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Article ; Online: Recurrent ischemic stroke secondary to cardiac papillary fibroelastoma.

Sallustio, Fabrizio / Trebbastoni, Alessandro / Nicolini, Ettore / Manfredonia, Laura / Wolf, Lorenzo Guerrieri

2023

Language	English
Publishing date	2023-12-06
Publishing country	Italy
Document type	Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-023-02411-x
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Article ; Online: Benefit from successful recanalization in an Italian cohort of stroke patients receiving endovascular treatments according to the DIRECT-MT trial criteria.

Cappellari, Manuel / Saia, Valentina / Pracucci, Giovanni / Sallustio, Fabrizio / Zini, Andrea / Bergui, Mauro / Zivelonghi, Cecilia / Mangiafico, Salvatore / Toni, Danilo

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2022 Volume 29, Issue 3, Page(s) 291–300

Abstract: Introduction: To identify predictors of 3-month mRS score and to estimate the benefit from successful recanalization across baseline subgroups of Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) cohort of stroke patients receiving ... ...

Abstract	Introduction: To identify predictors of 3-month mRS score and to estimate the benefit from successful recanalization across baseline subgroups of Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) cohort of stroke patients receiving endovascular treatments according to the DIRECT-MT criteria. Methods: Using a model of propensity score matching, we retrospectively identified an IRETAS cohort of 137 patients receiving bridging who were matched with 137 patients receiving MT alone according to the DIRECT-MT criteria. Results: Differences were found between DIRECT-MT and IRETAS cohorts for 3-month mRS score 0 to 1 (23.5% vs. 33.1%) and 0 to 2 (36.7% vs. 47.1%), successful (82% vs. 76.7%) and complete recanalization (32.3% vs. 58.8%). Among unfavorable predictors for 3-month mRS shift, diabetes mellitus (18.9% vs. 13.9%) and asymptomatic intracerebral hemorhage (ICH) (34.8% vs. 25.5%) were more frequent in the DIRECT-MT, whereas age ≥80 years (23.7% vs. 15.3%) and pre-stroke mRS score >0 (16.1% vs. 7.8%) were more frequent in the IRETAS.The direction of effect on the 3-month mRS shift (6 to 0) favored successful recanalization across all strata. Greatest benefit from successful recanalization was observed in patients with most severe strokes (NIHSS ≥20, OR:4.002; 16-19, OR:3.292; 2-5, OR:2.470) and most proximal occlusion site (intra-cranial ICA, OR:4.092; M1-MCA, OR:3.705; M2-MCA, OR:2.001), in younger patients (18-59 years, OR:3.677; 60-79, OR:3.267; ≥80, OR:1.993), and in patients who started the treatment earlier (onset-to-groin time ≤205 min, OR:4.361; onset-to-groin time >205, OR:2.326). Conclusions: The benefit from successful recanalization for 3-month mRS shift in the direction of favorable outcome was different across baseline subgroups.
MeSH term(s)	Humans ; Aged, 80 and over ; Retrospective Studies ; Treatment Outcome ; Stroke/diagnostic imaging ; Stroke/surgery ; Thrombectomy/methods ; Endovascular Procedures/methods
Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199221086429
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Zs.A 6325: Show issues

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Article ; Online: The success of mechanical thrombectomy in acute ischaemic stroke is strictly dependent on ischaemic core size and time to treatment.

Sallustio, Fabrizio / Di Legge, Silvia

Evidence-based medicine

2015 Volume 20, Issue 6, Page(s) 211–212

MeSH term(s)	Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Male ; Stroke/therapy ; Thrombectomy/methods ; Tissue Plasminogen Activator/therapeutic use
Chemical Substances	Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2015-12
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	1324346-9
ISSN	1473-6810 ; 1356-5524
ISSN (online)	1473-6810
ISSN	1356-5524
DOI	10.1136/ebmed-2015-110226
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Zs.A 4793: Show issues

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Article ; Online: Letter by Sallustio et al Regarding Article, "Endovascular Thrombectomy and Stroke Physicians: Equity, Access, and Standards".

Sallustio, Fabrizio / Davoli, Alessandro / Koch, Giacomo

Stroke

2017 Volume 48, Issue 10, Page(s) e317

Language	English
Publishing date	2017-10
Publishing country	United States
Document type	Letter
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.117.018938
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Zs.A 448: Show issues

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Article ; Online: Temporal lobe atrophy as a potential predictor of functional outcome in older adults with acute ischemic stroke.

