LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 23

Search options

  1. Article: The Clinical and Pathological Characteristics That Differentiate Cases With "Low Estrogen Receptor Expression" From Triple-Negative Breast Cancer.

    Karaali, Cem / Emiroğlu, Mümin / Değirmenci, Mustafa / Keser, Murat / Salimoğlu, Semra / Kelten Talu, Canan

    European journal of breast health

    2023  Volume 20, Issue 1, Page(s) 19–24

    Abstract: Objective: Estrogen receptor (ER) expression is an immunohistochemical marker that is examined in all invasive breast cancers and has prognostic and predictive value. ER-positive breast cancers refer to those that show positivity for ER at 1% cellular ... ...

    Abstract Objective: Estrogen receptor (ER) expression is an immunohistochemical marker that is examined in all invasive breast cancers and has prognostic and predictive value. ER-positive breast cancers refer to those that show positivity for ER at 1% cellular expression or higher. The American Society of Clinical Oncology/College of American Pathologists guidelines suggest using the term "low ER-positive breast cancer" for tumors with ER expression between 1% and 10%. Low ER-positive breast cancers exhibit similarities, in terms of disease-free survival and overall survival rates, to triple-negative breast cancers (TNBCs) rather than ER-positive breast cancers. In this study, our aim was to compare the clinicopathological characteristics of low ER-positive breast cancer cases diagnosed and followed in our clinic with TNBCs.
    Materials and methods: A total of 26 cases of low ER-positive breast cancer diagnosed at University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital between 2010 and 2016 were retrieved from hospital records. The relevant histopathology slides and blocks were retrieved and re-evaluated retrospectively through microscopic examination. Thirteen cases that met the criteria were included in the study. Additionally, a consecutive series of 13 TNBC cases that did not receive neoadjuvant treatment within the same time period were identified.
    Results: In the low ER-positive group, the presence of tumor necrosis, as well as histological grade, nuclear grade and Ki-67 proliferation index were significantly lower compared to the TNBC group. Ductal carcinoma
    Conclusion: Although our study consisted of a small number of cases, some features showed significant differences between low ER-positive breast cancers and TNBCs. Histological and nuclear grades, as well as the presence of a DCIS component, were associated with low ER-positive breast cancer. In contrast, the presence of tumor necrosis, as well as Grade 3 features and a high Ki-67 proliferation index indicated TNBC.
    Language English
    Publishing date 2023-12-27
    Publishing country Turkey
    Document type Journal Article
    ISSN 2587-0831
    ISSN 2587-0831
    DOI 10.4274/ejbh.galenos.2023.2023-6-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: The effect of the compassion levels of healthcare workers on their psychological well-being.

    Demirel, Yüksel / Çağatay, Hüseyin Tolga / Ertuğrul, Bekir / Başaran, Esin / Salimoğlu, Serap

    Work (Reading, Mass.)

    2023  Volume 77, Issue 1, Page(s) 253–262

    Abstract: Background: A sense of compassion has a core importance in health service delivery. Research on the psychological impact of being compassionate on healthcare workers is limited.: Objective: This research aims to examine the effect of compassion ... ...

    Abstract Background: A sense of compassion has a core importance in health service delivery. Research on the psychological impact of being compassionate on healthcare workers is limited.
    Objective: This research aims to examine the effect of compassion levels of healthcare workers on their psychological well-being.
    Methods: This was a cross-sectional and descriptive study. The population of the research consists of health personnel working throughout Ankara, the capital. The study was carried out with 414 healthcare workers. A personal information form, compassion scale and psychological well-being scale were used in the research questionnaire.
    Results: A positive and significant relationship was found between compassion and psychological well-being scores. It was determined that compassion positively affected psychological well-being levels. The level of compassion showed that there was a significant difference between the groups according to the variables of gender, family structure, job satisfaction and whether they would choose the same profession again. The level of psychological well-being was found to be significantly different between the groups in education, job satisfaction and making the same profession choice again.
    Conclusion: It is a professional requirement that health professionals in patient care have a sense of compassion and reflect this feeling in their conduct. Research shows that the greater the compassion, the higher the psychological well-being. Therefore, undertaking training initiatives to make healthcare workers more compassionate can contribute to patient care and at the same time to the psychological well-being of healthcare workers.
    MeSH term(s) Humans ; Empathy ; Burnout, Professional/psychology ; Compassion Fatigue/psychology ; Psychological Well-Being ; Cross-Sectional Studies ; Health Personnel/psychology ; Job Satisfaction ; Surveys and Questionnaires ; Quality of Life/psychology
    Language English
    Publishing date 2023-08-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1394194-x
    ISSN 1875-9270 ; 1051-9815
    ISSN (online) 1875-9270
    ISSN 1051-9815
    DOI 10.3233/WOR-230035
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Oncoplastic reduction mammoplasty for breast cancer in women with macromastia: long term aesthetic, functional and satisfaction outcomes.

