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  1. Article: »Zaire« bakom största ebolaepidemin någonsin - Ger högst dödlighet av de fyra humanpatogena ebolavirusen.

    Olsen, Björn / Salaneck, Erik

    Lakartidningen

    2014  Volume 111, Issue 44-45, Page(s) 1960–1962

    Title translation "Zaire" behind the largest Ebola epidemic ever. Highest mortality of the four human pathogenic Ebola viruses.
    MeSH term(s) Democratic Republic of the Congo/epidemiology ; Ebolavirus/pathogenicity ; Epidemics ; Hemorrhagic Fever, Ebola/drug therapy ; Hemorrhagic Fever, Ebola/mortality ; Hemorrhagic Fever, Ebola/transmission ; Humans ; Risk Factors
    Language Swedish
    Publishing date 2014-10-28
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.411: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report.

    Nissen, Karolina / Hagbom, Marie / Krambrich, Janina / Akaberi, Dario / Sharma, Sumit / Ling, Jiaxin / Hoffman, Tove / Svensson, Lennart / Bondeson, Kåre / Salaneck, Erik

    Heliyon

    2021  Volume 7, Issue 2, Page(s) e06328

    Abstract: Possible pre- or asymptomatic transmission has been reported, both from SARS-CoV and from MERS-CoV outbreaks, although this appears to be uncommon. In contrast, during the COVID-19 pandemic, an increasing number of studies and case reports indicate that ... ...

    Abstract Possible pre- or asymptomatic transmission has been reported, both from SARS-CoV and from MERS-CoV outbreaks, although this appears to be uncommon. In contrast, during the COVID-19 pandemic, an increasing number of studies and case reports indicate that pre- or asymptomatic transmission of SARS-CoV-2 is not only possible but also occurs frequently. We report repeated rRT-PCR detection of SARS-CoV-2 in a health care worker and demonstrate infective ability up to three days prior to mild COVID-19 symptoms. rRT-PCR indicated high viral levels approximately three days after exposure. Viral samples collected one and three days prior to symptoms exhibited infectivity on Vero E6 cells, confirmed by detection of double-stranded RNA by immunofluorescence, assessment of cytopathic effect (CPE) and rRT-PCR. SARS-CoV-2 specific IgM and IgG antibodies were detected by day 9 and 15, respectively, after symptom onset. We propose that this provides evidence for potential early presymptomatic transmission of SARS-CoV-2 and that infectivity may be manifest shortly after exposure.
    Language English
    Publishing date 2021-02-19
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e06328
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  3. Article ; Online: Civil-Military Collaboration to Facilitate Rapid Deployment of a Mobile Laboratory in Early Response to COVID-19: A High-Readiness Exercise.

    Bacchus, Philip / Nissen, Karolina / Berg, Johanna / Bråve, Andreas / Gyll, Jenny / Larsson, Christer / Muradrasoli, Shaman / Tellström, Andreas / Salaneck, Erik

    Health security

    2021  Volume 19, Issue 5, Page(s) 488–497

    Abstract: Rapid and adaptable diagnostic capabilities are of great importance in the face of emerging infectious diseases. In an outbreak, timely establishment of diagnostic routines is crucial to identifying cases and preventing the spread of the disease, ... ...

    Abstract Rapid and adaptable diagnostic capabilities are of great importance in the face of emerging infectious diseases. In an outbreak, timely establishment of diagnostic routines is crucial to identifying cases and preventing the spread of the disease, especially when faced with high-consequence pathogens. In this article, we describe a multiagency exercise including the rapid deployment and diagnostic adaptation of the Swedish Armed Forces mobile laboratory (biological field analysis laboratory) in the context of COVID-19. This deployment was initiated as a high-readiness exercise at the end of January 2020, when the global development of the outbreak was still uncertain. Through collaboration with the Public Health Agency of Sweden and a civilian hospital, a real-time reverse transcriptase polymerase chain reaction method specific to SARS-CoV-2 was made available and adapted to the mobile laboratory, and the team established and evaluated a functional and efficient diagnostic asset along with a logistical support chain. We also organized and evaluated mobile testing teams, and the method was later used in large-scale, national, cross-sectional COVID-19 surveys in several regions of Sweden. In this article, we focus on the challenges of overbridging the civil-military interface in this context and identifying lessons learned and added values to the response during the early pandemic. We propose that the experiences from this exercise and governmental agency collaboration are valuable in preparation for future outbreaks.
    MeSH term(s) COVID-19 ; Cross-Sectional Studies ; Humans ; Laboratories ; Military Personnel ; SARS-CoV-2
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823049-8
    ISSN 2326-5108 ; 2326-5094
    ISSN (online) 2326-5108
    ISSN 2326-5094
    DOI 10.1089/hs.2021.0011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Corrigendum to "Presymptomatic viral shedding and infective ability of SARS-CoV-2; a case report" [Heliyon 7, (2), (February 2021), Article e06328].

