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  1. Book ; Audio / Video ; Thesis: Bioactivation of dermal scaffolds using Pancreatic Stem Cells (PSCs) for wound healing

    Salem, Haitham

    2007  

    Author's details vorgelegt von Haitham Salem
    Language English
    Size 1 CD-ROM, 12 cm
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Lübeck, Univ., Diss., 2007
    HBZ-ID HT015932164
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Apathy as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Texas Alzheimer's Research and Care Consortium (TARCC) Cohort-Based Analysis.

    Salem, Haitham / Suchting, Robert / Gonzales, Mitzi M / Seshadri, Sudha / Teixeira, Antonio L

    Journal of Alzheimer's disease : JAD

    2023  Volume 92, Issue 1, Page(s) 129–139

    Abstract: Background: Apathy is among the neuropsychiatric symptoms frequently observed in people with cognitive impairment. It has been postulated to be a potential predictor of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD).: ... ...

    Abstract Background: Apathy is among the neuropsychiatric symptoms frequently observed in people with cognitive impairment. It has been postulated to be a potential predictor of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD).
    Objective: To detect conversion rates from MCI to AD, and to determine the effect of apathy on the progression to AD in patients with MCI enrolled in the Texas Alzheimer's Research and Care Consortium (TARCC) cohort.
    Methods: Apathy was determined by a positive response to the respective item in the Neuropsychiatric Inventory -Questionnaire (NPI-Q) completed by family members or caregivers. The final dataset included 2,897 observations from 1,092 individuals with MCI at the baseline. Kaplan-Meier survival curves were estimated to provide indices of the probability of conversion to AD over time across all individuals as well as between those with and without apathy. Cox proportional hazards regression measured the hazard associated with apathy and several other predictors of interest.
    Results: Over a period of 8.21 years, 17.3% of individuals had conversion from MCI to AD (n = 190 of 1,092 total individuals) across observations. The median time-to-conversion across all participants was 6.41 years. Comparing individuals with apathy (n = 158) versus without apathy (n = 934), 36.1% and 14.2% had conversion to AD, respectively. The median time-to-conversion was 3.79 years for individuals with apathy and 6.83 years for individuals without apathy. Cox proportional hazards regression found significant effects of several predictors, including apathy, on time-to-conversion. Age and cognitive performance were found to moderate the relationship between apathy and time-to-conversion.
    Conclusions: Apathy is associated with progression from MCI to AD, suggesting that it might improve risk prediction and aid targeted intervention delivery.
    MeSH term(s) Humans ; Alzheimer Disease/psychology ; Apathy/physiology ; Texas ; Neuropsychological Tests ; Cognitive Dysfunction/psychology ; Disease Progression
    Language English
    Publishing date 2023-01-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Kyphoplasty experience in an elderly.

    Akbaş, Mert / Salem, Haitham Hamdy / Dinç, Bora / Karslı, Bilge

    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology

    2021  Volume 32, Issue 4, Page(s) 238–239

    Abstract: Objective: Vertebral compression fractures due to osteoporosis are seen frequently. Osteoporotic compression fractures can cause severe pain, limitation of physical activities and impairment of quality of life. Kyphoplasty, a minimally invasive ... ...

    Title translation Yaşlıda kifoplasti deneyimimiz.
    Abstract Objective: Vertebral compression fractures due to osteoporosis are seen frequently. Osteoporotic compression fractures can cause severe pain, limitation of physical activities and impairment of quality of life. Kyphoplasty, a minimally invasive procedure, could be effective in many cases and can provide fast pain relief.
    Case: A patient with a history of falling from a height of 8 months duration visited our pain clinic. Opioids and anti-inflammatory analgesics were administered together with physical therapy and facet joint injections with no improvement. Radiological examination of the patient showed collapse fracture of L2 and L4 vertebrae on top of severe osteoporosis. Kyphoplasty was performed at the level of L2 vertebrae followed by 50% relieve in her pain (VAS score reduction from 8 to 3) and hence she was capable to resume her daily activities.
    Conclusion: Percutaneous balloon kyphoplasty is a safe and effective procedure for the treatment of elder patient with osteoporotic vertebral compression fractures.
    MeSH term(s) Aged ; Diagnosis, Differential ; Female ; Humans ; Kyphoplasty ; Lumbar Vertebrae ; Osteoporosis, Postmenopausal ; Osteoporotic Fractures/diagnosis ; Osteoporotic Fractures/diagnostic imaging ; Osteoporotic Fractures/surgery ; Pain Measurement ; Spinal Fractures/diagnosis ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery
    Language English
    Publishing date 2021-01-04
    Publishing country Turkey
    Document type Case Reports ; Letter
    ZDB-ID 1283669-2
    ISSN 1300-0012
    ISSN 1300-0012
    DOI 10.14744/agri.2019.36693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Factors Associated with Apathy in Alzheimer's Disease: A Cross-Sectional Analysis of the Texas Alzheimer's Research and Care Consortium (TARCC) Study.

