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Article ; Online: Role of oxidative stress in angiogenesis and the therapeutic potential of antioxidants in breast cancer.

Mdkhana, B / Goel, S / Saleh, M A / Siddiqui, R / Khan, N A / Elmoselhi, A B

European review for medical and pharmacological sciences

2022 Volume 26, Issue 13, Page(s) 4677–4692

Abstract: The escalation of cancer cases globally, especially breast cancer, is of concern. Angiogenesis is hallmark of cancer pathogenesis and plays an important role in cancer progression and metastasis. Pro-angiogenic agents, secreted by tumor cells, form new ... ...

Abstract	The escalation of cancer cases globally, especially breast cancer, is of concern. Angiogenesis is hallmark of cancer pathogenesis and plays an important role in cancer progression and metastasis. Pro-angiogenic agents, secreted by tumor cells, form new blood vessels, and produce reactive oxygen species (ROS). ROS promote angiogenesis via two major pathways: namely Vascular Endothelial Growth Factor (VEGF) dependent and non-VEGF dependent pathways. As a consequence of unbalanced ROS overproduction and low antioxidants levels, oxidative stress occurs and promotes angiogenesis in breast cancer tissues. Thus, the potential use of antioxidants as a preventive therapy in breast cancer. Preclinical studies depict that vitamins A and E may counter oxidative stress resulting in reduction of metastasis and viability of breast cancer. Furthermore, clinical studies demonstrate a decline in breast cancer risk in postmenopausal women upon the consumption of antioxidants. Herein, we discuss various pro-angiogenic agents that may play an important role in breast cancer angiogenesis. Moreover, the contribution of oxidative stress in inducing the angiogenic process is extensively reviewed here. Furthermore, the findings of pre-clinical and clinical studies on the use of antioxidants, namely vitamins A and E, in breast cancer are deliberated upon, along with the role of angiogenesis in cancer therapy.
MeSH term(s)	Antioxidants/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Breast Neoplasms/pathology ; Female ; Humans ; Neovascularization, Pathologic/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factors/metabolism ; Vitamins/therapeutic use
Chemical Substances	Antioxidants ; Reactive Oxygen Species ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Vitamins
Language	English
Publishing date	2022-07-20
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202207_29192
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Article ; Online: Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Gülave, Berfin / Budda, Divakar / Saleh, M A A / van Hasselt, J G C / de Lange, E C M

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2023 Volume 187, Page(s) 106482

Abstract: Morphine blood-brain barrier (BBB) transport is governed by passive diffusion, active efflux and saturable active influx. This may result in nonlinear plasma concentration-dependent brain extracellular fluid ( ... ...

Abstract	Morphine blood-brain barrier (BBB) transport is governed by passive diffusion, active efflux and saturable active influx. This may result in nonlinear plasma concentration-dependent brain extracellular fluid (brain
MeSH term(s)	Humans ; Morphine/pharmacokinetics ; Blood-Brain Barrier ; Brain/metabolism ; Biological Transport ; Computer Simulation
Chemical Substances	Morphine (76I7G6D29C)
Language	English
Publishing date	2023-05-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2023.106482
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Article: Investigation of potential environmental radiation risks associated with artisanal gold mining in Zamfara State, Nigeria

Garba, N. N / Odoh, C. M / Nasiru, R / Saleh, M. A

Environmental earth sciences. 2021 Feb., v. 80, no. 3

2021

Abstract: A total number of 166 average measurements were taken using a handheld radiation meter. The mean terrestrial gamma radiation dose rate (TRD) was 32 nGy h⁻¹ which is less than the world average value of 59 nGy h⁻¹. Kaura Namoda has the highest TRD with a ... ...

