LIVIVO - Search results -

Search results

Result 1 - 10 of total 355

Search options

Article ; Online: The natural selection that shapes our genomes.

Salas, Antonio

Forensic science international. Genetics

2018 Volume 39, Page(s) 57–60

Abstract: Most of the variation in the human genome (∼95%) is constrained, directly or indirectly, by purifying selection and GC-biased gene conversion, according to a recent article by Pouyet et al. (2018). The use of 'non-neutral' variation to infer human ... ...

Abstract	Most of the variation in the human genome (∼95%) is constrained, directly or indirectly, by purifying selection and GC-biased gene conversion, according to a recent article by Pouyet et al. (2018). The use of 'non-neutral' variation to infer human demographies can lead to undesirable biases; for example, in estimation of the time of the most recent common ancestor. Further examination of 'neutral' variation in entire human genomes from The 1000 Genomes Project reveals that ∼99% of this variation lacks exonic function, but ∼35% of it falls in introns. In addition, estimates of biogeographical ancestry using 'non-neutral' SNPs differ very marginally from inferences obtained from 'neutral' variation. Additional investigations should be carried out before establishing the roadmap for future human population and forensic genetic studies.
MeSH term(s)	DNA Transposable Elements ; Evolution, Molecular ; Genetic Variation ; Genome, Human ; Genomics ; Humans ; Polymorphism, Single Nucleotide ; Selection, Genetic
Chemical Substances	DNA Transposable Elements
Language	English
Publishing date	2018-12-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2493339-9
ISSN	1878-0326 ; 1872-4973
ISSN (online)	1878-0326
ISSN	1872-4973
DOI	10.1016/j.fsigen.2018.12.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6764: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Chatting with ChatGPT to learn about safety of COVID-19 vaccines - A perspective.

Salas, Antonio / Rivero-Calle, Irene / Martinón-Torres, Federico

Human vaccines & immunotherapeutics

2023 Volume 19, Issue 2, Page(s) 2235200

Abstract: Vaccine hesitancy is among the top 10 threats to global health, according to the World Health Organization (WHO). In this exploration, we delve into ChatGPT capacity to generate opinions on vaccine hesitancy by interrogating this AI chatbot for the 50 ... ...

Abstract	Vaccine hesitancy is among the top 10 threats to global health, according to the World Health Organization (WHO). In this exploration, we delve into ChatGPT capacity to generate opinions on vaccine hesitancy by interrogating this AI chatbot for the 50 most prevalent counterfait messages, false and true contraindications, and myths circulating on the internet regarding vaccine safety. Our results indicate that, while the present version of ChatGPT's default responses may be incomplete, they are generally satisfactory. Although ChatGPT cannot substitute an expert or the scientific evidence itself, this form of AI has the potential to guide users toward information that aligns well with scientific evidence.
MeSH term(s)	Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Internet ; Software ; Vaccination Hesitancy
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2023.2235200
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6967: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Is SARS-CoV-2 an oncogenic virus?

Gómez-Carballa, Alberto / Martinón-Torres, Federico / Salas, Antonio

The Journal of infection

2022 Volume 85, Issue 5, Page(s) 573–607

MeSH term(s)	COVID-19 ; Humans ; Oncogenic Viruses ; RNA, Viral ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-08-09
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2022.08.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 48: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recognising the asymptomatic enemy.

Cebey-López, Miriam / Salas, Antonio

The Lancet. Infectious diseases

2020 Volume 21, Issue 3, Page(s) 305–306

MeSH term(s)	Biological Evolution ; Gene Expression ; Humans ; Prospective Studies
Keywords	covid19
Language	English
Publishing date	2020-09-24
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(20)30587-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5743: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Radiographic and anatomic landmarks to approach the anterior capsule in hip arthroscopy.

Salas, Antonio Porthos

Journal of hip preservation surgery

2015 Volume 2, Issue 4, Page(s) 431–437

Abstract: Hip arthroscopy (HA) is considered to be a very difficult and demanding surgical procedure, special instruments, an image intensifier and a fracture table or hip distractor are required to access the hip joint, the most common and worldwide used HA ... ...

