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Article ; Online: Safety of core muscle training immediately after abdominal surgery: systematic review.

Perrodin, Stéphanie F / Salm, Lilian / Beldi, Guido

BJS open

2023 Volume 7, Issue 6

MeSH term(s)	Humans ; Muscles ; Abdominal Core/surgery ; Muscle Strength
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1093/bjsopen/zrad142
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Article ; Online: Gata6

Salm, Lilian / Shim, Raymond / Noskovicova, Nina / Kubes, Paul

Trends in immunology

2023 Volume 44, Issue 2, Page(s) 129–145

Abstract: There are striking similarities between the sea urchin cavity macrophage-like phagocytes (coelomocytes) and mammalian cavity macrophages in not only their location, but also their behaviors. These cells are crucial for maintaining homeostasis within the ... ...

Abstract	There are striking similarities between the sea urchin cavity macrophage-like phagocytes (coelomocytes) and mammalian cavity macrophages in not only their location, but also their behaviors. These cells are crucial for maintaining homeostasis within the cavity following a breach, filling the gap and functioning as a barrier between vital organs and the environment. In this review, we summarize the evolving literature regarding these Gata6
MeSH term(s)	Animals ; GATA6 Transcription Factor/immunology ; Macrophages, Peritoneal/immunology ; Mammals/immunology ; Phagocytes/immunology ; Sea Urchins/immunology
Chemical Substances	GATA6 Transcription Factor
Language	English
Publishing date	2023-01-07
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2022.12.002
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Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Function of Connexin-43 in Macrophages.

Rodjakovic, Daniel / Salm, Lilian / Beldi, Guido

International journal of molecular sciences

2021 Volume 22, Issue 3

Abstract: Recent studies have helped to increase the understanding of the function of Connexin-43 (Cx43) in macrophages (Mφ). The various roles of Cx43 in Mφs range from migration, antigen-presentation and some forms of intercellular communication to more delicate ...

Abstract	Recent studies have helped to increase the understanding of the function of Connexin-43 (Cx43) in macrophages (Mφ). The various roles of Cx43 in Mφs range from migration, antigen-presentation and some forms of intercellular communication to more delicate processes, such as electrochemical support in the propagation of the heartbeat, immunomodulatory regulation in the lungs and in macrophage-differentiation. Its relevance in pathophysiology becomes evident in inflammatory bowel disease (IBD), tumours and HIV, in which aberrant functioning of Cx43 has been described. However, the involvement of Cx43 in other Mφ functions, such as phagocytosis and polarisation, and its involvement in other types of local and systemic inflammation, are still unclear and need further research.
MeSH term(s)	Animals ; Antigen Presentation ; Cell Communication/immunology ; Cell Movement/immunology ; Connexin 43/genetics ; Connexin 43/metabolism ; Humans ; Intestines/cytology ; Intestines/immunology ; Lung/cytology ; Lung/immunology ; Macrophage Activation ; Macrophages/immunology ; Macrophages/metabolism ; Mice, Knockout ; Models, Animal ; Myocardium/cytology ; Myocardium/immunology ; Phagocytosis/immunology ; Systemic Inflammatory Response Syndrome/immunology ; Mice
Chemical Substances	Connexin 43 ; GJA1 protein, human ; GJA1 protein, mouse
Language	English
Publishing date	2021-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22031412
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Article ; Online: Intestinal dysbiosis as an intraoperative predictor of septic complications: evidence from human surgical cohorts and preclinical models of peritoneal sepsis.

Spari, Daniel / Zwicky, Simone N / Yilmaz, Bahtiyar / Salm, Lilian / Candinas, Daniel / Beldi, Guido

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22921

Abstract: Major surgery exposes the intestinal microbiota to inflammatory and antibiotic stressors, which alter the microbiota composition of the intestinal lumen and fecal contents. However, it is not sufficiently understood, if such dysbiosis develops already ... ...

