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  1. Article ; Online: Our Role in Radiation Disaster Preparedness.

    Salner, Andrew L

    International journal of radiation oncology, biology, physics

    2017  Volume 100, Issue 4, Page(s) 849–850

    MeSH term(s) Disaster Planning/methods ; Disaster Planning/organization & administration ; Humans ; Natural Disasters ; Radiation Oncology/organization & administration ; Terrorism/trends ; United States
    Language English
    Publishing date 2017-12-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2017.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Connecticut Cancer Partnership: the development of a statewide comprehensive control program.

    Salner, Andrew L

    Connecticut medicine

    2012  Volume 76, Issue 6, Page(s) 327–330

    MeSH term(s) Centers for Disease Control and Prevention (U.S.) ; Connecticut ; Health Promotion/economics ; Health Promotion/organization & administration ; Humans ; Interinstitutional Relations ; Neoplasms/prevention & control ; Program Development ; Public Health ; United States
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412600-2
    ISSN 0010-6178
    ISSN 0010-6178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lutetium Lu-177 Dotatate Flare Reaction.

    Salner, Andrew L / Blankenship, Bette / Dunnack, Hayley / Niemann, Christopher / Bertsch, Helaine

    Advances in radiation oncology

    2020  Volume 6, Issue 1, Page(s) 100623

    Abstract: Purpose: Lutetium Lu-177 dotatate is the first peptide receptor radionuclide therapy approved by the US Food and Drug Administration. Well-designed studies in Europe have shown dramatic effectiveness in improving progression-free survival in patients ... ...

    Abstract Purpose: Lutetium Lu-177 dotatate is the first peptide receptor radionuclide therapy approved by the US Food and Drug Administration. Well-designed studies in Europe have shown dramatic effectiveness in improving progression-free survival in patients with gastroenteropancreatic neuroendocrine tumors, which are progressive and generally metastatic. This therapy is a molecular targeted therapy linking a beta-emitting radioisotope to dotatate, which binds tightly to somatostatin receptors on neuroendocrine tumors cells. Various adverse effects of this therapy have been reported in the literature, including potential toxicity to renal, hepatic, and hematologic tissues and risk of second malignancy. Our study sought to explore acute adverse effects in this patient population.
    Methods and materials: We tracked adverse effects and patient experience in our first year of therapy experience with this new agent.
    Results: In our first 12 patients who received Lutetium Lu-177 dotatate, tumor flare reactions occurred in 5 patients due to worsening symptoms of bone or soft tissue metastasis. This flare reaction can be mitigated with short course of corticosteroid therapy or other strategies.
    Conclusions: Flare reaction is common in patients with progressive metastatic gastroenteropancreatic neuroendocrine tumors and can be managed successfully with several strategies.
    Language English
    Publishing date 2020-11-26
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2020.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Interventions to promote adherence to endocrine therapy among breast cancer survivors: A meta-analysis.

    Finitsis, David J / Vose, Brittany A / Mahalak, Justin G / Salner, Andrew L

    Psycho-oncology

    2018  Volume 28, Issue 2, Page(s) 255–263

    Abstract: Objective: Adjuvant endocrine therapy (AET) significantly reduces risk of breast cancer recurrence in those patients whose tumor tests hormone (estrogen and/or progesterone) receptor positive. Many who are prescribed AET do not adhere adequately. ... ...

