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  1. Article ; Online: Exposure to different occupational chemicals and clinical phenotype of a cohort of patients with systemic sclerosis.

    Freire, Mayka / Sopeña, Bernardo / González-Quintela, Arturo / Del Castillo, Alfredo Guillén / Moraga, Eduardo Callejas / Lledó-Ibañez, Gema M / Rubio-Rivas, Manuel / Trapiella, Luis / Argibay, Ana / Tolosa, Carles / Alfonso, Begoña Marí / Vargas-Hitos, Jose Antonio / Salas, Xavier Pla / González-Echávarri, Cristina / Chamorro, Antonio-J / Fraile, Isabel Perales / García, Andrés González / de la Red Bellvis, Gloria / Bello, David Bernal /
    Salomó, Antoni Castro / Jiménez Pérez de Heredia, Iratxe / Marín-Ballve, Adela / Rodríguez-Pintó, Ignasi / Saez-Comet, Luis / Ortego-Centeno, Norberto / Todolí-Parra, José Antonio / Fonollosa Pla, Vicent / Simeón-Aznar, Carmen Pilar

    Autoimmunity reviews

    2024  Volume 23, Issue 5, Page(s) 103542

    Language English
    Publishing date 2024-04-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2024.103542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author Correction: Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension.

    Guillén-Del-Castillo, Alfredo / Meseguer, Manuel López / Fonollosa-Pla, Vicent / Giménez, Berta Sáez / Colunga-Argüelles, Dolores / Revilla-López, Eva / Rubio-Rivas, Manuel / Ropero, Maria Jose Cristo / Argibay, Ana / Barberá, Joan Albert / Salas, Xavier Pla / Meñaca, Amaya Martínez / Vuelta, Ana Belén Madroñero / Padrón, Antonio Lara / Comet, Luis Sáez / Morera, Juan Antonio Domingo / González-Echávarri, Cristina / Mombiela, Teresa / Ortego-Centeno, Norberto /
    González, Manuela Marín / Tolosa-Vilella, Carles / Blanco, Isabel / Subías, Pilar Escribano / Simeón-Aznar, Carmen Pilar

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 12947

    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-17525-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension.

    Guillén-Del-Castillo, Alfredo / Meseguer, Manuel López / Fonollosa-Pla, Vicent / Giménez, Berta Sáez / Colunga-Argüelles, Dolores / Revilla-López, Eva / Rubio-Rivas, Manuel / Ropero, Maria Jose Cristo / Argibay, Ana / Barberá, Joan Albert / Salas, Xavier Pla / Meñaca, Amaya Martínez / Vuelta, Ana Belén Madroñero / Padrón, Antonio Lara / Comet, Luis Sáez / Morera, Juan Antonio Domingo / González-Echávarri, Cristina / Mombiela, Teresa / Ortego-Centeno, Norberto /
    González, Manuela Marín / Tolosa-Vilella, Carles / Blanco, Isabel / Subías, Pilar Escribano / Simeón-Aznar, Carmen Pilar

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5289

    Abstract: To assess severity markers and outcomes of patients with systemic sclerosis (SSc) with or without pulmonary arterial hypertension (PAH-SSc/non-PAH-SSc), and the impact of interstitial lung disease (ILD) on PAH-SSc. Non-PAH-SSc patients from the Spanish ... ...

    Abstract To assess severity markers and outcomes of patients with systemic sclerosis (SSc) with or without pulmonary arterial hypertension (PAH-SSc/non-PAH-SSc), and the impact of interstitial lung disease (ILD) on PAH-SSc. Non-PAH-SSc patients from the Spanish SSc registry and PAH-SSc patients from the Spanish PAH registry were included. A total of 364 PAH-SSc and 1589 non-PAH-SSc patients were included. PAH-SSc patients had worse NYHA-functional class (NYHA-FC), worse forced vital capacity (FVC) (81.2 ± 20.6% vs 93.6 ± 20.6%, P < 0.001), worse tricuspid annular plane systolic excursion (TAPSE) (17.4 ± 5.2 mm vs 19.9 ± 6.7 mm, P < 0.001), higher incidence of pericardial effusion (30% vs 5.2%, P < 0.001) and similar prevalence of ILD (41.8% vs. 44.9%). In individuals with PAH-SSc, ILD was associated with worse hemodynamics and pulmonary function tests (PFT). Up-front combination therapy was used in 59.8% and 61.7% of patients with and without ILD, respectively. Five-year transplant-free survival rate was 41.1% in PAH-SSc patients and 93.9% in non-PAH-SSc patients (P < 0.001). Global survival of PAH-SSc patients was not affected by ILD regardless its severity. The multivariate survival analysis in PAH-SSc patients confirmed age at diagnosis, worse NYHA-FC, increased PVR, reduced DLCO, and lower management with up-front combination therapy as major risk factors. In conclusion, in PAH-SSc cohort risk of death was greatly increased by clinical, PFT, and hemodynamic factors, whereas it was decreased by up-front combination therapy. Concomitant ILD worsened hemodynamics and PFT in PAH-SSc but not survival regardless of FVC impairment.
    MeSH term(s) Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary ; Lung Diseases, Interstitial/etiology ; Pulmonary Arterial Hypertension ; Scleroderma, Systemic/drug therapy
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-09353-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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