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Article ; Online: Effect of culture parameters on the heat tolerance and inorganic polyphosphate accumulation by Lacticaseibacillus rhamnosus CRL1505, a multifunctional bacterium.

Correa Deza, M A / Salva, S / Grillo-Puertas, M / Font, G M / Gerez, C L

World journal of microbiology & biotechnology

2023 Volume 39, Issue 7, Page(s) 182

Abstract: Lacticaseibacillus rhamnosus CRL1505 can be used in functional products as a probiotic powder (dried live cells) or as a postbiotic intracellular extract containing inorganic polyphosphate as a functional biopolymer. Thus, the aim of this work was to ... ...

Abstract	Lacticaseibacillus rhamnosus CRL1505 can be used in functional products as a probiotic powder (dried live cells) or as a postbiotic intracellular extract containing inorganic polyphosphate as a functional biopolymer. Thus, the aim of this work was to optimize the production of Lr-CRL1505 depending on the target of the functional product (probiotic or postbiotic). For this purpose, the effect of culture parameters (pH, growth phase) on cell viability, heat tolerance and polyphosphate accumulation by Lacticaseibacillus rhamnosus CRL1505 was evaluated. Fermentations at free pH produced less biomass (0.6 log units) than at controlled pH while the growth phase affected both polyphosphate accumulation and cell heat tolerance. Exponential phase cultures showed 4-15 times greater survival rate against heat shock and 49-62% increased polyphosphate level, compared with the stationary phase. Results obtained allowed setting the appropriate culture conditions for the production of this strain according to its potential application, i.e., as live probiotic cells in powder form or postbiotic. In the first case, running fermentations at pH 5.5 and harvesting the cells at the exponential phase are the best conditions for obtaining a high live biomass yield capable of overcoming heat stress. Whereas the postbiotic formulations production requires fermentations at free pH and harvesting the cells in exponential phase to increase the intracellular polyphosphate level as a first step.
MeSH term(s)	Lacticaseibacillus rhamnosus ; Thermotolerance ; Lacticaseibacillus ; Polyphosphates ; Powders ; Probiotics
Chemical Substances	Polyphosphates ; Powders
Language	English
Publishing date	2023-05-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1499109-3
ISSN	1573-0972 ; 0959-3993
ISSN (online)	1573-0972
ISSN	0959-3993
DOI	10.1007/s11274-023-03625-0
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Book ; Online: Investigating the Violation of Charge Parity Symmetry Through Top Quark Chromo-Electric Dipole Moments by Using Machine Learning Techniques

Işıldak, B. / Hayreter, A. / Hüdaverdi, M. / Ilgın, F. / Salva, S. / Şimşek, E. / Güyer, S.

2023

Abstract: There are a number of studies in the literature on search for Charge-Parity (CP) violating signals in top quark productions at the LHC. In most of these studies, ChromoMagnetic Dipole Moments (CMDM) and ChromoElectric Dipole Moments (CEDM) of top quarks ... ...

Abstract	There are a number of studies in the literature on search for Charge-Parity (CP) violating signals in top quark productions at the LHC. In most of these studies, ChromoMagnetic Dipole Moments (CMDM) and ChromoElectric Dipole Moments (CEDM) of top quarks is bounded either by deviations from the Standard Model (SM) cross sections or by T-odd asymmetries in di-muon channels. However, the required precision on these cross section values are far beyond from that of ATLAS or CMS experiments can reach. In this letter, the investigation of CEDM based asymmetries in the semileptonic top pair decays are presented as T-odd asymmetries in CMS experiment. Expected asymmetry values are determined at the detector level using MadGraph5, Pythia8 and Delphes softwares along with the discrimination of the signal and the background with Deep Neural Networks (DNN). Comment: 10 pages
Keywords	High Energy Physics - Experiment ; High Energy Physics - Phenomenology ; High Energy Physics - Theory
Subject code	621
Publishing date	2023-06-20
Publishing country	us
Document type	Book ; Online
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Article ; Online: Can Lacticaseibacillus rhamnosus CRL1505 postbiotic improve emergency myelopoiesis in immunocompromised mice?