    Abstract Objective: Adjuvant endocrine therapy (AET) significantly reduces risk of breast cancer recurrence in those patients whose tumor tests hormone (estrogen and/or progesterone) receptor positive. Many who are prescribed AET do not adhere adequately. Studies have sought to examine the effects of interventions to enhance patients' AET adherence, with strikingly mixed results. In order to reconcile a disparate literature, this paper aims to (1) quantitatively review the aggregate effect of interventions designed to optimize AET adherence within the current literature and (2) meta-analyze these effects across studies' by intervention design.
    Methods: Duplicate searches were conducted using multiple electronic databases as well as hand searches of recent year conference abstracts. Studies were included that (1) tested an intervention to promote AET adherence; (2) reported at least one measure of medication adherence; and (3) reported (or provided upon request) data sufficient to calculate effect size. Effect sizes were calculated using random effects models.
    Results: Seven studies representing eight unique interventions were included. We observed an overall null effect across all interventions (k = 8; d [95% CI] = 0.28 [-0.05, 0.61]); however, sensitivity analyses showed that interventions that used bi-directional communication showed statistically significant effects relative to control groups within each study (k = 4; d [95% CI] = 0.59 [0.23, 0.95]) while those relying only on providing information to the patient (one-way communication) did not (k = 4; d [95% CI] = -0.03 [-0.27, 0.20]).
    Conclusions: Interventions that promote patient self-report may improve AET adherence through enhancing patient engagement. Investigators and clinicians who wish to optimize medication adherence in this population can consider this approach.
    MeSH term(s) Antineoplastic Agents, Hormonal/therapeutic use ; Breast Neoplasms/metabolism ; Breast Neoplasms/psychology ; Breast Neoplasms/therapy ; Cancer Survivors/statistics & numerical data ; Chemotherapy, Adjuvant/statistics & numerical data ; Combined Modality Therapy ; Female ; Humans ; Medication Adherence/statistics & numerical data ; Neoplasm Recurrence, Local/prevention & control ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism
    Chemical Substances Antineoplastic Agents, Hormonal ; Receptors, Estrogen ; Receptors, Progesterone
    Language English
    Publishing date 2018-12-28
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1118536-3
    ISSN 1099-1611 ; 1057-9249
    ISSN (online) 1099-1611
    ISSN 1057-9249
    DOI 10.1002/pon.4959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Descriptive Survey Study of Patient Needs and Preferences for Cancer Pain Self-Management Support.

    Anderson, Alice Jane / Starkweather, Angela / Cong, Xiaomei / Xu, Wanli / Judge, Michelle P / Schulman-Green, Dena / Zhang, Yiming / Salner, Andrew L / Dornelas, Ellen A

    Oncology nursing forum

    2022  Volume 49, Issue 1, Page(s) 46–57

    Abstract: Objectives: To characterize the needs and preferences for pain self-management support (SMS) among patients with cancer during the transition of cancer care from the hospital to the home setting.: Sample & setting: 38 participants with cancer pain at ...

    Abstract Objectives: To characterize the needs and preferences for pain self-management support (SMS) among patients with cancer during the transition of cancer care from the hospital to the home setting.
    Sample & setting: 38 participants with cancer pain at a research-intensive cancer center in New England.
    Methods & variables: A descriptive, cross-sectional survey study was conducted to investigate relationships among preferred and received support, extent and management of transitional change, and pain outcomes. Pain intensity and interference were measured using the Brief Pain Inventory-Short Form, transitional change was measured using the Measurement of Transitions in Cancer Scale, and SMS was measured using dichotomous questions.
    Results: About half of participants reported concordance between preferred and received cancer pain SMS in the hospital and at home. The extent of transitional change in cancer care was found to be a significant predictor of average pain intensity in the hospital and pain interference at home. Satisfaction with cancer pain SMS was a significant predictor of pain intensity at home.
    Implications for nursing: The extent of change during care transitions should be considered when fulfilling patient needs and preferences for cancer pain SMS to optimize outcomes.
    MeSH term(s) Adenosine Monophosphate ; Cancer Pain/therapy ; Cross-Sectional Studies ; Humans ; Neoplasms/complications ; Neoplasms/therapy ; Pain/etiology ; Self-Management
    Chemical Substances Adenosine Monophosphate (415SHH325A)
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604886-9
    ISSN 1538-0688 ; 0190-535X ; 1538-0688
    ISSN (online) 1538-0688 ; 0190-535X
    ISSN 1538-0688
    DOI 10.1188/22.ONF.46-57
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A randomized controlled trial of two mail-based lifestyle interventions for breast cancer survivors.

    Park, Crystal L / Cho, Dalnim / Salner, Andrew L / Dornelas, Ellen

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2016  Volume 24, Issue 7, Page(s) 3037–3046

    Abstract: Purpose: Although breast cancer survivors' lifestyle choices affect their subsequent health, a majority do not engage in healthy behaviors. Because treatment end is a "teachable moment" for potentially altering lifestyle change for breast cancer ... ...

