Article ; Online: B-cell modulation with anti-CD79b antibodies ameliorates experimental autoimmune encephalitis in mice.
European journal of immunology
2022 Volume 52, Issue 4, Page(s) 656–668
Abstract: B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion ... ...
| Abstract | B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell depletion will also affect regulatory B cells that are known to suppress autoimmune responses. In our studies, we describe an alternative approach based on targeting CD79b that induces only partial B-cell depletion and achieves therapeutic effects by B-cell modulation. Prophylactic and therapeutic treatment with an antibody against CD79b and also a deglycosylated variant of this antibody, lacking effector function like antibody-dependent cellular cytotoxicity or complement activation, significantly reduced the development and progression of EAE in mice. Our data show that modulation of B cells via CD79b is equally effective as almost complete B-cell depletion with anti-CD20 antibodies and may constitute an alternative approach to treat MS. |
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| MeSH term(s) | Animals ; Antibodies ; Antigens, CD20 ; Autoimmune Diseases ; Autoimmunity ; B-Lymphocytes ; Encephalitis/drug therapy ; Encephalitis/pathology ; Mice | ||||||||||
| Chemical Substances | Antibodies ; Antigens, CD20 | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2022-01-11 | ||||||||||
| Publishing country | Germany | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 120108-6 | ||||||||||
| ISSN | 1521-4141 ; 0014-2980 | ||||||||||
| ISSN (online) | 1521-4141 | ||||||||||
| ISSN | 0014-2980 | ||||||||||
| DOI | 10.1002/eji.202149523 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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