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  1. Book ; Online ; E-Book: The Wiley encyclopedia of health psychology

    Paul, Robert D. / Salminen, Lauren E. / Heaps, Jodi / Cohen, Lee M.

    2021  

    Title variant Encyclopedia of health psychology
    Author's details edited by Robert H. Paul, Co edited by Lauren E. Salminen, Jodi Heaps, editor-in-chief Lee M. Cohen
    Language English
    Dates of publication 2021-2021
    Size 1 Online-Ressource (4 Bände (2163 Seiten)), Illustrationen
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Note Enhält Band 1 - 4
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020869277
    ISBN 978-1-119-67578-5 ; 978-1-119-67576-1 ; 9781119057833 ; 1-119-67578-2 ; 1-119-67576-6 ; 1119057833
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Sex is a defining feature of neuroimaging phenotypes in major brain disorders.

    Salminen, Lauren E / Tubi, Meral A / Bright, Joanna / Thomopoulos, Sophia I / Wieand, Alyssa / Thompson, Paul M

    Human brain mapping

    2021  Volume 43, Issue 1, Page(s) 500–542

    Abstract: Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which ... ...

    Abstract Sex is a biological variable that contributes to individual variability in brain structure and behavior. Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions. Still, sex differences in MRI outcomes are understudied, particularly in clinical samples with known sex differences in disease risk, prevalence, and expression of clinical symptoms. Here we review the existing literature on sex differences in adult brain structure in normative samples and in 14 distinct psychiatric and neurological disorders. We discuss commonalities and sources of variance in study designs, analysis procedures, disease subtype effects, and the impact of these factors on MRI interpretation. Lastly, we identify key problems in the neuroimaging literature on sex differences and offer potential recommendations to address current barriers and optimize rigor and reproducibility. In particular, we emphasize the importance of large-scale neuroimaging initiatives such as the Enhancing NeuroImaging Genetics through Meta-Analyses consortium, the UK Biobank, Human Connectome Project, and others to provide unprecedented power to evaluate sex-specific phenotypes in major brain diseases.
    MeSH term(s) Brain/anatomy & histology ; Brain/diagnostic imaging ; Brain Diseases/diagnostic imaging ; Brain Diseases/pathology ; Humans ; Magnetic Resonance Imaging ; Mental Disorders/diagnostic imaging ; Mental Disorders/pathology ; Neuroimaging ; Phenotype ; Sex Characteristics
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.25438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review.

    Salminen, Lauren E / Paul, Robert H

    Reviews in the neurosciences

    2014  Volume 25, Issue 6, Page(s) 805–819

    Abstract: Normal aging involves a gradual breakdown of physiological processes that leads to a decline in cognitive functions and brain integrity, yet the onset and progression of decline are variable among older individuals. While many biological changes may ... ...

    Abstract Normal aging involves a gradual breakdown of physiological processes that leads to a decline in cognitive functions and brain integrity, yet the onset and progression of decline are variable among older individuals. While many biological changes may contribute to this degree of variability, oxidative stress is a key mechanism of the aging process that can cause direct damage to cellular architecture within the brain. Oligodendrocytes are at a high risk for oxidative damage due to their role in myelin maintenance and production and limited repair mechanisms, suggesting that white matter may be particularly vulnerable to oxidative activity. Antioxidant defense enzymes within the brain, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST), are crucial for breaking down the harmful end products of oxidative phosphorylation. Previous studies have revealed that allele variations of polymorphisms that encode these antioxidants are associated with abnormalities in SOD, CAT, GPx, and GST activity in the central nervous system. This review will focus on the role of oxidative stress in the aging brain and the impact of decreased antioxidant defense on brain integrity and cognitive function. Directions for future research investigations of antioxidant defense genes will also be discussed.
    MeSH term(s) Aging/genetics ; Aging/metabolism ; Animals ; Antioxidants/physiology ; Brain/metabolism ; Brain/physiopathology ; Brain Diseases/genetics ; Brain Diseases/metabolism ; Brain Diseases/physiopathology ; Cognition Disorders/genetics ; Cognition Disorders/metabolism ; Cognition Disorders/physiopathology ; Genetic Markers/physiology ; Humans ; Oxidative Stress/genetics
    Chemical Substances Antioxidants ; Genetic Markers
    Language English
    Publishing date 2014-08-25
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 639035-3
    ISSN 2191-0200 ; 0334-1763
    ISSN (online) 2191-0200
    ISSN 0334-1763
    DOI 10.1515/revneuro-2014-0046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cortical microstructural associations with CSF amyloid and pTau.

