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  1. Article: Advances in Understanding

    Salloum, Tamara / Tokajian, Sima / Hirt, Robert P

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 702240

    Abstract: Leishmaniasis is a vector-borne disease caused by a protozoa parasite from over ... ...

    Abstract Leishmaniasis is a vector-borne disease caused by a protozoa parasite from over 20
    Language English
    Publishing date 2021-09-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.702240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bacillus spp. isolated from soil in Lebanon can simultaneously degrade methomyl in contaminated soils and enhance plant growth

    Omeiri, Mohamad / Khnayzer, Rony / Yusef, Hoda / Tokajian, Sima / Salloum, Tamara / Mokh, Samia

    Biocatalysis and agricultural biotechnology. 2022 Jan., v. 39

    2022  

    Abstract: The extensive use of methomyl as a pesticide contributed to its pervasive existence as a pollutant of soil and water resources. In this study, bacteria were isolated from polluted agricultural soils and identified as Bacillus paramycoides and Bacillus ... ...

    Abstract The extensive use of methomyl as a pesticide contributed to its pervasive existence as a pollutant of soil and water resources. In this study, bacteria were isolated from polluted agricultural soils and identified as Bacillus paramycoides and Bacillus proteolyticus. Their methomyl biodegradation efficiencies were evaluated under various experimental conditions in vitro. Bacterial growth was optimized in terms of methomyl concentrations, resulting in maximum growth at 100 mg/L. A considerable degradation was achieved with methomyl being the sole carbon source. Under these conditions, Bacillus spp. degraded 60.6%–62.9% of methomyl in liquid medium when cultured separately, compared to 74.3% degradation when cultured as a consortium within 48 h. Moreover, methomyl bioremediation of artificially contaminated soil varied between 88.3% and 93.2% depending on the used bacterium and soil sterilization status. Furthermore, cell-free extracts of both isolates were tested to inspect their methomyl-degradation activities. The enzymes implicated in such action were mainly located extracellularly, with a lower quota of enzymes available in the intracellular and periplasmic extract. The tested Bacillus spp. also demonstrated considerable corn growth enhancing traits in terms of germination percentages, shoot and root lengths and weights, which were adversely affected by methomyl application. These results illustrate the beneficial use of Bacillus spp. as promising candidates in the bioremediation of methomyl-contaminated sites in conjunction with their contribution as biofertilizers.
    Keywords Bacillus (bacteria) ; agricultural biotechnology ; bacteria ; bacterial growth ; biocatalysis ; biodegradation ; biofertilizers ; bioremediation ; carbon ; corn ; germination ; liquids ; methomyl ; plant growth ; pollutants ; polluted soils ; soil sterilization ; Lebanon
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2642052-1
    ISSN 1878-8181
    ISSN 1878-8181
    DOI 10.1016/j.bcab.2022.102280
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: From Normal Flora to Brain Abscesses: A Review of

    Issa, Elio / Salloum, Tamara / Tokajian, Sima

    Frontiers in microbiology

    2020  Volume 11, Page(s) 826

    Abstract: Streptococcus ... ...

    Abstract Streptococcus intermedius
    Language English
    Publishing date 2020-05-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.00826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: COVID-19 Pandemic in Lebanon: One Year Later, What Have We Learnt?

    Koweyes, Jad / Salloum, Tamara / Haidar, Siwar / Merhi, Georgi / Tokajian, Sima

    mSystems

    2021  Volume 6, Issue 2

    Abstract: Lebanon is witnessing an unprecedented crisis with the rapid spread of coronavirus disease 2019 (COVID-19), financial meltdown, economic collapse, and the Beirut Port explosion. The first wave began in February 2020, following which the country ... ...

    Abstract Lebanon is witnessing an unprecedented crisis with the rapid spread of coronavirus disease 2019 (COVID-19), financial meltdown, economic collapse, and the Beirut Port explosion. The first wave began in February 2020, following which the country experienced several episodes and peaks while alternating between lockdowns and phased liftings. One year of the pandemic revealed that effective mitigation could not be separated from the collapse of the ongoing economic, political, and health sectors. Scaling up vaccination, preparedness, and response capacities is essential to control community transmission. The World Health Organization (WHO), National Council for Scientific Research-Lebanon (CNRS-L), nongovernmental organizations (NGOs), and humanitarian responses proved to be the safety net for the country during the current pandemic.
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/mSystems.00351-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular characterization of a carbapenem-resistant Enterobacter hormaechei ssp. xiangfangensis co-harbouring bla

    Makhlouf, Jana / Merhi, Georgi / Salloum, Tamara / Abboud, Edmond / Tokajian, Sima

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2021  Volume 93, Page(s) 104924

    Abstract: Enterobacter cloacae complex (ECC) members are rapidly emerging as successful nosocomial pathogens, especially, with the emergence of carbapenem-resistant clones. In this study, we performed a comprehensive molecular characterization of a carbapenem- ... ...

