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  1. Article ; Online: Brief Cost Analysis of Surgical Personal Protective Equipment During the COVID-19 Pandemic.

    Kapinos, Kandice A / Salley, Jordan R / Day, Andrew

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2022  Volume 25, Issue 8, Page(s) 1317–1320

    Abstract: Objectives: This study aimed to compare the costs incurred and saved from universal use of N95 respirators with surgical masks for operating room providers in the United States during the COVID-19 pandemic.: Methods: We built a decision analytic ... ...

    Abstract Objectives: This study aimed to compare the costs incurred and saved from universal use of N95 respirators with surgical masks for operating room providers in the United States during the COVID-19 pandemic.
    Methods: We built a decision analytic model to compare direct medical costs of healthcare workers (HCWs) infected with COVID-19 during operating room procedures from expected transmission when using an N95 respirator relative to a surgical mask. We also examined quarantine costs.
    Results: Results varied depending upon prevalence and false-negative rates of tests, but if N95 respirators reduce transmission by 2.8%, prevalence is at 1%, and testing yields 20% false negatives, providers should be willing to pay an additional $0.64 per HCW for the additional protection. Under this scenario, approximately 11 COVID-19 cases would be averted among HCWs per day.
    Conclusions: Potential savings depend on disease prevalence, rate of asymptomatic patients with COVID-19, accuracy of testing, the marginal cost of respirators, and the quarantine period. We provide a range of calculations to show under which conditions N95 respirators are cost saving.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Costs and Cost Analysis ; Humans ; Pandemics/prevention & control ; Personal Protective Equipment ; SARS-CoV-2 ; United States
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2022.03.015
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    Zs.A 5904: Show issues Location:
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  2. Article ; Online: Vanishing lung syndrome: a consequence of mixed tobacco and marijuana use.

    Salley, Jordan R / Kukkar, Vishal / Felde, Lanna

    BMJ case reports

    2021  Volume 14, Issue 5

    Abstract: Idiopathic giant bullous emphysema or vanishing lung syndrome (VLS) is a rare, chronic radiological diagnosis characterised by giant emphysematous bullae located primarily in the upper lobes of the lungs. This highly morbid phenotype of chronic ... ...

    Abstract Idiopathic giant bullous emphysema or vanishing lung syndrome (VLS) is a rare, chronic radiological diagnosis characterised by giant emphysematous bullae located primarily in the upper lobes of the lungs. This highly morbid phenotype of chronic obstructive pulmonary disease leads to severe progressive dyspnoea and significant disability. Here, we describe a 48-year-old man with a history significant for long-term tobacco and cannabis smoking, who is found to have VLS. We present a review of recent findings on the association between VLS and the additive effect of marijuana and tobacco.
    MeSH term(s) Humans ; Lung ; Male ; Marijuana Smoking/adverse effects ; Marijuana Use ; Middle Aged ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/etiology ; Nicotiana ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-239255
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  3. Article ; Online: The Nose Knows That Margins Matter.

    Day, Andrew T / Salley, Jordan R / Nijhawan, Rajiv I

    Annals of surgical oncology

    2021  Volume 28, Issue 7, Page(s) 3468–3469

    MeSH term(s) Humans ; Margins of Excision ; Nose
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-09881-4
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  4. Article ; Online: Comparing Long-Term Outcomes in Tracheostomy Placed in the First Year of Life.

    Salley, Jordan R / Kou, Yann-Fuu / Shah, Gopi B / Johnson, Romaine F

    The Laryngoscope

    2021  Volume 131, Issue 9, Page(s) 2115–2120

    Abstract: Objectives//hypothesis: To characterize long-term outcomes in pediatric patients requiring tracheotomy in the first year of life.: Study design: Retrospective case series.: Methods: A retrospective longitudinal registry of tracheostomy patients ... ...