López, Andrés Gramajo / Vasile, Brenda / Kolling, Yanina / Ivir, Maximiliano / Gutiérrez, Florencia / Alvarez, Susana / Salva, Susana

Microbes and infection

2024 , Page(s) 105311

Abstract: We evaluated whether viable and non-viable Lacticaseibacillus rhamnosus CRL1505 (Lr05V or Lr05NV, respectively) was able to improve emergency myelopoiesis induced by Streptococcus pneumoniae (Sp) infection. Adult Swiss-mice were orally treated with Lr05V ...

Abstract	We evaluated whether viable and non-viable Lacticaseibacillus rhamnosus CRL1505 (Lr05V or Lr05NV, respectively) was able to improve emergency myelopoiesis induced by Streptococcus pneumoniae (Sp) infection. Adult Swiss-mice were orally treated with Lr05V or Lr05NV during five consecutive days. The Lr05V and Lr05NV groups and untreated control group received an intraperitoneal dose of cyclophosphamide (Cy-150 mg/kg). Then, the mice were nasally challenged with Sp (10
Language	English
Publishing date	2024-02-09
Publishing country	France
Document type	Journal Article
ZDB-ID	1465093-9
ISSN	1769-714X ; 1286-4579
ISSN (online)	1769-714X
ISSN	1286-4579
DOI	10.1016/j.micinf.2024.105311
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Article ; Online: Inorganic Additive Improves the Survival of the Probiotic Lacticaseibacillus rhamnosus CRL1505 During Spray Drying, Rehydration, and Storage.

Correa Deza, M A / Díaz Vergara, L / Salva, S / Montenegro, M A / Font de Valdez, G / Gerez, C L

Current microbiology

2021 Volume 78, Issue 11, Page(s) 3863–3871

Abstract: In previous in vitro studies, an inorganic additive ( ... ...

Abstract	In previous in vitro studies, an inorganic additive (MCM
MeSH term(s)	Culture Media ; Fluid Therapy ; Powders ; Probiotics ; Spray Drying
Chemical Substances	Culture Media ; Powders
Language	English
Publishing date	2021-09-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-021-02648-w
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Article: The Role of Immunobiotics and Postbiotics in the Recovery of Immune Cell Populations From Respiratory Mucosa of Malnourished Hosts: Effect on the Resistance Against Respiratory Infections.

Salva, Susana / Kolling, Yanina / Ivir, Maximiliano / Gutiérrez, Florencia / Alvarez, Susana

Frontiers in nutrition

2021 Volume 8, Page(s) 704868

Abstract: Malnutrition is associated with a state of secondary immunodeficiency, which is characterized by a worsening of the immune response against infectious agents. Despite important advances in vaccines and antibiotic therapies, the respiratory infections are ...

Abstract	Malnutrition is associated with a state of secondary immunodeficiency, which is characterized by a worsening of the immune response against infectious agents. Despite important advances in vaccines and antibiotic therapies, the respiratory infections are among the leading causes of increased morbidity and mortality, especially in immunosuppressed hosts. In this review, we examine the interactions between immunobiotics-postbiotics and the immune cell populations of the respiratory mucosa. In addition, we discuss how this cross talk affects the maintenance of a normal generation of immune cells, that is crucial for the establishment of protective innate and adaptive immune responses. Particular attention will be given to the alterations in the development of phagocytic cells, T and B lymphocytes in bone marrow, spleen and thymus in immunosuppression state by protein deprivation. Furthermore, we describe our research that demonstrated that the effectiveness of immunobiotics nasal administration in accelerating the recovery of the respiratory immune response in malnourished hosts. Finally, we propose the peptidoglycan from the immunobiotic
Language	English
Publishing date	2021-08-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2021.704868
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Article: The Role of Microbiota and Immunobiotics in Granulopoiesis of Immunocompromised Hosts.

Salva, Susana / Alvarez, Susana

Frontiers in immunology

2017 Volume 8, Page(s) 507

Abstract: The number of granulocytes is maintained by a regulated balance between granulopoiesis in the bone marrow and clearance and destruction in peripheral tissues. Granulopoiesis plays a fundamental role in the innate immune response. Therefore, factors ... ...