Abstract	A total number of 166 average measurements were taken using a handheld radiation meter. The mean terrestrial gamma radiation dose rate (TRD) was 32 nGy h⁻¹ which is less than the world average value of 59 nGy h⁻¹. Kaura Namoda has the highest TRD with a value of 38 nGy h⁻¹, while Bakura has the lowest TRD with a value of 28 nGy h⁻¹. The mean activity concentrations of ²²⁶Ra, ²³²Th and ⁴⁰ K in soil samples were measured using HPGe and were found to be 18 ± 2 Bq kg⁻¹, 22 ± 3 Bq kg⁻¹ and 251 ± 7 Bq kg⁻¹, respectively. Highest activities of ²²⁶Ra, ²³²Th and ⁴⁰ K were all found to be in Zurmi local government area with respective values of 31 ± 3 Bq kg⁻¹, 34 ± 3 Bq kg⁻¹ and 419 ± 10 Bq kg⁻¹. The radiological hazards indices associated with the measured activity concentrations were determined as 69 Bq kg⁻¹, 0.2, 0.24, 32 nGyh⁻¹ and 0.05 mSvy⁻¹ for radium equivalent (Raₑq), external hazard index (Hₑₓ), absorbed dose rate (DR) and annual effective dose (AED), respectively. It can be concluded that despite the illegal mining activities within the area, the radiation exposure level in the area is normal and will not pose any immediate radiation effect to humans and their environs.
Keywords	gamma radiation ; gold ; local government ; radium ; soil ; traditional technology ; Nigeria
Language	English
Dates of publication	2021-02
Size	p. 76.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-021-09367-2
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Article: Molecular characterization of Alfalfa mosaic virus (AMV) isolates in alfalfa and other plant species in different regions in Saudi Arabia

Abdalla, O. A / AL-Saleh, M. A / AL-Shahwan, I. M / Amer, M. A

European journal of plant pathology. 2020 Feb., v. 156, no. 2

2020

Abstract: In a survey conducted in 2012 and 2013, 1166 samples from alfalfa plants and 202 samples from symptomatic weeds and cultivated plants growing adjacent to alfalfa fields were collected. Using DAS-ELISA, Alfalfa mosaic virus (AMV) was detected in 58.4% of ... ...

Abstract	In a survey conducted in 2012 and 2013, 1166 samples from alfalfa plants and 202 samples from symptomatic weeds and cultivated plants growing adjacent to alfalfa fields were collected. Using DAS-ELISA, Alfalfa mosaic virus (AMV) was detected in 58.4% of the alfalfa samples and in 63.9% of the weeds and cultivated plants samples. ELISA detection of AMV was confirmed by testing representative samples from all regions by RT-PCR using a pair of primers (AMV/F and AMV/R) specific to the AMV coat protein (CP) gene. The size of the major product obtained from AMV-infected plants was identical to the 700 bp size expected from the CP gene of AMV. The amino acids and the nucleotide sequences of 17 Saudi AMV isolates from alfalfa, and 16 from other cultivated plants and weeds detected in different regions in Saudi Arabia showed a percentage of similarity that ranged between 87.9%–100% among them and 86.2% - 100% when compared with sequences of 15 different AMV isolates reported in the GenBank. This is the first time AMV was detected in Vigna unguiculata and in the following weed plant species: Chenopodium quinoa, Convolvulus arvensis, Malva parviflora, Hibiscus spp., Hippuris vulgaris, Cichorium intybus, and Flaveria trinervia in Saudi Arabia.
Keywords	alfalfa ; Alfalfa mosaic virus ; amino acids ; coat proteins ; enzyme-linked immunosorbent assay ; genes ; Medicago sativa ; nucleotide sequences ; plant diseases and disorders ; plant viruses ; reverse transcriptase polymerase chain reaction ; surveys ; weeds ; Saudi Arabia
Language	English
Dates of publication	2020-02
Size	p. 603-613.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1196520-4
ISSN	0929-1873
ISSN	0929-1873
DOI	10.1007/s10658-019-01910-z
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Article: The geogenic influence on 220Rn activity concentration in soil gas of Johor state, Malaysia

Haruna, R / Saleh, M. A / Hashim, S / Hamzah, K / Zainal, J / Rusli, N / Sanusi, M. S. M

Environmental earth sciences. 2021 Mar., v. 80, no. 5

2021

Abstract: The contribution of thoron (²²⁰Rn) to natural radiation exposure is commonly neglected. However, dry porous surfaces with relatively high ²³²Th content can pose a thoron radiation hazard to the environment. Therefore, this research aims at establishing a ...

