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Article ; Online: Avanzando juntos, alcanzando retos….

Revista internacional de andrologia

2020 Volume 18, Issue 4, Page(s) 127–128

Title translation	Advancing together, achieving challenges.
MeSH term(s)	Andrology ; Editorial Policies ; Humans ; Journal Impact Factor ; Periodicals as Topic/trends
Language	Spanish
Publishing date	2020-10-12
Publishing country	Spain
Document type	Editorial
ISSN	1698-0409
ISSN (online)	1698-0409
DOI	10.1016/j.androl.2020.09.001
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Article ; Online: The End of an Era: Withdrawal of Xiapex (Clostridium histolyticum Collagenase) from the European Market.

Cocci, Andrea / Russo, Giorgio Ivan / Salamanca, Juan Ignacio Martinez / Ralph, David / Palmieri, Alessandro / Mondaini, Nicola

European urology

2019 Volume 77, Issue 5, Page(s) 660–661

MeSH term(s)	Collagenases/supply & distribution ; Collagenases/therapeutic use ; European Union ; Humans ; Male ; Penile Induration/drug therapy
Chemical Substances	Collagenases (EC 3.4.24.-) ; xiapex (EC 3.4.24.-)
Language	English
Publishing date	2019-12-04
Publishing country	Switzerland
Document type	Letter
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2019.11.019
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Infección por SARS-CoV-2: implicaciones para la salud sexual y reproductiva. Una declaración de posición de la Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA).

José, Ferran García / González, Juan G Álvarez / Molina, Juan Manuel Corral / Arnau, Lluis Bassas / Iribarren, Ignacio Moncada / Jabaloyas, José Maria Martínez / Rico, Fernando Meijide / García-Baquero, Rodrigo / Gayá, Mariano Rosselló / García, Enrique Lledó / López, Carmen Luque / Castro, Rafael Prieto / Salamanca, Juan Ignacio Martinez

Revista internacional de andrologia

2020 Volume 18, Issue 3, Page(s) 117–123

Abstract: Objective: The main objective of this revision is to summarize the current existing evidence of the potential adverse effects of SARS-CoV-2 on the male reproductive system and provide the recommendations of the Asociación Española de Andrología, ... ...

Title translation	SARS-CoV-2 infection: implications for sexual and reproductive health. A position statement of the Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA).
Abstract	Objective: The main objective of this revision is to summarize the current existing evidence of the potential adverse effects of SARS-CoV-2 on the male reproductive system and provide the recommendations of the Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA) concerning the implications of COVID-19 infection in the management of male infertilty patients and testicular endocrine dysfunction. Methods: A comprehensive systematic literature search of the databases of PubMed, Web of Science, Embase, Medline, Cochrane and MedRxiv, was carried out. Results: The presence of orchitis as a potential complication of the infection by SARS-CoV-2 has not yet been confirmed. One study reported that 19% of males with COVID-19 infection had scrotal symptoms suggestive of viral orchitis which could not be confirmed. It is possible that the virus, rather than infecting the testes directly, may induce a secondary autoimmune response leading to autoimmune orchitis. COVID-19 has been associated with coagulation disorders and thus the orchitis could be the result of segmental vasculitis. Existing data concerning the presence of the virus in semen are contradictory. Only one study reported the presence of RNA in 15.8% of patients with COVID-19. However, the presence of nucleic acid or antigen in semen is not synonyms of viral replication capacity and infectivity. It has been reported an increase in serum levels of LH in males with COVID-19 and a significant reduction in the T/LH and FSH/LH ratios, consistent with subclinical hypogonadism. Conclusions: The findings of recent reports related to the potential effects of COVID-19 infection on the male reproductive system are based on poorly designed, small sample size studies that provide inconclusive, contradictory results. Since there still exists a theoretical possibility of testicular damage and male infertilty as a result of the infection by COVID-19, males of reproductive age should be evaluated for gonadal function and semen analysis. With regard to the sexual transmission of the virus, there is not sufficient evidence to recommend asymptomatic couples to abstein from having sex in order to protect themselves from being infected by the virus. Additional studies are needed to understand the long-term effects of SARS-CoV-2 on male reproductive function, including male fertility potential and endocrine testicular function.
MeSH term(s)	Adult ; Betacoronavirus/isolation & purification ; Betacoronavirus/pathogenicity ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/complications ; Follicle Stimulating Hormone/blood ; Humans ; Hypogonadism/blood ; Hypogonadism/etiology ; Immunoglobulin G/analysis ; Leukocytes ; Luteinizing Hormone/blood ; Male ; Orchitis/etiology ; Orchitis/virology ; Pandemics ; Pneumonia, Viral/complications ; Prostate/virology ; RNA, Viral/analysis ; Reproductive Health ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Semen/virology ; Semen Preservation ; Sexual Health ; Spain ; Testis/immunology ; Testis/pathology ; Testis/virology ; Testosterone/blood ; Vasculitis/etiology ; Young Adult
Chemical Substances	Immunoglobulin G ; RNA, Viral ; Testosterone (3XMK78S47O) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Keywords	covid19
Language	Spanish
Publishing date	2020-06-23
Publishing country	Spain
Document type	Practice Guideline
ISSN	1698-0409
ISSN (online)	1698-0409
DOI	10.1016/j.androl.2020.06.001
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Article ; Online: Current practices regarding corporotomy localization during penoscrotal inflatable penile implant surgery: a multicenter cohort study.