    Teixeira, Antonio L / Salem, Haitham / Martins, Lais B / Gonzales, Mitzi M / Seshadri, Sudha / Suchting, Robert

    Journal of Alzheimer's disease : JAD

    2022  Volume 86, Issue 1, Page(s) 403–411

    Abstract: Background: Apathy is among the most frequent neuropsychiatric syndromes in Alzheimer's disease (AD).: Objective: To determine the prevalence of apathy and the associated clinical and laboratorial parameters (focus on inflammatory biomarkers) in ... ...

    Abstract Background: Apathy is among the most frequent neuropsychiatric syndromes in Alzheimer's disease (AD).
    Objective: To determine the prevalence of apathy and the associated clinical and laboratorial parameters (focus on inflammatory biomarkers) in patients with dementia enrolled at the Texas Alzheimer's Research and Care Consortium (TARCC) study.
    Methods: This is a cross-sectional analysis of TARCC baseline. Participants were evaluated through different clinical tools, including the Mini-Mental State Examination (MMSE) and the Lawton-Brody Instrumental Activities of Daily Life (IADL)/Physical Self-Maintenance Scale (PSMS). Apathy was defined by a positive response to the respective item in the Neuropsychiatric Inventory-Questionnaire applied to caregivers. Serum levels of 16 biomarkers were determined by HumanMap multiplex immunoassay. Comparisons between apathy versus non-apathy groups were carried out with non-parametric tests. Logistic regression and the least absolute shrinkage and selection operator (LASSO) were used to separately model apathy as a function of each biomarker, adjusted for the potential confounders.
    Results: From 1,319 patients with AD (M/F: 579/740, mean age ± SD: 75.3 ± 8.4), 373 (28.3%) exhibited apathy. When categorized according to the presence of apathy, the groups had significant differences in sex, diabetes diagnosis, and tobacco use. The apathy group also had worse cognitive performance and daily functioning than the non-apathy group as assessed, respectively, by MMSE and IADL/PSMS. Higher levels of interleukin-6, interleukin-10, and leptin were associated with higher odds of apathy.
    Conclusion: Apathy is associated with cognitive and functional status in AD. The association between apathy and peripheral inflammatory mediators deserves further investigation.
    MeSH term(s) Alzheimer Disease/psychology ; Apathy ; Cross-Sectional Studies ; Humans ; Neuropsychological Tests ; Texas/epidemiology
    Language English
    Publishing date 2022-02-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-215314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Stem Cells in Alzheimer's Disease: Current Standing and Future Challenges.

    Salem, Haitham / Colpo, Gabriela D / Teixeira, Antonio L

    Advances in experimental medicine and biology

    2018  Volume 1079, Page(s) 93–102

    Abstract: To date, there is no definitive treatment for Alzheimer's disease (AD). The realm of stem cells is very promising in regenerative medicine, particularly for neurodegenerative diseases. Various types of stem cells have been used in preclinical/clinical ... ...

    Abstract To date, there is no definitive treatment for Alzheimer's disease (AD). The realm of stem cells is very promising in regenerative medicine, particularly for neurodegenerative diseases. Various types of stem cells have been used in preclinical/clinical trials for AD aiming the development of an elusive disease modifying therapy. Over the last decade, much knowledge has been gained in this field regarding types of cells, routes and timing of administration, and outcomes of stem cells-based strategies for AD. In this chapter, we will trace the state of art and the challenges facing the use of stem cells in AD.
    MeSH term(s) Alzheimer Disease/therapy ; Humans ; Regenerative Medicine ; Stem Cells/cytology
    Language English
    Publishing date 2018-06-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/5584_2018_214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of white matter hyperintensities with migraine phenotypes and response to treatment.

    Ahmed, Sherihan Rezk / Mohamed, Amr Abdel Monem / Salem, Haitham Hamdy / Helmy, Shahinaz / Moustafa, Ramez Reda / Borham, Sherien Mohamed Farag

    Acta neurologica Belgica

    2022  Volume 123, Issue 5, Page(s) 1725–1733

    Abstract: Introduction: White matter hyperintensities (WMHs) are frequently found in migraineurs. However, their clinical significance and correlation to different migraine phenotypes and treatment responses are not well defined. The study aimed to examine the ... ...