Abstract	The contribution of thoron (²²⁰Rn) to natural radiation exposure is commonly neglected. However, dry porous surfaces with relatively high ²³²Th content can pose a thoron radiation hazard to the environment. Therefore, this research aims at establishing a baseline data for ²²⁰Rn activity concentration in soil gas and categorise the measured data based on the geology of Johor state, Malaysia. The activity concentration of ²²⁰Rn in soil gas was measured using RAD7 alpha detector. The measured ²²⁰Rn activity concentration data varied from MDA to 159.07 ± 3.40 Bq/L. Kruskal–Wallis test on the ²²⁰Rn concentration data among the geological formations and soil types reveals a statistically significant result, p = 0.006 and p = 0.005, respectively. An isoconcentration map of ²²⁰Rn in soil gas is created. The map indicates higher concentration values generally characterised the Districts of Muar and Ledang.
Keywords	geology ; radon ; soil air ; Malaysia
Language	English
Dates of publication	2021-03
Size	p. 178.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-021-09413-z
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Article ; Online: Effects of lifestyle physical activity and sedentary behaviour interventions on disease activity and patient- and clinician- important health outcomes in rheumatoid arthritis: a systematic review with meta-analysis.

Brady, Sophia M / Veldhuijzen van Zanten, Jet J C S / Dinas, Petros C / Nightingale, Tom E / Metsios, George S / Elmsmari, Saleh M A / Duda, Joan L / Kitas, George D / Fenton, Sally A M

BMC rheumatology

2023 Volume 7, Issue 1, Page(s) 27

Abstract: Background: Lifestyle physical activity (PA) is defined as any type of PA undertaken as part of daily life. It can include engagement in activities of daily living (i.e., household chores, gardening, walking to work), incidental PA, walking and/or ... ...

Abstract	Background: Lifestyle physical activity (PA) is defined as any type of PA undertaken as part of daily life. It can include engagement in activities of daily living (i.e., household chores, gardening, walking to work), incidental PA, walking and/or reducing sedentary or sitting behaviours (SB). Regular PA is recommended for people with Rheumatoid Arthritis (RA) to reduce disease activity and systemic inflammation, as well as to improve patient- and clinician-important health outcomes. However, there is no summarised evidence of the effectiveness of interventions specifically targeting lifestyle PA and SB in this population. The aims of this systematic review with meta-analysis were to evaluate interventions targeting lifestyle PA and/or SB on 1) disease activity; 2) PA, SB and 3) patient- and clinician-important outcomes in people with RA. Methods: Eight databases [Medline, Cochrane Library CENTRAL, Web of Science, PsychINFO, Cumulative Index to Nursing & Allied Health Literature, Scopus, Excerpta Medica database and Physiotherapy Evidence Database] were searched from inception-August 2022. Inclusion criteria required interventions to target lifestyle PA and/or SB, conducted in adults with RA, assessing patient- and/or clinician-important outcomes. Results: Of 880 relevant articles, 16 interventions met the inclusion criteria. Meta-analyses showed statistically significant effects of interventions on disease activity (standardised mean difference = -0.12 (95% confidence interval = -0.23 to -0.01, I Conclusions: Lifestyle PA interventions led to increased PA, reductions in SB and improvements in disease activity and other patient- and/or clinician-important health outcomes in people with RA. Future interventions should be less heterogenous in content, structure, focus and outcome measures used to aid understanding of the most effective intervention components for improving health. More SB interventions are needed to determine their effectiveness at producing clinical benefits.
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2918121-5
ISSN	2520-1026 ; 2520-1026
ISSN (online)	2520-1026
ISSN	2520-1026
DOI	10.1186/s41927-023-00352-9
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Article: Minimal genomic variability in Merremia mosaic virus isolates endemic in Merremia spp and cultivated tomato in Puerto Rico

Idris, Ali M / Al-Saleh, M. A / M Zakri, A / Brown, J. K

Virusdisease. 2019 Mar., v. 30, no. 1

2019

Abstract: Merremia mosaic virus (MerMV), a bipartite begomovirus, was identified for the first time as a pathogen of commercial tomato plantings. Infection of tomato by MerMV caused mild leaf curling and yellow foliar mosaic symptoms. Herein, the MerMV was ... ...