Abstract	Major surgery exposes the intestinal microbiota to inflammatory and antibiotic stressors, which alter the microbiota composition of the intestinal lumen and fecal contents. However, it is not sufficiently understood, if such dysbiosis develops already during surgery and if alterations in microbiota may be the cause of surgical complications. End-of-surgery composition of the microbiota in the rectum was assessed in 41 patients undergoing either rectal or duodenopancreatic resection and was compared to baseline before surgery using 16S-rRNA sequencing. A subset of patients developed severe dysbiosis at the end of surgery, which was characterized by an overgrowth of the Proteobacteria phylum that includes the facultative pathogen E. coli. To test if dysbiosis impacts on surgical outcomes, dysbiosis was modeled in mice by a single oral administration of vancomycin prior to cecal ligation and puncture. Dysbiosis was associated with impaired post-surgical survival, dysregulation of the host's immune response, elevated bacterial virulence and reduced bacterial metabolism of carbon sources. In conclusion, dysbiosis can be detected already at the end of surgery in a fraction of patients undergoing major surgery. Modelling surgery-associated dysbiosis in mice using single-shot administration of vancomycin induced dysbiosis and resulted in elevated mortality.
MeSH term(s)	Humans ; Mice ; Animals ; Dysbiosis/microbiology ; Vancomycin ; Escherichia coli/genetics ; Rectum ; Sepsis/microbiology ; RNA, Ribosomal, 16S/genetics
Chemical Substances	Vancomycin (6Q205EH1VU) ; RNA, Ribosomal, 16S
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49034-z
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Article ; Online: Hepatic blood flow regulation but not oxygen extraction capability is impaired in prolonged experimental abdominal sepsis.

Liu, Shengchen / Kohler, Andreas / Langer, Rupert / Jakob, Manuel O / Salm, Lilian / Blank, Annika / Beldi, Guido / Jakob, Stephan M

American journal of physiology. Gastrointestinal and liver physiology

2022 Volume 323, Issue 4, Page(s) G348–G361

Abstract: Impaired oxygen utilization has been proposed to play a significant role in sepsis-induced liver dysfunction, but its magnitude and temporal course during prolonged resuscitation is controversial. The aim of this study is to evaluate the capability of ... ...

Abstract	Impaired oxygen utilization has been proposed to play a significant role in sepsis-induced liver dysfunction, but its magnitude and temporal course during prolonged resuscitation is controversial. The aim of this study is to evaluate the capability of the liver to increase oxygen extraction in sepsis during repeated acute portal vein blood flow reduction. Twenty anesthetized and mechanically ventilated pigs with hepatic hemodynamic monitoring were randomized to fecal peritonitis or controls (n = 10, each). After 8-h untreated sepsis, the animals were resuscitated for three days. The ability to increase hepatic O<sub>2</sub> extraction was evaluated by repeated, acute decreases in hepatic oxygen delivery (Do<sub>2</sub>) via reduction of portal flow. Blood samples for liver function and liver biopsies were obtained repeatedly. Although liver function tests, ATP content, and Do<sub>2</sub> remained unaltered, there were signs of liver injury in blood samples and overt liver cell necrosis in biopsies. With acute portal vein occlusion, hepatic Do<sub>2</sub> decreased more in septic animals compared with controls [max. decrease: 1.66 ± 0.68 mL/min/kg in sepsis vs. 1.19 ± 0.42 mL/min/kg in controls; portal venous flow (Qpv) reduction-sepsis interaction: P = 0.028]. Hepatic arterial buffer response (HABR) was impaired but recovered after 3-day resuscitation, whereas hepatic oxygen extraction increased similarly during the procedures in both groups (max. increase: 0.27 ± 0.13 in sepsis vs. 0.18 ± 0.09 in controls; all P > 0.05). Our data indicate maintained capacity of the liver to acutely increase O<sub>2</sub> extraction, whereas blood flow regulation is transiently impaired with the potential to contribute to liver injury in sepsis.NEW & NOTEWORTHY The capacity to acutely increase hepatic O<sub>2</sub> extraction with portal flow reduction is maintained in sepsis with accompanying liver injury, but hepatic blood flow regulation is impaired.
MeSH term(s)	Adenosine Triphosphate ; Animals ; Hemodynamics ; Hepatic Artery ; Liver Circulation/physiology ; Oxygen ; Sepsis ; Swine
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial, Veterinary ; Research Support, Non-U.S. Gov't
ZDB-ID	603840-2
ISSN	1522-1547 ; 0193-1857
ISSN (online)	1522-1547
ISSN	0193-1857
DOI	10.1152/ajpgi.00109.2022
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Article ; Online: Impact of changing the surgical team for wound closure on surgical site infection: A matched case-control study.