    Abstract Purpose: Although breast cancer survivors' lifestyle choices affect their subsequent health, a majority do not engage in healthy behaviors. Because treatment end is a "teachable moment" for potentially altering lifestyle change for breast cancer survivors, we developed and tested two mail-based interventions for women who recently completed primary treatment.
    Methods: One hundred seventy-three survivors were randomly assigned to (1) Targeting the Teachable Moment (TTMI, n = 57), (2) Standard Lifestyle Management (SLM, n = 58), or (3) usual care (UC, n = 58) control group. Participants who were assigned to TTMI and SLM received relevant treatment materials biweekly for 4 months. Participants were assessed at baseline (T1, before randomization), post-treatment (T2, 4 months), and follow-up (T3, 7 months). Fruit and vegetable (F/V) intake, fat intake, and moderate-to-vigorous physical activity (MVPA) were assessed.
    Results: Results showed promise for these mail-based interventions for changes in health behaviors: Survivors in TTMI (+.47) and SLM (+.45) reported increased F/V intake, whereas those in UC (-.1) reported decreased F/V intake from T1 to T2. Changes in minutes of MVPA from T1 to T2 were higher in SLM than UC and marginally higher in TTMI than UC. However, these differences were due to decreased MVPA in UC rather than increased MVPA in the intervention groups. There were no group differences regarding fat intake. Survivors reported high satisfaction and preference for mail-based interventions, supporting feasibility.
    Conclusions: Mail-based lifestyle interventions for breast cancer survivors may benefit F/V intake and physical activity. Further testing and optimizing of these interventions is warranted.
    MeSH term(s) Breast Neoplasms/mortality ; Breast Neoplasms/psychology ; Breast Neoplasms/rehabilitation ; Breast Neoplasms/therapy ; Female ; Health Behavior ; Humans ; Life Style ; Middle Aged ; Postal Service/methods ; Survivors
    Language English
    Publishing date 2016-07
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-016-3129-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Serious adverse events in African-American cancer patients with sickle cell trait and inherited haemoglobinopathies in a SEER-Medicare claims cohort.

    Hoag, Jessica R / Andemariam, Biree / Wang, Xiaoyan / Gregorio, David I / Jones, Beth A / Sporn, Jonathan / Salner, Andrew L / Swede, Helen

    British journal of cancer

    2019  Volume 120, Issue 8, Page(s) 861–863

    Abstract: African-American (AA) cancer patients have long-experienced worse outcomes compared to non-Hispanic whites (NHW). No studies to date have evaluated the prognostic impact of sickle cell trait (SCT) and other inherited haemoglobinopathies, of which several ...

    Abstract African-American (AA) cancer patients have long-experienced worse outcomes compared to non-Hispanic whites (NHW). No studies to date have evaluated the prognostic impact of sickle cell trait (SCT) and other inherited haemoglobinopathies, of which several are disproportionately high in the AA population. In a cohort analysis of treated patients diagnosed with breast or prostate cancer in the linked SEER-Medicare database, the relative risk (RR) for ≥1 serious adverse events (AEs), defined as hospitalisations or emergency department visits, was estimated for 371 AA patients with a haemoglobinopathy (AA+) compared to patients without haemoglobinopathies (17,303 AA-; 144,863 NHW-). AA+ patients had significantly increased risk for ≥1 AEs compared to AA- (RR = 1.19; 95% CI 1.11-1.27) and NHW- (RR = 1.23; 95% CI 1.15-1.31) patients. The magnitude of effect was similar by cancer type, and in analyses of AA+ with SCT only. Our findings suggest a novel hypothesis for disparities in cancer outcomes.
    MeSH term(s) African Americans ; Drug-Related Side Effects and Adverse Reactions/pathology ; Female ; Hemoglobinopathies/blood ; Hemoglobinopathies/complications ; Hemoglobinopathies/epidemiology ; Hemoglobinopathies/pathology ; Humans ; Male ; Medicare ; Neoplasms/blood ; Neoplasms/complications ; Neoplasms/epidemiology ; Neoplasms/pathology ; Patients ; Risk Factors ; SEER Program ; Sickle Cell Trait/blood ; Sickle Cell Trait/complications ; Sickle Cell Trait/epidemiology ; Sickle Cell Trait/pathology ; United States/epidemiology ; Whites
    Language English
    Publishing date 2019-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-019-0416-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Perceptions of clinical support for employed breast cancer survivors managing work and health challenges.