    Abstract Introduction: White matter hyperintensities (WMHs) are frequently found in migraineurs. However, their clinical significance and correlation to different migraine phenotypes and treatment responses are not well defined. The study aimed to examine the association of WMHs with migraine clinical patterns and treatment response.
    Aim of work: We aimed to evaluate the association between WMHs and migraine phenotypes and explore the relationship of WMHs to treatment response.
    Methods: Our cross-sectional study formed of 500 migraineurs who sought treatment in Kafr el-sheik university hospital and underwent (3 T) MRI to evaluate WMHs. Different migraine phenotypes were compared between patients with and without WMHs. According to reduced headache pain intensity and frequency, these patients were divided into treatment responder and non-responder groups.
    Results: A total of 145 patients (29%) had WMHs. Patients with WMHs were significantly older, had a longer disease duration, and higher attack frequency. Patients who did not respond to acute and maintenance medications had a higher frequency of WMHs and high WMHs Scheltens score. Migraine with Aura and the presence of vomiting and dizziness were predictors for the development of WMHs.
    Conclusion: WMHs are more common in migraine with aura. It is more frequent in migraine associated with vomiting and dizziness. WMHs increased with advancing age and more severe disease burden. Poorer response to acute and prophylactic medications was found in patients with WMHs.
    MeSH term(s) Humans ; White Matter/diagnostic imaging ; Migraine with Aura ; Dizziness ; Cross-Sectional Studies ; Migraine Disorders/diagnostic imaging ; Magnetic Resonance Imaging ; Epilepsy ; Vertigo ; Leukoaraiosis
    Language English
    Publishing date 2022-07-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-022-02015-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Temporal multi-step predictive modeling of remission in major depressive disorder using early stage treatment data; STAR*D based machine learning approach.

    Salem, Haitham / Huynh, Tung / Topolski, Natasha / Mwangi, Benson / Trivedi, Madhukar H / Soares, Jair C / Rush, A John / Selvaraj, Sudhakar

    Journal of affective disorders

    2022  Volume 324, Page(s) 286–293

    Abstract: Background: Artificial intelligence is currently being used to facilitate early disease detection, better understand disease progression, optimize medication/treatment dosages, and uncover promising novel treatments and potential outcomes.: Methods: ... ...

    Abstract Background: Artificial intelligence is currently being used to facilitate early disease detection, better understand disease progression, optimize medication/treatment dosages, and uncover promising novel treatments and potential outcomes.
    Methods: Utilizing the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we built a machine learning model to predict depression remission rates using same clinical data as features for each of the first three antidepressant treatment steps in STAR*D. We only used early treatment data (baseline and first follow up) in each STAR*D step to temporally analyze predictive features of remission at the end of the step.
    Results: Our model showed significant prediction performance across the three treatment steps, At step 1, Model accuracy was 66 %; sensitivity-65 %, specificity-67 %, positive predictive value (PPV)-65.5 %, and negative predictive value (NPV)-66.6 %. At step 2, model accuracy was 71.3 %, sensitivity-74.3 %, specificity-69 %, PPV-64.5 %, and NPV-77.9 %. At step 3, accuracy reached 84.6 %; sensitivity-69 %, specificity-88.8 %, PPV-67 %, and NPV-91.1 %. Across all three steps, the early Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR) scores were key elements in predicting the final treatment outcome. The model also identified key sociodemographic factors that predicted treatment remission at different steps.
    Limitations: The retrospective design, lack of replication in an independent dataset, and the use of "a complete case analysis" model in our analysis.
    Conclusions: This proof-of-concept study showed that using early treatment data, multi-step temporal prediction of depressive symptom remission results in clinically useful accuracy rates. Whether these predictive models are generalizable deserves further study.
    MeSH term(s) Humans ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/drug therapy ; Artificial Intelligence ; Retrospective Studies ; Antidepressive Agents/therapeutic use ; Treatment Outcome ; Machine Learning ; Citalopram/therapeutic use
    Chemical Substances Antidepressive Agents ; Citalopram (0DHU5B8D6V)
    Language English
    Publishing date 2022-12-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2022.12.076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sexual dysfunction in male patients with Parkinson's disease: related factors and impact on quality of life.

    Shalash, Ali / Hamid, Eman / Elrassas, Hanan / Abushouk, Abdelrahman Ibrahim / Salem, Haitham Hamdy

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2020  Volume 41, Issue 8, Page(s) 2201–2206

    Abstract: Background: Sexual dysfunction (SD) is a common, yet under-reported, non-motor symptom (NMS) of Parkinson's disease (PD). The present study investigated the sexual functions in PD male patients, its correlation with motor and other NMSs, and their ... ...