    Abstract Enterobacter cloacae complex (ECC) members are rapidly emerging as successful nosocomial pathogens, especially, with the emergence of carbapenem-resistant clones. In this study, we performed a comprehensive molecular characterization of a carbapenem-resistant E. hormaechei ssp. xiangfangensis LAU_ENC1. hsp60 and average nucleotide identity (ANI) were used for its identification. The repertoire of resistance genes and phage content were analyzed. Plasmid sequences were extracted and compared to closest references. The isolate LAU_ENC1 was identified as an E. hormaechei ssp. xiangfangensis and belonged to ST-114A sub-cluster. bla
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteriophages/physiology ; Carbapenems/pharmacology ; Drug Resistance, Bacterial/genetics ; Enterobacter/genetics ; Enterobacter/virology ; Genes, Bacterial
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2021-05-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2021.104924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: SARS-CoV-2 genomic epidemiology: data and sequencing infrastructure.

    Merhi, Georgi / Koweyes, Jad / Salloum, Tamara / Khoury, Charbel Al / Haidar, Siwar / Tokajian, Sima

    Future microbiology

    2022  Volume 17, Page(s) 1001–1007

    Abstract: ... Background: ... Genomic surveillance of SARS-CoV-2 is critical in monitoring viral lineages. Available data reveal a significant gap between low- and middle-income countries and the rest of the world. ... Methods: ... The SARS-CoV-2 sequencing costs ... ...

    Abstract Background: Genomic surveillance of SARS-CoV-2 is critical in monitoring viral lineages. Available data reveal a significant gap between low- and middle-income countries and the rest of the world. Methods: The SARS-CoV-2 sequencing costs using the Oxford Nanopore MinION device and hardware prices for data computation in Lebanon were estimated and compared with those in developed countries. SARS-CoV-2 genomes deposited on the Global Initiative on Sharing All Influenza Data per 1000 COVID-19 cases were determined per country. Results: Sequencing costs in Lebanon were significantly higher compared with those in developed countries. Low- and middle-income countries showed limited sequencing capabilities linked to the lack of support, high prices, long delivery delays and limited availability of trained personnel. Conclusion: The authors recommend the mobilization of funds to develop whole-genome sequencing-based surveillance platforms and the implementation of genomic epidemiology to better identify and track outbreaks, leading to appropriate and mindful interventions.
    MeSH term(s) COVID-19/epidemiology ; Genome, Viral ; Genomics ; Humans ; SARS-CoV-2/genetics ; Sequence Analysis
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2021-0207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genomic Characterization of Mutli-Drug Resistant

    Bitar, Ibrahim / Salloum, Tamara / Merhi, Georgi / Hrabak, Jaroslav / Araj, George F / Tokajian, Sima

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 922976

    Abstract: Resistance to ceftolozane/tazobactam (C/T) ... ...

    Abstract Resistance to ceftolozane/tazobactam (C/T) in
    MeSH term(s) Cephalosporins ; Genomics ; Inosine Monophosphate ; Multilocus Sequence Typing ; Pseudomonas aeruginosa/genetics ; Tazobactam/pharmacology ; beta-Lactamases/genetics
    Chemical Substances Cephalosporins ; Inosine Monophosphate (131-99-7) ; ceftolozane (37A4IES95Q) ; beta-Lactamases (EC 3.5.2.6) ; Tazobactam (SE10G96M8W)
    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.922976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Whole-genome sequence analysis of carbapenem-resistant Enterobacteriaceae recovered from hospitalized patients.

    El Khoury, Maria / Salloum, Tamara / Al Kodsi, Ibrahim / Jisr, Tamima / El Chaar, Mira / Tokajian, Sima

    Journal of global antimicrobial resistance

    2023  Volume 34, Page(s) 150–160

    Abstract: Objectives: Carbapenems are among the few effective antibiotics against multidrug-resistant Enterobacteriaceae. This study aimed at characterizing the plasmid content and resistome of clinical carbapenem-resistant Enterobacteriaceae (CRE) recovered from ...

    Abstract Objectives: Carbapenems are among the few effective antibiotics against multidrug-resistant Enterobacteriaceae. This study aimed at characterizing the plasmid content and resistome of clinical carbapenem-resistant Enterobacteriaceae (CRE) recovered from 2016 to 2019 from hospitalized patients in Lebanon.
    Methods: Plasmid typing and whole-genome sequencing were used to study the genomic characteristics of 65 clinical CREs including 27 Escherichia coli, 24 Klebsiella pneumoniae, one Klebsiella quasipneumoniae, three Morganella morganii, three Citrobacter freundii, five Enterobacter hormaechei, and two Serratia marcescens.
    Results: bla
    Conclusions: We analysed the clonality and resistance determinants of 65 multidrug-resistant (MDR) Enterobacteriaceae recovered in the period from 2016 to 2019 from a large tertiary hospital in Lebanon. NDM variants, OXA-48, and OXA-181 were the most prevalent detected carbapenemases and were mostly linked to the dissemination of IncL, IncX3, and IncF. This study reinforces the need to track the spread and dominance of clinically relevant carbapenemase-encoding plasmids in healthcare settings.
    MeSH term(s) Humans ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Enterobacteriaceae/genetics ; Escherichia coli/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Sequence Analysis
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2023.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Molecular characterization of a carbapenem-resistant Enterobacter hormaechei ssp. xiangfangensis co-harbouring blaNDM-1 and a chromosomally encoded phage-linked blaCTX-M-15 genes

