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  1. Article ; Online: FoxR is an AraC-like transcriptional regulator of ferrioxamine uptake in Salmonella enterica.

    Saldaña-Ahuactzi, Zeus / Knodler, Leigh A

    Molecular microbiology

    2022  Volume 118, Issue 4, Page(s) 369–386

    Abstract: Salmonella enterica spp. produce siderophores to bind iron with high affinity and can also use three xenosiderophores secreted by other microorganisms, ferrichrome, coprogen, and ferrioxamine. Here we focused on FoxA, a TonB-dependent transporter of ... ...

    Abstract Salmonella enterica spp. produce siderophores to bind iron with high affinity and can also use three xenosiderophores secreted by other microorganisms, ferrichrome, coprogen, and ferrioxamine. Here we focused on FoxA, a TonB-dependent transporter of ferrioxamines. Adjacent to foxA is a gene annotated as a helix-turn-helix (HTH) domain-containing protein, SL0358 (foxR), in the Salmonella enterica serovar Typhimurium SL1344 genome. FoxR shares homology with transcriptional regulators belonging to the AraC/XylS family. foxR is syntenic with foxA in the Enterobacteriaceae family, suggesting their functional relatedness. Both foxA and foxR are repressed by the ferric uptake regulator (Fur) under iron-rich growth conditions. When iron is scarce, FoxR acts as a transcriptional activator of foxA by directly binding to its upstream regulatory region. A point mutation in the HTH domain of FoxR abolished this binding, as did mutation of a direct repeat motif in the foxA upstream regulatory region. Desferrioxamine (DFOE) enhanced FoxR protein stability and foxA transcription but did not affect the affinity of FoxR binding to the foxA regulatory region. In summary, we have identified FoxR as a new member of the AraC/XylS family that regulates xenosiderophore-mediated iron uptake by S. Typhimurium and likely other Enterobacteriaceae members.
    MeSH term(s) Deferoxamine/chemistry ; Deferoxamine/metabolism ; Siderophores/genetics ; Siderophores/metabolism ; Ferrichrome/metabolism ; Salmonella enterica/genetics ; Salmonella enterica/metabolism ; Cytarabine ; Bacterial Outer Membrane Proteins/metabolism ; Iron/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial/genetics
    Chemical Substances ferrioxamine B (4A0UG9NR9K) ; Deferoxamine (J06Y7MXW4D) ; Siderophores ; Ferrichrome (15630-64-5) ; Cytarabine (04079A1RDZ) ; Bacterial Outer Membrane Proteins ; Iron (E1UOL152H7) ; Transcription Factors ; Bacterial Proteins
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.14970
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2502: Show issues Location:
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  2. Article ; Online: The Assembly of Flagella in Enteropathogenic

    Soria-Bustos, Jorge / Saldaña-Ahuactzi, Zeus / Samadder, Partha / Yañez-Santos, Jorge A / Laguna, Ygnacio Martínez / Cedillo-Ramírez, María L / Girón, Jorge A

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: ... In ... ...

    Abstract In enteropathogenic
    MeSH term(s) Humans ; Enteropathogenic Escherichia coli/genetics ; Enteropathogenic Escherichia coli/metabolism ; Type III Secretion Systems/genetics ; Type III Secretion Systems/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; HeLa Cells ; Gene Expression Regulation, Bacterial ; Flagella/genetics ; Flagella/metabolism
    Chemical Substances Type III Secretion Systems ; Escherichia coli Proteins ; QseB protein, E coli
    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232213705
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  3. Article: Recombinant

    Espinosa-Mazariego, Karina / Saldaña-Ahuactzi, Zeus / Ochoa, Sara A / González-Pedrajo, Bertha / Cevallos, Miguel A / Rodríguez-Martínez, Ricardo / Romo-Castillo, Mariana / Hernández-Castro, Rigoberto / Cruz-Córdova, Ariadnna / Xicohtencatl-Cortes, Juan

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: The CS21 pilus produced by enterotoxigenic : Aim: This study aimed to determine whether : Methods: A kanamycin cassette was used to replace the : Results: Bioinformatic alignment analysis of the LngA proteins showed hypervariable regions and ... ...

