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  1. Article ; Online: Management of Hemorrhoidal Disease in Special Conditions: A Word of Caution.

    Salusso, Paola / Testa, Valentina / Mochet, Sylvie / Arezzo, Alberto / Allaix, Marco Ettore / Salzano, Antonio / Morino, Mario / Mistrangelo, Massimiliano

    Reviews on recent clinical trials

    2020  Volume 16, Issue 1, Page(s) 22–31

    Abstract: Background: Hemorrhoids are a common disease that is often considered an easy problem to solve. Unfortunately, some particular clinical conditions, including Inflammatory Bowel Diseases (IBD), pregnancy, immunosuppression, coagulopathy, cirrhosis with ... ...

    Abstract Background: Hemorrhoids are a common disease that is often considered an easy problem to solve. Unfortunately, some particular clinical conditions, including Inflammatory Bowel Diseases (IBD), pregnancy, immunosuppression, coagulopathy, cirrhosis with portal hypertension, and proctitis after radiotherapy, challenge hemorrhoids management and the outcomes.
    Methods: Research and online contents related to hemorrhoids' treatment in special conditions are reviewed in order to help colorectal surgeons in daily practice.
    Results: There are very limited data about the outcomes of hemorrhoids treatment in these subgroups of patients. Patients in pregnancy can be effectively treated with medical therapy, reserving surgical intervention in highly selected and urgent cases. In case of thrombosed haemorrhoids, the excision allows a fast symptoms' resolution, with a low incidence of recurrence and a long remission interval. In case of immunosuppressed patients, there is no consensus for the best treatment, even in most HIV positive patients, a surgical procedure can be safely proposed when indicated. There is no sufficient data in the literature related to transplanted patients. The surgical treatment of hemorrhoids in patients with IBD, especially Crohn's Disease, can be unsafe, although there is a paucity of literature on this topic. In case of previous pelvic radiotherapy, it must always be considered that severe complications, like abscesses and fistulas with subsequent pelvic and retroperitoneal sepsis, can occur after surgical treatment of hemorrhoids, so a conservative treatment is advocated. Moreover, caution is recommended in treating patients with coagulopathy, considering possible complications (mostly bleeding) also after outpatient treatments. In case of portal hypertension and cirrhosis, a 'conservative treatment' is recommended. Bleeding hemorrhoids can be treated with hemorrhoidectomy when they do not respond to other treatments.
    Conclusion: International literature is very scant about the treatment of patients affected by hemorrhoids in particular situations. A word of caution and concern even about the indication for minor outpatient procedures must be expressed in these patients, in order to avoid possible life-threatening complications. The first-line treatment is the conservative medical approach associated with the treatment of the primary disease.
    MeSH term(s) Crohn Disease ; Hemorrhoidectomy ; Hemorrhoids/complications ; Hemorrhoids/diagnosis ; Hemorrhoids/therapy ; Humans ; Inflammatory Bowel Diseases ; Recurrence ; Treatment Outcome
    Language English
    Publishing date 2020-04-06
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2251879-4
    ISSN 1876-1038 ; 1574-8871
    ISSN (online) 1876-1038
    ISSN 1574-8871
    DOI 10.2174/1574887115666200406121308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Oral neomycin and bacitracin are effective in preventing surgical site infections in elective colorectal surgery: a multicentre, randomized, parallel, single-blinded trial (COLORAL-1).

    Arezzo, Alberto / Mistrangelo, Massimiliano / Bonino, Marco Augusto / Salusso, Paola / Forcignanò, Edoardo / Vettoretto, Nereo / Botteri, Emanuele / Cillara, Nicola / Ottonello, Roberto / Testa, Valentina / De Rosa, Francesco Giuseppe / Corcione, Silvia / Passera, Roberto / Morino, Mario

    Updates in surgery

    2021  Volume 73, Issue 5, Page(s) 1775–1786

    Abstract: Several regimens of oral and intravenous antibiotics (OIVA) have been proposed with contradicting results, and the role of mechanical bowel preparation (MBP) is still controversial. This study aims to assess the effectiveness of oral antibiotic ... ...

    Abstract Several regimens of oral and intravenous antibiotics (OIVA) have been proposed with contradicting results, and the role of mechanical bowel preparation (MBP) is still controversial. This study aims to assess the effectiveness of oral antibiotic prophylaxis in preventing Surgical Site Infections (SSI) in elective colorectal surgery. In a multicentre trial, we randomized patients undergoing elective colorectal resection surgery, comparing the effectiveness of OIVA versus intravenous antibiotics (IVA) regimens to prevent SSI as the primary outcome (NCT04438655). In addition to intravenous Amoxicillin/Clavulanic, patients in the OIVA group received Oral Neomycin and Bacitracin 24 h before surgery. MBP was administered according to local habits which were not changed for the study. The trial was terminated during the COVID-19 pandemic, as many centers failed to participate as well as the pandemic changed the rules for engaging patients. Two-hundred and four patients were enrolled (100 in the OIVA and 104 in the IVA group); 3 SSIs (3.4%) were registered in the OIVA and 14 (14.4%) in the IVA group (p = 0.010). No difference was observed in terms of anastomotic leak. Multivariable analysis indicated that OIVA reduced the rate of SSI (OR 0.21 / 95% CI 0.06-0.78 / p = 0.019), while BMI is a risk factor of SSI (OR 1.15 / 95% CI 1.01-1.30 p = 0.039). Subgroup analysis indicated that 0/22 patients who underwent OIVA/MBP + vs 13/77 IVA/MBP- experienced an SSI (p = 0.037). The early termination of the study prevents any conclusion regarding the interpretation of the data. Nonetheless, Oral Neomycin/Bacitracin and intravenous beta-lactam/beta-lactamases inhibitors seem to reduce SSI after colorectal resections, although not affecting the anastomotic leak in this trial. The role of MBP requires more investigation.
    MeSH term(s) Administration, Oral ; Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis ; Bacitracin ; COVID-19 ; Cathartics/therapeutic use ; Colectomy ; Colorectal Surgery/adverse effects ; Elective Surgical Procedures ; Humans ; Neomycin ; Pandemics ; Preoperative Care ; SARS-CoV-2 ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/prevention & control
    Chemical Substances Anti-Bacterial Agents ; Cathartics ; Bacitracin (1405-87-4) ; Neomycin (I16QD7X297)
    Language English
    Publishing date 2021-06-20
    Publishing country Italy
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-01112-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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