van Renterghem, Koenraad / Jacobs, Brecht / Yafi, Faysal / Osmonov, Daniar / Ralph, David / Venturino, Luca / Barnard, John Taylor / Ziegelmann, Matthew / Wang, Run / Kannady, Chris / Lentz, Aaron / Garcia, Enrique Lledo / Andrianne, Robert / Bettochi, Carlo / Hatzichristodoulou, George / Gross, Martin / Faix, Antoine / Otero, Javier Romero / Salamanca, Juan Ignacio Martinez /

Sedigh, Omidreza / Albersen, Maarten / Dinkelman-Smit, Marij / Mykoniatis, Ioannis

International journal of impotence research

2021 Volume 34, Issue 3, Page(s) 302–307

Abstract: Literature concerning corporotomy location in multicomponent inflatable penile prosthetic surgery via a penoscrotal approach is scarce if not nonexistent. Aim of our study was to report practices in low-, moderate-, and high-volume penile implant centers ...

Abstract	Literature concerning corporotomy location in multicomponent inflatable penile prosthetic surgery via a penoscrotal approach is scarce if not nonexistent. Aim of our study was to report practices in low-, moderate-, and high-volume penile implant centers regarding corporotomy location and evaluate its potential impact on intraoperative and short-term postoperative complications. Data from 18 (13 European and 5 American) implant centers were collected retrospectively between September 1st, 2018 and August 31st, 2019. Variables included: intraoperative proximal and distal corpus cavernosum length measurement, total corporal length measurement, total penile implant cylinder length, and length of rear tip extenders. Eight hundred and nine virgin penile implant cases were included in the analysis. Mean age of participants was 61.5 ± 9.6 years old. In total, 299 AMS 700™ (Boston Scientific, USA) and 510 Coloplast Titan® (Minneapolis, MN USA) devices were implanted. The mean proximal/distal corporal measurement ratio during corporotomy was 0.93 ± 0.29 while no statistical difference was found among low-, moderate-, and high-volume penile implant centers. A statistically significant correlation between lower proximal/distal measurement ratio and higher age (p = 0.0013), lower BMI (p < 0.0001), lower use of rear tip extenders (RTE) (p = 0.04), lower RTE length (p < 0.0001), and absence of diabetes (p = 0.0004) was reported. In a 3-month follow up period, 49 complications and 37 revision procedures were reported. This is the first study reporting the current practices regarding corporotomy location during IPP placement in a multicenter cohort, particularly when including such a high number of patients. Nevertheless, the retrospective design and the short follow up period limits the study outcomes. Corporotomy location during penoscrotal IPP implantation does not correlate with intraoperative or short-term postoperative complication rates. Future studies with longer follow up are needed in order to evaluate the association of corporotomy location with long-term complications.
MeSH term(s)	Aged ; Erectile Dysfunction/etiology ; Humans ; Male ; Middle Aged ; Penile Implantation/methods ; Penile Prosthesis/adverse effects ; Penis/surgery ; Retrospective Studies
Language	English
Publishing date	2021-04-12
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-021-00431-w
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Zs.A 2910: Show issues

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Article ; Online: Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie's disease in a multicenter clinical study.