    Emiroglu, Mustafa / Karaali, Cem / Salimoglu, Semra / Sert, Ismail / Aydın, Cengiz

    Contemporary oncology (Poznan, Poland)

    2016  Volume 20, Issue 3, Page(s) 256–260

    Abstract: Aim of the study: Despite the increase in studies concerning oncoplastic reduction mammoplasty (ORM), data showing long-term aesthetic and patient satisfaction for ORM in patients with macromastia remain limited. Therefore, this study evaluated the long- ...

    Abstract Aim of the study: Despite the increase in studies concerning oncoplastic reduction mammoplasty (ORM), data showing long-term aesthetic and patient satisfaction for ORM in patients with macromastia remain limited. Therefore, this study evaluated the long-term results of tumorectomy and concomitant bilateral ORM for early-stage breast cancer patients with macromastia in terms of cosmesis, patient satisfaction, and functional outcomes.
    Material and methods: Retrospective data of patients with macromastia undergoing ORM for breast cancer between 1996 and 2011 were examined and evaluated regarding the aesthetic results, patient satisfaction, and functional outcomes.
    Results: The median age of the 82 patients was 50 years. The median follow-up was 120 months (range: 28-212 months). The median breast volume was 1402 cm(3), and the median weight of the excised breast material was 679 g. A good or excellent evaluation of the cosmetic outcome was as follows: self-evaluation: 84.1% at the early-stage, 80.3% at the later stage; panel evaluation: 75.4% at the late-stage. Median patient satisfaction rates were 9.1% for early-stage disease and 8.8% for late-stage disease. Reduced mobility and intertrigo improved by three-fold during the post-operative period.
    Conclusions: ORM for early-stage breast cancer in women with macromastia results in good cosmesis in both the early-stage and long-term, and is quite acceptable for use in patients. Patients reacted favorably to the prospect of having their breast cancer and macromastia treated in a single session, and positive results continued over the long-term.
    Language English
    Publishing date 2016-03-04
    Publishing country Poland
    Document type Journal Article
    ISSN 1428-2526
    ISSN 1428-2526
    DOI 10.5114/wo.2015.55272
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Loss of Nuclear ARID-1A Expressions Is Associated with Hormone Receptor Status in Breast Cancers.

    Ünçel, Melek / Diniz, Gülden / Aköz, Gamze / Ekin, Zübeyde Yıldırım / Sayhan, Sevil / Yardım, Serdar / Salimoğlu, Semra

    European journal of breast health

    2019  Volume 15, Issue 2, Page(s) 125–129

    Abstract: Objective: Breast cancer is the most common cancer among women worldwide. Adenine thymine-rich interactive domain 1A (ARIDIA) is a tumor suppressor gene involved in chromatin remodeling and it encodes the ARIDIA protein. Recent studies have shown the ... ...