Abstract	Merremia mosaic virus (MerMV), a bipartite begomovirus, was identified for the first time as a pathogen of commercial tomato plantings. Infection of tomato by MerMV caused mild leaf curling and yellow foliar mosaic symptoms. Herein, the MerMV was identified in symptomatic Merremia quinquefolia and M. aegyptia (Convolvulaceae) plants exhibiting bright yellow or yellow-green foliar mosaic symptoms, respectively. The full-length begomoviral components were amplified from total DNA isolated from two wild species of Merremia and commercial tomato plants during 1991–1998. The DNA was subjected to rolling circle amplification, restriction digestion, and DNA sequencing. The resultant 19 and 26 apparently full-length DNA-A and DNA-B components were ~ 2557 and ~ 2492 bases, respectively. The 140-base common region was 97.9% identical between DNA-A and -B components, a predictive evidence for cognate DNA-A and -B components. Although the DNA-A components were highly conserved at 96–100%, the DNA-B components diverged at ~ 89 to 100%, respectively. The overall clonal genomic features strongly suggested that MerMV lineage has been under host-selection for some time, and only recently, has undergone a host-shift, putatively, from wild convolvulaceous species to tomato (Solanaceae). Phylogenetically, MerMV grouped with other bipartite begomoviruses indigenous to the Caribbean region, with MerMV DNA-A components forming three clusters, and the DNA-B components grouped in one clade. Both clades contained only one closet relative, an isolate of MerMV from Venezuela, MerMV-VE. Biolistic inoculation of M. quinquefolia and tomato seedlings with the DNA-A and -B components of PR68 and PR80 resulted in development of symptoms like those observed in naturally-infected species, respectively.
Keywords	DNA ; Merremia mosaic virus ; Merremia quinquefolia ; Solanaceae ; biolistics ; genetic variation ; genomics ; leaf curling ; pathogens ; phylogeny ; seedlings ; sequence analysis ; tomatoes ; Caribbean ; Puerto Rico ; Venezuela
Language	English
Dates of publication	2019-03
Size	p. 84-94.
Publishing place	Springer India
Document type	Article
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-017-0412-6
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Article: Management of Maxillofacial Gunshot Injuries With Emphasis on Damage Control Surgery During the Yemen Civil War. Review of 173 Victims From a Level 1 Trauma Hospital in Najran, Kingdom of Saudi Arabia.

Daniels, John S / Albakry, Ibrahim / Braimah, Ramat O / Samara, Mohammed I / Albalasi, Rabea A / Al-Rayshan, Saleh M A

Craniomaxillofacial trauma & reconstruction

2021 Volume 15, Issue 1, Page(s) 58–65

Abstract: Study design: Studies on the concept of Damage Control Surgery (DCS) in the management of firearm injuries to the oral and maxillofacial region are still scarce, hence the basis for the current study.: Objectives: The objectives of the current study ... ...