    Nissen, Karolina / Hagbom, Marie / Krambrich, Janina / Akaberi, Dario / Sharma, Sumit / Ling, Jiaxin / Hoffman, Tove / Lundkvist, Åke / Svensson, Lennart / Bondeson, Kåre / Salaneck, Erik

    Heliyon

    2022  Volume 8, Issue 2, Page(s) e08906

    Abstract: This corrects the article DOI: 10.1016/j.heliyon.2021.e06328.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.heliyon.2021.e06328.].
    Language English
    Publishing date 2022-02-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e08906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Plaque-forming units from air samples: Letter to Editor. Re: Jefferson et al., Indoor Air, 2022.

    Rufino de Sousa, Nuno / Steponaviciute, Laura / Margerie, Lucille / Nissen, Karolina / Kjellin, Midori / Reinius, Björn / Salaneck, Erik / Udekwu, Klas I / Rothfuchs, Antonio Gigliotti

    Indoor air

    2022  Volume 32, Issue 11, Page(s) e13169

    MeSH term(s) Air Pollution, Indoor/analysis ; Air Microbiology ; Air Pollutants/analysis
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2022-11-27
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.13169
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    In stock of ZB MED Bonn / Germany

    Z 7724: Show issues

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  6. Article ; Online: Corrigendum. Re: de Sousa, N.R., et al., 2022. Detection and isolation of airborne SARS-CoV-2 in a hospital setting. Indoor air, 32(3), e13023.

    Rufino de Sousa, Nuno / Steponaviciute, Laura / Margerie, Lucille / Nissen, Karolina / Kjellin, Midori / Reinius, Björn / Salaneck, Erik / Udekwu, Klas I / Rothfuchs, Antonio Gigliotti

    Indoor air

    2022  Volume 32, Issue 8, Page(s) e13085

    MeSH term(s) Air Pollution, Indoor ; COVID-19 ; Hospitals ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-08-28
    Publishing country England
    Document type Letter ; Published Erratum
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.13085
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    In stock of ZB MED Bonn / Germany

    Z 7724: Show issues

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  7. Article ; Online: Detection and isolation of airborne SARS-CoV-2 in a hospital setting.

    Rufino de Sousa, Nuno / Steponaviciute, Laura / Margerie, Lucille / Nissen, Karolina / Kjellin, Midori / Reinius, Björn / Salaneck, Erik / Udekwu, Klas I / Rothfuchs, Antonio Gigliotti

    Indoor air

    2022  Volume 32, Issue 3, Page(s) e13023

    Abstract: Transmission mechanisms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. In particular, aerosol transmission remains unclear, with viral detection in air and demonstration of its infection potential being ... ...

    Abstract Transmission mechanisms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. In particular, aerosol transmission remains unclear, with viral detection in air and demonstration of its infection potential being actively investigated. To this end, we employed a novel electrostatic collector to sample air from rooms occupied by COVID-19 patients in a major Swedish hospital. Electrostatic air sampling in conjunction with extraction-free, reverse-transcriptase polymerase chain reaction (hid-RT-PCR) enabled detection of SARS-CoV-2 in air from patient rooms (9/22; 41%) and adjoining anterooms (10/22; 45%). Detection with hid-RT-PCR was concomitant with viral RNA presence on the surface of exhaust ventilation channels in patients and anterooms more than 2 m from the COVID-19 patient. Importantly, it was possible to detect active SARS-CoV-2 particles from room air, with a total of 496 plaque-forming units (PFUs) being isolated, establishing the presence of infectious, airborne SARS-CoV-2 in rooms occupied by COVID-19 patients. Our results support circulation of SARS-CoV-2 via aerosols and urge the revision of existing infection control frameworks to include airborne transmission.
    MeSH term(s) Air Pollution, Indoor ; COVID-19 ; Hospitals ; Humans ; RNA, Viral/analysis ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.13023
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    In stock of ZB MED Bonn / Germany

    Z 7724: Show issues

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  8. Article ; Online: Long-distance airborne dispersal of SARS-CoV-2 in COVID-19 wards.