    Abstract Objective: Breast cancer is the most common cancer among women worldwide. Adenine thymine-rich interactive domain 1A (ARIDIA) is a tumor suppressor gene involved in chromatin remodeling and it encodes the ARIDIA protein. Recent studies have shown the loss of ARIDIA protein expression in different carcinomas may have a prognostic significance. In the present study, we aimed to evaluate the interactions between ARIDIA loss and molecular subtypes of breast carcinomas.
    Materials and methods: ARIDIA expressions were studied in 292 formalin- fixed, paraffin- embedded breast carcinoma specimens and its association with different pathological and clinical parameters was evaluated.
    Results: Loss of ARIDIA expression was detected in 123 cases. There was no statistically significant association between ARID-1A expression and molecular subtype of breast carcinomas (p=0.110) or HER2 amplification (p=0.909). Contrarily, there was a significant association between ARIDIA expression and presence of estrogen (p=0.047) or progesterone receptors (p=0.023). Besides a statistically significant relationship was found between loss of ARID1A, and the presence of both in situ component (p=0.016) and lymph node metastasis (p=0.001).
    Conclusion: In this study, we have demonstrated that loss of ARID1A expression positively correlates with hormone receptor status as well as tumor aggressiveness.
    Language English
    Publishing date 2019-04-01
    Publishing country Turkey
    Document type Journal Article
    ISSN 2587-0831
    ISSN 2587-0831
    DOI 10.5152/ejbh.2019.4677
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Oncoplastic reduction mammoplasty for breast cancer in women with macromastia: Oncological long-term outcomes.

    Emiroglu, Mustafa / Salimoglu, Semra / Karaali, Cem / Sert, Ismail / Gungor, Osman / Sert, Fatma / Aydın, Cengiz

    Asian journal of surgery

    2017  Volume 40, Issue 1, Page(s) 41–47

    Abstract: Objective: To evaluate the long-term results of tumorectomy and concomitant bilateral oncoplastic reduction mammoplasty (ORM) for early stage breast cancer patients with macromastia in terms of local disease control and long-term oncological results.: ...

    Abstract Objective: To evaluate the long-term results of tumorectomy and concomitant bilateral oncoplastic reduction mammoplasty (ORM) for early stage breast cancer patients with macromastia in terms of local disease control and long-term oncological results.
    Patients and method: Data of 82 patients with macromastia undergoing ORM for breast cancer between 1996 and 2011 were retrospectively examined and evaluated with regard to oncological results.
    Results: The median age was 50 years. The median follow-up was 121 months (range 28-212 months). The median breast volume was 1402 cm
    Conclusions: From the standpoint of local disease control and long-term observation, ORM can be considered a very safe and acceptable treatment for early stage breast cancer in women with macromastia.
    MeSH term(s) Adult ; Aged ; Breast/abnormalities ; Breast/surgery ; Breast Neoplasms/complications ; Breast Neoplasms/mortality ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/complications ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/surgery ; Carcinoma, Intraductal, Noninfiltrating/complications ; Carcinoma, Intraductal, Noninfiltrating/mortality ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Carcinoma, Lobular/complications ; Carcinoma, Lobular/mortality ; Carcinoma, Lobular/surgery ; Female ; Follow-Up Studies ; Humans ; Hypertrophy/complications ; Hypertrophy/surgery ; Mammaplasty/methods ; Mastectomy, Segmental ; Middle Aged ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2017-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2015.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: The effect of phenol concentration on the treatment of pilonidal sinus disease: Early results of a prospective randomized study.

    Emiroglu, Mustafa / Karaali, Cem / Salimoglu, Semra / Sert, Ismail / Ugurlu, Levent / AydÄ N, Cengiz

    International surgery

    2016  

    Abstract: Objective: Our hypothesis was that a low concentration (30%) of phenol would be more effective than a high concentration (80%) in the treatment of pilonidal disease. The purpose of our study was to compare the effects of high and low doses of liquid ... ...

    Abstract Objective: Our hypothesis was that a low concentration (30%) of phenol would be more effective than a high concentration (80%) in the treatment of pilonidal disease. The purpose of our study was to compare the effects of high and low doses of liquid phenol in the treatment of pilonidal disease.
    Summary of background data: In the treatment of the pilonidal disease, the phenolization technique and concentration of the phenol solution is not well defined.
    Methods: Consecutive patients being treated for pilonidal disease with high and low concentrations of phenol were included in this randomized prospective study. The demographic data, pilonidal disease characteristics, and results of phenol application were examined.
    Results: Of 101 subjects, 52 were treated with 80% phenol while 49 were treated with 30% phenol. The mean observation period was approximately 1 year. The total recovery rate was higher among the 80% phenol group (P: 0.046). The recovery period, the period of leave from work, and complication rates were similar in both groups (p: 0.414, 0.328, 0.256). Also, in the Likert-type survey administered by validated methods, there was no difference in the degree of satisfaction (P: 0.494).
    Conclusion: The low concentrations of phenol did not achieve faster recovery, faster return to work, or less complications in the treatment of pilonidal disease. An 80% concentration of phenol should be used for a higher rate of recovery.
    Language English
    Publishing date 2016-03-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 80343-1
    ISSN 2520-2456 ; 0020-8868
    ISSN (online) 2520-2456
    ISSN 0020-8868
    DOI 10.9738/INTSURG-D-15-00120.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Comparison of Clinical and Pathological Differences of Breast Cancer Patients under 35 and above 55 Years of Age.