    Abstract Background: Sexual dysfunction (SD) is a common, yet under-reported, non-motor symptom (NMS) of Parkinson's disease (PD). The present study investigated the sexual functions in PD male patients, its correlation with motor and other NMSs, and their impact on health-related quality of life (HRQoL).
    Methods: The sexual functions of 40 PD male patients were assessed using the International Index of Erectile Function (IIEF) and compared to 25 healthy age-matched controls. Patients were evaluated using the NMS Scale (NMSS) and the Arabic version of the Parkinson's-Disease Questionnaire (PDQ-39). We compared the sexual functions of younger (≤ 55 years) and elder (> 55 years) males and tested the correlations between sexual functions and motor, other NMSs, and HRQoL.
    Results: Seventy percent of PD male patients reported erectile dysfunction. They showed significantly worse total (p < 0.001) and subscores of IIEF, compared to healthy controls. The total IIEF was inversely correlated to age of patients (p = 0.013), age at onset (p = 0.043), total, cognitive/mood, gastrointestinal and urinary domains of NMSS, and the cognitive domain of PDQ-39 (p = 0.013). Age was the main predictor (ß = - 0.581, p = 0.006) of SD. Elder patients showed worse sexual functions, stronger correlations to other NMSs, and more impact on HRQoL than younger patients.
    Conclusion: Sexual functions are worse among PD male patients with age as the main predictor. SD was associated with worse cognitive/mood and urinary domains of NMSS and has a negative impact on the patients' HRQoL among elder males.
    MeSH term(s) Age of Onset ; Aged ; Humans ; Male ; Parkinson Disease/complications ; Parkinson Disease/epidemiology ; Quality of Life ; Sexual Dysfunction, Physiological/epidemiology ; Sexual Dysfunction, Physiological/etiology ; Surveys and Questionnaires
    Language English
    Publishing date 2020-03-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-020-04328-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Correlations between peripheral levels of inflammatory mediators and frontolimbic structures in bipolar disorder: an exploratory analysis.

    Mohite, Satyajit / Salem, Haitham / Cordeiro, Thiago / Tannous, Jonika / Mwangi, Benson / Selvaraj, Sudhakar / Soares, Jair C / Sanches, Marsal / Teixeira, Antonio L

    CNS spectrums

    2021  Volume 27, Issue 5, Page(s) 639–644

    Abstract: Background: Altered peripheral immune/inflammatory system and brain volumetric changes have been implicated in the pathophysiology of bipolar disorder (BD). This study aimed to evaluate how peripheral levels of cytokines are related to volumetric brain ... ...

    Abstract Background: Altered peripheral immune/inflammatory system and brain volumetric changes have been implicated in the pathophysiology of bipolar disorder (BD). This study aimed to evaluate how peripheral levels of cytokines are related to volumetric brain changes in euthymic patients with BD.
    Methods: Euthymic patients with BD (n = 21) and healthy controls (n = 22) were enrolled in this exploratory study. Blood samples were collected on the same day of clinical assessment and neuroimaging. Cytokines were measured through cytometric bead array method. Neuroimaging data were acquired using a sagittal three-dimensional magnetic resonance imaging T1-weighted fast field echo sequence and was processed using FreeSurfer.
    Results: Compared to controls, BD patients had significantly lower volumes in the cingulate, medial-orbitofrontal (MOF) and parahippocampal regions. We found a negative correlation between right MOF volume and interferon-gamma levels (
    Conclusion: Our results support the involvement of inflammatory pathways in structural brain changes in BD.
    MeSH term(s) Humans ; Bipolar Disorder ; Gray Matter/pathology ; Interleukin-10 ; Inflammation Mediators ; Interferon-gamma ; Magnetic Resonance Imaging/methods ; Brain
    Chemical Substances Interleukin-10 (130068-27-8) ; Inflammation Mediators ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/S1092852921000596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Prolonged delirium misdiagnosed as a mood disorder.

    Cao, Fei / Salem, Haitham / Nagpal, Caesa / Teixeira, Antonio L

    Dementia & neuropsychologia

    2017  Volume 11, Issue 2, Page(s) 206–208

    Abstract: Delirium can be conceptualized as an acute decline in cognitive function that typically lasts from hours to a few days. Prolonged delirium can also affect patients with multiple predisposing and/or precipitating factors. In clinical practice, prolonged ... ...

    Abstract Delirium can be conceptualized as an acute decline in cognitive function that typically lasts from hours to a few days. Prolonged delirium can also affect patients with multiple predisposing and/or precipitating factors. In clinical practice, prolonged delirium is often unrecognized, and can be misdiagnosed as other psychiatric disorders. We describe a case of a 59-year-old male presenting with behavioral and cognitive symptoms that was first misdiagnosed as a mood disorder in a general hospital setting. After prolonged delirium due to multiple factors was confirmed, the patient was treated accordingly with symptomatic management. He evolved with progressive improvement of his clinical status. Early diagnosis and management of prolonged delirium are important to improve patient prognosis and avoid iatrogenic measures.
    Language English
    Publishing date 2017-08-22
    Publishing country Brazil
    Document type Case Reports
    ISSN 1980-5764
    ISSN 1980-5764
    DOI 10.1590/1980-57642016dn11-020014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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