Abstract	Hip arthroscopy (HA) is considered to be a very difficult and demanding surgical procedure, special instruments, an image intensifier and a fracture table or hip distractor are required to access the hip joint, the most common and worldwide used HA technique is entering blindly to the central compartment with the use of fluoroscopy and continuous distraction; with the potential danger if performed in unskillful hands of labral penetrations, labral resections and scuffing of the femoral head cartilage. Our technique describes the arthroscopic management of femoroacetabular impingement (FAI), performing a preoperative planning using radiographic and anatomic landmarks to approach the anterior capsule without the use of fluoroscopy. Access to the hip joint is made extra-articularly from the peritrochanteric compartment palpating the greater trochanter and posteriorly penetrating the iliotibial band sliding the arthroscopic sheath and obturator from the trochanteric border to the anterior femoral neck to visualize the anterior capsule bursa and anterior capsule fibers and posteriorly following our previous landmarks perform an anterior oblique Inverted 'T' or 'H' capsulotomy with a radiofrequency wand to access the cam-type impingement and distraction is made under direct controlled arthroscopic vision. Our technique in HA aiming the anterior capsule using radiographic and anatomic landmarks is safe, reliable and reproducible in FAI with big cams, deep sockets and cases with mild arthritis where the capsule is thick, stiff and calcified.
Language	English
Publishing date	2015-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2773022-0
ISSN	2054-8397
ISSN	2054-8397
DOI	10.1093/jhps/hnv056
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Hip Arthroscopy in Adolescents Through an Extra-Capsular Approach.

Salas, Antonio Porthos / Mazek, Jacek / María, Andrew Carlo / Taffinder, David Santiago / Velasco-Vazquez, Hector

Arthroscopy techniques

2023 Volume 12, Issue 6, Page(s) e867–e871

Abstract: Hip arthroscopic treatment for femoroacetabular impingement syndrome and labral tears is the gold standard in the adult and adolescent population, as we all know the most common surgical approach to the hip is entering the central compartment with ... ...

Abstract	Hip arthroscopic treatment for femoroacetabular impingement syndrome and labral tears is the gold standard in the adult and adolescent population, as we all know the most common surgical approach to the hip is entering the central compartment with fluoroscopy and with continuous distraction. A periportal capsulotomy in traction must be done to have visibility and instrument maneuverability. These maneuvers avoid scuffing the femoral head cartilage. In adolescents, extreme care must be taken in hip distraction, as the force used can cause iatrogenic neurovascular lesions, avascular necrosis, and lacerations of the genitals and foot/ankle. Experienced surgeons around the world have developed an extracapsular approach to the hip with smaller capsulotomies with a low complication rate. This approach to the hip has brought attention in the adolescent population because it is more secure and simple. Less force of distraction is needed because the capsulotomy is done first. This surgical technique allows observation of the cam morphology while entering to the hip without distraction. We describe an extracapsular approach as an option to treat femoral acetabular impingement syndrome and labral tears in the pediatric and adolescent population.
Language	English
Publishing date	2023-05-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2653101-X
ISSN	2212-6287
ISSN	2212-6287
DOI	10.1016/j.eats.2023.02.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Sensogenomics and the Biological Background Underlying Musical Stimuli: Perspectives for a New Era of Musical Research.

Navarro, Laura / Martinón-Torres, Federico / Salas, Antonio

Genes

2021 Volume 12, Issue 9

Abstract: What is the actual impact of music on the human being and the scope for scientific research in this realm? Compared to other areas, the study of the relationship between music and human biology has received limited attention. At the same time, evidence ... ...

Abstract	What is the actual impact of music on the human being and the scope for scientific research in this realm? Compared to other areas, the study of the relationship between music and human biology has received limited attention. At the same time, evidence of music's value in clinical science, neuroscience, and social science keeps increasing. This review article synthesizes the existing knowledge of genetics related to music. While the success of genomics has been demonstrated in medical research, with thousands of genes that cause inherited diseases or a predisposition to multifactorial disorders identified, much less attention has been paid to other human traits. We argue for the development of a new discipline, sensogenomics, aimed at investigating the impact of the sensorial input on gene expression and taking advantage of new, discovery-based 'omic' approaches that allow for the exploration of the whole transcriptome of individuals under controlled experiments and circumstances.
MeSH term(s)	Auditory Perception/physiology ; Autism Spectrum Disorder/physiopathology ; Autism Spectrum Disorder/psychology ; Biological Evolution ; Gene Expression ; Genomics/methods ; Humans ; Memory/physiology ; Music ; Williams Syndrome/etiology ; Williams Syndrome/genetics
Language	English
Publishing date	2021-09-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12091454
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Outcomes of remission induction therapy for ANCA-associated vasculitis in the elderly.

Aqeel, Faten / Xu, Lillian / Salas, Antonio / Wen, Yumeng / Eid, Shaker M / Geetha, Duvuru

Clinical rheumatology

2023 Volume 42, Issue 9, Page(s) 2427–2435

Abstract: Objective: Treatment regimens combining glucocorticoids with cyclophosphamide or rituximab or both are used to induce remission in ANCA-associated glomerulonephritis (ANCA-GN). There is a paucity of data on the efficacy and safety of these regimens in ... ...