    Emiroğlu, Mustafa / Karaali, Cem / Sert, İsmail / Salimoğlu, Semra / Uğurlu, Levent / Aksoy, Süleyman / Aydın, Cengiz

    The journal of breast health

    2015  Volume 11, Issue 3, Page(s) 123–127

    Abstract: Objective: In this study, we aimed to evaluate the clinical, pathologic and management differences between breast cancer patients under 35 years of age and postmenopausal patients above 55 years of age.: Materials and methods: Patients who were ... ...

    Abstract Objective: In this study, we aimed to evaluate the clinical, pathologic and management differences between breast cancer patients under 35 years of age and postmenopausal patients above 55 years of age.
    Materials and methods: Patients who were operated on for breast cancer between November 2003 and March 2013 in our hospital were retrospectively analyzed. Patients were separated into two Groups according their age; Group 1 (<35 years) and Group 2 (>55 years).
    Results: 94 patients with breast cancer, 45 patients in Group 1 and 49 patients in Group 2, were included in the study. The mean follow-up was 51 (19-121) months and 50 (19-120) months in Groups 1 and 2, respectively. Stages of breast cancer at the time of diagnosis were similar between the two groups. The groups were similar in terms of rates of re-excision (p=0.42), local recurrence (p=0.34) and solid organ metastases (p=0.182). The number of oncoplastic and reconstructive procedures were higher in Group 1 (p=0.04). Regarding pathological results, the rate of grade 3 tumors, those with Ki-67>12 and triple negative breast cancer were found to be higher in Group 1. In addition, the number of patients receiving chemotherapy was significantly higher in Group 1 (p=0.03).
    Conclusion: Oncologic results were similar between young patients and postmenopausal patients. Nevertheless, tumor biology was found to be worse in young patients. In addition, oncoplastic and reconstructive approaches were significantly higher in young patients.
    Language English
    Publishing date 2015-07-01
    Publishing country Turkey
    Document type Journal Article
    ISSN 1306-0945
    ISSN 1306-0945
    DOI 10.5152/tjbh.2015.2539
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Metaplastic Breast Carcinoma: Analysis of Clinical and Pathologic Characteristics - A Case Series.

    Salimoğlu, Semra / Sert, İsmail / Emiroğlu, Mustafa / Karaali, Cem / Kuzukıran, Dilek / Kırmızı, Yasemin Akyüz / Diniz, Gülden / Aydın, Cengiz

    The journal of breast health

    2016  Volume 12, Issue 2, Page(s) 63–66

    Abstract: Objective: Metaplastic breast cancer (MBC) is a rare type of breast cancer that is considered to be clinically aggressive. The clinical significance and prognostic risk factors of MBC are limited. This study comprises a retrospective analysis of the ... ...

    Abstract Objective: Metaplastic breast cancer (MBC) is a rare type of breast cancer that is considered to be clinically aggressive. The clinical significance and prognostic risk factors of MBC are limited. This study comprises a retrospective analysis of the clinical and pathologic findings of a series of patients treated for MBC.
    Materials and methods: The files of 657 patients who underwent surgery because of breast cancer at our clinic were examined and the data found on 11 patients who were diagnosed as having MBC were analyzed.
    Results: With a median age of 56 years, all patients were postmenopausal and presented with a palpable mass on physical examination. Symptoms of ulceration and skin involvement were seen in only one patient. Eight patients were diagnosed as having squamous cell carcinoma (SCC), and 3 had both SCC and osseous differentiation. The median diameter was 3.8 cm (max. 14 cm; min. 1.5 cm). Lymph node metastasis was detected in 5 (45%) patients. Progesterone (PR) and estrogen (ER) were both negative in 11 (100%) patients and 10 (90.9%) patients, respectively, and CerbB2 was negative in 7 (63.6%) patients. Patients were followed up for a median period of 15 months (range, 6-40 months); at the end of which, 10 patients survived and one died of cardiac arrest at 7 months post-operatively. No instances of local recurrence or distant organ metastasis were found in any patients. The overall patient survival rate was 90%.
    Conclusion: There is no consensus on the clinical significance or best treatment approach for metaplastic carcinoma. In our study, patients with MBC were of advanced age, had tumors with large margins, high negativity for hormone receptors, and moderate- to well-differentiated histology.
    Language English
    Publishing date 2016-04-01
    Publishing country Turkey
    Document type Journal Article
    ISSN 1306-0945
    ISSN 1306-0945
    DOI 10.5152/tjbh.2016.2837
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Erratum to: how do surgeons approach breast cancer surgery in Turkey? A national survey.