Salm, Lilian / Chapalley, Dimitri / Perrodin, Stéphanie Fabienne / Tschan, Franziska / Candinas, Daniel / Beldi, Guido

PloS one

2020 Volume 15, Issue 11, Page(s) e0241712

Abstract: Background: Wound closure is performed at the end of the procedure, when the attention of the surgical team may decrease due to tiredness. The aim of this study was to assess the influence of changing the surgical team for wound closure on the rate of ... ...

Abstract	Background: Wound closure is performed at the end of the procedure, when the attention of the surgical team may decrease due to tiredness. The aim of this study was to assess the influence of changing the surgical team for wound closure on the rate of surgical site infection (SSI). Methods: A two-armed observational monocentric matched case-control study was performed in a time series design. During the baseline period, closure of the abdominal wall was performed by the main surgical team. The intervention consisted of closure of the abdominal wall and skin by an independent surgical team. Matching was based on gender, BMI, length of surgery, type of surgery, elective versus emergency surgery and ASA score. The primary outcome was SSI rate 30 days after surgery. Results: A total of 72 patients in the intervention group were matched with 72 patients in the baseline group. The SSI rate after 30 days in the intervention group was 10% (n = 7) and in the baseline group 21% (n = 15) (p = 0.064). Redo-Surgery as result of infection (e.g. opening the wound, drainage or reoperation) was significantly higher in the baseline group (19.4% vs 2.7%; p = 0.014). Mortality, length of stay, rehospitalisation and complication rates 30 days after surgery did not differ significantly. Conclusion: Changing the surgical team for wound closure did not reduce the overall rate of SSI, but the rate of redo-surgery as a result of SSI. Despite being potentially beneficial, organizational factors are a main limiting factor of changing the surgical team for the wound closure. Trial registration: Clinicaltrial.gov NCT04503642.
MeSH term(s)	Abdomen/surgery ; Abdominal Wound Closure Techniques/adverse effects ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Elective Surgical Procedures/adverse effects ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Reoperation/statistics & numerical data ; Surgeons ; Surgical Wound Infection/epidemiology
Language	English
Publishing date	2020-11-05
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Observational Study
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0241712
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Article ; Online: The Role of HbA1c as a Positive Perioperative Predictor of Surgical Site and Other Postoperative Infections: An Explorative Analysis in Patients Undergoing Minor to Major Surgery.

Kopp Lugli, Andrea / Marti, Walter R / Salm, Lilian / Mujagic, Edin / Bundi, Marcel / von Strauss, Marco / Bucheli Laffer, Evelin / Landin, Julia / Fux, Christoph A / Coslovsky, Michael / Weber, Walter Paul / Kindler, Christoph

World journal of surgery

2021 Volume 46, Issue 2, Page(s) 391–399

Abstract: Background: Patients with diabetes mellitus type 2 (DM2) inhere impaired peripheral insulin action leading to higher perioperative morbidity and mortality rates, with hospital-acquired infections being one important complication. This post hoc, ... ...