    Nissen, Karolina / Krambrich, Janina / Akaberi, Dario / Hoffman, Tove / Ling, Jiaxin / Lundkvist, Åke / Svensson, Lennart / Salaneck, Erik

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 19589

    Abstract: Evidence suggests that SARS-CoV-2, as well as other coronaviruses, can be dispersed and potentially transmitted by aerosols directly or via ventilation systems. We therefore investigated ventilation openings in one COVID-19 ward and central ducts that ... ...

    Abstract Evidence suggests that SARS-CoV-2, as well as other coronaviruses, can be dispersed and potentially transmitted by aerosols directly or via ventilation systems. We therefore investigated ventilation openings in one COVID-19 ward and central ducts that expel indoor air from three COVID-19 wards at Uppsala University Hospital, Sweden, during April and May 2020. Swab samples were taken from individual ceiling ventilation openings and surfaces in central ducts. Samples were subsequently subjected to rRT-PCR targeting the N and E genes of SARS-CoV-2. Central ventilation HEPA filters, located several stories above the wards, were removed and portions analyzed in the same manner. In two subsequent samplings, SARS-CoV-2 N and E genes were detected in seven and four out of 19 room vents, respectively. Central ventilation HEPA exhaust filters from the ward were found positive for both genes in three samples. Corresponding filters from two other, adjacent COVID-19 wards were also found positive. Infective ability of the samples was assessed by inoculation of susceptible cell cultures but could not be determined in these experiments. Detection of SARS-CoV-2 in central ventilation systems, distant from patient areas, indicate that virus can be transported long distances and that droplet transmission alone cannot reasonably explain this, especially considering the relatively low air change rates in these wards. Airborne transmission of SARS-CoV-2 must be taken into consideration for preventive measures.
    MeSH term(s) Aerosols ; Animals ; Betacoronavirus/genetics ; Betacoronavirus/physiology ; COVID-19 ; Chlorocebus aethiops ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Filtration ; Hospitals ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; RNA, Viral/analysis ; SARS-CoV-2 ; Ventilation ; Vero Cells
    Chemical Substances Aerosols ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-76442-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2.

    Hoffman, Tove / Nissen, Karolina / Krambrich, Janina / Rönnberg, Bengt / Akaberi, Dario / Esmaeilzadeh, Mouna / Salaneck, Erik / Lindahl, Johanna / Lundkvist, Åke

    Infection ecology & epidemiology

    2020  Volume 10, Issue 1, Page(s) 1754538

    Abstract: COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for ...

    Abstract COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.
    Keywords covid19
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627673-2
    ISSN 2000-8686
    ISSN 2000-8686
    DOI 10.1080/20008686.2020.1754538
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  10. Article: Soft tissue infection caused by Legionella bozemanii in a patient with ongoing immunosuppressive treatment.

    Neiderud, Carl-Johan / Vidh, Angela Lagerqvist / Salaneck, Erik

    Infection ecology & epidemiology

    2013  Volume 3

    Abstract: The Legionellaceae family consists of approximately 50 species, of which the most commonly identified species is L. pneumophila, the causative agent of Legionnaires' disease. Other Legionella ssp. most often cause clinical infections in the immune- ... ...

    Abstract The Legionellaceae family consists of approximately 50 species, of which the most commonly identified species is L. pneumophila, the causative agent of Legionnaires' disease. Other Legionella ssp. most often cause clinical infections in the immune-compromised patients, in which L. bozemanii has been known to cause both pneumonia and lung abscesses. In the presented case, a soft tissue infection in a patient with ongoing immunosuppression was determined to be due to L. bozemanii. Hence, in immune-deficient patients, L. bozemanii could be considered a possible agent in soft tissue infections when other common pathogens have been ruled out.
    Language English
    Publishing date 2013-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627673-2
    ISSN 2000-8686
    ISSN 2000-8686
    DOI 10.3402/iee.v3i0.20739
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