Abstract	Objective: Treatment regimens combining glucocorticoids with cyclophosphamide or rituximab or both are used to induce remission in ANCA-associated glomerulonephritis (ANCA-GN). There is a paucity of data on the efficacy and safety of these regimens in elderly patients with ANCA-GN. This study aimed to examine outcomes and adverse events in elderly AAV patients with three induction regimens: cyclophosphamide (CYC), cyclophosphamide and rituximab (CYC + RTX), and rituximab (RTX). Methods: This single-center retrospective cohort study included patients 60 years and older diagnosed with ANCA-GN. Baseline characteristics and outcomes across several clinical parameters were recorded and compared for significance using Kruskal-Wallis test, Chi-squared test, Fisher exact test, univariate, and multivariate logistic regression as appropriate. Cox proportional hazard regression model was used for survival analysis. Results: Seventy-five patients were included. The mean (SD) age at diagnosis was 70 (± 6) years. The mean (SD) follow-up duration was 5.17 (± 3.47) years. Remission induction therapy with glucocorticoids plus CYC was used in 25 patients, glucocorticoids plus CYC and RTX in 12 patients, and glucocorticoids plus RTX in 38 patients. RTX-treated patients had a higher baseline estimated glomerular filtration ratio (eGFR) (p = 0.00009). High remission rates were achieved in all groups (100% vs. 100% vs. 94.6% respectively, p = 0.368). The incidence of end-stage renal disease (ESRD) at one year was 8% among all groups (p = 0.999). There was no difference in the number of infections requiring hospitalization (p = 0.822), but a statistical difference in leukopenia was noted (32% vs. 25% vs. 3% respectively, p = 0.005). The use of RTX only was associated with reduced leukopenia (aOR = 0.1, 95% CI = 0.005-0.8) after adjusting for other variables. Conclusions: CYC, CYC + RTX, and RTX are equally effective for remission induction in elderly patients with ANCA-GN. Induction therapy with RTX only was associated with a lower risk of leukopenia compared to CYC-containing regimens. Infections requiring hospitalization were similar among all groups. End-stage kidney disease at one year was comparable among the 3 groups. Key Points • Cyclophosphamide, Rituximab, and Cyclophosphamide+Rituximab are equally effective in remission induction in elderly patients with ANCA glomerulonephritis. • The use of Rituximab only was associated with a lower risk of bone marrow suppression compared to Cyclophosphamide only. • More information is needed on the comparative safety of induction therapy strategies in elderly ANCA glomerulonephritis patients.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Rituximab/therapeutic use ; Glucocorticoids/therapeutic use ; Antibodies, Antineutrophil Cytoplasmic ; Retrospective Studies ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Cyclophosphamide ; Glomerulonephritis/drug therapy ; Kidney Failure, Chronic ; Remission Induction ; Treatment Outcome ; Immunosuppressive Agents
Chemical Substances	Rituximab (4F4X42SYQ6) ; Glucocorticoids ; Antibodies, Antineutrophil Cytoplasmic ; Cyclophosphamide (8N3DW7272P) ; Immunosuppressive Agents
Language	English
Publishing date	2023-05-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-023-06644-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1740: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Sensogenomics and the Biological Background Underlying Musical Stimuli: Perspectives for a New Era of Musical Research

Navarro, Laura / Martinón-Torres, Federico / Salas, Antonio

Genes. 2021 Sept. 21, v. 12, no. 9

2021

Abstract	What is the actual impact of music on the human being and the scope for scientific research in this realm? Compared to other areas, the study of the relationship between music and human biology has received limited attention. At the same time, evidence of music’s value in clinical science, neuroscience, and social science keeps increasing. This review article synthesizes the existing knowledge of genetics related to music. While the success of genomics has been demonstrated in medical research, with thousands of genes that cause inherited diseases or a predisposition to multifactorial disorders identified, much less attention has been paid to other human traits. We argue for the development of a new discipline, sensogenomics, aimed at investigating the impact of the sensorial input on gene expression and taking advantage of new, discovery-based ‘omic’ approaches that allow for the exploration of the whole transcriptome of individuals under controlled experiments and circumstances.
Keywords	biomedical research ; gene expression ; genomics ; humans ; music ; neurophysiology ; social sciences ; transcriptome
Language	English
Dates of publication	2021-0921
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12091454
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Timing of COVID-19 Vaccine in the Setting of Anti-CD20 Therapy: A Primer for Nephrologists.

Kant, Sam / Kronbichler, Andreas / Salas, Antonio / Bruchfeld, Annette / Geetha, Duvuru

Kidney international reports

2021 Volume 6, Issue 5, Page(s) 1197–1199

Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Editorial
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2021.03.876
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED