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Article: Metabolomics-Based Approach for Coffee Beverage Improvement in the Context of Processing, Brewing Methods, and Quality Attributes

Farag, Mohamed A. / Zayed, Ahmed / Sallam, Ibrahim E. / Abdelwareth, Amr / Wessjohann, Ludger A.

Foods. 2022 Mar. 18, v. 11, no. 6

2022

Abstract: Coffee is a worldwide beverage of increasing consumption, owing to its unique flavor and several health benefits. Metabolites of coffee are numerous and could be classified on various bases, of which some are endogenous to coffee seeds, i.e., alkaloids, ... ...

Abstract	Coffee is a worldwide beverage of increasing consumption, owing to its unique flavor and several health benefits. Metabolites of coffee are numerous and could be classified on various bases, of which some are endogenous to coffee seeds, i.e., alkaloids, diterpenes, sugars, and amino acids, while others are generated during coffee processing, for example during roasting and brewing, such as furans, pyrazines, and melanoidins. As a beverage, it provides various distinct flavors, i.e., sourness, bitterness, and an astringent taste attributed to the presence of carboxylic acids, alkaloids, and chlorogenic acids. To resolve such a complex chemical makeup and to relate chemical composition to coffee effects, large-scale metabolomics technologies are being increasingly reported in the literature for proof of coffee quality and efficacy. This review summarizes the applications of various mass spectrometry (MS)- and nuclear magnetic resonance (NMR)-based metabolomics technologies in determining the impact of coffee breeding, origin, roasting, and brewing on coffee chemical composition, and considers this in relation to quality control (QC) determination, for example, by classifying defected and non-defected seeds or detecting the adulteration of raw materials. Resolving the coffee metabolome can aid future attempts to yield coffee seeds of desirable traits and best flavor types.
Keywords	adulterated products ; astringency ; bitterness ; chemical composition ; coffee (beverage) ; diterpenoids ; furans ; mass spectrometry ; melanoidins ; metabolites ; metabolome ; metabolomics ; nuclear magnetic resonance spectroscopy ; pyrazines ; quality control ; sourness
Language	English
Dates of publication	2022-0318
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11060864
Database	NAL-Catalogue (AGRICOLA)

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Article: Metabolomics-Based Approach for Coffee Beverage Improvement in the Context of Processing, Brewing Methods, and Quality Attributes.

Farag, Mohamed A / Zayed, Ahmed / Sallam, Ibrahim E / Abdelwareth, Amr / Wessjohann, Ludger A

Foods (Basel, Switzerland)

2022 Volume 11, Issue 6

Abstract	Coffee is a worldwide beverage of increasing consumption, owing to its unique flavor and several health benefits. Metabolites of coffee are numerous and could be classified on various bases, of which some are endogenous to coffee seeds, i.e., alkaloids, diterpenes, sugars, and amino acids, while others are generated during coffee processing, for example during roasting and brewing, such as furans, pyrazines, and melanoidins. As a beverage, it provides various distinct flavors, i.e., sourness, bitterness, and an astringent taste attributed to the presence of carboxylic acids, alkaloids, and chlorogenic acids. To resolve such a complex chemical makeup and to relate chemical composition to coffee effects, large-scale metabolomics technologies are being increasingly reported in the literature for proof of coffee quality and efficacy. This review summarizes the applications of various mass spectrometry (MS)- and nuclear magnetic resonance (NMR)-based metabolomics technologies in determining the impact of coffee breeding, origin, roasting, and brewing on coffee chemical composition, and considers this in relation to quality control (QC) determination, for example, by classifying defected and non-defected seeds or detecting the adulteration of raw materials. Resolving the coffee metabolome can aid future attempts to yield coffee seeds of desirable traits and best flavor types.
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11060864
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications.

Sallam, Ibrahim E / Abdelwareth, Amr / Attia, Heba / Aziz, Ramy K / Homsi, Masun Nabhan / von Bergen, Martin / Farag, Mohamed A

Microorganisms

2021 Volume 9, Issue 5

Abstract: Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from ... ...

Abstract	Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota-tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits.
Language	English
Publishing date	2021-04-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9050965
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Metabolite profiling of three Opuntia ficus-indica fruit cultivars using UPLC-QTOF-MS in relation to their antioxidant potential

Farag, Mohamed A / Sallam, Ibrahim E / Fekry, Mostafa I / Zaghloul, Soumaya S / El-Dine, Riham S

Food bioscience. 2020 Aug., v. 36

2020

Abstract: Opuntia ficus-indica is the economically important cactus species belonging to the Cactaceae family. Its importance arises from its nutritional value and various biological activities such as antioxidant, anticancer and antimicrobial activities. This ... ...

Abstract	Opuntia ficus-indica is the economically important cactus species belonging to the Cactaceae family. Its importance arises from its nutritional value and various biological activities such as antioxidant, anticancer and antimicrobial activities. This study attempts to characterize the metabolic profile of three O. ficus cultivars having different colors, i.e., red ‘Rose’, greenish white ‘Bianca’ and yellow-orange represented by peels and pulp tissues using ultra-performance liquid chromatography coupled to high resolution time of flight mass spectrometry (UPLC-QTOF-MS). A total of 45 metabolites were identified mainly flavonoids: isorhamnetin conjugates and phenolic acids, whereas betaxanthins and coumarins were present at lower levels. Principle component analysis and orthogonal projection discriminant analysis showed that dihydroxy psoralen-O-hexoside and glycosidic conjugates of ferulic acid were the most discriminatory metabolites among the peels and pulps within the different cultivars. On the other hand, the level of flavonoids was comparable among the cultivars. The antioxidant activity of peels and pulps extracts were further measured using 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) assays. ‘‘Rose’’ cultivar peel rich in dihydroxy psoralen-O-hexoside showed the highest antioxidant activity in both assays. This suggested that coumarins and flavonoids mediated high antioxidant activity of O. ficus-indica fruits although present at low levels.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; Ficus benghalensis ; Opuntia ficus-indica ; antimicrobial properties ; antioxidant activity ; antioxidants ; cacti and succulents ; color ; coumarins ; cultivars ; discriminant analysis ; ferulic acid ; fruit peels ; fruit pulp ; fruits ; isorhamnetin ; mass spectrometry ; metabolites ; nutritive value ; principal component analysis ; ultra-performance liquid chromatography
Language	English
Dates of publication	2020-08
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2212-4292
DOI	10.1016/j.fbio.2020.100673
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications

Sallam, Ibrahim E / Abdelwareth, Amr / Attia, Heba / Aziz, Ramy K / Homsi, Masun Nabhan / von Bergen, Martin / Farag, Mohamed A

Microorganisms. 2021 Apr. 29, v. 9, no. 5

2021

Abstract	Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota–tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits.
Keywords	antioxidants ; artificial intelligence ; bioavailability ; biotransformation ; drugs ; human health ; humans ; hydrolysis ; intestinal microorganisms ; metabolism ; metabolites ; phlorotannins
Language	English
Dates of publication	2021-0429
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9050965
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of Antioxidant Activity and Biotransformation of

Sallam, Ibrahim E / Rolle-Kampczyk, Ulrike / Schäpe, Stephanie Serena / Zaghloul, Soumaya S / El-Dine, Riham S / Shao, Ping / Bergen, Martin von / Farag, Mohamed A

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 21

Abstract: Opuntia ficus- ... ...

Abstract	Opuntia ficus-indica
MeSH term(s)	Opuntia ; Antioxidants/pharmacology ; Fruit ; Gastrointestinal Microbiome ; Plant Extracts/pharmacology ; Flavonoids ; Glycosides ; Biotransformation
Chemical Substances	Antioxidants ; piscidic acid (511BQ884F7) ; phloretic acid (6QNC6P18SR) ; Plant Extracts ; Flavonoids ; Glycosides
Language	English
Publishing date	2022-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27217568
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Article ; Online: Impact of different processing methods on the phenolics and neuroprotective activity of

Ezzat, Marwa I / Issa, Marwa Y / Sallam, Ibrahim E / Zaafar, Dalia / Khalil, Heba M A / Mousa, Mohamed R / Sabry, Dina / Gawish, Aya Y / Elghandour, Ahmed H / Mohsen, Engy

Food & function

2022 Volume 13, Issue 14, Page(s) 7794–7812

Abstract: Age-related diseases, including dementia, are a major health concern affecting daily human life. Strawberry ( ...

Abstract	Age-related diseases, including dementia, are a major health concern affecting daily human life. Strawberry (
MeSH term(s)	Aging ; Aluminum Chloride ; Animals ; Female ; Fragaria/chemistry ; Fruit/chemistry ; Galactose/adverse effects ; Galactose/metabolism ; Humans ; Phenols/analysis ; Phytochemicals/analysis ; Plant Extracts/metabolism ; Rats ; Rats, Wistar
Chemical Substances	Phenols ; Phytochemicals ; Plant Extracts ; Aluminum Chloride (3CYT62D3GA) ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo00645f
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Z 7872: Show issues

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Article: Impact of different processing methods on the phenolics and neuroprotective activity of Fragaria ananassa Duch. extracts in a d-galactose and aluminum chloride-induced rat model of aging

Ezzat, Marwa I. / Issa, Marwa Y. / Sallam, Ibrahim E. / Zaafar, Dalia / Khalil, Heba M. A. / Mousa, Mohamed R. / Sabry, Dina / Gawish, Aya Y. / Elghandour, Ahmed H. / Mohsen, Engy

Food & function. 2022 July 18, v. 13, no. 14

2022

Abstract: Age-related diseases, including dementia, are a major health concern affecting daily human life. Strawberry (Fragaria ananassa Duch.) is the most eaten fruit worldwide due to its exceptional aroma and flavor. However, it's rapid softening and decay limit ...

Abstract	Age-related diseases, including dementia, are a major health concern affecting daily human life. Strawberry (Fragaria ananassa Duch.) is the most eaten fruit worldwide due to its exceptional aroma and flavor. However, it's rapid softening and decay limit its shelf-life. Freezing and boiling represent the well-known conservation methods to extend its shelf-life. Therefore, we aimed to discover the phytochemical content differences of fresh and processed strawberries associated with investigating and comparing their neuroprotective effects in a rat model of aging. Female Wistar rats were orally pretreated with fresh, boiled, and frozen F. ananassa methanolic extracts (250 mg kg⁻¹) for 2 weeks, and then these extracts were concomitantly exposed to d-galactose [65 mg kg⁻¹, subcutaneously (S/C)] and AlCl₃ (200 mg kg⁻¹, orally) for 6 weeks to develop aging-like symptoms. The results of UPLC/ESI-MS phytochemical profiling revealed 36 secondary metabolites, including phenolics, flavonoids, and their glycoside derivatives. Compared with boiled and frozen extracts, the fresh extract ameliorated the behavioral deficits including anxiety and cognitive dysfunction, upregulated brain HO-1 and Nrf2 levels, and markedly reduced caspase-3 and PPAR-γ levels. Moreover, LDH and miRNA-9, 124 and 132 protein expressions were reduced. The histological architecture of the brain hippocampus was restored and glial fibrillary acidic protein (GFAP) immunoexpression was downregulated. In conclusion, the fresh extract has neuroprotective activity that could have a promising role in ameliorating age-related neurodegeneration.
Keywords	Fragaria ananassa ; aluminum ; animal models ; anxiety ; caspase-3 ; cognitive disorders ; dementia ; females ; flavonoids ; flavor ; fruits ; galactose ; glycosides ; hippocampus ; histology ; humans ; neurodegenerative diseases ; neuroprotective effect ; odors ; phenolic compounds ; secondary metabolites ; shelf life ; strawberries
Language	English
Dates of publication	2022-0718
Size	p. 7794-7812.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo00645f
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 7872: Show issues

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Article: Metabolomics reveals impact of seven functional foods on metabolic pathways in a gut microbiota model.

Farag, Mohamed A / Abdelwareth, Amr / Sallam, Ibrahim E / El Shorbagi, Mohamed / Jehmlich, Nico / Fritz-Wallace, Katarina / Serena Schäpe, Stephanie / Rolle-Kampczyk, Ulrike / Ehrlich, Anja / Wessjohann, Ludger A / von Bergen, Martin

Journal of advanced research

2020 Volume 23, Page(s) 47–59

Abstract: Functional food defined as dietary supplements that in addition to their nutritional values, can beneficially modulate body functions becomes more and more popular but the reaction of the intestinal microbiota to it is largely unknown. In order to ... ...

Abstract	Functional food defined as dietary supplements that in addition to their nutritional values, can beneficially modulate body functions becomes more and more popular but the reaction of the intestinal microbiota to it is largely unknown. In order to analyse the impact of functional food on the microbiota itself it is necessary to focus on the physiology of the microbiota, which can be assessed in a whole by untargeted metabolomics. Obtaining a detailed description of the gut microbiota reaction to food ingredients can be a key to understand how these organisms regulate and bioprocess many of these food components. Extracts prepared from seven chief functional foods, namely green tea, black tea,
Language	English
Publishing date	2020-01-03
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2541849-X
ISSN	2090-1224 ; 2090-1232
ISSN (online)	2090-1224
ISSN	2090-1232
DOI	10.1016/j.jare.2020.01.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Global Forum of Cancer Surgeons: Perspectives on Barriers to Surgical Care for Cancer Patients and Potential Solutions.

Are, Chandrakanth / McMasters, Kelly M / Giuliano, Armando / Yanala, Ujwal / Balch, Charles / Anderson, Benjamin O / Berman, Russell / Audisio, Riccardo / Kovacs, Tibor / Savant, Dhairyasheel / Toprani, Rajendra / Amira, Gamal / Sallam, Ibrahim / Baek, Jeong Heum / Baek, Moo-Jun / Park, Do Joong / Beulo, Gregorio Quintero / Rocha, Enrique Bargallo / Said, Hector Martinez /

Cheema, Muhammad / AliKhan, Abul / Mack, Lloyd / Chen, Gong / Quadros, Claudio Almeida / Reis, Tarcisio / de Castro Ribeiro, Heber Salvador / Zippel, Douglas / Ramirez, Augusto Leon / Seto, Yasuyuki / Yoshida, Kazuhiro / Mori, Masaki

Annals of surgical oncology

2019 Volume 26, Issue 6, Page(s) 1577–1582

MeSH term(s)	Attitude of Health Personnel ; Delivery of Health Care/standards ; Humans ; Neoplasms/surgery ; Surgeons/standards
Language	English
Publishing date	2019-03-25
Publishing country	United States
Document type	Editorial
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-019-07301-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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