    Abstract The CS21 pilus produced by enterotoxigenic
    Aim: This study aimed to determine whether
    Methods: A kanamycin cassette was used to replace the
    Results: Bioinformatic alignment analysis of the LngA proteins showed hypervariable regions and clustered the clinical ETEC strains into three groups. Variations in amino acid residues affect the adherence percentages of recombinant ECBL strains with
    Conclusion: In this study, ECBL carrying the
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12020337
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  4. Article ; Online: The EcpD Tip Adhesin of the

    Mondal, Rajesh / Saldaña-Ahuactzi, Zeus / Soria-Bustos, Jorge / Schultz, Andrew / Yañez-Santos, Jorge A / Laguna, Ygnacio Martínez / Cedillo-Ramírez, María L / Girón, Jorge A

    International journal of molecular sciences

    2022  Volume 23, Issue 18

    Abstract: The attachment of ... ...

    Abstract The attachment of enteropathogenic
    MeSH term(s) Adhesins, Escherichia coli/genetics ; Adhesins, Escherichia coli/metabolism ; Bacterial Adhesion ; Enteropathogenic Escherichia coli/metabolism ; Escherichia coli Infections/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Fibronectins/metabolism ; Fimbriae Proteins/genetics ; Fimbriae Proteins/metabolism ; Fimbriae, Bacterial/metabolism ; Humans ; Laminin/metabolism ; Mucins/metabolism
    Chemical Substances Adhesins, Escherichia coli ; Escherichia coli Proteins ; Extracellular Matrix Proteins ; Fibronectins ; Laminin ; Mucins ; Fimbriae Proteins (147680-16-8)
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231810350
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  5. Article: The Transcription of Flagella of Enteropathogenic

    Avelino-Flores, Fabiola / Soria-Bustos, Jorge / Saldaña-Ahuactzi, Zeus / Martínez-Laguna, Ygnacio / Yañez-Santos, Jorge A / Cedillo-Ramírez, María L / Girón, Jorge A

    Microorganisms

    2022  Volume 10, Issue 4

    Abstract: The flagella of ... ...

    Abstract The flagella of enteropathogenic
    Language English
    Publishing date 2022-04-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10040792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Fis Nucleoid Protein Negatively Regulates the Phase Variation

    Saldaña-Ahuactzi, Zeus / Soria-Bustos, Jorge / Martínez-Santos, Verónica I / Yañez-Santos, Jorge A / Martínez-Laguna, Ygnacio / Cedillo-Ramirez, María Lilia / Puente, José L / Girón, Jorge A

    Frontiers in microbiology

    2022  Volume 13, Page(s) 882563

    Abstract: ... ...

    Abstract In
    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.882563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Isolation and Identification of Two Brucella Species from a Volcanic Lake in Mexico.

    Ramos-Ramírez, Lesset Del Consuelo / Saldaña-Ahuactzi, Zeus / Morales-Lara, Laura / Martínez-Laguna, Ygnacio / Castañeda-Roldán, Elsa Iracena

    Current microbiology

    2020  Volume 77, Issue 11, Page(s) 3565–3572

    Abstract: Brucellosis is a zoonosis caused by bacteria of the Brucella genus. Any source of contamination that could be infectious must be monitored to reduce the risk of exposure to brucellosis, so the purpose of this work was to determine the presence of ... ...

