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  1. Article: Increase in invasive group A streptococcal infections in Milan, Italy: a genomic and clinical characterization.

    Mangioni, Davide / Fox, Valeria / Saltini, Paola / Lombardi, Andrea / Bussini, Linda / Carella, Francesco / Cariani, Lisa / Comelli, Agnese / Matinato, Caterina / Muscatello, Antonio / Teri, Antonio / Terranova, Leonardo / Cento, Valeria / Carloni, Sara / Bartoletti, Michele / Alteri, Claudia / Bandera, Alessandra

    Frontiers in microbiology

    2024  Volume 14, Page(s) 1287522

    Abstract: Background: Group A Streptococcus (GAS) causes multiple clinical manifestations, including invasive (iGAS) or even life-threatening (severe-iGAS) infections. After the drop in cases during COVID-19 pandemic, in 2022 a sharp increase of GAS was reported ... ...

    Abstract Background: Group A Streptococcus (GAS) causes multiple clinical manifestations, including invasive (iGAS) or even life-threatening (severe-iGAS) infections. After the drop in cases during COVID-19 pandemic, in 2022 a sharp increase of GAS was reported globally.
    Methods: GAS strains collected in 09/2022-03/2023 in two university hospitals in Milan, Italy were retrospectively analyzed. Clinical/epidemiological data were combined with whole-genome sequencing to: (i) define resistome/virulome, (ii) identify putative transmission chains, (iii) explore associations between
    Results: Twenty-eight isolates were available, 19/28 (67.9%) from adults and 9/28 (32.1%) from pediatric population. The criteria for iGAS were met by 19/28 cases (67.9%), of which 11/19 (39.3%) met the further criteria for severe-iGAS. Pediatric cases were mainly non-invasive infections (8/9, 88.9%), adult cases were iGAS and severe-iGAS in 18/19 (94.7%) and 10/19 (52.6%), respectively. Thirteen
    Conclusions: This study showed that multiple
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1287522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evidence gaps on weight gain in people living with HIV: a scoping review to define a research agenda.

    Guaraldi, Giovanni / Bonfanti, Paolo / Di Biagio, Antonio / Gori, Andrea / Milić, Jovana / Saltini, Paola / Segala, Francesco V / Squillace, Nicola / Taramasso, Lucia / Cingolani, Antonella

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 230

    Abstract: Background: Combined antiretroviral therapy (cART) dramatically improved survival in people living with HIV (PLWH) but is associated with weight gain (WG), raising concern for a possible obesity epidemic in PLWH. This scoping review aims to identify the ...

    Abstract Background: Combined antiretroviral therapy (cART) dramatically improved survival in people living with HIV (PLWH) but is associated with weight gain (WG), raising concern for a possible obesity epidemic in PLWH. This scoping review aims to identify the gaps in the existing evidence on WG in PLWH and generate a future research agenda.
    Methods: This review was conducted according to the methodology for scoping studies and reported according to the PRISMA Extension for Scoping Review checklist. Articles published in English in the last 10 years indexed in Pubmed, WHO Global Index Medicus, or Embase were searched using specific queries focused on WG in PLWH.
    Results: Following the selection process, 175 included articles were reviewed to search for the available evidence on four specific topics: (I) definition of WG in PLWH, (II) pathogenesis of WG in PLWH, (III) impact of ART on WG, (IV) correlation of WG with clinical outcomes. A summary of the data enabled us to identify gaps and clearly define the following research agenda: (I) develop a data-driven definition of WG in PLWH and define noninvasive assessment methods for body weight and fat composition; (II) further investigate the interaction between HIV/cART and immunity, metabolism, and adipose tissue; (III) establish the specific role of individual drugs on WG; (IV) clarify the independent role of WG, cART, HIV, and metabolic factors on clinical events.
    Conclusions: The proposed research agenda may help define future research and fill the knowledge gaps that have emerged from this review.
    MeSH term(s) Humans ; HIV Infections/epidemiology ; Evidence Gaps ; Weight Gain ; Obesity/complications ; Body Weight
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Systematic Review ; Review ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08174-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Preventing HIV mother-to-child transmission in a vertically infected pregnant woman with multiclass drug resistance, role of bis-in-die dolutegravir and neonatal AZT prophylaxis: A case report.

    Saltini, Paola / Tassis, Beatrice / Ronchi, Alice / Tagliabue, Claudia / Di Pietro, Giada / Dellepiane, Rosa Maria / Muscatello, Antonio / Giacomelli, Andrea / Pugni, Lorenza / Ferrazzi, Enrico / Bandera, Alessandra / Bozzi, Giorgio

    Heliyon

    2023  Volume 10, Issue 1, Page(s) e23072

    Abstract: A suppressive antiretroviral therapy (ART) is necessary to prevent mother-to-child transmission (MTCT) of HIV during pregnancy. During this period, it is recommended to continue an ongoing safe and suppressive regimen, but history of multiclass drug- ... ...