Cocci, Andrea / Ralph, David / Djinovic, Rados / Hatzichristodoulou, Georgios / Morelli, Girolamo / Salonia, Andrea / Capogrosso, Paolo / Romano, Andrea / Cito, Gianmartin / Di Maida, Fabrizio / Fernández-Pascual, Esaú / Romero-Otero, Javier / Egydio, Paulo / Falcone, Marco / Preto, Mirko / Chiriacò, Giovanni / Beck, Jack / Albersen, Maarten / Minhas, Suks /

Cacciamani, Giovanni / Salamanca, Juan Ignacio Martinez / Mondani, Nicola / Minervini, Andrea / Russo, Giorgio Ivan

Scientific reports

2021 Volume 11, Issue 1, Page(s) 166

Abstract: In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a ... ...

Abstract	In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a multicentre study from 6 andrological centres were retrospectively reviewed. Three standardized surgical techniques were performed. Group 1: plaque incision grafting (PIG) with penile prosthesis implant (PPI); Group 2: PIG without PPI; Group 3: Nesbit technique. Hospital stay, operative time, postoperative complications and PC persistency/recurrence (> 20°) were evaluated. Overall satisfaction and functional outcomes were assessed through International Index of Erectile Function-Erectile Function (IIEF-EF), Peyronie's Disease Questionnaire (PDQ), Female Sexual Function Index (FSFI) administered pre and 3 months postoperatively. Of all, 25 (27.8%) patients received grafting procedure + PPI (Group 1), 18 (20.0%) patients belonged to Group 2, and 47 (52.2%) to Group 3. Bovine pericardium graft and collagen fleece have been used in in 22 (51.2%) and 21 (48.8%) patients, respectively. Median penile length after surgery was 13.0 cm (IQR 12.0-15.0). After surgery, Group 1 showed higher increase in penile length after surgery and better improvements in terms of PDQ-PS. In contrast, both IIEF-EF and FSFI scores did not differ among groups. Overall, 86 (95.6%) did not report any complication. 4 (4.4%) patients had PC recurrence; of those, 2 (8.0%), 1 (5.6%) and 1 (2.1%) cases were observed in Group 1, Group 2 and Group 3, respectively. In case of persistent PC after CCH, surgical correction by grafting with or without concomitant PPI or Nesbit technique emerged as a technically feasible, effective and safe procedure, with no significant postoperative complications.
MeSH term(s)	Adult ; Clostridium histolyticum/metabolism ; Humans ; Injections, Intralesional ; Male ; Microbial Collagenase/pharmacology ; Middle Aged ; Patient Satisfaction ; Penile Implantation ; Penile Induration/surgery ; Postoperative Period ; Retrospective Studies ; Surveys and Questionnaires ; Treatment Outcome
Chemical Substances	Microbial Collagenase (EC 3.4.24.3)
Language	English
Publishing date	2021-01-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-80551-3
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Article ; Online: Delaying Surgical Treatment of Penile Fracture Results in Poor Functional Outcomes: Results from a Large Retrospective Multicenter European Study.

Bozzini, Giorgio / Albersen, Maarten / Otero, Javier Romero / Margreiter, Markus / Cruz, Eduard Garcia / Mueller, Alexander / Gratzke, Christian / Serefoglu, Ege Can / Salamanca, Juan Ignacio Martinez / Verze, Paolo

European urology focus

2016 Volume 4, Issue 1, Page(s) 106–110

Abstract: Background: Penile fracture is a rare clinical entity that represents a urologic emergency. It involves traumatic rupture of the tunica albuginea of the corpora cavernosa due to twisting or bending of the penile shaft during erection.: Objective: To ... ...