Sallustio, Fabrizio / Mascolo, Alfredo Paolo / Marrama, Federico / D'Agostino, Federica / Proietti, Marco / Greco, Laura / Di Giuliano, Francesca / Alemseged, Fana / Gandini, Roberto / Martorana, Alessandro / Diomedi, Marina / Koch, Giacomo

Acta neurologica Belgica

2023 Volume 123, Issue 4, Page(s) 1291–1299

Abstract: Background: To explore whether temporal lobe atrophy predicts 3-month functional outcome in a population of patients with anterior circulation acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT).: Methods: We retrospectively ... ...

Abstract	Background: To explore whether temporal lobe atrophy predicts 3-month functional outcome in a population of patients with anterior circulation acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT). Methods: We retrospectively selected patients > 65 years from our prospective endovascular stroke registry between June 2013 and August 2018. According to 3-month modified Rankin Scale (mRS), patients were divided in two groups, named good (mRS ≤ 2) and poor (mRS > 2) outcome. Measures of temporal lobe atrophy (i.e., interuncal distance [IUD], medial temporal lobe thickness [mTLT] and radial width of temporal horn [rWTH]) were assessed on pre-treatment CT scan. Cutoff values for good outcome were obtained for IUD, mTLT and rWTH by means of non-parametric ROC curve analysis. Multivariate analysis was performed to identify predictors of outcome. Ordinal shift analysis based on cutoff values was built to evaluate differences in 3-month mRS. Results: Among 340 patients, 130 (38.2%) had good and 210 (61.8%) had poor outcome. We found the following cutoff values for good outcome: < 25 mm for IUD, > 15 mm for mTLT and < 4 mm for rWTH. Lower IUD (OR 0.71; 95% CI 0.63-0.80; p < 0.0001) and rWTH (OR 0.73; 95% CI 0.61-0.87; p < 0.0001) and higher mTLT (OR 1.30; 95% CI 1.14-1.49; p < 0.0001) were independently associated with good outcome. Ordinal shift analysis based on cutoff values revealed significant differences in the rate of good outcome for rWTH (49 vs 27%; p < 0.0001), mTLT (52 vs 21%; p < 0.0001) and IUD (57 vs 17%; p < 0.0001). Conclusions: Assessment of temporal lobe atrophy may predict functional outcome in patients with AIS treated with MT.
MeSH term(s)	Humans ; Aged ; Ischemic Stroke/etiology ; Retrospective Studies ; Treatment Outcome ; Prospective Studies ; Stroke/diagnostic imaging ; Stroke/therapy ; Stroke/etiology ; Temporal Lobe/diagnostic imaging ; Atrophy/etiology ; Thrombectomy ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Brain Ischemia/etiology
Language	English
Publishing date	2023-01-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-02167-w
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Article ; Online: Clinical worsening despite intravenous thrombolysis in acute ischemic stroke secondary to carotid plaque rupture.

Sallustio, Fabrizio / Samà, Domenico / Mascolo, Alfredo Paolo / Marrama, Federico / Fresilli, Mauro / Diomedi, Marina

Journal of thrombosis and thrombolysis

2020 Volume 49, Issue 3, Page(s) 497–498

Abstract: First-line therapy of acute ischemic stroke is intravenous thrombolysis (IVT) irrespective of etiology. We report on a patient with acute ischemic stroke secondary to carotid plaque rupture who experienced plaque thrombosis and marked clinical worsening ... ...

Abstract	First-line therapy of acute ischemic stroke is intravenous thrombolysis (IVT) irrespective of etiology. We report on a patient with acute ischemic stroke secondary to carotid plaque rupture who experienced plaque thrombosis and marked clinical worsening despite IVT. While the latter is the gold standard therapy optimal platelets inhibition should be guaranteed to allow a safe as possible carotid intervention. Hereby we discuss all available strategies to be considered in order to better individualized treatment decision-making.
MeSH term(s)	Administration, Intravenous ; Aged ; Carotid Arteries/diagnostic imaging ; Humans ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/drug therapy ; Ischemic Stroke/etiology ; Male ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/drug therapy ; Thrombolytic Therapy
Language	English
Publishing date	2020-02-28
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-020-02067-x
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Zs.A 4352: Show issues

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Article ; Online: Reply to: Efficacy and Safety of Mechanical Thrombectomy in Older Adults with Acute Ischemic Stroke: Methodological Concerns.