    Abstract Brucellosis is a zoonosis caused by bacteria of the Brucella genus. Any source of contamination that could be infectious must be monitored to reduce the risk of exposure to brucellosis, so the purpose of this work was to determine the presence of Brucella spp. on surface water and tilapia (Oreochromis niloticus) skin from a volcanic lake in Mexico. A seasonal sampling during 2016-2017 was carried out at fifteen specific sites for water sampling and five sites for the collection of tilapia fish. From all water and fish samples tested, we found only three isolates of Brucella species. We isolated and identified B. abortus from surface water through bacteriological and molecular techniques, and B. abortus and B. suis from the same tilapia skin sample. The isolated strains likely came from breeding animals that are common to the region, such as infected pigs or cattle with Brucella abortus or B. suis, respectively. A similar finding has not been reported in a water from volcanic lake or tilapia fish in Mexico. We concluded that B. abortus and B. suis are present on the surface water of the volcanic lake and tilapia skin as possible contaminants derived from biological material from cows and pigs carrying this bacterium.
    MeSH term(s) Animals ; Brucella abortus ; Brucellosis/veterinary ; Cattle ; Female ; Lakes ; Mexico ; Swine
    Language English
    Publishing date 2020-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-020-02184-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1446: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Isolation and Identification of Two Brucella Species from a Volcanic Lake in Mexico

    Ramos-Ramírez, Lesset Del Consuelo / Saldaña-Ahuactzi, Zeus / Morales-Lara, Laura / Martínez-Laguna, Ygnacio / Castañeda-Roldán, Elsa Iracena

    Current microbiology. 2020 Nov., v. 77, no. 11

    2020  

    Abstract: Brucellosis is a zoonosis caused by bacteria of the Brucella genus. Any source of contamination that could be infectious must be monitored to reduce the risk of exposure to brucellosis, so the purpose of this work was to determine the presence of ... ...

    Abstract Brucellosis is a zoonosis caused by bacteria of the Brucella genus. Any source of contamination that could be infectious must be monitored to reduce the risk of exposure to brucellosis, so the purpose of this work was to determine the presence of Brucella spp. on surface water and tilapia (Oreochromis niloticus) skin from a volcanic lake in Mexico. A seasonal sampling during 2016–2017 was carried out at fifteen specific sites for water sampling and five sites for the collection of tilapia fish. From all water and fish samples tested, we found only three isolates of Brucella species. We isolated and identified B. abortus from surface water through bacteriological and molecular techniques, and B. abortus and B. suis from the same tilapia skin sample. The isolated strains likely came from breeding animals that are common to the region, such as infected pigs or cattle with Brucella abortus or B. suis, respectively. A similar finding has not been reported in a water from volcanic lake or tilapia fish in Mexico. We concluded that B. abortus and B. suis are present on the surface water of the volcanic lake and tilapia skin as possible contaminants derived from biological material from cows and pigs carrying this bacterium.
    Keywords Brucella melitensis biovar Abortus ; Oreochromis niloticus ; bacteria ; brucellosis ; fish ; lakes ; risk reduction ; surface water ; zoonoses ; Mexico
    Language English
    Dates of publication 2020-11
    Size p. 3565-3572.
    Publishing place Springer US
    Document type Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-020-02184-z
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    In stock of ZB MED Bonn / Germany

    Z 80/708: Show issues

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  9. Article ; Online: Clinical Characteristics of Coronavirus Disease (COVID-19) in Mexican Children and Adolescents.

    Flores-Alanis, Alejandro / Saldaña-Ahuactzi, Zeus / Parra-Ortega, Israel / López-Ramírez, Pablo / Salazar-García, Marcela / Alemán-García, Yolanda P / Cruz-Rangel, Armando / Moreno-Paredes, Alba / Diaz-Rojas, Adrián / Maldonado-Bernal, Carmen / Quevedo-Moran, Jessica / Luna-Pineda, Victor M

    Viruses

    2022  Volume 14, Issue 10

    Abstract: Background: We analyzed the demographic, clinical, and diagnostic data of children and adolescents in Mexico, from the first case of coronavirus disease (COVID-19) to 28 February 2022.: Methods: Using the open databases of the Ministry of Health and ... ...