    Nir, Talia M / Villalón-Reina, Julio E / Salminen, Lauren E / Haddad, Elizabeth / Zheng, Hong / Thomopoulos, Sophia I / Jack, Clifford R / Weiner, Michael W / Thompson, Paul M / Jahanshad, Neda

    Molecular psychiatry

    2023  

    Abstract: Diffusion MRI (dMRI) can be used to probe microstructural properties of brain tissue and holds great promise as a means to non-invasively map Alzheimer's disease (AD) pathology. Few studies have evaluated multi-shell dMRI models such as neurite ... ...

    Abstract Diffusion MRI (dMRI) can be used to probe microstructural properties of brain tissue and holds great promise as a means to non-invasively map Alzheimer's disease (AD) pathology. Few studies have evaluated multi-shell dMRI models such as neurite orientation dispersion and density imaging (NODDI) and mean apparent propagator (MAP)-MRI in cortical gray matter where many of the earliest histopathological changes occur in AD. Here, we investigated the relationship between CSF pTau
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02321-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: 20-year depressive symptoms, dementia, and structural neuropathology in older women.

    Petkus, Andrew J / Wang, Xinhui / Younan, Diana / Salminen, Lauren E / Resnick, Susan M / Rapp, Stephen R / Espeland, Mark A / Gatz, Margaret / Widaman, Keith F / Casanova, Ramon / Chui, Helena / Barnard, Ryan T / Gaussoin, Sarah A / Goveas, Joseph S / Hayden, Kathleen M / Henderson, Victor W / Sachs, Bonnie C / Saldana, Santiago / Shadyab, Aladdin H /
    Shumaker, Sally A / Chen, Jiu-Chiuan

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  

    Abstract: Introduction: The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes.: Methods: Utilizing joint latent class mixture models, we identified longitudinal trajectories of annually ... ...

    Abstract Introduction: The course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes.
    Methods: Utilizing joint latent class mixture models, we identified longitudinal trajectories of annually assessed depressive symptoms and dementia risk over 21 years in 957 older women (baseline age 72.7 years old) from the Women's Health Initiative Memory Study. In a subsample of 569 women who underwent structural magnetic resonance imaging, we examined whether estimates of cerebrovascular disease and Alzheimer's disease (AD)-related neurodegeneration were associated with identified trajectories.
    Results: Five trajectories of depressive symptoms and dementia risk were identified. Compared to women with minimal symptoms, women who reported mild and stable and emerging depressive symptoms were at the highest risk of developing dementia and had more cerebrovascular disease and AD-related neurodegeneration.
    Discussion: There are heterogeneous profiles of depressive symptoms and dementia risk. Common neuropathological factors may contribute to both depression and dementia. Highlights The progression of depressive symptoms and concurrent dementia risk is heterogeneous. Emerging depressive symptoms may be a prodromal symptom of dementia. Cerebrovascular disease and AD are potentially shared neuropathological factors.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Alzheimer's Related Neurodegeneration Mediates Air Pollution Effects on Medial Temporal Lobe Atrophy.

