Article ; Online: Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment.
Clinical and experimental pharmacology & physiology
2021 Volume 48, Issue 10, Page(s) 1317–1326
Abstract: Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible ... ...
| Abstract | Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible changes in thyroid-stimulating hormone (TSH), free thyroxin (fT4) and free triiodothyronine (fT3) levels during isotretinoin treatment and analyzing the possible factors which may contribute to such changes. In the present study, 47 patients received (0.5 mg/kg oral isotretinoin) for treatment of severe acne. TSH, fT4 and fT3 were measured at baseline, after 3 and 6 months. ANOVA tests were used for statistical analyses. The levels of fT4 and fT3 decreased significantly during isotretinoin treatment (from 0.85 ± 0.04 and 3.1 ± 0.26 at baseline to 0.81 ± 0.023 and 2.76 ± 0.2 after 6 months, respectively). The decrease was accompanied by significant elevation of TSH (0.66 ± 0.05 at baseline to 0.695 ± 0.05 after 6 months). The duration of therapy (but not the dose) has significantly affected all the hormonal changes. Previous incomplete or intermittent isotretinoin treatment had significantly influenced the changes in fT4 only, while gender affected the changes of TSH. Isotretinoin treatment can decrease fT4, fT3 and increase TSH. The pattern of these changes was affected by gender and previous isotretinoin therapy. Different doses of isotretinoin did not affect the hormonal changes, but the duration has been the major influencing factor. |
|---|---|
| MeSH term(s) | Acne Vulgaris/blood ; Acne Vulgaris/drug therapy ; Acne Vulgaris/pathology ; Adolescent ; Adult ; Dermatologic Agents/adverse effects ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Isotretinoin/adverse effects ; Isotretinoin/therapeutic use ; Male ; Thyroid Function Tests ; Thyroid Gland/drug effects ; Thyroid Gland/metabolism ; Thyrotropin/blood ; Thyroxine/blood ; Triiodothyronine/blood ; Young Adult |
| Chemical Substances | Dermatologic Agents ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Isotretinoin (EH28UP18IF) ; Thyroxine (Q51BO43MG4) |
| Language | English |
| Publishing date | 2021-07-29 |
| Publishing country | Australia |
| Document type | Journal Article |
| ZDB-ID | 189277-0 |
| ISSN | 1440-1681 ; 0305-1870 ; 0143-9294 |
| ISSN (online) | 1440-1681 |
| ISSN | 0305-1870 ; 0143-9294 |
| DOI | 10.1111/1440-1681.13552 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 990: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.