Abstract	The number of granulocytes is maintained by a regulated balance between granulopoiesis in the bone marrow and clearance and destruction in peripheral tissues. Granulopoiesis plays a fundamental role in the innate immune response. Therefore, factors affecting the normal granulopoiesis lead to alterations in innate defenses and reduce the resistance against infections. In this study, we give a description on recent advances regarding the molecular and cellular events that regulate steady-state and emergency granulopoiesis, which are crucial processes for the generation of protective innate immune responses. Particular attention will be given to emergency granulopoiesis alterations in immunosuppression states caused by malnutrition and chemotherapy. The role of microbiota in maintaining a steady-state granulopoiesis and the immunological mechanisms involved are also discussed. Moreover, we describe the findings of our laboratory demonstrating that the dietary supplementation with immunobiotics is an interesting alternative to improve steady-state and emergency granulopoiesis, the respiratory innate immune response, and the resistance against respiratory pathogens in immunocompromised hosts.
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.00507
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Article ; Online: Lactobacillus rhamnosus CRL1505 nasal administration improves recovery of T-cell mediated immunity against pneumococcal infection in malnourished mice.

Barbieri, N / Herrera, M / Salva, S / Villena, J / Alvarez, S

Beneficial microbes

2017 Volume 8, Issue 3, Page(s) 393–405

Abstract: Immunobiotic lactic acid bacteria have become an interesting alternative for the prevention of respiratory infections. Previously, we demonstrated that the nasal administration of Lactobacillus rhamnosus CRL1505, during repletion of malnourished mice, ... ...

Abstract	Immunobiotic lactic acid bacteria have become an interesting alternative for the prevention of respiratory infections. Previously, we demonstrated that the nasal administration of Lactobacillus rhamnosus CRL1505, during repletion of malnourished mice, resulted in diminished susceptibility to the challenge with the respiratory pathogen Streptococcus pneumoniae. Considering the known alterations induced by malnutrition on T lymphocytes and the importance of this cell population on the protection against respiratory pathogens, we aimed to study the effect of L. rhamnosus CRL1505 nasal administration on the recovery of T cell-mediated defences against pneumococcal infection in malnourished mice under nutritional recovery. Malnourished mice received a balanced conventional diet (BCD) for seven days or BCD for seven days with nasal L. rhamnosus CRL1505 supplementation during last two days of the treatment. After the treatments mice were infected with S. pneumoniae. Flow cytometry studies were carried out in bone marrow, thymus, spleen and lung to study T cells, and Th
Language	English
Publishing date	2017-05-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2561259-1
ISSN	1876-2891 ; 1876-2883
ISSN (online)	1876-2891
ISSN	1876-2883
DOI	10.3920/BM2016.0152
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Article ; Online: Pneumonia in immunocompetent patients: combination antibiotic therapy.

Salva, S / Borgatta, B / Rello, J

Minerva anestesiologica

2014 Volume 80, Issue 4, Page(s) 495–503

Abstract: Pneumonia's burden is still important worldwide not only because of its high incidence and mortality, but also for the elevated costs related to it. Despite the concerted efforts to reduce the incidence of sepsis-related complications, they continue to ... ...

Abstract	Pneumonia's burden is still important worldwide not only because of its high incidence and mortality, but also for the elevated costs related to it. Despite the concerted efforts to reduce the incidence of sepsis-related complications, they continue to represent a major human and economic burden. The cornerstone of sepsis management is early appropriate empiric broad spectrum antibiotics, resuscitation, and source control. The association between inappropriate use of antibiotics and increased mortality is the rationale for the use of empiric antibiotic combination therapy in critically ill patients. The aim of this manuscript was to discuss recent literature regarding the management of severe pneumonia, both community-acquired and hospital-acquired/ventilator-associated, in critically ill patients. Use of combination therapy is warranted in severe infections with shock; considerations should be made on the importance of optimal antibiotic administration and adverse reactions, thus providing guidance for a rational use of antibiotics.
MeSH term(s)	Algorithms ; Anti-Bacterial Agents/therapeutic use ; Cross Infection/drug therapy ; Drug Therapy, Combination ; Humans ; Immunocompetence ; Pneumonia, Bacterial/drug therapy ; Pneumonia, Ventilator-Associated/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2014-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
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Article ; Online: Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable

Gramajo Lopez, Andrés / Gutiérrez, Florencia / Saavedra, Lucila / Hebert, Elvira Maria / Alvarez, Susana / Salva, Susana

Frontiers in immunology

2021 Volume 12, Page(s) 647049

Abstract: Myelosuppression is the major dose-limiting toxicity of cancer chemotherapy. There have been many attempts to find new strategies that reduce myelosuppression. The dietary supplementation with lactic acid bacteria (LAB) improved respiratory innate immune ...

