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  1. Article ; Online: Higher cytotoxic activities of CD8

    Salem, Mohamed Labib / Atia, Ismail / Elmashad, Nehal M

    BMC immunology

    2023  Volume 24, Issue 1, Page(s) 24

    Abstract: Introduction: Cytotoxic (CD8+) and natural killer (NK) cells play critical roles in anti-tumor immunity. Dysfunction in these cells is considered as one of the extrinsic mechanisms for tumor relapse.: Aim: We aimed in this study to assess cytotoxic ... ...

    Abstract Introduction: Cytotoxic (CD8+) and natural killer (NK) cells play critical roles in anti-tumor immunity. Dysfunction in these cells is considered as one of the extrinsic mechanisms for tumor relapse.
    Aim: We aimed in this study to assess cytotoxic activities of CD8 + T and NK cells in the peripheral blood from lung cancer patients before and after induction of chemotherapy.
    Subjects and methods: Healthy (n = 5) volunteers and lung cancer patients (n = 15:5 before, 5 during, and 5 after induction of chemotherapy) were recruited. Flow cytometry was used to analyze the numbers of CD8 + T cells, NK and CD56
    Results: After culture, significant increases in the number of GzB expressing cells gated on CD3+, CD4+, CD8 + and NKCD8 + T cells in the PBMCs from lung cancer patients before induction of chemotherapy as compared to control individuals as well as patients during and after induction of chemotherapy. Serum levels of IL-1 and CXCL8 in patients before induction of chemotherapy showed 37- and 40-fold increases, respectively, as compared to control individuals. Both GzB expression and cytokines levels in patients during and after chemotherapy were similar.
    Conclusion: Polyclonal stimulation of PBMCs can restore the cytolytic activities of cytotoxic CD8 and NK cells from lung cancer patients even after chemotherapy.
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Leukocytes, Mononuclear/metabolism ; Neoplasm Recurrence, Local/metabolism ; Killer Cells, Natural ; Cytokines/metabolism ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041500-X
    ISSN 1471-2172 ; 1471-2172
    ISSN (online) 1471-2172
    ISSN 1471-2172
    DOI 10.1186/s12865-023-00553-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Routine childhood immunization may protect against COVID-19.

    Salman, Samar / Salem, Mohamed Labib

    Medical hypotheses

    2020  Volume 140, Page(s) 109689

    Keywords covid19
    Language English
    Publishing date 2020-03-25
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109689
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    Zs.A 1132: Show issues Location:
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  3. Article ; Online: Could injured skin be a reservoir for SARS-CoV-2 virus spread?

    Elgarhy, Lamia Hamouda / Salem, Mohamed Labib

    Clinics in dermatology

    2020  Volume 38, Issue 6, Page(s) 762–763

    MeSH term(s) COVID-19/transmission ; Humans ; Skin/virology ; Skin Diseases, Viral/transmission
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Letter
    ZDB-ID 1064149-x
    ISSN 1879-1131 ; 0738-081X
    ISSN (online) 1879-1131
    ISSN 0738-081X
    DOI 10.1016/j.clindermatol.2020.06.004
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  4. Article ; Online: Brief in vitro IL-12 conditioning of CD8

    Salem, Mohamed Labib / Salman, Samar / Barnawi, Ibrahim O

    Cancer immunology, immunotherapy : CII

    2021  Volume 70, Issue 10, Page(s) 2751–2759

    Abstract: Cancer immunotherapy represents a potential treatment approach through non-specific and specific enhancement of the immune responses. Adoptive cell therapy (ACT) is a potential modality of immunotherapy that depends on harvesting T cells from the tumor- ... ...

    Abstract Cancer immunotherapy represents a potential treatment approach through non-specific and specific enhancement of the immune responses. Adoptive cell therapy (ACT) is a potential modality of immunotherapy that depends on harvesting T cells from the tumor-bearing host, activating them in vitro and infusing them back to the same host. Several cytokines, in particular IL-2, IL-7 and IL-15, have been used to enhance survival T cells in vitro. Although effective, conditioning of T cells in vitro with these cytokines requires long-term culture which results in the loss of expression of their trafficking receptors mainly CD62L. It also results in exhaustion of the activated T cells and reduction in their functions upon adoptive transfer in vivo. Our recent studies and those of other groups showed that brief (3 days) conditioning of CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/metabolism ; Cell- and Tissue-Based Therapy/methods ; Humans ; Immunotherapy/methods ; Interleukin-12/metabolism ; Mice
    Chemical Substances Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2021-05-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-021-02887-7
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    Zs.A 1237: Show issues Location:
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  5. Article ; Online: The possible beneficial adjuvant effect of influenza vaccine to minimize the severity of COVID-19.

    Salem, Mohamed Labib / El-Hennawy, Dina

    Medical hypotheses

    2020  Volume 140, Page(s) 109752

    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  8. Article ; Online: Could injured skin be a reservoir for SARS-CoV-2 virus spread?

    Elgarhy, Lamia Hamouda / Salem, Mohamed Labib

    Clinics in Dermatology ; ISSN 0738-081X

    2020  

    Keywords Dermatology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.clindermatol.2020.06.004
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Routine childhood immunization may protect against COVID-19

    Salman, Samar / Salem, Mohamed Labib

    Medical Hypotheses

    2020  Volume 140, Page(s) 109689

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109689
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
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  10. Article ; Online: Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses.

    Salem, Mohamed Labib

    Immunology letters

    2011  Volume 137, Issue 1-2, Page(s) 9–14

    Abstract: Traditionally, expression of toll-like receptors (TLRs) has been associated with innate immune cells in particular professional antigen presenting cells and natural killer cells. This led to the concept that the adjuvant effects of ligation of TLR in a ... ...

    Abstract Traditionally, expression of toll-like receptors (TLRs) has been associated with innate immune cells in particular professional antigen presenting cells and natural killer cells. This led to the concept that the adjuvant effects of ligation of TLR in a host occur mainly in innate immune cells. However, this concept has been challenged by recent studies including ours demonstrating that T cells express appreciated levels of different TLRs, which can serve as costimulatory co-receptors during polyclonal and antigen-specific stimulation of T cells. Because T cells express low levels of TLRs as compared to innate immune cells, increasing the expression levels of TLRs in T cells can significantly maximize their responses to the costimulatory effects of TLR ligation. This review article focuses on the potential role of TLR expression in T cells in their responses to vaccination regimen containing TLR agonists and how it can be modulated to optimize anti-tumor immunity.
    MeSH term(s) Animals ; Antigens, Neoplasm/immunology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cancer Vaccines ; Humans ; Immunomodulation ; Immunotherapy, Adoptive ; Lymphocyte Activation/drug effects ; Receptor Cross-Talk ; Signal Transduction ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Toll-Like Receptors/agonists ; Toll-Like Receptors/immunology
    Chemical Substances Antigens, Neoplasm ; Antineoplastic Agents ; Cancer Vaccines ; Toll-Like Receptors
    Language English
    Publishing date 2011-06-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2011.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1512: Show issues Location:
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