Motta, Caterina / Koch, Giacomo / Sallustio, Fabrizio

Journal of the American Geriatrics Society

2017 Volume 65, Issue 9, Page(s) 2113–2114

MeSH term(s)	Aged ; Brain Ischemia ; Humans ; Ischemia ; Stroke ; Thrombectomy
Language	English
Publishing date	2017-07-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.14999
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Article ; Online: Haemodynamic impairment along the Alzheimer's disease continuum.

Diomedi, Marina / Rocco, Alessandro / Bonomi, Chiara Giuseppina / Mascolo, Alfredo Paolo / De Lucia, Vincenzo / Marrama, Federico / Sallustio, Fabrizio / Koch, Giacomo / Martorana, Alessandro

European journal of neurology

2021 Volume 28, Issue 7, Page(s) 2168–2173

Abstract: Background and purpose: Alzheimer's disease (AD) is considered a clinical and biological continuum identified via cerebrospinal fluid (CSF) or imaging biomarkers. Chronic hypoperfusion is held as one of the main features of Alzheimer's disease, as part ... ...

Abstract	Background and purpose: Alzheimer's disease (AD) is considered a clinical and biological continuum identified via cerebrospinal fluid (CSF) or imaging biomarkers. Chronic hypoperfusion is held as one of the main features of Alzheimer's disease, as part of the processes causing neuronal degeneration. The mechanism responsible for such condition is still debated, although recently a direct connection with amyloid peptides has been shown. Here the aim was to investigate whether measures of hypoperfusion change along the AD continuum. Methods: Seventy patients with mild AD were recruited and stratified according to their CSF biomarker profile-as indicated by the National Institute on Aging and Alzheimer's Association research framework-into patients with either isolated amyloid pathology (A+T-) or full-blown AD (A+T+), and further layered according to apolipoprotein E genotype. After evaluation of vascular risk factors, a transcranial Doppler was performed on each patient, to evaluate mean flow velocity and pulsatility index in the middle cerebral artery, and to calculate the breath-holding index. Patients were compared to a cohort of 17 healthy controls. Results: The breath-holding index was reduced in the AD continuum and was inversely correlated to CSF amyloid β42 levels. Such correlation was stronger in the A+T+ than in the A+T- group, and unexpectedly reached statistical significance only in the E3 and not in the E4 genotype carriers. Conclusions: These results suggest a tight and effective relationship between amyloid β42, vascular hypoperfusion, cerebrovascular reactivity and epsilon genotype.
MeSH term(s)	Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides ; Biomarkers ; Cognitive Dysfunction ; Hemodynamics ; Humans ; Peptide Fragments ; tau Proteins
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; Peptide Fragments ; tau Proteins
Language	English
Publishing date	2021-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.14834
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: CT Perfusion as a Predictor of the Final Infarct Volume in Patients with Tandem Occlusion.

Lacidogna, Giordano / Pitocchi, Francesca / Mascolo, Alfredo Paolo / Marrama, Federico / D'Agostino, Federica / Rocco, Alessandro / Mori, Francesco / Maestrini, Ilaria / Sabuzi, Federico / Cavallo, Armando / Morosetti, Daniele / Garaci, Francesco / Di Giuliano, Francesca / Floris, Roberto / Sallustio, Fabrizio / Diomedi, Marina / Da Ros, Valerio

Journal of personalized medicine

2023 Volume 13, Issue 2

Abstract: Background: CT perfusion (CTP) is used in patients with anterior circulation acute ischemic stroke (AIS) for predicting the final infarct volume (FIV). Tandem occlusion (TO), involving both intracranial large vessels and the ipsilateral cervical ... ...