    Abstract Background: We analyzed the demographic, clinical, and diagnostic data of children and adolescents in Mexico, from the first case of coronavirus disease (COVID-19) to 28 February 2022.
    Methods: Using the open databases of the Ministry of Health and a tertiary pediatric hospital, we obtained demographic and clinical data from the beginning of the COVID-19 pandemic until 28 February 2022. In addition, quantitative reverse-transcription polymerase chain reaction outputs were used to determine the viral load, and structural protein-based serology was performed to evaluate IgG antibody levels.
    Results: Of the total 437,832 children and adolescents with COVID-19, 1187 died. Of these patients, 1349 were admitted to the Hospital Infantil de Mexico Federico Gómez, and 11 died. Obesity, asthma, and immunosuppression were the main comorbidities, and fever, cough, and headache were the main symptoms. In this population, many patients have a low viral load and IgG antibody levels.
    Conclusion: During the first 2 years of the COVID-19 pandemic in Mexico, children and adolescents had low incidence and mortality. They are a heterogeneous population, but many patients had comorbidities such as obesity, asthma, and immunosuppression; symptoms such as fever, cough, and headache; and low viral load and IgG antibodies.
    MeSH term(s) Humans ; Adolescent ; Child ; Pandemics ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cough ; Mexico/epidemiology ; SARS-CoV-2 ; Immunoglobulin G ; Fever ; Headache ; Obesity ; Asthma/epidemiology
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14102162
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  10. Article ; Online: Intracellular niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica.

    Powers, TuShun R / Haeberle, Amanda L / Predeus, Alexander V / Hammarlöf, Disa L / Cundiff, Jennifer A / Saldaña-Ahuactzi, Zeus / Hokamp, Karsten / Hinton, Jay C D / Knodler, Leigh A

    PLoS pathogens

    2021  Volume 17, Issue 8, Page(s) e1009280

    Abstract: Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium colonizes epithelial cells lining the gastrointestinal tract. S. Typhimurium has an ... ...

    Abstract Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that causes diarrheal disease in humans and animals. During salmonellosis, S. Typhimurium colonizes epithelial cells lining the gastrointestinal tract. S. Typhimurium has an unusual lifestyle in epithelial cells that begins within an endocytic-derived Salmonella-containing vacuole (SCV), followed by escape into the cytosol, epithelial cell lysis and bacterial release. The cytosol is a more permissive environment than the SCV and supports rapid bacterial growth. The physicochemical conditions encountered by S. Typhimurium within the epithelial cytosol, and the bacterial genes required for cytosolic colonization, remain largely unknown. Here we have exploited the parallel colonization strategies of S. Typhimurium in epithelial cells to decipher the two niche-specific bacterial virulence programs. By combining a population-based RNA-seq approach with single-cell microscopic analysis, we identified bacterial genes with cytosol-induced or vacuole-induced expression signatures. Using these genes as environmental biosensors, we defined that Salmonella is exposed to oxidative stress and iron and manganese deprivation in the cytosol and zinc and magnesium deprivation in the SCV. Furthermore, iron availability was critical for optimal S. Typhimurium replication in the cytosol, as well as entC, fepB, soxS, mntH and sitA. Virulence genes that are typically associated with extracellular bacteria, namely Salmonella pathogenicity island 1 (SPI1) and SPI4, showed increased expression in the cytosol compared to vacuole. Our study reveals that the cytosolic and vacuolar S. Typhimurium virulence gene programs are unique to, and tailored for, residence within distinct intracellular compartments. This archetypical vacuole-adapted pathogen therefore requires extensive transcriptional reprogramming to successfully colonize the mammalian cytosol.
    MeSH term(s) Adaptation, Physiological ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cytosol/metabolism ; Cytosol/microbiology ; Gene Expression Regulation, Bacterial ; Genomic Islands ; HeLa Cells ; Humans ; RNA-Seq ; Salmonella Infections/metabolism ; Salmonella Infections/microbiology ; Salmonella enterica/physiology ; Virulence
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2021-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1009280
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