    Petkus, Andrew J / Salminen, Lauren E / Wang, Xinhui / Driscoll, Ira / Millstein, Joshua / Beavers, Daniel P / Espeland, Mark A / Braskie, Meredith N / Thompson, Paul M / Casanova, Ramon / Gatz, Margaret / Chui, Helena C / Resnick, Susan M / Kaufman, Joel D / Rapp, Stephen R / Shumaker, Sally / Younan, Diana / Chen, Jiu-Chiuan

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Exposure to ambient air pollution, especially particulate matter with aerodynamic diameter <2.5 μm ( ... ...

    Abstract Exposure to ambient air pollution, especially particulate matter with aerodynamic diameter <2.5 μm (PM
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.29.23299144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adaptive Identification of Cortical and Subcortical Imaging Markers of Early Life Stress and Posttraumatic Stress Disorder.

    Salminen, Lauren E / Morey, Rajendra A / Riedel, Brandalyn C / Jahanshad, Neda / Dennis, Emily L / Thompson, Paul M

    Journal of neuroimaging : official journal of the American Society of Neuroimaging

    2019  Volume 29, Issue 3, Page(s) 335–343

    Abstract: Background and purpose: Posttraumatic stress disorder (PTSD) is a heterogeneous condition associated with a range of brain imaging abnormalities. Early life stress (ELS) contributes to this heterogeneity, but we do not know how a history of ELS ... ...

    Abstract Background and purpose: Posttraumatic stress disorder (PTSD) is a heterogeneous condition associated with a range of brain imaging abnormalities. Early life stress (ELS) contributes to this heterogeneity, but we do not know how a history of ELS influences traditionally defined brain signatures of PTSD. Here, we used a novel machine learning method - evolving partitions to improve classification (EPIC) - to identify shared and unique structural neuroimaging markers of ELS and PTSD in 97 combat-exposed military veterans.
    Methods: We used EPIC with repeated cross-validation (CV) to determine how combinations of cortical thickness, surface area, and subcortical brain volumes could contribute to classification of PTSD (n = 40) versus controls (n = 57), and classification of ELS within the PTSD (ELS
    Results: On average, EPIC classified PTSD with 69% accuracy (SD = 5%), and ELS with 64% accuracy in the PTSD group (SD = 10%), and 62% accuracy in controls (SD = 6%). EPIC selected unique sets of individual features that classified each group with 75-85% accuracy in post hoc analyses; combinations of regions marginally improved classification from the individual atlas-defined brain regions. Across analyses, surface area in the right posterior cingulate was the only variable that was repeatedly selected as an important feature for classification of PTSD and ELS.
    Conclusions: EPIC revealed unique patterns of features that distinguished PTSD and ELS in this sample of combat-exposed military veterans, which may represent distinct biotypes of stress-related neuropathology.
    MeSH term(s) Adult ; Aged ; Brain/diagnostic imaging ; Female ; Humans ; Machine Learning ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Stress Disorders, Post-Traumatic/diagnostic imaging ; Stress, Psychological/diagnostic imaging ; Veterans ; Young Adult
    Language English
    Publishing date 2019-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1071724-9
    ISSN 1552-6569 ; 1051-2284
    ISSN (online) 1552-6569
    ISSN 1051-2284
    DOI 10.1111/jon.12600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Association between late-life air pollution exposure and medial temporal lobe atrophy in older women.

    Wang, Xinhui / Salminen, Lauren E / Petkus, Andrew J / Driscoll, Ira / Millstein, Joshua / Beavers, Daniel P / Espeland, Mark A / Erus, Guray / Braskie, Meredith N / Thompson, Paul M / Gatz, Margaret / Chui, Helena C / Resnick, Susan M / Kaufman, Joel D / Rapp, Stephen R / Shumaker, Sally / Brown, Mark / Younan, Diana / Chen, Jiu-Chiuan

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: Ambient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining exposure effects on the MTL were ... ...