Abstract	Background: CT perfusion (CTP) is used in patients with anterior circulation acute ischemic stroke (AIS) for predicting the final infarct volume (FIV). Tandem occlusion (TO), involving both intracranial large vessels and the ipsilateral cervical internal carotid artery could generate hemodynamic changes altering perfusion parameters. Our aim is to evaluate the accuracy of CTP in the prediction of the FIV in TOs. Methods: consecutive patients with AIS due to middle cerebral artery occlusion, referred to a tertiary stroke center between March 2019 and January 2021, with an automated CTP and successful recanalization (mTICI = 2b - 3) after endovascular treatment were retrospectively included in the tandem group (TG) or in the control group (CG). Patients with parenchymal hematoma type 2, according to ECASS II classification of hemorrhagic transformations, were excluded in a secondary analysis. Demographic, clinical, radiological, time intervals, safety, and outcome measures were collected. Results: among 319 patients analyzed, a comparison between the TG (N = 22) and CG (n = 37) revealed similar cerebral blood flow (CBF) > 30% (29.50 ± 32.33 vs. 15.76 ± 20.93 Conclusion: automated CTP could represent a good predictor of FIV in patients with AIS due to TO.
Language	English
Publishing date	2023-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13020342
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Article ; Online: Mechanical thrombectomy for in-hospital stroke: data from the Italian Registry of Endovascular Treatment in Acute Stroke.

Naldi, Andrea / Pracucci, Giovanni / Cavallo, Roberto / Saia, Valentina / Boghi, Andrea / Lochner, Piergiorgio / Casetta, Ilaria / Sallustio, Fabrizio / Zini, Andrea / Fainardi, Enrico / Cappellari, Manuel / Tassi, Rossana / Bracco, Sandra / Bigliardi, Guido / Vallone, Stefano / Nencini, Patrizia / Bergui, Mauro / Mangiafico, Salvatore / Toni, Danilo

Journal of neurointerventional surgery

2023 Volume 15, Issue e3, Page(s) e426–e432

Abstract: Background: The benefit, safety, and time intervals of mechanical thrombectomy (MT) in patients with in-hospital stroke (IHS) are unclear. We sought to evaluate the outcomes and treatment times for IHS patients compared with out-of-hospital stroke (OHS) ...

Abstract	Background: The benefit, safety, and time intervals of mechanical thrombectomy (MT) in patients with in-hospital stroke (IHS) are unclear. We sought to evaluate the outcomes and treatment times for IHS patients compared with out-of-hospital stroke (OHS) patients receiving MT. Methods: We analyzed data from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS) between 2015 and 2019. We compared the functional outcomes (modified Rankin Scale (mRS) scores) at 3 months, recanalization rates, and symptomatic intracranial hemorrhage (sICH) after MT. Time intervals from stroke onset-to-imaging, onset-to-groin, and onset-to-end MT were recorded for both groups, as were door-to-imaging and door-to-groin for OHS. A multivariate analysis was performed. Results: Of 5619 patients, 406 (7.2%) had IHS. At 3 months, IHS patients had a lower rate of mRS 0-2 (39% vs 48%, P<0.001) and higher mortality (30.1% vs 19.6%, P<0.001). Recanalization rates and sICH were similar. Time intervals (min, median (IQR)) from stroke onset-to-imaging, onset-to-groin, and onset-to-end MT were favorable for IHS (60 (34-106) vs 123 (89-188.5); 150 (105-220) vs 220 (168-294); 227 (164-303) vs 293 (230-370); all P<0.001), whereas OHS had lower door-to-imaging and door-to-groin times compared with stroke onset-to-imaging and onset-to-groin for IHS (29 (20-44) vs 60 (34-106), P<0.001; 113 (84-151) vs 150 (105-220); P<0.001). After adjustment, IHS was associated with higher mortality (aOR 1.77, 95% CI 1.33 to 2.35, P<0.001) and a shift towards worse functional outcomes in the ordinal analysis (aOR 1.32, 95% CI 1.06 to 1.66, P=0.015). Conclusion: Despite favorable time intervals for MT, IHS patients had worse functional outcomes than OHS patients. Delays in IHS management were detected.
MeSH term(s)	Humans ; Treatment Outcome ; Stroke/diagnostic imaging ; Stroke/surgery ; Intracranial Hemorrhages/etiology ; Hospitals ; Thrombectomy/methods ; Registries ; Italy/epidemiology ; Endovascular Procedures/methods ; Brain Ischemia/therapy ; Retrospective Studies
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2022-019939
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