    Makhlouf, Jana / Merhi, Georgi / Salloum, Tamara / Abboud, Edmond / Tokajian, Sima

    Infection, genetics, and evolution. 2021 Sept., v. 93

    2021  

    Abstract: Enterobacter cloacae complex (ECC) members are rapidly emerging as successful nosocomial pathogens, especially, with the emergence of carbapenem-resistant clones. In this study, we performed a comprehensive molecular characterization of a carbapenem- ... ...

    Abstract Enterobacter cloacae complex (ECC) members are rapidly emerging as successful nosocomial pathogens, especially, with the emergence of carbapenem-resistant clones. In this study, we performed a comprehensive molecular characterization of a carbapenem-resistant E. hormaechei ssp. xiangfangensis LAU_ENC1. hsp60 and average nucleotide identity (ANI) were used for its identification. The repertoire of resistance genes and phage content were analyzed. Plasmid sequences were extracted and compared to closest references. The isolate LAU_ENC1 was identified as an E. hormaechei ssp. xiangfangensis and belonged to ST-114A sub-cluster. blaNDM₋₁, blaCTX₋M₋₁₅, blaOXA₋₁, and blaACT₋₁₆ genes were detected as β-lactam resistance determinants. A chromosomal hybrid intact phage, Enterobacter phage LAU1, with blaCTX₋M₋₁₅ integrated in its direct vicinity within an ISEcp1 - blaCTX₋M₋₁₅ - wbuC - ∆Tn2 rare cassette was detected. blaNDM₋₁ was integrated within a novel IncFII conjugative plasmid, pLAU_ENC1, through an IS3000- ΔISAba125-blaNDM₋₁-bleMBL−//−Tn5403 cassette. To our knowledge, this is the first report of a multi-drug resistant (MDR) E. hormaechei ssp. xiangfangensis carrying a blaCTX₋M₋₁₅ integrated within the proximity of a provirus chromosomal region. Treatment options for MDR ECC members are becoming scarce, thus warranting an increased monitoring of the dissemination of these pathogens in clinical settings.
    Keywords Enterobacter cloacae ; Enterobacter hormaechei ; bacteriophages ; cross infection ; evolution ; hybrids ; multiple drug resistance ; plasmids ; proviruses
    Language English
    Dates of publication 2021-09
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2021.104924
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Detection and genomic characterization of mcr-9 in Enterobacter hormaechei recovered from a pediatric patient in Lebanon

    Khodor, Ragheed / Salloum, Tamara / El Jisr, Tamima / El Chaar, Mira / Tokajian, Sima

    Infection, genetics, and evolution. 2021 Oct., v. 94

    2021  

    Abstract: The emergence and spread of mobilized colistin resistance (mcr) genes are a global health concern.In this study, we report the detection and genomic characterization of mcr-9 in a colistin-susceptible Enterobacter hormaechei (EH23) recovered from a ... ...

    Abstract The emergence and spread of mobilized colistin resistance (mcr) genes are a global health concern.In this study, we report the detection and genomic characterization of mcr-9 in a colistin-susceptible Enterobacter hormaechei (EH23) recovered from a pediatric patient in Lebanon.EH23 was susceptible to colistin with a minimal inhibitory concentration (MIC) of 0.25 mg/L. Studying the mcr-9 genetic environment revealed that it was chromosomal and was bracketed by IS903 and IS26. QseCB, a two-component regulatory system, mediating the inducible expression of mcr-9 gene was not detected within the mcr-9 cassette but elsewhere on the genome. EH23 was 99.96% similar based on average nucleotide identity (ANI) to another mcr-negative E. hormaechei OIPH-N069 isolate recovered from Japan. wgSNP-based phylogenetic analysis divided all mcr-9 positive E. hormaechei isolates into five clades (I to V), with isolates from the same ST being clustered together.The silent spread of mcr-9, particularly in the globally successful ST-78 Enterobacter lineage, is worrisome and requires close monitoring in humans and animals.
    Keywords Enterobacter hormaechei ; Japan ; colistin ; genes ; genomics ; infection ; minimum inhibitory concentration ; patients ; phylogeny ; Lebanon
    Language English
    Dates of publication 2021-10
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2021.105014
    Database NAL-Catalogue (AGRICOLA)

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    ab Jg. 2022: Lesesaal (EG)

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