Abstract	Myelosuppression is the major dose-limiting toxicity of cancer chemotherapy. There have been many attempts to find new strategies that reduce myelosuppression. The dietary supplementation with lactic acid bacteria (LAB) improved respiratory innate immune response and the resistance against respiratory pathogens in immunosupressed hosts. Although LAB viability is an important factor in achieving optimal protective effects, non-viable LAB are capable of stimulating immunity. In this work, we studied the ability of oral preventive administration of viable and non-viable
MeSH term(s)	Administration, Oral ; Animals ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Bone Marrow Cells/metabolism ; Cyclophosphamide/toxicity ; Immunity, Innate/drug effects ; Immunity, Innate/immunology ; Immunocompromised Host/drug effects ; Immunocompromised Host/immunology ; Immunosuppressive Agents/toxicity ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Lactobacillus/immunology ; Lactobacillus rhamnosus/immunology ; Leukocyte Count ; Lymphocytes/drug effects ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Male ; Mice ; Myeloid Cells/drug effects ; Myeloid Cells/immunology ; Myelopoiesis/drug effects ; Myelopoiesis/immunology ; Probiotics/administration & dosage
Chemical Substances	Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2021-04-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.647049
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Article ; Online: Lactobacillus rhamnosus postbiotic-induced immunomodulation as safer alternative to the use of live bacteria.

Salva, Susana / Tiscornia, Inés / Gutiérrez, Florencia / Alvarez, Susana / Bollati-Fogolín, Mariela

Cytokine

2021 Volume 146, Page(s) 155631

Abstract: Many attempts have been made to search for safer immunomodulatory agents that enhance the immune response and reduce the number and severity of infections in at-risk populations. The use of postbiotics, non-viable microbial cells or cell fractions that ... ...

Abstract	Many attempts have been made to search for safer immunomodulatory agents that enhance the immune response and reduce the number and severity of infections in at-risk populations. The use of postbiotics, non-viable microbial cells or cell fractions that confer a health benefit to the consumer, represents a safe and attractive way to modulate and enhance the immune function in order to improve human health. Therefore, the aim of this work is to evaluate the immunoregulatory effect of Lactobacillus rhamnosus CRL1505 postbiotics in a complex culture system using human intestinal epithelial cells (IECs) and dendritic cells (DCs) differentiated from peripheral blood mononuclear cells. First, we demonstrated that L. rhamnosus CRL1505 differentially modulate human IECs and DCs after the challenge with the TLR4 agonist LPS. The CRL1505 strain down-regulated CD40, CD80 and CD86 expression in DCs, and increased their production of TNF-α, IL-1β, IL-6 and IL-10. Interestingly, the non-viable strain was able to modulate the immune response of both types of human cells. Then, we showed that cell wall (CW1505) and peptidoglycan (PG1505) from L. rhamnosus CRL1505 modulated TLR4-triggered immune response in IECs and DCs. Of interest, CW1505 showed a strong stimulatory effect while the PG1505 presented immune characteristics that were more similar to viable and non-viable CRL1505. To date, several molecules of immunobiotics were identified, that can be connected to specific host-responses. We hereby demonstrated that peptidoglycan of L. rhamnosus CRL1505 is a key molecule for the immunobiotic properties of this strain in human IECs and DCs. Likewise, the result of these studies could provide predictive tools for the in vivo efficacy of postbiotics and the scientific basis for their future applications in immunocompromised patients.
MeSH term(s)	Cytokines/metabolism ; Dendritic Cells/metabolism ; Enterocytes/metabolism ; HT29 Cells ; Humans ; Immunomodulation ; Lactobacillus rhamnosus/immunology ; Microbial Viability ; Models, Biological ; NF-kappa B/metabolism
Chemical Substances	Cytokines ; NF-kappa B
Language	English
Publishing date	2021-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2021.155631
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