    Abstract Objectives//hypothesis: To characterize long-term outcomes in pediatric patients requiring tracheotomy in the first year of life.
    Study design: Retrospective case series.
    Methods: A retrospective longitudinal registry of tracheostomy patients was queried for patients who underwent tracheotomy from birth to 11 months. Primary outcomes were decannulation and survival. Secondary outcomes included neurocognitive quality of life assessed with the PedsQL Family Impact Module (scored from worst to best, 0 to 100 points).
    Results: The study included 337 children. Thirty (8.90%) were neonates and 307 (91.10%) were infants. The population was 56.08% male (n = 189), and the racial and ethnicity composition were equally distributed (29.97% White, 31.45% Black, and 31.16% Hispanic). Significant differences between neonates and postneonates included birth weight in grams (2,731.40 vs. 1,950.44, P < .05), extreme prematurity (13.33% vs. 38.88%, P = .01), upper airway obstruction (80.00% vs. 42.67%, P < .05), and the need for mechanical ventilation (40.00% vs. 83.71%, P < .05). Despite these differences, long-term outcomes were similar: decannulation (X
    Conclusion: There were demographic differences between neonatal and infantile tracheostomy patients, but they did not affect long-term outcomes. The presence of a tracheostomy caused a significant impact on a family's quality of life.
    Level of evidence: 3 Laryngoscope, 131:2115-2120, 2021.
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29440
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  5. Article ; Online: Stepped Behavioral and Biological Screening for Oral Oncogenic HPV DNA in Middle-aged and Elderly Adults: A Feasibility Study.

    Day, Andrew T / Sample, Reilly A / Salley, Jordan R / Oliver, Dwight / Dahlstrom, Kristina R / Sturgis, Erich M / Tiro, Jasmin A

    Cancer prevention research (Philadelphia, Pa.)

    2023  Volume 16, Issue 3, Page(s) 127–132

    Abstract: Novel preventive interventions are needed to address the rising incidence of human papillomavirus (HPV)-mediated oropharyngeal cancer (HPV+ OPC). This pilot study evaluated the feasibility of a stepped, behavioral and biological screening program for ... ...

    Abstract Novel preventive interventions are needed to address the rising incidence of human papillomavirus (HPV)-mediated oropharyngeal cancer (HPV+ OPC). This pilot study evaluated the feasibility of a stepped, behavioral and biological screening program for oral oncogenic HPV infection, an intermediate HPV+ OPC outcome.
    This was a cross-sectional, feasibility study. Eligible 45-74 years old adults identified from three clinical research registries were administered a behavioral risk survey (step 1). Participant tobacco use and sexual behavior history were translated into a quantifiable risk of oral oncogenic HPV DNA, according to prior National Health and Nutrition Examination Survey analyses. Females with >2% risk and males with >7% risk were offered biological screening for oral oncogenic HPV DNA (step 2) via an oral rinse and gargle specimen.
    A total of 292 individuals were contacted, but only 144 (49%) were reached. Among these, 56 individuals (19%) were uninterested and 18 (13%) were ineligible. Seventy individuals began the survey and 66 completed it (step 1), among whom 46 were classified as low-risk. Among the remaining 20 participants classified as high-risk for an oral oncogenic HPV infection, 5% were current smokers and the median participant had performed oral sex on 10 unique partners. During step 2 (biological screening), 45% (9/20) completed testing, all of whom tested negative for oral oncogenic HPV DNA.
    In this pilot of a stepped, oral oncogenic HPV screening program, enrollment and study completion were suboptimal. These barriers to screening should be characterized and addressed before reevaluating the feasibility of this program.
    Prevention relevance: Novel preventive interventions are needed to address the rising incidence of HPV+ OPC. In this feasibility study, we characterized barriers to a two-step, behavioral and biological screening program for oral oncogenic HPV infection, an intermediate outcome for HPV+ OPC.
    MeSH term(s) Middle Aged ; Male ; Aged ; Female ; Humans ; Adult ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/epidemiology ; Feasibility Studies ; Nutrition Surveys ; Cross-Sectional Studies ; Pilot Projects ; Oropharyngeal Neoplasms/diagnosis ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/prevention & control ; DNA ; Human Papillomavirus Viruses ; Risk Factors ; Papillomaviridae/genetics ; Prevalence
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2434717-6
    ISSN 1940-6215 ; 1940-6207
    ISSN (online) 1940-6215
    ISSN 1940-6207
    DOI 10.1158/1940-6207.CAPR-22-0371
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    Zs.A 6766: Show issues Location:
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  6. Article ; Online: Comparison of outcomes between thermal welding forceps, controlled ablation and monopolar electrosurgery for tonsillectomy in children.

