of the first menstrual period, and group B that given the same treatment in the next period. A visual pain scale measured the pain scale on the second day of the menstrual period.
    Result: most participants were in the age of 17 years old. The study found a lowering of pain scale significantly at both groups after treatment. The main menstrual pain scale were 6.87 ± 1.817 and 6.46±1.362 decreased to 3.48±1.928 and 4.24±2.010 after treatment (p=0.0001). Differences between the two groups were significant in the first period (p=0.0001) but not significant in the second period (p=0.410).
    Conclusion: the use of ginger oil several days before menstruation can reduce menstrual pain scale on students with primary dysmenorrhea; therefore, its use can be recommended to prevent the pain.
    MeSH term(s) Adolescent ; Dysmenorrhea/drug therapy ; Female ; Humans ; Pain Measurement ; Schools ; Students
    Language English
    Publishing date 2021-12-20
    Publishing country Spain
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1038713-4
    ISSN 1578-1283 ; 0213-9111
    ISSN (online) 1578-1283
    ISSN 0213-9111
    DOI 10.1016/j.gaceta.2021.06.010
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    Zs.A 2715: Show issues Location:
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  9. Article: Impact of online communication and type of media formats in enhancing orthodontic patients' knowledge.

    Al-Gunaid, Talat H / Alkhaibari, Ahmed A / Alrashidi, Basim S / Alrehaili, Mohammed A / Alatawi, Salamah A

    Journal of orthodontic science

    2021  Volume 10, Page(s) 23

    Abstract: Objectives: This study aimed to evaluate the extent to which online communication can enhance patients' knowledge of orthodontic topics, as well as compare the effectiveness of images, video, and text messages as tools for delivering orthodontic ... ...

    Abstract Objectives: This study aimed to evaluate the extent to which online communication can enhance patients' knowledge of orthodontic topics, as well as compare the effectiveness of images, video, and text messages as tools for delivering orthodontic information.
    Materials and methods: Two WhatsApp groups were created comprising 30 males and 33 females. The Google form template was used to formulate a 25-item questionnaire containing information related to orthodontic topics. At the beginning of the first stage, a link to the questionnaire was sent to the groups and their answers were given scores, which were referred to as (T1). During the second stage, a piece of daily information relevant to the field of orthodontics was sent to the groups over a 14-day period. On Day 15, the link to the previous questionnaire was sent again and the participants were asked to complete it for a second time. These answers were corrected, given scores, and labeled as (T2). Scores from the first and second stages were compared.
    Results: There was a significant increase in the average total score from the first questionnaire (T1 = 15.3) to the second questionnaire (T2 = 17.9). All types of media formats were greatly effective in improving the patients' knowledge. Images proved to be the best tool for delivering information and were considerably more effective than video and text messages.
    Conclusion: This study indicates that WhatsApp as an online communication tool could be used to effectively enhance the knowledge of orthodontic patients. Images are the best method for delivering information to orthodontic patients.
    Language English
    Publishing date 2021-10-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 2733594-X
    ISSN 2278-0203 ; 2278-1897
    ISSN (online) 2278-0203
    ISSN 2278-1897
    DOI 10.4103/jos.jos_115_21
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  10. Article: Adherence to the Mediterranean Diet Improved Clinical Scores and Inflammatory Markers in Children with Active Inflammatory Bowel Disease: A Randomized Trial.

    El Amrousy, Doaa / Elashry, Heba / Salamah, Abeer / Maher, Sara / Abd-Elsalam, Sherief M / Hasan, Samir

    Journal of inflammation research

    2022  Volume 15, Page(s) 2075–2086

    Abstract: Objective: The Mediterranean diet (MD) is a well-known style of diet that is full of antioxidants and may have anti-inflammatory effects. We evaluated the safety, tolerability, and effects of adherence to MD on disease activity and inflammatory markers ... ...

    Abstract Objective: The Mediterranean diet (MD) is a well-known style of diet that is full of antioxidants and may have anti-inflammatory effects. We evaluated the safety, tolerability, and effects of adherence to MD on disease activity and inflammatory markers in children and adolescents with active inflammatory bowel disease (IBD).
    Methods: This prospective, randomized study included 100 IBD patients aged twelve to eighteen years with mild to moderate disease activity (PCDAI score 10-45 or PUCAI 10-64). The included patients were divided into two groups of 50 patients each. Group I (26 patients with active CD and 24 patients with active UC) received MD with good adherence over 12 weeks with a KIDMED 8-point score, and group II (28 patients with active CD and 22 patients with active UC) received their usual diet with a KIDMED score ≤7 points. Patients in both groups received treatment similar for IBD activity.
    Results: Clinical remission was achieved in most of the patients after 12 weeks of treatment. Patients in the first group (adhering to an MD) showed a significant decrease in both clinical scores (PCDAI and PUCAI) and most inflammatory markers (CRP, calprotectin, TNF-α, IL17., IL 12 and IL13) compared to patients in their normal group, with earlier improvement in both PCDAI and CRP.
    Conclusion: Adherence to the MD improves clinical scores and inflammatory markers in children and adolescents with mild-moderate active IBD.
    Language English
    Publishing date 2022-03-29
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S349502
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