    Abstract A suppressive antiretroviral therapy (ART) is necessary to prevent mother-to-child transmission (MTCT) of HIV during pregnancy. During this period, it is recommended to continue an ongoing safe and suppressive regimen, but history of multiclass drug-resistance (MDR) might need tailored, uncommon approaches posing tolerability and toxicity issues. This is the case of a 33 years of age, vertically infected woman with MDR HIV infection suppressed on a darunavir/cobicistat + atazanavir regimen switched during pregnancy to lamivudine + darunavir/ritonavir + dolutegravir 50 mg bis-in-die, maintaining complete viral suppression and delivering via caesarian section and without zidovudine (AZT) intrapartum prophylaxis a healthy HIV-negative newborn who received AZT post-exposure prophylaxis and showed regular growth patterns up to 2 years. Our case shows how archived MDR might complicate the preservation of HIV RNA suppression and highlights the importance of a tailored, multidisciplinary approach for pregnant women with MDR HIV and their newborns.
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e23072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mucormycosis in CAPA, a Possible Fungal Super-Infection.

    Saltini, Paola / Palomba, Emanuele / Castelli, Valeria / Fava, Marco / Alagna, Laura / Biscarini, Simona / Mantero, Marco / Blasi, Francesco / Grancini, Anna / Bandera, Alessandra / Gori, Andrea / Muscatello, Antonio / Lombardi, Andrea

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 9

    Abstract: The occurrence of pulmonary fungal superinfection due ... ...

    Abstract The occurrence of pulmonary fungal superinfection due to
    Language English
    Publishing date 2021-08-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7090708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pneumocystis jirovecii pneumonia in HIV-negative patients, a frequently overlooked problem. A case series from a large Italian center.

    Bozzi, Giorgio / Saltini, Paola / Matera, Malvina / Morena, Valentina / Castelli, Valeria / Peri, Anna Maria / Taramasso, Lucia / Ungaro, Riccardo / Lombardi, Andrea / Muscatello, Antonio / Bono, Patrizia / Grancini, Anna / Maraschini, Anna / Matinato, Caterina / Gori, Andrea / Bandera, Alessandra

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 121, Page(s) 172–176

    Abstract: Background and objectives: Pneumocystis jirovecii pneumonia (PCP) still has substantial morbidity and mortality. For non-HIV patients, the course of infection is severe, and management guidelines are relatively recent. We collected all PCP cases ( ... ...

    Abstract Background and objectives: Pneumocystis jirovecii pneumonia (PCP) still has substantial morbidity and mortality. For non-HIV patients, the course of infection is severe, and management guidelines are relatively recent. We collected all PCP cases (European Organization for Research and Treatment of Cancer criteria) diagnosed in HIV-negative adult inpatients in 2019-2020 at our center in northern Italy.
    Results: Of 20 cases, nine had microbiologic evidence of probable (real-time polymerase chain reaction, RT-PCR) and 11 proven (immunofluorescence) PCP on respiratory specimens. Half were female; the median age was 71.5 years; 14 of 20 patients had hematologic malignancies, five had autoimmune/hyperinflammatory disorders, and one had a solid tumor. RT-PCR cycle threshold (Ct) was 24-37 for bronchoalveolar lavage (BAL) and 32-39 for sputum; Ct was 24-33 on BAL proven cases. Of 20 cases, four received additional diagnoses on BAL. At PCP diagnosis, all patients were not on anti-pneumocystis prophylaxis. We retrospectively assessed prophylaxis indications: 9/20 patients had a main indication, 5/9 because of prednisone treatment ≥ 20 mg (or equivalents) for ≥4 weeks. All patients underwent antimicrobial treatment according to guidelines; 18/20 with concomitant corticosteroids. A total of 4/20 patients died within 28 days from diagnosis.
    Conclusion: Despite appropriate treatment, PCP is still associated to high mortality (20%) among non-HIV patients. Strict adherence to prophylaxis guidelines, awareness of gray areas, and prompt diagnosis can help manage this frequently overlooked infection.
    MeSH term(s) Adult ; Aged ; Bronchoalveolar Lavage Fluid/microbiology ; Female ; HIV Infections/complications ; Humans ; Immunocompromised Host ; Male ; Pneumocystis carinii/genetics ; Pneumonia, Pneumocystis/diagnosis ; Pneumonia, Pneumocystis/drug therapy ; Pneumonia, Pneumocystis/epidemiology ; Real-Time Polymerase Chain Reaction ; Retrospective Studies
    Language English
    Publishing date 2022-05-11
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.05.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Treatment of SARS-CoV-2 relapse with remdesivir and neutralizing antibodies cocktail in a patient with X-linked agammaglobulinaemia.

    Palomba, Emanuele / Carrabba, Maria / Zuglian, Gianluca / Alagna, Laura / Saltini, Paola / Fortina, Valeria / Hu, Cinzia / Bandera, Alessandra / Fabio, Giovanna / Gori, Andrea / Muscatello, Antonio

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 110, Page(s) 338–340

    Abstract: During the coronavirus disease 2019 (COVID-19) pandemic, patients with humoral immunodeficiency are at higher risk of developing chronic infection and having a negative outcome. Few data are available on therapeutic options for this population. This case ...

    Abstract During the coronavirus disease 2019 (COVID-19) pandemic, patients with humoral immunodeficiency are at higher risk of developing chronic infection and having a negative outcome. Few data are available on therapeutic options for this population. This case report discusses the treatment of disease relapse with remdesivir and monoclonal antibodies in an adult patient with X-linked agammaglobulinaemia.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adult ; Agammaglobulinemia ; Alanine/analogs & derivatives ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/drug therapy ; Genetic Diseases, X-Linked ; Humans ; Recurrence ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2021-07-28
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.07.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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