Abstract	Study design: Studies on the concept of Damage Control Surgery (DCS) in the management of firearm injuries to the oral and maxillofacial region are still scarce, hence the basis for the current study. Objectives: The objectives of the current study is to share our experience in the management of maxillofacial gunshot injuries with emphasis on DCS and early definitive surgery. Methods: This was a retrospective study of combatant Yemeni patients with maxillofacial injuries who were transferred across the border from Yemen to Najran, Kingdom of Saudi Arabia. Demographics and etiology of injuries were stored. Paths of entry and exit of the projectiles were also noted. Also recorded were types of gunshot injury and treatment protocols adopted. Data was stored and analyzed using IBM SPSS Statistics for Windows Version 25 (Armonk, NY: IBM Corp). Results: A total of 408 victims, all males, were seen during the study period with 173 (42.4%) males sustaining gunshot injuries to the maxillofacial region. Their ages ranged from 21 to 56 years with mean ± SD (27.5 ± 7.6) years. One hundred and twenty-one (70.0%) victims had extraoral bullet entry, while 53 (30.0%) victims had intraoral entry route. Ocular injuries, consisting of 25 (14.5%) cases of ruptured globe and 6 (3.5%) cases of corneal injuries, were the most commonly associated injuries. A total of 78 (45.1%) hemodynamically unstable victims had DCS as the adopted treatment protocol while early definitive surgery was carried out in 47(27.2%) hemodynamically stable victims. ORIF was the treatment modality used for the fractures in 132 (76.3%) of the victims. Conclusions: We observed that 42.4% of the war victims sustained gunshot injuries. DCS with ORIF was the main treatment protocol adopted in the management of the hemodynamically unstable patients.
Language	English
Publishing date	2021-04-30
Publishing country	United States
Document type	Journal Article
ISSN	1943-3875
ISSN	1943-3875
DOI	10.1177/19433875211012211
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Article: Minimal genomic variability in Merremia mosaic virus isolates endemic in

Idris, Ali M / Al-Saleh, M A / M Zakri, A / Brown, J K

Virusdisease

2018 Volume 30, Issue 1, Page(s) 84–94

Abstract	Merremia mosaic virus (MerMV), a bipartite begomovirus, was identified for the first time as a pathogen of commercial tomato plantings. Infection of tomato by MerMV caused mild leaf curling and yellow foliar mosaic symptoms. Herein, the MerMV was identified in symptomatic
Language	English
Publishing date	2018-02-23
Publishing country	India
Document type	Journal Article
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-017-0412-6
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Article ; Online: Evaluation of exposure of pemphigus vulgaris patients to Mycobacterium tuberculosis and Aspergillus fumigatus.

Ali, R A / Elsherif, R H / Saleh, M A / Ismail, M H

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2016 Volume 35, Issue 11, Page(s) 1749–1752

Abstract: The purpose of this study was to screen pemphigus vulgaris (PV) (autoimmune bullous skin disease) for the presence of immunoglobulin G against Mycobacterium tuberculosis and Aspergillus fumigatus. The sera of 60 PV patients and 28 controls were screened ... ...

Abstract	The purpose of this study was to screen pemphigus vulgaris (PV) (autoimmune bullous skin disease) for the presence of immunoglobulin G against Mycobacterium tuberculosis and Aspergillus fumigatus. The sera of 60 PV patients and 28 controls were screened for the presence of immunoglobulin G against M. tuberculosis and A. fumigatus by enzyme-linked immune-sorbent assay. Forty patients were females and 20 were males. The range of IgG against M. tuberculosis was from 0.9 to 152.6 (median = 2.95) in the patients and was from 0 to 2.2 (median = 1.6) in the controls. Seven (11.7 %) patients and none of the controls exceeded the cut-off value. Four patients were on systemic steroids and azathioprine and three did not receive treatment before. The results showed that PV patients had significantly more IgG against M. tuberculosis than the controls; the p value was 0.006. The range of IgG against A. fumigatus was from 1.3 to 76.3 (median = 4.9) in the patients and was from 1 to 105.3 (median = 5.25) in the controls. Six (10 %) patients and eight (28.6 %) controls exceeded the cut-off value. The six patients were on systemic steroids and azathioprine. No significant difference was detected between PV patients and controls regarding exposure to A. fumigatus; the p value was 0.308. PV patients showed significantly more exposure to the M. tuberculosis than the controls. This suggests that M. tuberculosis may contribute to the pathogenesis of PV.
MeSH term(s)	Adult ; Aged ; Antibodies, Bacterial/blood ; Antibodies, Fungal/blood ; Aspergillosis/complications ; Aspergillosis/immunology ; Aspergillus fumigatus/immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Mycobacterium tuberculosis/immunology ; Pemphigus/etiology ; Pemphigus/pathology ; Tuberculosis/complications ; Tuberculosis/immunology ; Young Adult
Chemical Substances	Antibodies, Bacterial ; Antibodies, Fungal ; Immunoglobulin G
Language	English
Publishing date	2016-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-016-2721-x
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