    Dugan, Alicia G / Decker, Ragan E / Namazi, Sara / Cavallari, Jennifer M / Bellizzi, Keith M / Blank, Thomas O / Dornelas, Ellen A / Tannenbaum, Susan H / Shaw, William S / Swede, Helen / Salner, Andrew L

    Journal of cancer survivorship : research and practice

    2021  Volume 15, Issue 6, Page(s) 890–905

    Abstract: Purpose: A substantial portion of breast cancer survivors are active in the workforce, yet factors that allow survivors to balance work with cancer management and to return to work are poorly understood. We examined breast cancer survivors' most valued/ ... ...

    Abstract Purpose: A substantial portion of breast cancer survivors are active in the workforce, yet factors that allow survivors to balance work with cancer management and to return to work are poorly understood. We examined breast cancer survivors' most valued/desired types of support in early survivorship.
    Methods: Seventy-six employed breast cancer survivors answered an open-ended survey question assessing the most valued/desired support to receive from healthcare providers during early survivorship to manage work and health. Cutrona's (Journal of Social and Clinical Psychology 9:3-14, 1990) optimal matching theory and House's (1981) conceptualization of social support types informed our analyses. Data were content-analyzed to identify themes related to support, whether needed support was received or not, and the types of healthcare providers who provided support.
    Results: We identified six themes related to types of support. Informational support was valued and mostly received by survivors, but they expected more guidance related to work. Emotional support was valued but lacking, attributed mainly to providers' lack of personal connection and mental health support. Instrumental (practical) support was valued but received by a small number of participants. Quality of life support to promote well-being and functionality was valued and often received. Other themes included non-specific support and non-support.
    Conclusions: This study expands our understanding of how breast cancer survivors perceive work-related support from healthcare professionals. Findings will inform targeted interventions designed to improve the support provided by healthcare professionals.
    Implications for cancer survivors: Breast cancer survivors managing work and health challenges may benefit by having their unmet support needs fulfilled.
    MeSH term(s) Breast Neoplasms/therapy ; Cancer Survivors ; Female ; Humans ; Qualitative Research ; Quality of Life ; Social Support ; Survivors
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2388888-X
    ISSN 1932-2267 ; 1932-2259
    ISSN (online) 1932-2267
    ISSN 1932-2259
    DOI 10.1007/s11764-020-00982-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Comprehensive cancer control--impacting every physician.

    Salner, Andrew L / Silber, Andrea L M

    Connecticut medicine

    2012  Volume 76, Issue 6, Page(s) 325–326

    MeSH term(s) Connecticut ; Health Promotion/organization & administration ; Humans ; Neoplasms/epidemiology ; Neoplasms/prevention & control
    Language English
    Publishing date 2012-06
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 412600-2
    ISSN 0010-6178
    ISSN 0010-6178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Exploring implications of Medicaid participation and wait times for colorectal screening on early detection efforts in Connecticut--a secret-shopper survey.

    Patel, Vatsal B / Nahar, Richa / Murray, Betty / Salner, Andrew L

    Connecticut medicine

    2013  Volume 77, Issue 4, Page(s) 197–203

    Abstract: Background: Routine colorectal screening, decreases in incidence, and advances in treatment have lowered colorectal cancer mortality rates over the past three decades. Nevertheless, it remains the second most common cause of cancer death amongst men and ...