Abstract	Background: Patients with diabetes mellitus type 2 (DM2) inhere impaired peripheral insulin action leading to higher perioperative morbidity and mortality rates, with hospital-acquired infections being one important complication. This post hoc, observational study aimed to analyze the impact of surgical and metabolic stress as defined by the surrogate marker hemoglobin A1c (HbA1c), in relation to self-reported DM2, on perioperative infection rates in a subcohort of the Surgical Site Infection (SSI) Trial population. Methods: All patients of the SSI study were screened for HbA1c levels measured perioperatively for elective or emergency surgery and classified according to the American Diabetes Association HbA1c cutoff values. SSI and nosocomial infections, self-reported state of DM2 and type of surgery (minor, major) were assessed. Results: HbA1c levels were measured in 139 of 5175 patients (2.7%) of the complete SSI study group. Seventy patients (50.4%) self-reported DM2, while 69 (49.6%) self-reported to be non-diabetic. HbA1c levels indicating pre-diabetes were found in 48 patients (34.5%) and diabetic state in 64 patients (46%). Forty-five patients of the group self-reporting no diabetes (65.2%) were previously unaware of their metabolic derangement (35 pre-diabetic and 10 diabetic). Eighteen infections were detected. Most infections (17 of 18 events) were found in patients with HbA1c levels indicating pre-/diabetic state. The odds for an infection was 3.9-fold (95% CI 1.4 to 11.3) higher for patients undergoing major compared to minor interventions. The highest percentage of infections (38.5%) was found in the group of patients with an undiagnosed pre-/diabetic state undergoing major surgery. Conclusions: These results encourage investment in further studies evaluating a more generous and specific use of HbA1c screening in patients without self-reported diabetes undergoing major surgery. Trial registration Clinicaltrials.gov identifier: NCT01790529.
MeSH term(s)	Biomarkers ; Diabetes Mellitus, Type 2/complications ; Elective Surgical Procedures ; Glycated Hemoglobin A/analysis ; Humans ; Surgical Wound Infection/diagnosis ; Surgical Wound Infection/epidemiology
Chemical Substances	Biomarkers ; Glycated Hemoglobin A
Language	English
Publishing date	2021-11-08
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-021-06368-x
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Article ; Online: Correction to: The Role of HbA1c as a Positive Perioperative Predictor of Surgical Site and Other Postoperative Infections: An Explorative Analysis in Patients Undergoing Minor to Major Surgery.

World journal of surgery

2021 Volume 46, Issue 2, Page(s) 400

Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Published Erratum
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-021-06392-x
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Article ; Online: ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery.

Cell reports

2023 Volume 42, Issue 3, Page(s) 112269

Abstract: It is generally believed that environmental or cutaneous bacteria are the main origin of surgical infections. Therefore, measures to prevent postoperative infections focus on optimizing hygiene and improving asepsis and antisepsis. In a large cohort of ... ...

Abstract	It is generally believed that environmental or cutaneous bacteria are the main origin of surgical infections. Therefore, measures to prevent postoperative infections focus on optimizing hygiene and improving asepsis and antisepsis. In a large cohort of patients with infections following major surgery, we identified that the causative bacteria are mainly of intestinal origin. Postoperative infections of intestinal origin were also found in mice undergoing partial hepatectomy. CCR6
MeSH term(s)	Mice ; Animals ; Lymphocytes/metabolism ; Immunity, Innate ; Liver Regeneration ; Interleukins/metabolism ; Skin/metabolism
Chemical Substances	Interleukins
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112269
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Article: The LIM Protein Ajuba Augments Tumor Metastasis in Colon Cancer.

Dommann, Noëlle / Sánchez-Taltavull, Daniel / Eggs, Linda / Birrer, Fabienne / Brodie, Tess / Salm, Lilian / Baier, Felix Alexander / Medová, Michaela / Humbert, Magali / Tschan, Mario P / Beldi, Guido / Candinas, Daniel / Stroka, Deborah

Cancers

2020 Volume 12, Issue 7

Abstract: Colorectal cancer, along with its high potential for recurrence and metastasis, is a major health burden. Uncovering proteins and pathways required for tumor cell growth is necessary for the development of novel targeted therapies. Ajuba is a member of ... ...

Abstract	Colorectal cancer, along with its high potential for recurrence and metastasis, is a major health burden. Uncovering proteins and pathways required for tumor cell growth is necessary for the development of novel targeted therapies. Ajuba is a member of the LIM domain family of proteins whose expression is positively associated with numerous cancers. Our data shows that Ajuba is highly expressed in human colon cancer tissue and cell lines. Publicly available data from The Cancer Genome Atlas shows a negative correlation between survival and Ajuba expression in patients with colon cancer. To investigate its function, we transduced SW480 human colon cancer cells, with lentiviral constructs to knockdown or overexpress Ajuba protein. The transcriptome of the modified cell lines was analyzed by RNA sequencing. Among the pathways enriched in the differentially expressed genes, were cell proliferation, migration and differentiation. We confirmed our sequencing data with biological assays; cells depleted of Ajuba were less proliferative, more sensitive to irradiation, migrated less and were less efficient in colony formation. In addition, loss of Ajuba expression decreased the tumor burden in a murine model of colorectal metastasis to the liver. Taken together, our data supports that Ajuba promotes colon cancer growth, migration and metastasis and therefore is a potential candidate for targeted therapy.
Language	English
Publishing date	2020-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12071913
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