    Emiroğlu, Mustafa / Inal, Abdullah / Sert, İsmail / İlhan, Enver / Peker, Kemal / Gulcelik, Mehmet Ali / Güngör, Hilmi / Salimoğlu, Semra / Can, Didem / Ellidokuz, Hülya / Aydın, Cengiz

    Breast cancer (Tokyo, Japan)

    2015  Volume 22, Issue 4, Page(s) 427

    Language English
    Publishing date 2015-07
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2052429-8
    ISSN 1880-4233 ; 1340-6868
    ISSN (online) 1880-4233
    ISSN 1340-6868
    DOI 10.1007/s12282-013-0507-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: How do surgeons approach breast cancer surgery in Turkey? A national survey.

    Emiroğlu, Mustafa / Inal, Abdullah / Sert, İsmail / İlhan, Enver / Peker, Kemal / Gulcelik, Mehmet Ali / Gürçelik, Mehmet Ali / Güngör, Hilmi / Salimoğlu, Semra / Can, Didem / Ellidokuz, Hülya / Aydın, Cengiz

    Breast cancer (Tokyo, Japan)

    2015  Volume 22, Issue 4, Page(s) 421–426

    Abstract: Background: The aim of this study was to investigate the experience, practice and approaches of general surgeons in relation to the treatment of breast cancer in Turkey.: Methods: A survey was conducted between November 2012 and February 2013 with ... ...

    Abstract Background: The aim of this study was to investigate the experience, practice and approaches of general surgeons in relation to the treatment of breast cancer in Turkey.
    Methods: A survey was conducted between November 2012 and February 2013 with 453 general surgeons who claimed to perform breast surgery. Initial and most preferred approaches for breast cancer surgery and demographic features of participants were questioned. Initial approaches of surgeons for a suspected breast mass were assessed with a clinical scenario.
    Results: A total of 12.6 % of practicing general surgeons in Turkey responded to the survey. A multidisciplinary assessment was employed by 57.2 % of participants. The most frequently used diagnostic tool was needle biopsies (64.9 %) and the most frequently performed surgery for early stage cancers was breast-conserving surgery (72.2 %). The initial approach for locally advanced breast cancer was neoadjuvant chemotherapy (59.8 %) and mastectomy for metastatic cancer (22.7 %). Sentinel lymph node biopsies were utilized by 59.2 % of participants by different methods in appropriate cases. Oncoplastic breast surgery was performed by 9.0 % of participants, frequently or constantly. The surgeons' initial approaches for the clinical scenario were imaging (56.7 %) and biopsy (40.6 %).
    Conclusions: Although there are efforts to improve up-to-date approaches towards breast cancer surgery by surgeons, currently there are significant inadequacies for evidence-based medicine practices.
    MeSH term(s) Biopsy, Needle ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Cross-Sectional Studies ; Female ; Health Care Surveys ; Humans ; Mastectomy, Segmental/methods ; Mastectomy, Segmental/statistics & numerical data ; Neoadjuvant Therapy ; Sentinel Lymph Node Biopsy/methods ; Sentinel Lymph Node Biopsy/statistics & numerical data ; Sentinel Lymph Node Biopsy/utilization ; Surgeons/statistics & numerical data ; Surveys and Questionnaires ; Turkey
    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2052429-8
    ISSN 1880-4233 ; 1340-6868
    ISSN (online) 1880-4233
    ISSN 1340-6868
    DOI 10.1007/s12282-013-0500-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top