Abstract	Background: Penile fracture is a rare clinical entity that represents a urologic emergency. It involves traumatic rupture of the tunica albuginea of the corpora cavernosa due to twisting or bending of the penile shaft during erection. Objective: To determine the differences in preoperative diagnostic evaluation patterns and outcomes of penile fracture patients to investigate the impact of surgical delay on functional outcomes. Design, setting, and participants: A retrospective analysis was performed using data obtained from 137 patients presenting with penile fracture at seven different European academic medical centers between 1996 and 2013. Age, imaging modalities used, timing of surgical intervention, length of tunica albuginea defect, and surgical technique were recorded. Postoperative erectile function outcomes were assessed with the International Index of Erectile Function (IIEF-5), and the presence of postoperative penile curvature was noted. Outcome measurements and statistical analysis: The association between timing of surgical intervention and postoperative IIEF-5 results was evaluated with discriminant function analysis. Results and limitations: The median age of the patients was 34.50 yr (interquartile range [IQR]: 28.0-46.5 yr). Of the 137 patients, 82 (59.85%) underwent penile Doppler ultrasound, and 5 patients (3.64%) were evaluated with magnetic resonance imaging. All patients were treated surgically, and the duration between emergency room admission and surgical intervention was 5.0h (IQR: 3.6-8.0h). The median length of tunica albuginea defect was 10mm (IQR: 8-20mm). Postoperative IIEF-5 scores were 21 (IQR: 12-23) and 23 (IQR: 15-24) at the first and third postoperative months, respectively. Discriminant function analysis revealed that if the surgical intervention was performed >8.23hours after emergency room admission, postoperative erectile function was significantly worse (p=0.0051 at first month and p=0.0057 at third month postoperatively). Conclusions: Our multicenter study showed that delaying surgical intervention results in significantly impaired erectile function. Surgical treatment must be planned as soon as possible to avoid postoperative erectile dysfunction. Patient summary: We looked at sexual outcomes following the repair of penile fracture in a large European population. We found that outcomes worsened if surgical repair was delayed.
MeSH term(s)	Adult ; Erectile Dysfunction/complications ; Erectile Dysfunction/physiopathology ; Europe/epidemiology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Penile Diseases/pathology ; Penile Diseases/surgery ; Penis/diagnostic imaging ; Penis/injuries ; Penis/pathology ; Penis/surgery ; Postoperative Period ; Preoperative Care ; Retrospective Studies ; Rupture/complications ; Rupture/diagnostic imaging ; Rupture/pathology ; Rupture/surgery ; Time-to-Treatment/statistics & numerical data ; Ultrasonography, Doppler/methods
Language	English
Publishing date	2016-03-04
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ISSN	2405-4569
ISSN (online)	2405-4569
DOI	10.1016/j.euf.2016.02.012
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Article: Infección por SARS-CoV-2: implicaciones para la salud sexual y reproductiva. Una declaración de posición de la Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA)./ [SARS-CoV-2 infection: implications for sexual and reproductive health. A position statement of the Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA)]

Rev Int Androl

Abstract: OBJECTIVE: The main objective of this revision is to summarize the current existing evidence of the potential adverse effects of SARS-CoV-2 on the male reproductive system and provide the recommendations of the Asociación Española de Andrología, Medicina ...