    Abstract Background: Ambient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, existing MRI studies examining exposure effects on the MTL were cross-sectional and focused on the hippocampus, yielding mixed results.
    Method: To determine whether air pollution exposures were associated with MTL atrophy over time, we conducted a longitudinal study including 653 cognitively unimpaired community-dwelling older women from the Women's Health Initiative Memory Study with two MRI brain scans (MRI-1: 2005-6; MRI-2: 2009-10; M
    Results: On average, MTL volume decreased by 0.53±1.00cm
    Conclusion: In summary, higher late-life PM
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.28.23298708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Uncovering Biologically Coherent Peripheral Signatures of Health and Risk for Alzheimer's Disease in the Aging Brain.

    Riedel, Brandalyn C / Daianu, Madelaine / Ver Steeg, Greg / Mezher, Adam / Salminen, Lauren E / Galstyan, Aram / Thompson, Paul M

    Frontiers in aging neuroscience

    2018  Volume 10, Page(s) 390

    Abstract: Brain aging is a multifaceted process that remains poorly understood. Despite significant advances in technology, progress toward identifying reliable risk factors for suboptimal brain health requires realistically complex analytic methods to explain ... ...

    Abstract Brain aging is a multifaceted process that remains poorly understood. Despite significant advances in technology, progress toward identifying reliable risk factors for suboptimal brain health requires realistically complex analytic methods to explain relationships between genetics, biology, and environment. Here we show the utility of a novel unsupervised machine learning technique - Correlation Explanation (CorEx) - to discover how individual measures from structural brain imaging, genetics, plasma, and CSF markers can jointly provide information on risk for Alzheimer's disease (AD). We examined 829 participants (
    Language English
    Publishing date 2018-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2018.00390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cognitive and self-reported psychological outcomes of blast-induced mild traumatic brain injury in veterans: a preliminary study.

    Bolzenius, Jacob D / Roskos, P Tyler / Salminen, Lauren E / Paul, Robert H / Bucholz, Richard D

    Applied neuropsychology. Adult

    2015  Volume 22, Issue 2, Page(s) 79–87

    Abstract: The increased use of explosives in combat has resulted in a large number of returning veterans suffering from blast-related mild traumatic brain injury (mTBI) and self-reported complications. It remains unclear whether this increase in self-reported ... ...

    Abstract The increased use of explosives in combat has resulted in a large number of returning veterans suffering from blast-related mild traumatic brain injury (mTBI) and self-reported complications. It remains unclear whether this increase in self-reported difficulties is unique to the blast mechanism or stressful preinjury environment and whether cognitive-functioning deficits correspond with these difficulties in the postacute phase. This study examined the relationship between cognitive performance and self-reported psychological and somatic symptoms of blast-related mTBI compared with civilian mTBI, independent of comorbid posttraumatic stress disorder (PTSD) symptoms. Twelve veterans with blast-related mTBI were compared to 18 individuals with civilian mTBI on cognitive tests and self-report questionnaires. Univariate analyses failed to reveal differences on any individual cognitive test. Further, veterans reported more psychological and somatic complaints. These self-reported difficulties were not significantly correlated with neuropsychological performance. Overall, preliminary results suggest that in the postacute phase, subjective complaints related to blast-related mTBI do not covary with objective cognitive performance. Additionally, cognitive outcomes from blast-related mTBI were similar to those of civilian forms of mTBI. Future studies should identify the cognitive and self-reported sequelae of blast-related mTBI independent of comorbid PTSD in a larger sample of veterans.
    MeSH term(s) Adult ; Afghan Campaign 2001- ; Blast Injuries/complications ; Blast Injuries/psychology ; Brain Injuries/complications ; Brain Injuries/psychology ; Case-Control Studies ; Cognition Disorders/complications ; Cognition Disorders/psychology ; Humans ; Iraq War, 2003-2011 ; Male ; Middle Aged ; Neuropsychological Tests ; Self Report ; Stress Disorders, Post-Traumatic/complications ; Stress Disorders, Post-Traumatic/psychology ; Veterans/psychology ; Young Adult
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2327-9109
    ISSN (online) 2327-9109
    DOI 10.1080/23279095.2013.845823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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