    Salley, Jordan R / Johnson, Romaine / Mitchell, Ron B / Shah, Gopi / Coffey, Amy R

    International journal of pediatric otorhinolaryngology

    2021  Volume 152, Page(s) 110941

    Abstract: Objective: To compare recovery from tonsillectomy using thermal welding forceps (TWF), controlled ablation (CA), and monopolar electrosurgery (MES) in children.: Methods: This was a prospective single blinded observational study using data from ... ...

    Abstract Objective: To compare recovery from tonsillectomy using thermal welding forceps (TWF), controlled ablation (CA), and monopolar electrosurgery (MES) in children.
    Methods: This was a prospective single blinded observational study using data from electronic medical record (EMR) and caregiver completed patient diary, conducted at a community-based children's hospital within an academic program with tonsillectomy performed by attending surgeons. Children aged 3-17 years undergoing tonsillectomy or adenotonsillectomy by TWF, CA, or MES over a 4-year period were included. Demographics, intraoperative time for tonsillectomy, blood loss, patient diary documentation of pain levels, analgesic doses, diet type and events per day were recorded. In addition, EMR documentation of morbidity events (bleeding, visits for bleeding, return to operating room [OR], total visits or admissions, poor oral intake or dehydration) were noted. To assess for differences in baseline characteristics, we utilized analysis of variance and Pearson's χ
    Results: A total of 369 children were enrolled, and 346 who met inclusion criteria underwent tonsillectomy. The children were categorized by the instrument used by the surgeons: CA 32.4% (n = 112), MES 36.7% (n = 127), and TWF 30.9% (n = 107). Mean age overall was 6.8 ± 3.2 years, with 57.4% female and 42.6% male. Diary return rate was 52.3% (n = 181) overall, with CA at 48.2% (n = 54), MES at 44.8% (n = 57), and TWF at 65.4% (n = 70). Average pain on the day of surgery was different between instruments with CA having the lowest level of 2.0 compared to 2.7 for TWF and MES (p = 0.001). Maximum pain level for day of surgery were lowest for CA at 2.7 compared to 3.4 for MES and 3.5 for TWF (p = 0.003). Pain levels were lowest for TWF after postoperative day (POD) 6. Overall rate of bleeding was 9.3%, with 2.6% return to surgery for control of bleeding. TWF had the lowest rate of bleeds (4.7% versus CA 11.6% and MES 11.0%), return to surgery (0.0% versus CA 2.7% and MES 4.7%), the earliest and final return to regular diet at POD 5.8 and 8.1, respectively without reaching statistical significance.
    Conclusion: CA had significantly lowest early pain levels on day 0-1 and trended lowest up to POD 6, after which TWF was lowest but did not reach statistical significance. TWF had the earliest return to regular diet. Children undergoing CA and MES are more likely to have a postoperative bleed and a return to the OR than TWF suggesting improved ability to seal vessels with the latter instrument. Further study with a larger sample is needed.
    MeSH term(s) Child ; Child, Preschool ; Electrosurgery ; Female ; Humans ; Male ; Pain, Postoperative ; Postoperative Hemorrhage ; Prospective Studies ; Surgical Instruments ; Tonsillectomy/adverse effects ; Welding
    Language English
    Publishing date 2021-11-17
    Publishing country Ireland
    Document type Journal Article ; Observational Study
    ZDB-ID 754501-0
    ISSN 1872-8464 ; 0165-5876
    ISSN (online) 1872-8464
    ISSN 0165-5876
    DOI 10.1016/j.ijporl.2021.110941
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  7. Article ; Online: Unmet Needs and Receipt of Supportive Care Services in Head and Neck Cancer Patients Prior to Oncologic Treatment: A Prospective, Cross-Sectional Pilot Study.

    Day, Andrew T / Prestwood, Courtney A / Emmett, Thomas R / Eary, Rebecca L / Salley, Jordan R / Cerda, Vanessa / Mayfield Arnold, Elizabeth / Lee, Simon Craddock / Tiro, Jasmin A

    The Annals of otology, rhinology, and laryngology

    2023  Volume 132, Issue 11, Page(s) 1361–1372

    Abstract: Objective: To characterize the supportive care (SC) needs and receipt of SC services among head and neck cancer (HNC) patients prior to oncologic treatment and to explore the influence of social determinants of health on these outcomes.: Materials and ...

    Abstract Objective: To characterize the supportive care (SC) needs and receipt of SC services among head and neck cancer (HNC) patients prior to oncologic treatment and to explore the influence of social determinants of health on these outcomes.
    Materials and methods: Newly diagnosed HNC patients were surveyed via telephone prior to oncologic treatment between 10/2019 and 1/2021 using a prospective, cross-sectional, bi-institutional, pilot study design. The primary study outcome was unmet SC needs (Supportive Care Needs Survey-Short Form34 [SCNS-SF34]). Hospital type (university- vs county safety-net) was explored as an exposure. Descriptive statistics were performed using STATA16 (College Station, TX).
    Results: Among 158 potentially eligible patients, 129 were successfully contacted, 78 met the study criteria, and 50 completed the survey. The mean age was 61, 58% exhibited clinical stage III-IV disease, and 68% and 32% were treated at the university and county safety-net hospital, respectively. Patients were surveyed a median of 20 days after their first oncology visit and 17 days prior to initiation of oncology treatment. They had a median of 24 total needs (11 were met and 13 were unmet) and preferred to see a median of 4 SC services but received care from none. County safety-net patients had comparatively more unmet needs than university patients (14.5 vs 11.5,
    Conclusion: Pretreatment HNC patients at a bi-institutional academic medical center report a high number of unmet SC needs with corollary poor receipt of available SC services. Novel interventions to address this significant gap in care are needed.
    MeSH term(s) Humans ; Middle Aged ; Pilot Projects ; Cross-Sectional Studies ; Prospective Studies ; Health Services Needs and Demand ; Head and Neck Neoplasms/therapy ; Surveys and Questionnaires ; Quality of Life
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/00034894231154182
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  8. Article ; Online: Adherence to the American Cancer Society Head and Neck Cancer Survivorship Care Guideline According to Chart Review: A Nested Retrospective Cohort Pilot Study.

    Salley, Jordan R / Day, Andrew T / Balachandra, Sanjana / Mehr, Joshua / Sumer, Baran D / Sher, David J / Mayfield Arnold, Elizabeth / Danphuong Ho, Esther / Lee, Simon Craddock / Eary, Rebecca

    The Annals of otology, rhinology, and laryngology

    2022  Volume 132, Issue 5, Page(s) 481–491

    Abstract: Objectives: The purpose of this study was to explore adherence to the American Cancer Society (ACS) Head and Neck Cancer (HNC) Survivorship Care Guideline and their outlined 33 recommendations among posttreatment HNC survivors.: Methods: A bi- ... ...

    Abstract Objectives: The purpose of this study was to explore adherence to the American Cancer Society (ACS) Head and Neck Cancer (HNC) Survivorship Care Guideline and their outlined 33 recommendations among posttreatment HNC survivors.
    Methods: A bi-institutional, retrospective, nested cohort study of mucosal or salivary gland HNC survivors diagnosed in 2018 was designed. Guideline adherence was assessed via retrospective chart review between 0 and 13 months after completion of oncologic treatment according to 4 categories: (1) problem assessed, (2) problem diagnosed, (3) management offered; (4) problem treated. Adherence was defined as meeting a recommendation subcategory at least once over the 13-month period.
    Results: Among 60 randomly selected HNC survivors, a total of 38 were included in the final cohort after exclusion of individuals with ineligible cancers and those who died or were lost to follow-up over the study period. Approximately 95% of HNC survivors were assessed for HNC recurrence and screened for lung cancer. Certain common problems such as xerostomia, dysphagia, and hypothyroidism were screened for and managed in ≥70% of eligible survivors. Conversely, screening for other second primary cancers and assessment of a majority of other physical and psychosocial harms occurred in <70% of survivors, and in many cases none to a slim minority of survivors (eg, sleep apnea and sleep disturbance, body and self-image concerns). Only 5% of survivors received a survivorship care plan.
    Conclusion: Overall adherence to the ACS HNC Survivorship Care Guideline in early posttreatment survivors was suboptimal. Interventions are needed to better implement and operationalize these guideline recommendations.
    MeSH term(s) Humans ; Survivorship ; Pilot Projects ; American Cancer Society ; Retrospective Studies ; Cohort Studies ; Head and Neck Neoplasms/therapy
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120642-4
    ISSN 1943-572X ; 0003-4894
    ISSN (online) 1943-572X
    ISSN 0003-4894
    DOI 10.1177/00034894221098471
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  9. Article ; Online: Clinical and Biologic Characteristics and Outcomes in Young and Middle-Aged Patients With Laryngeal Cancer: A Retrospective Cohort Analysis.

    Geng, Calvin X / Tanamal, Priscilla / Arvisais-Anhalt, Simone / Tomasino, Massimo / Gheit, Tarik / Bishop, Justin A / Palsgrove, Doreen N / Wang, Ellen / Salley, Jordan R / Tibbetts, Kathleen M / Sumer, Baran D / Tillman, Brittny N / Day, Andrew T

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2022  Volume 167, Issue 4, Page(s) 688–698

    Abstract: Objective: To describe the clinical and biologic characteristics and outcomes of young and middle-aged (YMA; <65 years) patients according to the presence or absence of traditional risk factors for laryngeal cancer.: Study design: Retrospective ... ...

    Abstract Objective: To describe the clinical and biologic characteristics and outcomes of young and middle-aged (YMA; <65 years) patients according to the presence or absence of traditional risk factors for laryngeal cancer.
    Study design: Retrospective cohort analysis.
    Setting: Single-institution academic medical center.
    Methods: Patients without a history of clinically significant tobacco use or heavy alcohol use were defined as "nontraditional": ≤5 pack-years, ≤5 years smoked, ≤14 alcoholic drinks per week, and ≥15-year interval from last tobacco abuse use to diagnosis. Remaining patients were categorized as "traditional." Select tumor samples were evaluated for bacterial and viral DNA by multiplex polymerase chain reaction.
    Results: Seventy-eight YMA patients with primary laryngeal squamous cell carcinoma were identified, 23% (n = 18) of whom were nontraditional. Nontraditional patients were younger than traditional patients (median age, 51 vs 59 years;
    Conclusion: Almost one-quarter of YMA patients lacked characteristic risk factors for laryngeal squamous cell carcinoma, and their tumors exhibited a higher prevalence of high-risk HPV. The significance of HPV16 and other tumor viruses with outcomes in nontraditional patients should be evaluated further.
    MeSH term(s) Biological Products ; Cohort Studies ; DNA, Viral/analysis ; Head and Neck Neoplasms/complications ; Human papillomavirus 16 ; Humans ; Laryngeal Neoplasms/pathology ; Middle Aged ; Papillomaviridae/genetics ; Papillomavirus Infections/complications ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/epidemiology ; Prognosis ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances Biological Products ; DNA, Viral
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/01945998211073707
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