Abstract	OBJECTIVE: The main objective of this revision is to summarize the current existing evidence of the potential adverse effects of SARS-CoV-2 on the male reproductive system and provide the recommendations of the Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA) concerning the implications of COVID-19 infection in the management of male infertilty patients and testicular endocrine dysfunction. METHODS: A comprehensive systematic literature search of the databases of PubMed, Web of Science, Embase, Medline, Cochrane and MedRxiv, was carried out. RESULTS: The presence of orchitis as a potential complication of the infection by SARS-CoV-2 has not yet been confirmed. One study reported that 19% of males with COVID-19 infection had scrotal symptoms suggestive of viral orchitis which could not be confirmed. It is possible that the virus, rather than infecting the testes directly, may induce a secondary autoimmune response leading to autoimmune orchitis. COVID-19 has been associated with coagulation disorders and thus the orchitis could be the result of segmental vasculitis. Existing data concerning the presence of the virus in semen are contradictory. Only one study reported the presence of RNA in 15.8% of patients with COVID-19. However, the presence of nucleic acid or antigen in semen is not synonyms of viral replication capacity and infectivity. It has been reported an increase in serum levels of LH in males with COVID-19 and a significant reduction in the T/LH and FSH/LH ratios, consistent with subclinical hypogonadism. CONCLUSIONS: The findings of recent reports related to the potential effects of COVID-19 infection on the male reproductive system are based on poorly designed, small sample size studies that provide inconclusive, contradictory results. Since there still exists a theoretical possibility of testicular damage and male infertilty as a result of the infection by COVID-19, males of reproductive age should be evaluated for gonadal function and semen analysis. With regard to the sexual transmission of the virus, there is not sufficient evidence to recommend asymptomatic couples to abstein from having sex in order to protect themselves from being infected by the virus. Additional studies are needed to understand the long-term effects of SARS-CoV-2 on male reproductive function, including male fertility potential and endocrine testicular function.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #643096
Database	COVID19

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Article ; Online: Infección por SARS-CoV-2

José, Ferran García / González, Juan G. Álvarez / Molina, Juan Manuel Corral / Arnau, Lluis Bassas / Iribarren, Ignacio Moncada / Jabaloyas, José Maria Martínez / Rico, Fernando Meijide / García-Baquero, Rodrigo / Gayá, Mariano Rosselló / García, Enrique Lledó / López, Carmen Luque / Castro, Rafael Prieto / Salamanca, Juan Ignacio Martinez

Revista Internacional de Andrología

implicaciones para la salud sexual y reproductiva. Una declaración de posición de la Asociación Española de Andrología, Medicina Sexual y Reproductiva (ASESA)

2020 Volume 18, Issue 3, Page(s) 117–123

Keywords	Urology ; Reproductive Medicine ; covid19
Language	Spanish
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	1698-031X
DOI	10.1016/j.androl.2020.06.001
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Occipital condyle syndrome guiding diagnosis to metastatic prostate cancer.

Salamanca, Juan Ignacio Martinez / Murrieta, Concepcion / Jara, Jose / Munoz-Blanco, Jose Luis / Alvarez, Federico / De Villoria, Juan Guzman / Hernandez, Carlos

International journal of urology : official journal of the Japanese Urological Association

2006 Volume 13, Issue 7, Page(s) 1022–1024

Abstract: Occipital condyle syndrome (OCS) results from a unilateral occipital pain associated with an ipsilateral paresis of the 12th cranial nerve (hypoglossal), and is typically caused by metastasis of the skull base. OCS diagnosis occurred, in all cases ... ...

Abstract	Occipital condyle syndrome (OCS) results from a unilateral occipital pain associated with an ipsilateral paresis of the 12th cranial nerve (hypoglossal), and is typically caused by metastasis of the skull base. OCS diagnosis occurred, in all cases described in the published literature, when metastatic prostate cancer (MPC) was previously known. We present a case of a patient whose initial manifestation of MPC was OCS. The patient was treated with complete hormonal blockade and non-steroidal anti-inflammatory drugs as opposed to locoregional radiotherapy applied in other cases. After 18 month follow-up, the patient had a complete neurological and biochemical response.
MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/secondary ; Aged ; Biopsy ; Diagnosis, Differential ; Endosonography ; Humans ; Magnetic Resonance Imaging ; Male ; Occipital Bone ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Skull Base Neoplasms/diagnosis ; Skull Base Neoplasms/secondary ; Syndrome ; Tomography, X-Ray Computed
Language	English
Publishing date	2006-07
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1328401-0
ISSN	0919-8172
ISSN	0919-8172
DOI	10.1111/j.1442-2042.2006.01466.x
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Zs.MO 278: Show issues

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