    Abstract Background: Routine colorectal screening, decreases in incidence, and advances in treatment have lowered colorectal cancer mortality rates over the past three decades. Nevertheless, it remains the second most common cause of cancer death amongst men and women combined in U.S. Most cases of colon cancer are diagnosed at a late stage leading to poor survival outcomes for patients. After extensive research of publically available data, it would appear that the state of Connecticut does not have available state-wide data on patient wait times for routine colonoscopy screening. Furthermore, there are no publicly available, or Connecticut-specific, reports on Medicaid participation rates for colorectal screening amongst gastroenterologists (GI) in Connecticut. In 2012, the American Cancer Society report on Colorectal Cancer Screening Rates confirmed barriers to health-care access and disparities in health outcomes and survival rates for colon cancer patients based on race, ethnicity, and low socioeconomic status. Given this information, one could conjecture that low Medicaid participation rates among GIs could potentially have a more severe impact on health-care access and outcomes for underserved populations. At present, funding and human resources are being employed across the state of Connecticut to address bottlenecks in colorectal cancer screening. More specifically, patient navigation and outreach programs are emerging and expanding to address the gaps in services for hard-to-reach populations and the medically underserved. Low Medicaid participation rates and increased wait times for colonoscopy screening may impair the efficacy of colorectal cancer patient navigation and outreach efforts and potentially funding for future interventions. In this study, we report the results of our secret-shopper telephone survey comprising of 93 group and independent gastroenterologist (GI) practices in different counties of Connecticut.
    Methods: Reviewing online resources and yellow pages, researchers compiled a county-specific list of GI practices throughout Connecticut and conducted a secret-shopper survey by telephone. A standard script and set of questions was formulated and used for each telephone call to GI practices. Data was analyzed in context of statistics available to the public at large from the U.S. Census Bureau.
    Results: Overall, 46% of all 93 practices and 62% of individual GIs from all 93 practices state-wide reported Medicaid participation. About 35% of surveyed practices were independent practices; 41% of these reported Medicaid participation. About 65% of surveyed practices were group practices; 49% of these reported Medicaid participation. Approximately, 85% of all practices are in Fairfield, Hartford, orNew Haven counties. Of all three counties, New Haven reported the highest Medicaid participation rate by practices; 62% of all practices in New Haven reported participation. Fairfield reported the lowest Medicaid participation rate by practices; 29% of all practices in Fairfield reported participation. When Medicaid participation rates were calculated for total number of gastroenterologists from all practices in a given county (as opposed to participation rates by number of practices), Medicaid participation rates were 80% and 44% for New Haven and Fairfield, respectively. Of all practices in Hartford, only 50% reported Medicaid participation, whereas 67% of the total number of gastroenterologists (as opposed to practices) reported Medicaid participation. According to a recent national survey, 47% of gastroenterologists reported stopping accepting new Medicaid patients. Overall minimum and maximum wait times were reported to be the highest for Hartford, but wait times were long even for smaller counties, reflecting a possible imbalance in supply and demand or inefficiency in allocating the available resources.
    Conclusions: Only a limited number of gastroenterology practices in Connecticut accept Medicaid patients, notably in selected counties, but in all counties, and this may add to access barriers. It is yet unclear whether these disparities are significant enough to create a supply-demand imbalance and thus, have a significantly negative impact on health outcomes for the underserved. Nevertheless, with the high unemployment rates and impending implementation of mandated state-wide health-care reform as outlined in the Affordable Care Act, the Medicaid population in the state of Connecticut will increase, increasing future demand for services. In addition, based on the survey findings, longer wait times for colonoscopy screening are reported for the many of GI practices in Connecticut for Medicaid-insured as well as non-Medicaid patients. Longer wait times may have an impact on patient compliance, especially for the underserved populations that are hard to reach and ensure follow-up, contributing to potential delayed diagnosis. A Medicaid-associated disparity in this area will serve to exacerbate the problem for the underserved compared to those relatively well served. Those currently not seeking screening are at even higher risk of contributing to the higher mortality rate, and we need to find out how best to ensure that we can more uniformly apply screening and have the capacity to do so.
    MeSH term(s) Colorectal Neoplasms/diagnosis ; Connecticut ; Early Detection of Cancer/statistics & numerical data ; Gastroenterology/statistics & numerical data ; Health Services Accessibility/statistics & numerical data ; Humans ; Medicaid/statistics & numerical data ; Time Factors ; United States ; Waiting Lists
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 412600-2
    ISSN 0010-6178
    ISSN 0010-6178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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